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Items: 1 to 50 of 114

1.

Opening the Window of Immune Opportunity: Treating Childhood Asthma.

Lloyd CM, Saglani S.

Trends Immunol. 2019 Sep;40(9):786-798. doi: 10.1016/j.it.2019.07.004. Epub 2019 Aug 14. Review.

PMID:
31420279
2.

Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids.

Nagakumar P, Puttur F, Gregory LG, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

Eur Respir J. 2019 Aug 29;54(2). pii: 1801809. doi: 10.1183/13993003.01809-2018. Print 2019 Aug.

3.

Approaches to Asthma Diagnosis in Children and Adults.

Saglani S, Menzie-Gow AN.

Front Pediatr. 2019 Apr 17;7:148. doi: 10.3389/fped.2019.00148. eCollection 2019. Review.

4.

Advances in the aetiology, management, and prevention of acute asthma attacks in children.

Saglani S, Fleming L, Sonnappa S, Bush A.

Lancet Child Adolesc Health. 2019 May;3(5):354-364. doi: 10.1016/S2352-4642(19)30025-2. Epub 2019 Mar 20. Review. Erratum in: Lancet Child Adolesc Health. 2019 Aug;3(8):e13.

PMID:
30902628
5.

Biologics for paediatric severe asthma: trick or TREAT?

Saglani S, Bush A, Carroll W, Cunningham S, Fleming L, Gaillard E, Gupta A, Murray C, Nagakumar P, Paton J, Roberts G, Seddon P, Sinha I.

Lancet Respir Med. 2019 Apr;7(4):294-296. doi: 10.1016/S2213-2600(19)30045-1. Epub 2019 Feb 26. No abstract available.

6.

Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population-based cohort 2006-2016.

Bloom CI, Saglani S, Feary J, Jarvis D, Quint JK.

Eur Respir J. 2019 Apr 4;53(4). pii: 1802130. doi: 10.1183/13993003.02130-2018. Print 2019 Apr.

PMID:
30765507
7.

Severe asthma in children: therapeutic considerations.

Selby L, Saglani S.

Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):132-140. doi: 10.1097/ACI.0000000000000521.

PMID:
30720474
8.

Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze.

Robinson PFM, Pattaroni C, Cook J, Gregory L, Alonso AM, Fleming LJ, Lloyd CM, Bush A, Marsland BJ, Saglani S.

J Allergy Clin Immunol. 2019 Apr;143(4):1607-1610.e3. doi: 10.1016/j.jaci.2018.12.985. Epub 2018 Dec 21. No abstract available.

9.

Childhood Asthma: Advances Using Machine Learning and Mechanistic Studies.

Saglani S, Custovic A.

Am J Respir Crit Care Med. 2019 Feb 15;199(4):414-422. doi: 10.1164/rccm.201810-1956CI.

PMID:
30571146
10.

Developments in the field of allergy in 2017 through the eyes of Clinical and Experimental Allergy.

Roberts G, Almqvist C, Boyle R, Crane J, Hogan SP, Marsland B, Saglani S, Woodfolk JA.

Clin Exp Allergy. 2018 Dec;48(12):1606-1621. doi: 10.1111/cea.13318. Review.

PMID:
30489681
11.

Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.

12.

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?  A description of the protocol for the Breathing Together study.

Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM, Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.

Wellcome Open Res. 2018 May 17;3:60. doi: 10.12688/wellcomeopenres.14489.1. eCollection 2018.

13.

Lung function in primary ciliary dyskinesia: breaking the myth that this is a mild disease.

Saglani S.

Eur Respir J. 2018 Aug 23;52(2). pii: 1801365. doi: 10.1183/13993003.01365-2018. Print 2018 Aug. No abstract available.

PMID:
30139762
14.

Structurally Unsound? Why Airways Become Asthmatic.

Bush A, Saglani S.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):405-406. doi: 10.1165/rcmb.2018-0181ED. No abstract available.

15.

Airway granulocytes in severe preschool wheeze: Predictive of school-age asthma attacks or disease protection.

Saglani S.

Clin Exp Allergy. 2018 Jul;48(7):760-761. doi: 10.1111/cea.13186. No abstract available.

PMID:
29947137
16.

Should oral corticosteroids be prescribed for preschool viral wheeze?

Saglani S, Rosenthal M, Bush A.

Lancet Respir Med. 2018 Jun;6(6):e21. doi: 10.1016/S2213-2600(18)30146-2. No abstract available.

17.

The relationship between inflammation and remodeling in childhood asthma: A systematic review.

Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, Oyarzun MA, Fleming L, Bush A.

Pediatr Pulmonol. 2018 Jun;53(6):824-835. doi: 10.1002/ppul.23968. Epub 2018 Feb 22.

18.

Role of a prolonged inpatient admission when evaluating children with problematic severe asthma.

Nagakumar P, Gambir N, Sanghani N, Hall P, Jamalzadeh A, Beresford F, Saglani S, Bush A, Fleming L.

Eur Respir J. 2018 Jan 31;51(2). pii: 1701061. doi: 10.1183/13993003.01061-2017. Print 2018 Feb. No abstract available.

19.

Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children.

Jochmann A, Artusio L, Jamalzadeh A, Nagakumar P, Delgado-Eckert E, Saglani S, Bush A, Frey U, Fleming LJ.

Eur Respir J. 2017 Dec 21;50(6). pii: 1700910. doi: 10.1183/13993003.00910-2017. Print 2017 Dec.

20.

Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy.

Roberts G, Boyle R, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2017 Dec;47(12):1512-1525. doi: 10.1111/cea.13049. Epub 2017 Nov 20. Review.

21.

Severe asthma: looking beyond the amount of medication.

Bush A, Saglani S, Fleming L.

Lancet Respir Med. 2017 Nov;5(11):844-846. doi: 10.1016/S2213-2600(17)30379-X. Epub 2017 Oct 12. No abstract available.

22.

Severe therapy resistant asthma in children: translational approaches to uncover sub-phenotypes.

Martin Alonso A, Fainardi V, Saglani S.

Expert Rev Respir Med. 2017 Nov;11(11):867-874. doi: 10.1080/17476348.2017.1368391. Epub 2017 Aug 21. Review.

23.

Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies.

Martin Alonso A, Saglani S.

Front Pediatr. 2017 Jul 5;5:154. doi: 10.3389/fped.2017.00154. eCollection 2017. Review.

24.

Childhood severe asthma: New insights on remodelling and biomarkers.

Saglani S.

Paediatr Respir Rev. 2017 Sep;24:11-13. doi: 10.1016/j.prrv.2017.06.001. Epub 2017 Jun 12. Review.

25.

Development of allergic immunity in early life.

Lloyd CM, Saglani S.

Immunol Rev. 2017 Jul;278(1):101-115. doi: 10.1111/imr.12562. Review.

26.

Asthma Attacks in Children: Does Blocking IgE Reduce Rhinovirus Infections?

Saglani S, Bush A.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):941-942. doi: 10.1164/rccm.201706-1165ED. No abstract available.

27.

Severe asthma in children.

Bush A, Fleming L, Saglani S.

Respirology. 2017 Jul;22(5):886-897. doi: 10.1111/resp.13085. Epub 2017 May 25. Review.

28.

Managing the pediatric patient with refractory asthma: a multidisciplinary approach.

Cook J, Beresford F, Fainardi V, Hall P, Housley G, Jamalzadeh A, Nightingale M, Winch D, Bush A, Fleming L, Saglani S.

J Asthma Allergy. 2017 Apr 20;10:123-130. doi: 10.2147/JAA.S129159. eCollection 2017. Review.

29.

Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators.

Edwards MR, Saglani S, Schwarze J, Skevaki C, Smith JA, Ainsworth B, Almond M, Andreakos E, Belvisi MG, Chung KF, Cookson W, Cullinan P, Hawrylowicz C, Lommatzsch M, Jackson D, Lutter R, Marsland B, Moffatt M, Thomas M, Virchow JC, Xanthou G, Edwards J, Walker S, Johnston SL; members of the EARIP WP2 working group.

Eur Respir J. 2017 May 1;49(5). pii: 1602448. doi: 10.1183/13993003.02448-2016. Print 2017 May. Review.

30.

Asthma attacks: should we nail our colours to the mast (cell)?

Fleming L, Saglani S, Bush A.

Eur Respir J. 2016 Nov;48(5):1261-1264. doi: 10.1183/13993003.01614-2016. No abstract available.

31.

Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy.

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2016 Nov;46(11):1389-1397. doi: 10.1111/cea.12831. Review.

PMID:
27748974
32.

Allergy in severe asthma.

Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci Ö, Saglani S, Sergejeva S, Seys S, Simpson A, Bjermer L.

Allergy. 2017 Feb;72(2):207-220. doi: 10.1111/all.13072. Epub 2016 Nov 23. Review.

33.

Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function.

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CM.

J Allergy Clin Immunol. 2017 Jun;139(6):1819-1829.e11. doi: 10.1016/j.jaci.2016.09.022. Epub 2016 Oct 13.

34.

Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy.

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2016 Oct;46(10):1248-57. doi: 10.1111/cea.12823. Review.

PMID:
27682977
35.

Feasibility of lung clearance index in a clinical setting in pre-school children.

Downing B, Irving S, Bingham Y, Fleming L, Bush A, Saglani S.

Eur Respir J. 2016 Oct;48(4):1074-1080. doi: 10.1183/13993003.00374-2016. Epub 2016 Jul 7.

36.

How to manage a child with difficult asthma?

Saglani S, Fleming L.

Expert Rev Respir Med. 2016 Aug;10(8):873-9. doi: 10.1080/17476348.2016.1191355. Epub 2016 Jun 2. Review.

37.

Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach.

Bossley CJ, Fleming L, Ullmann N, Gupta A, Adams A, Nagakumar P, Bush A, Saglani S.

J Allergy Clin Immunol. 2016 Aug;138(2):413-420.e6. doi: 10.1016/j.jaci.2015.12.1347. Epub 2016 Apr 6.

38.

The utility of a multidomain assessment of steroid response for predicting clinical response to omalizumab.

Fleming L, Koo M, Bossley CJ, Nagakumar P, Bush A, Saglani S.

J Allergy Clin Immunol. 2016 Jul;138(1):292-294. doi: 10.1016/j.jaci.2015.12.1317. Epub 2016 Feb 28. No abstract available.

PMID:
26924468
39.

Prostacyclin as a Potential Novel Means to Manipulate Type 2 Innate Lymphoid Cell Function.

Saglani S, Lloyd CM.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):2-4. doi: 10.1164/rccm.201509-1773ED. No abstract available.

PMID:
26720782
40.

Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

Jochmann A, Artusio L, Robson K, Nagakumar P, Collins N, Fleming L, Bush A, Saglani S.

Pediatr Pulmonol. 2016 Aug;51(8):778-86. doi: 10.1002/ppul.23366. Epub 2015 Dec 17.

41.

Pathogenesis and prevention strategies of severe asthma exacerbations in children.

Cook J, Saglani S.

Curr Opin Pulm Med. 2016 Jan;22(1):25-31. doi: 10.1097/MCP.0000000000000223. Review.

PMID:
26574720
42.

Novel concepts in airway inflammation and remodelling in asthma.

Saglani S, Lloyd CM.

Eur Respir J. 2015 Dec;46(6):1796-804. doi: 10.1183/13993003.01196-2014. Epub 2015 Nov 5. Review.

43.

Multiple breath washouts in children can be shortened without compromising quality.

Ahmad F, Irving S, Alton E, Davies JC, Macleod K, Rosenthal M, Saunders C, Bush A, Saglani S, Fleming L.

Eur Respir J. 2015 Dec;46(6):1814-6. doi: 10.1183/13993003.00791-2015. Epub 2015 Oct 9. No abstract available.

44.

Ethnic Variation in Response to IM Triamcinolone in Children With Severe Therapy-Resistant Asthma.

Koo S, Gupta A, Fainardi V, Bossley C, Bush A, Saglani S, Fleming L.

Chest. 2016 Jan;149(1):98-105. doi: 10.1378/chest.14-3241. Epub 2016 Jan 6.

45.

Type 2 innate lymphoid cells in induced sputum from children with severe asthma.

Nagakumar P, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2016 Feb;137(2):624-626.e6. doi: 10.1016/j.jaci.2015.06.038. Epub 2015 Aug 12. No abstract available.

46.

Onset of Structural Airway Changes in Preschool Wheezers. A Window and Target for Secondary Asthma Prevention?

Saglani S, Bush A.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):121-2. doi: 10.1164/rccm.201505-0989ED. No abstract available.

47.

The need to differentiate between adults and children when treating severe asthma.

Fainardi V, Saglani S.

Expert Rev Respir Med. 2015 Aug;9(4):419-28. doi: 10.1586/17476348.2015.1068693. Epub 2015 Jul 15. Review.

48.

Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation.

Moeller A, Carlsen KH, Sly PD, Baraldi E, Piacentini G, Pavord I, Lex C, Saglani S; ERS Task Force Monitoring Asthma in Children.

Eur Respir Rev. 2015 Jun;24(136):204-15. doi: 10.1183/16000617.00003914. Review.

49.

Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Lee DC, Walker SA, Byrne AJ, Gregory LG, Buckley J, Bush A, Shaheen SO, Saglani S, Lloyd CM.

Thorax. 2015 Jun;70(6):528-36. doi: 10.1136/thoraxjnl-2014-205280. Epub 2015 Apr 3.

50.

Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.

Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley CJ, Buckley J, Ullmann N, Grychtol R, Campbell G, Maglione M, Koo S, Fleming L, Gregory L, Snelgrove RJ, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.

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