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Lung clearance index and steroid response in pediatric severe asthma.

Irving S, Fleming L, Ahmad F, Biggart E, Bingham Y, Cook J, Hall P, Jamalzadeh A, Nagakumar P, Bossley C, Gupta A, Macleod K, Saglani S, Bush A.

Pediatr Pulmonol. 2020 Feb 6. doi: 10.1002/ppul.24675. [Epub ahead of print]


Dynamics of human monocytes and airway macrophages during healthy aging and after transplant.

Byrne AJ, Powell JE, O'Sullivan BJ, Ogger PP, Hoffland A, Cook J, Bonner KL, Hewitt RJ, Wolf S, Ghai P, Walker SA, Lukowski SW, Molyneaux PL, Saglani S, Chambers DC, Maher TM, Lloyd CM.

J Exp Med. 2020 Mar 2;217(3). pii: e20191236. doi: 10.1084/jem.20191236.


Medical algorithm: Diagnosis and treatment of preschool asthma.

Bush A, Saglani S.

Allergy. 2020 Jan 3. doi: 10.1111/all.14172. [Epub ahead of print] No abstract available.


Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma.

Turner PJ, Fleming L, Saglani S, Southern J, Andrews NJ, Miller E; SNIFFLE-4 Study Investigators.

J Allergy Clin Immunol. 2019 Dec 18. pii: S0091-6749(19)31712-9. doi: 10.1016/j.jaci.2019.12.010. [Epub ahead of print]


Enhanced frequency and function of follicular T cells in the tonsils of house dust mite-sensitized children.

Foster WS, Grime CJ, Tan HL, Williams GS, Robinson MJ, Carlesso G, Saglani S, Lloyd CM, Harker JA.

Allergy. 2019 Dec 14. doi: 10.1111/all.14150. [Epub ahead of print] No abstract available.


Developments in the mechanisms of allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part I.

Roberts G, Almqvist C, Boyle R, Crane J, Hogan SP, Marsland B, Saglani S, Woodfolk JA.

Clin Exp Allergy. 2019 Dec;49(12):1541-1549. doi: 10.1111/cea.13532. Review.


Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II.

Roberts G, Almqvist C, Boyle R, Crane J, Hogan SP, Marsland B, Saglani S, Woodfolk JA.

Clin Exp Allergy. 2019 Dec;49(12):1550-1557. doi: 10.1111/cea.13535. Review.


Opening the Window of Immune Opportunity: Treating Childhood Asthma.

Lloyd CM, Saglani S.

Trends Immunol. 2019 Sep;40(9):786-798. doi: 10.1016/ Epub 2019 Aug 14. Review.


Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids.

Nagakumar P, Puttur F, Gregory LG, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

Eur Respir J. 2019 Aug 29;54(2). pii: 1801809. doi: 10.1183/13993003.01809-2018. Print 2019 Aug.


Approaches to Asthma Diagnosis in Children and Adults.

Saglani S, Menzie-Gow AN.

Front Pediatr. 2019 Apr 17;7:148. doi: 10.3389/fped.2019.00148. eCollection 2019. Review.


Advances in the aetiology, management, and prevention of acute asthma attacks in children.

Saglani S, Fleming L, Sonnappa S, Bush A.

Lancet Child Adolesc Health. 2019 May;3(5):354-364. doi: 10.1016/S2352-4642(19)30025-2. Epub 2019 Mar 20. Review. Erratum in: Lancet Child Adolesc Health. 2019 Aug;3(8):e13.


Biologics for paediatric severe asthma: trick or TREAT?

Saglani S, Bush A, Carroll W, Cunningham S, Fleming L, Gaillard E, Gupta A, Murray C, Nagakumar P, Paton J, Roberts G, Seddon P, Sinha I.

Lancet Respir Med. 2019 Apr;7(4):294-296. doi: 10.1016/S2213-2600(19)30045-1. Epub 2019 Feb 26. No abstract available.


Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population-based cohort 2006-2016.

Bloom CI, Saglani S, Feary J, Jarvis D, Quint JK.

Eur Respir J. 2019 Apr 4;53(4). pii: 1802130. doi: 10.1183/13993003.02130-2018. Print 2019 Apr.


Severe asthma in children: therapeutic considerations.

Selby L, Saglani S.

Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):132-140. doi: 10.1097/ACI.0000000000000521.


Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze.

Robinson PFM, Pattaroni C, Cook J, Gregory L, Alonso AM, Fleming LJ, Lloyd CM, Bush A, Marsland BJ, Saglani S.

J Allergy Clin Immunol. 2019 Apr;143(4):1607-1610.e3. doi: 10.1016/j.jaci.2018.12.985. Epub 2018 Dec 21. No abstract available.


Childhood Asthma: Advances Using Machine Learning and Mechanistic Studies.

Saglani S, Custovic A.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):414-422. doi: 10.1164/rccm.201810-1956CI. Review.


Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy.

Roberts G, Almqvist C, Boyle R, Crane J, Hogan SP, Marsland B, Saglani S, Woodfolk JA.

Clin Exp Allergy. 2018 Dec;48(12):1606-1621. doi: 10.1111/cea.13318. Review.


Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.


Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?  A description of the protocol for the Breathing Together study.

Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM, Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.

Wellcome Open Res. 2018 May 17;3:60. doi: 10.12688/wellcomeopenres.14489.1. eCollection 2018.


Lung function in primary ciliary dyskinesia: breaking the myth that this is a mild disease.

Saglani S.

Eur Respir J. 2018 Aug 23;52(2). pii: 1801365. doi: 10.1183/13993003.01365-2018. Print 2018 Aug. No abstract available.


Structurally Unsound? Why Airways Become Asthmatic.

Bush A, Saglani S.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):405-406. doi: 10.1165/rcmb.2018-0181ED. No abstract available.


Airway granulocytes in severe preschool wheeze: Predictive of school-age asthma attacks or disease protection.

Saglani S.

Clin Exp Allergy. 2018 Jul;48(7):760-761. doi: 10.1111/cea.13186. No abstract available.


Should oral corticosteroids be prescribed for preschool viral wheeze?

Saglani S, Rosenthal M, Bush A.

Lancet Respir Med. 2018 Jun;6(6):e21. doi: 10.1016/S2213-2600(18)30146-2. No abstract available.


The relationship between inflammation and remodeling in childhood asthma: A systematic review.

Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, Oyarzun MA, Fleming L, Bush A.

Pediatr Pulmonol. 2018 Jun;53(6):824-835. doi: 10.1002/ppul.23968. Epub 2018 Feb 22.


Role of a prolonged inpatient admission when evaluating children with problematic severe asthma.

Nagakumar P, Gambir N, Sanghani N, Hall P, Jamalzadeh A, Beresford F, Saglani S, Bush A, Fleming L.

Eur Respir J. 2018 Jan 31;51(2). pii: 1701061. doi: 10.1183/13993003.01061-2017. Print 2018 Feb. No abstract available.


Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children.

Jochmann A, Artusio L, Jamalzadeh A, Nagakumar P, Delgado-Eckert E, Saglani S, Bush A, Frey U, Fleming LJ.

Eur Respir J. 2017 Dec 21;50(6). pii: 1700910. doi: 10.1183/13993003.00910-2017. Print 2017 Dec.


Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy.

Roberts G, Boyle R, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2017 Dec;47(12):1512-1525. doi: 10.1111/cea.13049. Epub 2017 Nov 20. Review.


Severe asthma: looking beyond the amount of medication.

Bush A, Saglani S, Fleming L.

Lancet Respir Med. 2017 Nov;5(11):844-846. doi: 10.1016/S2213-2600(17)30379-X. Epub 2017 Oct 12. No abstract available.


Severe therapy resistant asthma in children: translational approaches to uncover sub-phenotypes.

Martin Alonso A, Fainardi V, Saglani S.

Expert Rev Respir Med. 2017 Nov;11(11):867-874. doi: 10.1080/17476348.2017.1368391. Epub 2017 Aug 21. Review.


Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies.

Martin Alonso A, Saglani S.

Front Pediatr. 2017 Jul 5;5:154. doi: 10.3389/fped.2017.00154. eCollection 2017. Review.


Childhood severe asthma: New insights on remodelling and biomarkers.

Saglani S.

Paediatr Respir Rev. 2017 Sep;24:11-13. doi: 10.1016/j.prrv.2017.06.001. Epub 2017 Jun 12. Review.


Development of allergic immunity in early life.

Lloyd CM, Saglani S.

Immunol Rev. 2017 Jul;278(1):101-115. doi: 10.1111/imr.12562. Review.


Asthma Attacks in Children: Does Blocking IgE Reduce Rhinovirus Infections?

Saglani S, Bush A.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):941-942. doi: 10.1164/rccm.201706-1165ED. No abstract available.


Severe asthma in children.

Bush A, Fleming L, Saglani S.

Respirology. 2017 Jul;22(5):886-897. doi: 10.1111/resp.13085. Epub 2017 May 25. Review.


Managing the pediatric patient with refractory asthma: a multidisciplinary approach.

Cook J, Beresford F, Fainardi V, Hall P, Housley G, Jamalzadeh A, Nightingale M, Winch D, Bush A, Fleming L, Saglani S.

J Asthma Allergy. 2017 Apr 20;10:123-130. doi: 10.2147/JAA.S129159. eCollection 2017. Review.


Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators.

Edwards MR, Saglani S, Schwarze J, Skevaki C, Smith JA, Ainsworth B, Almond M, Andreakos E, Belvisi MG, Chung KF, Cookson W, Cullinan P, Hawrylowicz C, Lommatzsch M, Jackson D, Lutter R, Marsland B, Moffatt M, Thomas M, Virchow JC, Xanthou G, Edwards J, Walker S, Johnston SL; members of the EARIP WP2 working group.

Eur Respir J. 2017 May 1;49(5). pii: 1602448. doi: 10.1183/13993003.02448-2016. Print 2017 May. Review.


Asthma attacks: should we nail our colours to the mast (cell)?

Fleming L, Saglani S, Bush A.

Eur Respir J. 2016 Nov;48(5):1261-1264. doi: 10.1183/13993003.01614-2016. No abstract available.


Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy.

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2016 Nov;46(11):1389-1397. doi: 10.1111/cea.12831. Review.


Allergy in severe asthma.

Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci Ö, Saglani S, Sergejeva S, Seys S, Simpson A, Bjermer L.

Allergy. 2017 Feb;72(2):207-220. doi: 10.1111/all.13072. Epub 2016 Nov 23. Review.


Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function.

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CM.

J Allergy Clin Immunol. 2017 Jun;139(6):1819-1829.e11. doi: 10.1016/j.jaci.2016.09.022. Epub 2016 Oct 13.


Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy.

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2016 Oct;46(10):1248-57. doi: 10.1111/cea.12823. Review.


Feasibility of lung clearance index in a clinical setting in pre-school children.

Downing B, Irving S, Bingham Y, Fleming L, Bush A, Saglani S.

Eur Respir J. 2016 Oct;48(4):1074-1080. doi: 10.1183/13993003.00374-2016. Epub 2016 Jul 7.


How to manage a child with difficult asthma?

Saglani S, Fleming L.

Expert Rev Respir Med. 2016 Aug;10(8):873-9. doi: 10.1080/17476348.2016.1191355. Epub 2016 Jun 2. Review.


Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach.

Bossley CJ, Fleming L, Ullmann N, Gupta A, Adams A, Nagakumar P, Bush A, Saglani S.

J Allergy Clin Immunol. 2016 Aug;138(2):413-420.e6. doi: 10.1016/j.jaci.2015.12.1347. Epub 2016 Apr 6.


The utility of a multidomain assessment of steroid response for predicting clinical response to omalizumab.

Fleming L, Koo M, Bossley CJ, Nagakumar P, Bush A, Saglani S.

J Allergy Clin Immunol. 2016 Jul;138(1):292-294. doi: 10.1016/j.jaci.2015.12.1317. Epub 2016 Feb 28. No abstract available.


Prostacyclin as a Potential Novel Means to Manipulate Type 2 Innate Lymphoid Cell Function.

Saglani S, Lloyd CM.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):2-4. doi: 10.1164/rccm.201509-1773ED. No abstract available.


Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

Jochmann A, Artusio L, Robson K, Nagakumar P, Collins N, Fleming L, Bush A, Saglani S.

Pediatr Pulmonol. 2016 Aug;51(8):778-86. doi: 10.1002/ppul.23366. Epub 2015 Dec 17.


Pathogenesis and prevention strategies of severe asthma exacerbations in children.

Cook J, Saglani S.

Curr Opin Pulm Med. 2016 Jan;22(1):25-31. doi: 10.1097/MCP.0000000000000223. Review.


Novel concepts in airway inflammation and remodelling in asthma.

Saglani S, Lloyd CM.

Eur Respir J. 2015 Dec;46(6):1796-804. doi: 10.1183/13993003.01196-2014. Epub 2015 Nov 5. Review.


Multiple breath washouts in children can be shortened without compromising quality.

Ahmad F, Irving S, Alton E, Davies JC, Macleod K, Rosenthal M, Saunders C, Bush A, Saglani S, Fleming L.

Eur Respir J. 2015 Dec;46(6):1814-6. doi: 10.1183/13993003.00791-2015. Epub 2015 Oct 9. No abstract available.

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