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Items: 14


Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist.

Myagmar BE, Ismaili T, Swigart PM, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC.

Circ Res. 2019 Sep 13;125(7):699-706. doi: 10.1161/CIRCRESAHA.118.314416. Epub 2019 Aug 20.


Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia.

Jasoliya M, Sacca F, Sahdeo S, Chedin F, Pane C, Brescia Morra V, Filla A, Pook M, Cortopassi G.

PLoS One. 2019 Jun 3;14(6):e0217776. doi: 10.1371/journal.pone.0217776. eCollection 2019.


Pharmacology of JNJ-28583113: A novel TRPM2 antagonist.

Fourgeaud L, Dvorak C, Faouzi M, Starkus J, Sahdeo S, Wang Q, Lord B, Coate H, Taylor N, He Y, Qin N, Wickenden A, Carruthers N, Lovenberg TW, Penner R, Bhattacharya A.

Eur J Pharmacol. 2019 Jun 15;853:299-307. doi: 10.1016/j.ejphar.2019.03.043. Epub 2019 Apr 6.


In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride.

Datta S, He G, Tomilov A, Sahdeo S, Denison MS, Cortopassi G.

Environ Health Perspect. 2017 Aug 22;125(8):087015. doi: 10.1289/EHP1404.


Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans.

Hayashi G, Jasoliya M, Sahdeo S, Saccà F, Pane C, Filla A, Marsili A, Puorro G, Lanzillo R, Brescia Morra V, Cortopassi G.

Hum Mol Genet. 2017 Aug 1;26(15):2864-2873. doi: 10.1093/hmg/ddx167.


A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents.

Datta S, Sahdeo S, Gray JA, Morriseau C, Hammock BD, Cortopassi G.

Mitochondrion. 2016 Nov;31:79-83. doi: 10.1016/j.mito.2016.10.001. Epub 2016 Oct 4.


Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.

Copik AJ, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, Dietrich PJ, Fitch B, Raymond JR, Ford AP, Button D, Milla ME.

PLoS One. 2015 Jan 21;10(1):e0115701. doi: 10.1371/journal.pone.0115701. eCollection 2015.


Shc depletion stimulates brown fat activity in vivo and in vitro.

Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G.

Aging Cell. 2014 Dec;13(6):1049-58. doi: 10.1111/acel.12267. Epub 2014 Sep 26.


Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia.

Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA.

Hum Mol Genet. 2014 Dec 20;23(25):6848-62. doi: 10.1093/hmg/ddu408. Epub 2014 Aug 11.


High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects.

Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G.

Mitochondrion. 2014 Jul;17:116-25. doi: 10.1016/j.mito.2014.07.002. Epub 2014 Jul 14.


Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator.

Sahdeo S, Wallace T, Hirakawa R, Knoflach F, Bertrand D, Maag H, Misner D, Tombaugh GC, Santarelli L, Brameld K, Milla ME, Button DC.

J Pharmacol Exp Ther. 2014 Aug;350(2):455-68. doi: 10.1124/jpet.113.210963. Epub 2014 Jun 10.


Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection.

Fash DM, Khdour OM, Sahdeo SJ, Goldschmidt R, Jaruvangsanti J, Dey S, Arce PM, Collin VC, Cortopassi GA, Hecht SM.

Bioorg Med Chem. 2013 Apr 15;21(8):2346-2354. doi: 10.1016/j.bmc.2013.01.075. Epub 2013 Feb 13.


Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries.

Morisseau C, Sahdeo S, Cortopassi G, Hammock BD.

Anal Biochem. 2013 Mar 1;434(1):105-11. doi: 10.1016/j.ab.2012.11.017. Epub 2012 Dec 3.


Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction.

Copik AJ, Ma C, Kosaka A, Sahdeo S, Trane A, Ho H, Dietrich PS, Yu H, Ford AP, Button D, Milla ME.

Mol Pharmacol. 2009 Mar;75(3):713-28. doi: 10.1124/mol.108.050765. Epub 2008 Dec 24.


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