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Items: 35

1.

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1.

Fettelschoss V, Burda P, Sagné C, Coelho D, De Laet C, Lutz S, Suormala T, Fowler B, Pietrancosta N, Gasnier B, Bornhauser B, Froese DS, Baumgartner MR.

J Biol Chem. 2017 Jul 14;292(28):11980-11991. doi: 10.1074/jbc.M117.784819. Epub 2017 Jun 1.

2.

SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.

Verdon Q, Boonen M, Ribes C, Jadot M, Gasnier B, Sagné C.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3602-E3611. doi: 10.1073/pnas.1617066114. Epub 2017 Apr 17.

3.

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis J, Wang Q, Hopper JL, Southey MC, Broeks A, Schmidt MK, Lophatananon A, Muir K, Beckmann MW, Fasching PA, Dos-Santos-Silva I, Peto J, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel P, Truong T, Bojesen SE, Flyger H, González-Neira A, Perez JI, Anton-Culver H, Eunjung L, Arndt V, Brenner H, Meindl A, Schmutzler RK, Brauch H, Hamann U, Aittomäki K, Blomqvist C, Ito H, Matsuo K, Bogdanova N, Dörk T, Lindblom A, Margolin S, Kosma VM, Mannermaa A, Tseng CC, Wu AH, Lambrechts D, Wildiers H, Chang-Claude J, Rudolph A, Peterlongo P, Radice P, Olson JE, Giles GG, Milne RL, Haiman CA, Henderson BE, Goldberg MS, Teo SH, Yip CH, Nord S, Borresen-Dale AL, Kristensen V, Long J, Zheng W, Pylkäs K, Winqvist R, Andrulis IL, Knight JA, Devilee P, Seynaeve C, Figueroa J, Sherman ME, Czene K, Darabi H, Hollestelle A, van den Ouweland AM, Humphreys K, Gao YT, Shu XO, Cox A, Cross SS, Blot W, Cai Q, Ghoussaini M, Perkins BJ, Shah M, Choi JY, Kang D, Lee SC, Hartman M, Kabisch M, Torres D, Jakubowska A, Lubinski J, Brennan P, Sangrajrang S, Ambrosone CB, Toland AE, Shen CY, Wu PE, Orr N, Swerdlow A, McGuffog L, Healey S, Lee A, Kapuscinski M, John EM, Terry MB, Daly MB, Goldgar DE, Buys SS, Janavicius R, Tihomirova L, Tung N, Dorfling CM, van Rensburg EJ, Neuhausen SL, Ejlertsen B, Hansen TV, Osorio A, Benitez J, Rando R, Weitzel JN, Bonanni B, Peissel B, Manoukian S, Papi L, Ottini L, Konstantopoulou I, Apostolou P, Garber J, Rashid MU, Frost D; EMBRACE, Izatt L, Ellis S, Godwin AK, Arnold N, Niederacher D, Rhiem K, Bogdanova-Markov N, Sagne C, Stoppa-Lyonnet D, Damiola F; GEMO Study Collaborators, Sinilnikova OM, Mazoyer S, Isaacs C, Claes KB, De Leeneer K, de la Hoya M, Caldes T, Nevanlinna H, Khan S, Mensenkamp AR; HEBON, Hooning MJ, Rookus MA, Kwong A, Olah E, Diez O, Brunet J, Pujana MA, Gronwald J, Huzarski T, Barkardottir RB, Laframboise R, Soucy P, Montagna M, Agata S, Teixeira MR; kConFab Investigators, Park SK, Lindor N, Couch FJ, Tischkowitz M, Foretova L, Vijai J, Offit K, Singer CF, Rappaport C, Phelan CM, Greene MH, Mai PL, Rennert G, Imyanitov EN, Hulick PJ, Phillips KA, Piedmonte M, Mulligan AM, Glendon G, Bojesen A, Thomassen M, Caligo MA, Yoon SY, Friedman E, Laitman Y, Borg A, von Wachenfeldt A, Ehrencrona H, Rantala J, Olopade OI, Ganz PA, Nussbaum RL, Gayther SA, Nathanson KL, Domchek SM, Arun BK, Mitchell G, Karlan BY, Lester J, Maskarinec G, Woolcott C, Scott C, Stone J, Apicella C, Tamimi R, Luben R, Khaw KT, Helland Å, Haakensen V, Dowsett M, Pharoah PD, Simard J, Hall P, García-Closas M, Vachon C, Chenevix-Trench G, Antoniou AC, Easton DF, Edwards SL.

Nat Genet. 2016 Apr;48(4):374-86. doi: 10.1038/ng.3521. Epub 2016 Feb 29.

4.

Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts.

Perriaud L, Marcel V, Sagne C, Favaudon V, Guédin A, De Rache A, Guetta C, Hamon F, Teulade-Fichou MP, Hainaut P, Mergny JL, Hall J.

Carcinogenesis. 2014 Dec;35(12):2706-15. doi: 10.1093/carcin/bgu206. Epub 2014 Sep 30.

5.

PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitro hepatocellular carcinoma models.

Guillot C, Favaudon V, Herceg Z, Sagne C, Sauvaigo S, Merle P, Hall J, Chemin I.

BMC Cancer. 2014 Aug 20;14:603. doi: 10.1186/1471-2407-14-603.

6.

Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures.

Sagne C, Marcel V, Bota M, Martel-Planche G, Nobrega A, Palmero EI, Perriaud L, Boniol M, Vagner S, Cox DG, Chan CS, Mergny JL, Olivier M, Ashton-Prolla P, Hall J, Hainaut P, Achatz MI.

Carcinogenesis. 2014 Apr;35(4):807-15. doi: 10.1093/carcin/bgt381. Epub 2013 Dec 11.

7.

An extended proteome map of the lysosomal membrane reveals novel potential transporters.

Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A.

Mol Cell Proteomics. 2013 Jun;12(6):1572-88. doi: 10.1074/mcp.M112.021980. Epub 2013 Feb 24.

8.

A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects.

Sagne C, Marcel V, Amadou A, Hainaut P, Olivier M, Hall J.

Cell Death Dis. 2013 Feb 14;4:e492. doi: 10.1038/cddis.2013.24.

9.

Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy.

Jézégou A, Llinares E, Anne C, Kieffer-Jaquinod S, O'Regan S, Aupetit J, Chabli A, Sagné C, Debacker C, Chadefaux-Vekemans B, Journet A, André B, Gasnier B.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3434-43. doi: 10.1073/pnas.1211198109. Epub 2012 Nov 20. Erratum in: Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3197.

10.

Successful prediction of substrate-binding pocket in SLC17 transporter sialin.

Pietrancosta N, Anne C, Prescher H, Ruivo R, Sagné C, Debacker C, Bertrand HO, Brossmer R, Acher F, Gasnier B.

J Biol Chem. 2012 Mar 30;287(14):11489-97. doi: 10.1074/jbc.M111.313056. Epub 2012 Feb 13.

11.

Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin.

Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S, Gasnier B.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E210-7. doi: 10.1073/pnas.1115581109. Epub 2012 Jan 9.

12.

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.

Marcel V, Dichtel-Danjoy ML, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, Olivier M, Hall J, Mollereau B, Hainaut P, Bourdon JC.

Cell Death Differ. 2011 Dec;18(12):1815-24. doi: 10.1038/cdd.2011.120. Epub 2011 Sep 23. Review.

13.

Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences.

Narboux-Nême N, Sagné C, Doly S, Diaz SL, Martin CB, Angenard G, Martres MP, Giros B, Hamon M, Lanfumey L, Gaspar P, Mongeau R.

Neuropsychopharmacology. 2011 Nov;36(12):2538-50. doi: 10.1038/npp.2011.142. Epub 2011 Aug 3.

14.

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms.

Marcel V, Tran PL, Sagne C, Martel-Planche G, Vaslin L, Teulade-Fichou MP, Hall J, Mergny JL, Hainaut P, Van Dyck E.

Carcinogenesis. 2011 Mar;32(3):271-8. doi: 10.1093/carcin/bgq253. Epub 2010 Nov 26.

PMID:
21112961
15.

Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis.

Sharifi A, Kousi M, Sagné C, Bellenchi GC, Morel L, Darmon M, Hulková H, Ruivo R, Debacker C, El Mestikawy S, Elleder M, Lehesjoki AE, Jalanko A, Gasnier B, Kyttälä A.

Hum Mol Genet. 2010 Nov 15;19(22):4497-514. doi: 10.1093/hmg/ddq381. Epub 2010 Sep 7.

16.

p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter.

Marcel V, Vijayakumar V, Fernández-Cuesta L, Hafsi H, Sagne C, Hautefeuille A, Olivier M, Hainaut P.

Oncogene. 2010 May 6;29(18):2691-700. doi: 10.1038/onc.2010.26. Epub 2010 Mar 1.

PMID:
20190805
17.

Molecular and cellular basis of lysosomal transmembrane protein dysfunction.

Ruivo R, Anne C, Sagné C, Gasnier B.

Biochim Biophys Acta. 2009 Apr;1793(4):636-49. doi: 10.1016/j.bbamcr.2008.12.008. Epub 2008 Dec 24. Review.

18.

Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.

Rutsch F, Gailus S, Miousse IR, Suormala T, Sagné C, Toliat MR, Nürnberg G, Wittkampf T, Buers I, Sharifi A, Stucki M, Becker C, Baumgartner M, Robenek H, Marquardt T, Höhne W, Gasnier B, Rosenblatt DS, Fowler B, Nürnberg P.

Nat Genet. 2009 Feb;41(2):234-9. doi: 10.1038/ng.294. Epub 2009 Jan 11.

PMID:
19136951
19.

Molecular physiology and pathophysiology of lysosomal membrane transporters.

Sagné C, Gasnier B.

J Inherit Metab Dis. 2008 Apr;31(2):258-66. doi: 10.1007/s10545-008-0879-9. Epub 2008 Apr 15. Review.

PMID:
18425435
20.

Molecular pathogenesis of sialic acid storage diseases: insight gained from four missense mutations and a putative polymorphism of human sialin.

Ruivo R, Sharifi A, Boubekeur S, Morin P, Anne C, Debacker C, Graziano JC, Sagné C, Gasnier B.

Biol Cell. 2008 Sep;100(9):551-9. doi: 10.1042/BC20070166.

PMID:
18399798
21.

Functional characterization of wild-type and mutant human sialin.

Morin P, Sagné C, Gasnier B.

EMBO J. 2004 Nov 24;23(23):4560-70. Epub 2004 Oct 28.

22.

Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study.

Agulhon C, Rostaing P, Ravassard P, Sagné C, Triller A, Giros B.

J Comp Neurol. 2003 Jul 14;462(1):71-89.

PMID:
12761825
23.
24.

Identification and characterization of a lysosomal transporter for small neutral amino acids.

Sagné C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7206-11. Epub 2001 Jun 5.

25.

Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter.

Jaber M, Dumartin B, Sagné C, Haycock JW, Roubert C, Giros B, Bloch B, Caron MG.

Eur J Neurosci. 1999 Oct;11(10):3499-511.

PMID:
10564358
26.

Neurotransmitter transporters in the central nervous system.

Masson J, Sagné C, Hamon M, El Mestikawy S.

Pharmacol Rev. 1999 Sep;51(3):439-64. Review. No abstract available.

PMID:
10471414
27.

Noncovalent and covalent labeling of vesicular monoamine transporter with tetrabenazine and ketanserin derivatives; purification of photolabeled protein.

Henry JP, Sagné C, Isambert MF, Gasnier B.

Methods Enzymol. 1998;296:73-83. No abstract available.

PMID:
9779441
28.

The vesicular monoamine transporter: from chromaffin granule to brain.

Henry JP, Sagné C, Bedet C, Gasnier B.

Neurochem Int. 1998 Mar;32(3):227-46. Review.

PMID:
9587917
29.

Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases.

Sagné C, El Mestikawy S, Isambert MF, Hamon M, Henry JP, Giros B, Gasnier B.

FEBS Lett. 1997 Nov 10;417(2):177-83.

30.

Molecular pharmacology of the vesicular monoamine transporter.

Henry JP, Sagné C, Botton D, Isambert MF, Gasnier B.

Adv Pharmacol. 1998;42:236-9. No abstract available.

PMID:
9327887
31.

The photoactivatable inhibitor 7-azido-8-iodoketanserin labels the N terminus of the vesicular monoamine transporter from bovine chromaffin granules.

Sagné C, Isambert MF, Vandekerckhove J, Henry JP, Gasnier B.

Biochemistry. 1997 Mar 18;36(11):3345-52.

PMID:
9116013
32.
33.

Involvement of the peptide sensitive channel in the translocation of basic peptides into mitochondria.

Juin P, Pelleschi M, Sagné C, Henry JP, Thieffry M, Vallette FM.

Biochem Biophys Res Commun. 1995 Jun 6;211(1):92-9.

PMID:
7540008
34.

Biochemistry and molecular biology of the vesicular monoamine transporter from chromaffin granules.

Henry JP, Botton D, Sagne C, Isambert MF, Desnos C, Blanchard V, Raisman-Vozari R, Krejci E, Massoulie J, Gasnier B.

J Exp Biol. 1994 Nov;196:251-62. Review.

35.

Expression and regulation of the bovine vesicular monoamine transporter gene.

Krejci E, Gasnier B, Botton D, Isambert MF, Sagné C, Gagnon J, Massoulié J, Henry JP.

FEBS Lett. 1993 Nov 29;335(1):27-32.

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