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Items: 1 to 50 of 102

1.

Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells.

Elster D, Tollot M, Schlegelmilch K, Ori A, Rosenwald A, Sahai E, von Eyss B.

Nat Commun. 2018 Sep 12;9(1):3781. doi: 10.1038/s41467-018-06266-2.

2.

TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells.

Elster D, Tollot M, Schlegelmilch K, Ori A, Rosenwald A, Sahai E, von Eyss B.

Nat Commun. 2018 Aug 6;9(1):3115. doi: 10.1038/s41467-018-05370-7. Erratum in: Nat Commun. 2018 Sep 12;9(1):3781.

3.

Publisher Correction: Mechanisms and impact of altered tumour mechanics.

Mohammadi H, Sahai E.

Nat Cell Biol. 2018 Sep;20(9):1099. doi: 10.1038/s41556-018-0163-7.

PMID:
29991753
4.

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy.

Sparks H, Kondo H, Hooper S, Munro I, Kennedy G, Dunsby C, French P, Sahai E.

Nat Commun. 2018 Jul 9;9(1):2662. doi: 10.1038/s41467-018-04820-6.

5.

Mechanisms and impact of altered tumour mechanics.

Mohammadi H, Sahai E.

Nat Cell Biol. 2018 Jul;20(7):766-774. doi: 10.1038/s41556-018-0131-2. Epub 2018 Jun 27. Review. Erratum in: Nat Cell Biol. 2018 Sep;20(9):1099.

PMID:
29950570
6.

Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export.

Ege N, Dowbaj AM, Jiang M, Howell M, Hooper S, Foster C, Jenkins RP, Sahai E.

Cell Syst. 2018 Jun 27;6(6):692-708.e13. doi: 10.1016/j.cels.2018.05.006. Epub 2018 Jun 18.

7.

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation.

Arwert EN, Harney AS, Entenberg D, Wang Y, Sahai E, Pollard JW, Condeelis JS.

Cell Rep. 2018 May 1;23(5):1239-1248. doi: 10.1016/j.celrep.2018.04.007.

8.

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.

Böttcher JP, Bonavita E, Chakravarty P, Blees H, Cabeza-Cabrerizo M, Sammicheli S, Rogers NC, Sahai E, Zelenay S, Reis e Sousa C.

Cell. 2018 Feb 22;172(5):1022-1037.e14. doi: 10.1016/j.cell.2018.01.004. Epub 2018 Feb 8.

9.

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.

Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G, Godinho SA.

J Cell Biol. 2018 Jan 2;217(1):195-209. doi: 10.1083/jcb.201704102. Epub 2017 Nov 13.

10.

Evolution and cancer medicine - transformative insights.

Sahai E, Swanton C; and Marshall Symposium.

Nat Rev Clin Oncol. 2017 Dec;14(12):709-710. doi: 10.1038/nrclinonc.2017.121. Epub 2017 Aug 22. No abstract available.

PMID:
28829058
11.

Integrating Models to Quantify Environment-Mediated Drug Resistance.

Picco N, Sahai E, Maini PK, Anderson ARA.

Cancer Res. 2017 Oct 1;77(19):5409-5418. doi: 10.1158/0008-5472.CAN-17-0835. Epub 2017 Jul 28. Erratum in: Cancer Res. 2018 Feb 15;78(4):1124.

12.

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.

Takaki T, Montagner M, Serres MP, Le Berre M, Russell M, Collinson L, Szuhai K, Howell M, Boulton SJ, Sahai E, Petronczki M.

Nat Commun. 2017 Jul 24;8:16013. doi: 10.1038/ncomms16013.

13.

Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.

Gosens R, Giangreco A, Sahai E, Chambers RC.

Eur Respir Rev. 2017 Jun 28;26(144). pii: 170060. doi: 10.1183/16000617.0060-2017. Print 2017 Jun 30. No abstract available.

14.

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion.

Labernadie A, Kato T, Brugués A, Serra-Picamal X, Derzsi S, Arwert E, Weston A, González-Tarragó V, Elosegui-Artola A, Albertazzi L, Alcaraz J, Roca-Cusachs P, Sahai E, Trepat X.

Nat Cell Biol. 2017 Mar;19(3):224-237. doi: 10.1038/ncb3478. Epub 2017 Feb 20.

15.

Tumor Microenvironment and Differential Responses to Therapy.

Hirata E, Sahai E.

Cold Spring Harb Perspect Med. 2017 Jul 5;7(7). pii: a026781. doi: 10.1101/cshperspect.a026781. Review.

PMID:
28213438
16.

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.

van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW.

Nat Commun. 2016 Dec 22;7:13874. doi: 10.1038/ncomms13874.

17.

Integrin signalling regulates YAP and TAZ to control skin homeostasis.

Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ.

Development. 2016 May 15;143(10):1674-87. doi: 10.1242/dev.133728. Epub 2016 Mar 17.

18.

Chris Marshall (1949-2015)--a personal reflection and tribute.

Sahai E.

J Cell Sci. 2015 Nov 15;128(22):4033-4. No abstract available.

19.

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.

Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, Hanby AM, Speirs V, Sahai E, Calvo F, Isacke CM.

Nat Commun. 2016 Jan 18;7:10305. doi: 10.1038/ncomms10305.

20.

Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.

Calvo F, Ranftl R, Hooper S, Farrugia AJ, Moeendarbary E, Bruckbauer A, Batista F, Charras G, Sahai E.

Cell Rep. 2015 Dec 29;13(12):2699-714. doi: 10.1016/j.celrep.2015.11.052. Epub 2015 Dec 17.

21.

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.

Del Pozo Martin Y, Park D, Ramachandran A, Ombrato L, Calvo F, Chakravarty P, Spencer-Dene B, Derzsi S, Hill CS, Sahai E, Malanchi I.

Cell Rep. 2015 Dec 22;13(11):2456-2469. doi: 10.1016/j.celrep.2015.11.025. Epub 2015 Dec 6.

22.

Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling.

Jenkins RP, Hanisch A, Soza-Ried C, Sahai E, Lewis J.

PLoS Comput Biol. 2015 Nov 20;11(11):e1004459. doi: 10.1371/journal.pcbi.1004459. eCollection 2015 Nov.

23.

Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.

Herraiz C, Calvo F, Pandya P, Cantelli G, Rodriguez-Hernandez I, Orgaz JL, Kang N, Chu T, Sahai E, Sanz-Moreno V.

J Natl Cancer Inst. 2015 Oct 13;108(1). pii: djv289. doi: 10.1093/jnci/djv289. Print 2016 Jan.

24.

Chris Marshall 1949-2015.

Lloyd A, Sahai E.

Nat Cell Biol. 2015 Oct;17(10):1229. doi: 10.1038/ncb3247. No abstract available.

PMID:
26419800
25.

Extrinsic factors can mediate resistance to BRAF inhibition in central nervous system melanoma metastases.

Seifert H, Hirata E, Gore M, Khabra K, Messiou C, Larkin J, Sahai E.

Pigment Cell Melanoma Res. 2016 Jan;29(1):92-100. doi: 10.1111/pcmr.12424. Epub 2015 Nov 3.

26.

MST kinases in development and disease.

Thompson BJ, Sahai E.

J Cell Biol. 2015 Sep 14;210(6):871-82. doi: 10.1083/jcb.201507005. Review.

27.

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Zelenay S, van der Veen AG, Böttcher JP, Snelgrove KJ, Rogers N, Acton SE, Chakravarty P, Girotti MR, Marais R, Quezada SA, Sahai E, Reis e Sousa C.

Cell. 2015 Sep 10;162(6):1257-70. doi: 10.1016/j.cell.2015.08.015. Epub 2015 Sep 3.

28.

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.

EMBO Rep. 2015 Oct;16(10):1394-408. doi: 10.15252/embr.201540107. Epub 2015 Aug 31.

29.

Cost-benefit analysis of the mechanisms that enable migrating cells to sustain motility upon changes in matrix environments.

Tozluoglu M, Mao Y, Bates PA, Sahai E.

J R Soc Interface. 2015 May 6;12(106). pii: 20141355. doi: 10.1098/rsif.2014.1355.

30.

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.

Hirata E, Girotti MR, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R, Sahai E.

Cancer Cell. 2015 Apr 13;27(4):574-88. doi: 10.1016/j.ccell.2015.03.008.

31.

Rho kinase inhibitors block melanoma cell migration and inhibit metastasis.

Sadok A, McCarthy A, Caldwell J, Collins I, Garrett MD, Yeo M, Hooper S, Sahai E, Kuemper S, Mardakheh FK, Marshall CJ.

Cancer Res. 2015 Jun 1;75(11):2272-84. doi: 10.1158/0008-5472.CAN-14-2156. Epub 2015 Apr 3.

32.

STRIPAK components determine mode of cancer cell migration and metastasis.

Madsen CD, Hooper S, Tozluoglu M, Bruckbauer A, Fletcher G, Erler JT, Bates PA, Thompson B, Sahai E.

Nat Cell Biol. 2015 Jan;17(1):68-80. doi: 10.1038/ncb3083. Epub 2014 Dec 22.

33.

An open data ecosystem for cell migration research.

Masuzzo P, Martens L; 2014 Cell Migration Workshop Participants, Ampe C, Anderson KI, Barry J, De Wever O, Debeir O, Decaestecker C, Dolznig H, Friedl P, Gaggioli C, Geiger B, Goldberg IG, Horn E, Horwitz R, Kam Z, Le Dévédec SE, Vignjevic DM, Moore J, Olivo-Marin JC, Sahai E, Sansone SA, Sanz-Moreno V, Strömblad S, Swedlow J, Textor J, Van Troys M, Zantl R.

Trends Cell Biol. 2015 Feb;25(2):55-8. doi: 10.1016/j.tcb.2014.11.005. Epub 2014 Dec 5.

PMID:
25484346
34.

Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells.

Manning CS, Hooper S, Sahai EA.

Oncogene. 2015 Aug 13;34(33):4320-32. doi: 10.1038/onc.2014.362. Epub 2014 Nov 10.

35.

Physical influences of the extracellular environment on cell migration.

Charras G, Sahai E.

Nat Rev Mol Cell Biol. 2014 Dec;15(12):813-24. doi: 10.1038/nrm3897. Epub 2014 Oct 30. Review.

PMID:
25355506
36.

Dendritic cells control fibroblastic reticular network tension and lymph node expansion.

Acton SE, Farrugia AJ, Astarita JL, Mourão-Sá D, Jenkins RP, Nye E, Hooper S, van Blijswijk J, Rogers NC, Snelgrove KJ, Rosewell I, Moita LF, Stamp G, Turley SJ, Sahai E, Reis e Sousa C.

Nature. 2014 Oct 23;514(7523):498-502. doi: 10.1038/nature13814.

37.

Editorial overview: cell adhesion and migration.

Huttenlocher A, Sahai E.

Curr Opin Cell Biol. 2014 Oct;30:v-vi. doi: 10.1016/j.ceb.2014.08.001. Epub 2014 Aug 29. No abstract available.

PMID:
25179864
38.

Retrograde flow of cadherins in collective cell migration.

Hirata E, Park D, Sahai E.

Nat Cell Biol. 2014 Jul;16(7):621-3. doi: 10.1038/ncb2995.

PMID:
24981633
39.

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.

40.

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids.

Linch M, Sanz-Garcia M, Rosse C, Riou P, Peel N, Madsen CD, Sahai E, Downward J, Khwaja A, Dillon C, Roffey J, Cameron AJ, Parker PJ.

Carcinogenesis. 2014 Feb;35(2):396-406. doi: 10.1093/carcin/bgt313. Epub 2013 Sep 26.

41.

Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions.

Tozluoğlu M, Tournier AL, Jenkins RP, Hooper S, Bates PA, Sahai E.

Nat Cell Biol. 2013 Jul;15(7):751-62. doi: 10.1038/ncb2775. Epub 2013 Jun 23.

PMID:
23792690
42.

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

Calvo F, Ege N, Grande-Garcia A, Hooper S, Jenkins RP, Chaudhry SI, Harrington K, Williamson P, Moeendarbary E, Charras G, Sahai E.

Nat Cell Biol. 2013 Jun;15(6):637-46. doi: 10.1038/ncb2756. Epub 2013 May 26.

43.

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.

Briones-Orta MA, Levy L, Madsen CD, Das D, Erker Y, Sahai E, Hill CS.

Cancer Res. 2013 Mar 15;73(6):1800-10. doi: 10.1158/0008-5472.CAN-12-1916. Epub 2013 Mar 6.

44.

Imaging tumor cell movement in vivo.

Entenberg D, Kedrin D, Wyckoff J, Sahai E, Condeelis J, Segall JE.

Curr Protoc Cell Biol. 2013 Mar;Chapter 19:Unit19.7. doi: 10.1002/0471143030.cb1907s58.

45.

Imbalance of desmoplastic stromal cell numbers drives aggressive cancer processes.

Kadaba R, Birke H, Wang J, Hooper S, Andl CD, Di Maggio F, Soylu E, Ghallab M, Bor D, Froeling FE, Bhattacharya S, Rustgi AK, Sahai E, Chelala C, Sasieni P, Kocher HM.

J Pathol. 2013 May;230(1):107-17. doi: 10.1002/path.4172. Epub 2013 Mar 21.

46.

New dimensions in cell migration.

Friedl P, Sahai E, Weiss S, Yamada KM.

Nat Rev Mol Cell Biol. 2012 Nov;13(11):743-7. doi: 10.1038/nrm3459. Epub 2012 Oct 17. Review.

PMID:
23072889
47.

Classifying collective cancer cell invasion.

Friedl P, Locker J, Sahai E, Segall JE.

Nat Cell Biol. 2012 Aug;14(8):777-83. doi: 10.1038/ncb2548. Review.

PMID:
22854810
48.

Autocrine IL-1β-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFα signalling to carcinoma-associated fibroblasts.

Chaudhry SI, Hooper S, Nye E, Williamson P, Harrington K, Sahai E.

Oncogene. 2013 Feb 7;32(6):747-58. doi: 10.1038/onc.2012.91. Epub 2012 Mar 26.

49.

In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.

Hirata E, Yukinaga H, Kamioka Y, Arakawa Y, Miyamoto S, Okada T, Sahai E, Matsuda M.

J Cell Sci. 2012 Feb 15;125(Pt 4):858-68. doi: 10.1242/jcs.089995. Epub 2012 Mar 7.

50.

ROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stroma.

Sanz-Moreno V, Gaggioli C, Yeo M, Albrengues J, Wallberg F, Viros A, Hooper S, Mitter R, Féral CC, Cook M, Larkin J, Marais R, Meneguzzi G, Sahai E, Marshall CJ.

Cancer Cell. 2011 Aug 16;20(2):229-45. doi: 10.1016/j.ccr.2011.06.018.

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