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Items: 42

1.

NanoDDS 2018: Engineering the next wave of nanomedicine and drug delivery systems.

Sahay G.

Adv Drug Deliv Rev. 2019 Apr;144:1-2. doi: 10.1016/j.addr.2019.09.001. No abstract available.

PMID:
31521228
2.

Brief update on endocytosis of nanomedicines.

Patel S, Kim J, Herrera M, Mukherjee A, Kabanov AV, Sahay G.

Adv Drug Deliv Rev. 2019 Apr;144:90-111. doi: 10.1016/j.addr.2019.08.004. Epub 2019 Aug 13. Review.

PMID:
31419450
3.

NanoDDS 2018: The 16th International Nanomedicine & Drug Delivery Symposium.

Hennink WE, Sahay G.

J Control Release. 2019 Aug 12;310:22-23. doi: 10.1016/j.jconrel.2019.08.009. [Epub ahead of print] No abstract available.

PMID:
31415829
4.

Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides.

Kim J, Narayana A, Patel S, Sahay G.

Theranostics. 2019 May 18;9(11):3191-3212. doi: 10.7150/thno.33921. eCollection 2019. Review.

5.

Lipid nanoparticles for delivery of messenger RNA to the back of the eye.

Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G.

J Control Release. 2019 Jun 10;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. Epub 2019 Apr 12.

PMID:
30986436
6.

Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models.

Lübtow MM, Nelke LC, Seifert J, Kühnemundt J, Sahay G, Dandekar G, Nietzer SL, Luxenhofer R.

J Control Release. 2019 Jun 10;303:162-180. doi: 10.1016/j.jconrel.2019.04.014. Epub 2019 Apr 11.

PMID:
30981815
7.

Micellar Formulation of Talazoparib and Buparlisib for Enhanced DNA Damage in Breast Cancer Chemoradiotherapy.

DuRoss AN, Neufeld MJ, Landry MR, Rosch JG, Eaton CT, Sahay G, Thomas CR Jr, Sun C.

ACS Appl Mater Interfaces. 2019 Apr 3;11(13):12342-12356. doi: 10.1021/acsami.9b02408. Epub 2019 Mar 21.

PMID:
30860347
8.

Nanoalginates via Inverse-Micelle Synthesis: Doxorubicin-Encapsulation and Breast Cancer Cytotoxicity.

Rosch JG, Brown AL, DuRoss AN, DuRoss EL, Sahay G, Sun C.

Nanoscale Res Lett. 2018 Nov 3;13(1):350. doi: 10.1186/s11671-018-2748-2.

9.

Facile Synthesis of Ligand-Free Iridium Nanoparticles and Their In Vitro Biocompatibility.

Brown AL, Winter H, Goforth AM, Sahay G, Sun C.

Nanoscale Res Lett. 2018 Jul 13;13(1):208. doi: 10.1186/s11671-018-2621-3.

10.

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis.

Robinson E, MacDonald KD, Slaughter K, McKinney M, Patel S, Sun C, Sahay G.

Mol Ther. 2018 Aug 1;26(8):2034-2046. doi: 10.1016/j.ymthe.2018.05.014. Epub 2018 Jun 15.

11.

Biodistribution and Toxicity of Micellar Platinum Nanoparticles in Mice via Intravenous Administration.

Brown AL, Kai MP, DuRoss AN, Sahay G, Sun C.

Nanomaterials (Basel). 2018 Jun 7;8(6). pii: E410. doi: 10.3390/nano8060410.

12.

Messenger RNA Delivery for Tissue Engineering and Regenerative Medicine Applications.

Patel S, Athirasala A, Menezes PP, Ashwanikumar N, Zou T, Sahay G, Bertassoni LE.

Tissue Eng Part A. 2019 Jan;25(1-2):91-112. doi: 10.1089/ten.TEA.2017.0444. Epub 2018 Jun 7. Review.

PMID:
29661055
13.

Supramolecular self assembly of nanodrill-like structures for intracellular delivery.

Ashwanikumar N, Plaut JS, Mostofian B, Patel S, Kwak P, Sun C, McPhail K, Zuckerman DM, Esener SC, Sahay G.

J Control Release. 2018 Jul 28;282:76-89. doi: 10.1016/j.jconrel.2018.02.041. Epub 2018 Mar 1.

14.

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA.

Patel S, Ashwanikumar N, Robinson E, DuRoss A, Sun C, Murphy-Benenato KE, Mihai C, Almarsson Ö, Sahay G.

Nano Lett. 2017 Sep 13;17(9):5711-5718. doi: 10.1021/acs.nanolett.7b02664. Epub 2017 Aug 24.

15.

Pembrolizumab reactivates pulmonary granulomatosis.

Al-Dliw M, Megri M, Shahoub I, Sahay G, Limjoco TI, Shweihat Y.

Respir Med Case Rep. 2017 Jul 28;22:126-129. doi: 10.1016/j.rmcr.2017.07.010. eCollection 2017.

16.

In vitro and ex vivo strategies for intracellular delivery.

Stewart MP, Sharei A, Ding X, Sahay G, Langer R, Jensen KF.

Nature. 2016 Oct 13;538(7624):183-192. doi: 10.1038/nature19764. Review.

PMID:
27734871
17.

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder.

Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G.

Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750.

18.

Effect of Steroid Prophylaxis on Nerve Function Impairment in Multi-bacillary Leprosy Patients on MDT-MB.

Sahay G, Kar HK, Gupta R.

Indian J Lepr. 2015 Jul-Sep;87(3):133-43.

PMID:
26999985
19.

Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers.

Stewart MP, Lorenz A, Dahlman J, Sahay G.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 May;8(3):465-78. doi: 10.1002/wnan.1377. Epub 2015 Nov 5. Review.

PMID:
26542891
20.

Neutrophil Responses to Sterile Implant Materials.

Jhunjhunwala S, Aresta-DaSilva S, Tang K, Alvarez D, Webber MJ, Tang BC, Lavin DM, Veiseh O, Doloff JC, Bose S, Vegas A, Ma M, Sahay G, Chiu A, Bader A, Langan E, Siebert S, Li J, Greiner DL, Newburger PE, von Andrian UH, Langer R, Anderson DG.

PLoS One. 2015 Sep 10;10(9):e0137550. doi: 10.1371/journal.pone.0137550. eCollection 2015.

21.

Small RNA combination therapy for lung cancer.

Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, Jacks T.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3553-61. doi: 10.1073/pnas.1412686111. Epub 2014 Aug 11.

22.

Niemann-Pick C1 affects the gene delivery efficacy of degradable polymeric nanoparticles.

Eltoukhy AA, Sahay G, Cunningham JM, Anderson DG.

ACS Nano. 2014 Aug 26;8(8):7905-13. doi: 10.1021/nn501630h. Epub 2014 Jul 16.

23.

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG.

Nat Nanotechnol. 2014 Aug;9(8):648-655. doi: 10.1038/nnano.2014.84. Epub 2014 May 11.

24.

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. doi: 10.1073/pnas.1322937111. Epub 2014 Feb 10. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753.

25.

Rational design of a biomimetic cell penetrating peptide library.

Karagiannis ED, Urbanska AM, Sahay G, Pelet JM, Jhunjhunwala S, Langer R, Anderson DG.

ACS Nano. 2013 Oct 22;7(10):8616-26. doi: 10.1021/nn4027382. Epub 2013 Sep 30.

26.

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery.

Alabi CA, Love KT, Sahay G, Yin H, Luly KM, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12881-6. doi: 10.1073/pnas.1306529110. Epub 2013 Jul 23.

27.

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.

Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG.

Nat Biotechnol. 2013 Jul;31(7):653-8. doi: 10.1038/nbt.2614. Epub 2013 Jun 23.

28.

Modular 'click-in-emulsion' bone-targeted nanogels.

Heller DA, Levi Y, Pelet JM, Doloff JC, Wallas J, Pratt GW, Jiang S, Sahay G, Schroeder A, Schroeder JE, Chyan Y, Zurenko C, Querbes W, Manzano M, Kohane DS, Langer R, Anderson DG.

Adv Mater. 2013 Mar 13;25(10):1449-54. doi: 10.1002/adma.201202881. Epub 2012 Dec 27.

29.

Core-shell hydrogel microcapsules for improved islets encapsulation.

Ma M, Chiu A, Sahay G, Doloff JC, Dholakia N, Thakrar R, Cohen J, Vegas A, Chen D, Bratlie KM, Dang T, York RL, Hollister-Lock J, Weir GC, Anderson DG.

Adv Healthc Mater. 2013 May;2(5):667-72. doi: 10.1002/adhm.201200341. Epub 2012 Dec 3.

30.

Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles.

Alabi CA, Sahay G, Langer R, Anderson DG.

Integr Biol (Camb). 2013 Jan;5(1):224-30. doi: 10.1039/c2ib20155k.

31.

FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes.

Alabi CA, Love KT, Sahay G, Stutzman T, Young WT, Langer R, Anderson DG.

ACS Nano. 2012 Jul 24;6(7):6133-41. doi: 10.1021/nn3013838. Epub 2012 Jun 22.

32.

Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation.

Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, Jeon A, Dong Y, Whitehead KA, Anderson DG.

J Am Chem Soc. 2012 Apr 25;134(16):6948-51. doi: 10.1021/ja301621z. Epub 2012 Apr 10.

PMID:
22475086
33.

Alkane-modified short polyethyleneimine for siRNA delivery.

Schroeder A, Dahlman JE, Sahay G, Love KT, Jiang S, Eltoukhy AA, Levins CG, Wang Y, Anderson DG.

J Control Release. 2012 Jun 10;160(2):172-6. doi: 10.1016/j.jconrel.2011.11.030. Epub 2011 Dec 2.

34.

Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.

Siegwart DJ, Whitehead KA, Nuhn L, Sahay G, Cheng H, Jiang S, Ma M, Lytton-Jean A, Vegas A, Fenton P, Levins CG, Love KT, Lee H, Cortez C, Collins SP, Li YF, Jang J, Querbes W, Zurenko C, Novobrantseva T, Langer R, Anderson DG.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):12996-3001. doi: 10.1073/pnas.1106379108. Epub 2011 Jul 22.

35.

Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery.

Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, Zurenko C, Querbes W, Langer RS, Anderson DG.

Mol Ther. 2011 Sep;19(9):1688-94. doi: 10.1038/mt.2011.141. Epub 2011 Jul 12.

36.

Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles.

Luxenhofer R, Sahay G, Schulz A, Alakhova D, Bronich TK, Jordan R, Kabanov AV.

J Control Release. 2011 Jul 15;153(1):73-82. doi: 10.1016/j.jconrel.2011.04.010. Epub 2011 Apr 13.

37.

Polymeric micelles with ionic cores containing biodegradable cross-links for delivery of chemotherapeutic agents.

Kim JO, Sahay G, Kabanov AV, Bronich TK.

Biomacromolecules. 2010 Apr 12;11(4):919-26. doi: 10.1021/bm9013364.

38.

Endocytosis of nanomedicines.

Sahay G, Alakhova DY, Kabanov AV.

J Control Release. 2010 Aug 3;145(3):182-95. doi: 10.1016/j.jconrel.2010.01.036. Epub 2010 Mar 10. Review.

39.

The utilization of pathogen-like cellular trafficking by single chain block copolymer.

Sahay G, Gautam V, Luxenhofer R, Kabanov AV.

Biomaterials. 2010 Mar;31(7):1757-64. doi: 10.1016/j.biomaterials.2009.11.020. Epub 2009 Dec 5.

40.

The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents.

Sahay G, Kim JO, Kabanov AV, Bronich TK.

Biomaterials. 2010 Feb;31(5):923-33. doi: 10.1016/j.biomaterials.2009.09.101. Epub 2009 Oct 22.

41.

Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA.

Yang Z, Sahay G, Sriadibhatla S, Kabanov AV.

Bioconjug Chem. 2008 Oct;19(10):1987-94. doi: 10.1021/bc800144a. Epub 2008 Aug 27.

42.

Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport.

Sahay G, Batrakova EV, Kabanov AV.

Bioconjug Chem. 2008 Oct;19(10):2023-9. doi: 10.1021/bc8002315. Epub 2008 Aug 27.

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