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Items: 1 to 50 of 104


Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells.

Saglani S, Gregory LG, Manghera AK, Branchett WJ, Uwadiae F, Entwistle LJ, Oliver RA, Vasiliou JE, Sherburn R, Lui S, Puttur F, Vöhringer D, Walker SA, Buckley J, Grychtol R, Fainardi V, Denney L, Byrne A, von Mutius E, Bush A, Lloyd CM.

Sci Immunol. 2018 Sep 7;3(27). pii: eaan4128. doi: 10.1126/sciimmunol.aan4128.


Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma?  A description of the protocol for the Breathing Together study.

Turner S, Custovic A, Ghazal P, Grigg J, Gore M, Henderson J, Lloyd CM, Marsland B, Power UF, Roberts G, Saglani S, Schwarze J, Shields M, Bush A.

Wellcome Open Res. 2018 May 17;3:60. doi: 10.12688/wellcomeopenres.14489.1. eCollection 2018.


Lung function in primary ciliary dyskinesia: breaking the myth that this is a mild disease.

Saglani S.

Eur Respir J. 2018 Aug 23;52(2). pii: 1801365. doi: 10.1183/13993003.01365-2018. Print 2018 Aug. No abstract available.


Structurally Unsound? Why Airways Become Asthmatic.

Bush A, Saglani S.

Am J Respir Cell Mol Biol. 2018 Jun 28. doi: 10.1165/rcmb.2018-0181ED. [Epub ahead of print] No abstract available.


Airway granulocytes in severe preschool wheeze: Predictive of school-age asthma attacks or disease protection.

Saglani S.

Clin Exp Allergy. 2018 Jul;48(7):760-761. doi: 10.1111/cea.13186. No abstract available.


Should oral corticosteroids be prescribed for preschool viral wheeze?

Saglani S, Rosenthal M, Bush A.

Lancet Respir Med. 2018 Jun;6(6):e21. doi: 10.1016/S2213-2600(18)30146-2. No abstract available.


The relationship between inflammation and remodeling in childhood asthma: A systematic review.

Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, Oyarzun MA, Fleming L, Bush A.

Pediatr Pulmonol. 2018 Jun;53(6):824-835. doi: 10.1002/ppul.23968. Epub 2018 Feb 22. Review.


Role of a prolonged inpatient admission when evaluating children with problematic severe asthma.

Nagakumar P, Gambir N, Sanghani N, Hall P, Jamalzadeh A, Beresford F, Saglani S, Bush A, Fleming L.

Eur Respir J. 2018 Jan 31;51(2). pii: 1701061. doi: 10.1183/13993003.01061-2017. Print 2018 Feb. No abstract available.


Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children.

Jochmann A, Artusio L, Jamalzadeh A, Nagakumar P, Delgado-Eckert E, Saglani S, Bush A, Frey U, Fleming LJ.

Eur Respir J. 2017 Dec 21;50(6). pii: 1700910. doi: 10.1183/13993003.00910-2017. Print 2017 Dec.


Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy.

Roberts G, Boyle R, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2017 Dec;47(12):1512-1525. doi: 10.1111/cea.13049. Epub 2017 Nov 20. Review.


Severe asthma: looking beyond the amount of medication.

Bush A, Saglani S, Fleming L.

Lancet Respir Med. 2017 Nov;5(11):844-846. doi: 10.1016/S2213-2600(17)30379-X. Epub 2017 Oct 12. No abstract available.


Severe therapy resistant asthma in children: translational approaches to uncover sub-phenotypes.

Martin Alonso A, Fainardi V, Saglani S.

Expert Rev Respir Med. 2017 Nov;11(11):867-874. doi: 10.1080/17476348.2017.1368391. Epub 2017 Aug 21. Review.


Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies.

Martin Alonso A, Saglani S.

Front Pediatr. 2017 Jul 5;5:154. doi: 10.3389/fped.2017.00154. eCollection 2017. Review.


Childhood severe asthma: New insights on remodelling and biomarkers.

Saglani S.

Paediatr Respir Rev. 2017 Sep;24:11-13. doi: 10.1016/j.prrv.2017.06.001. Epub 2017 Jun 12. Review.


Development of allergic immunity in early life.

Lloyd CM, Saglani S.

Immunol Rev. 2017 Jul;278(1):101-115. doi: 10.1111/imr.12562. Review.


Asthma Attacks in Children: Does Blocking IgE Reduce Rhinovirus Infections?

Saglani S, Bush A.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):941-942. doi: 10.1164/rccm.201706-1165ED. No abstract available.


Severe asthma in children.

Bush A, Fleming L, Saglani S.

Respirology. 2017 Jul;22(5):886-897. doi: 10.1111/resp.13085. Epub 2017 May 25. Review.


Managing the pediatric patient with refractory asthma: a multidisciplinary approach.

Cook J, Beresford F, Fainardi V, Hall P, Housley G, Jamalzadeh A, Nightingale M, Winch D, Bush A, Fleming L, Saglani S.

J Asthma Allergy. 2017 Apr 20;10:123-130. doi: 10.2147/JAA.S129159. eCollection 2017. Review.


Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators.

Edwards MR, Saglani S, Schwarze J, Skevaki C, Smith JA, Ainsworth B, Almond M, Andreakos E, Belvisi MG, Chung KF, Cookson W, Cullinan P, Hawrylowicz C, Lommatzsch M, Jackson D, Lutter R, Marsland B, Moffatt M, Thomas M, Virchow JC, Xanthou G, Edwards J, Walker S, Johnston SL; members of the EARIP WP2 working group.

Eur Respir J. 2017 May 1;49(5). pii: 1602448. doi: 10.1183/13993003.02448-2016. Print 2017 May. Review.


Asthma attacks: should we nail our colours to the mast (cell)?

Fleming L, Saglani S, Bush A.

Eur Respir J. 2016 Nov;48(5):1261-1264. doi: 10.1183/13993003.01614-2016. No abstract available.


Developments in the field of clinical allergy in 2015 through the eyes of Clinical and Experimental Allergy.

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2016 Nov;46(11):1389-1397. doi: 10.1111/cea.12831. Review.


Allergy in severe asthma.

Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci Ö, Saglani S, Sergejeva S, Seys S, Simpson A, Bjermer L.

Allergy. 2017 Feb;72(2):207-220. doi: 10.1111/all.13072. Epub 2016 Nov 23. Review.


Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function.

Andersson CK, Adams A, Nagakumar P, Bossley C, Gupta A, De Vries D, Adnan A, Bush A, Saglani S, Lloyd CM.

J Allergy Clin Immunol. 2017 Jun;139(6):1819-1829.e11. doi: 10.1016/j.jaci.2016.09.022. Epub 2016 Oct 13.


Developments in the field of allergy mechanisms in 2015 through the eyes of Clinical & Experimental Allergy.

Roberts G, Boyle R, Bryce PJ, Crane J, Hogan SP, Saglani S, Wickman M, Woodfolk JA.

Clin Exp Allergy. 2016 Oct;46(10):1248-57. doi: 10.1111/cea.12823. Review.


Feasibility of lung clearance index in a clinical setting in pre-school children.

Downing B, Irving S, Bingham Y, Fleming L, Bush A, Saglani S.

Eur Respir J. 2016 Oct;48(4):1074-1080. doi: 10.1183/13993003.00374-2016. Epub 2016 Jul 7.


How to manage a child with difficult asthma?

Saglani S, Fleming L.

Expert Rev Respir Med. 2016 Aug;10(8):873-9. doi: 10.1080/17476348.2016.1191355. Epub 2016 Jun 2. Review.


Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach.

Bossley CJ, Fleming L, Ullmann N, Gupta A, Adams A, Nagakumar P, Bush A, Saglani S.

J Allergy Clin Immunol. 2016 Aug;138(2):413-420.e6. doi: 10.1016/j.jaci.2015.12.1347. Epub 2016 Apr 6.


The utility of a multidomain assessment of steroid response for predicting clinical response to omalizumab.

Fleming L, Koo M, Bossley CJ, Nagakumar P, Bush A, Saglani S.

J Allergy Clin Immunol. 2016 Jul;138(1):292-4. doi: 10.1016/j.jaci.2015.12.1317. Epub 2016 Feb 28. No abstract available.


Prostacyclin as a Potential Novel Means to Manipulate Type 2 Innate Lymphoid Cell Function.

Saglani S, Lloyd CM.

Am J Respir Crit Care Med. 2016 Jan 1;193(1):2-4. doi: 10.1164/rccm.201509-1773ED. No abstract available.


Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

Jochmann A, Artusio L, Robson K, Nagakumar P, Collins N, Fleming L, Bush A, Saglani S.

Pediatr Pulmonol. 2016 Aug;51(8):778-86. doi: 10.1002/ppul.23366. Epub 2015 Dec 17.


Pathogenesis and prevention strategies of severe asthma exacerbations in children.

Cook J, Saglani S.

Curr Opin Pulm Med. 2016 Jan;22(1):25-31. doi: 10.1097/MCP.0000000000000223. Review.


Novel concepts in airway inflammation and remodelling in asthma.

Saglani S, Lloyd CM.

Eur Respir J. 2015 Dec;46(6):1796-804. doi: 10.1183/13993003.01196-2014. Epub 2015 Nov 5. Review.


Multiple breath washouts in children can be shortened without compromising quality.

Ahmad F, Irving S, Alton E, Davies JC, Macleod K, Rosenthal M, Saunders C, Bush A, Saglani S, Fleming L.

Eur Respir J. 2015 Dec;46(6):1814-6. doi: 10.1183/13993003.00791-2015. Epub 2015 Oct 9. No abstract available.


Ethnic Variation in Response to IM Triamcinolone in Children With Severe Therapy-Resistant Asthma.

Koo S, Gupta A, Fainardi V, Bossley C, Bush A, Saglani S, Fleming L.

Chest. 2016 Jan;149(1):98-105. doi: 10.1378/chest.14-3241. Epub 2016 Jan 6.


Type 2 innate lymphoid cells in induced sputum from children with severe asthma.

Nagakumar P, Denney L, Fleming L, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2016 Feb;137(2):624-626.e6. doi: 10.1016/j.jaci.2015.06.038. Epub 2015 Aug 12. No abstract available.


Onset of Structural Airway Changes in Preschool Wheezers. A Window and Target for Secondary Asthma Prevention?

Saglani S, Bush A.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):121-2. doi: 10.1164/rccm.201505-0989ED. No abstract available.


The need to differentiate between adults and children when treating severe asthma.

Fainardi V, Saglani S.

Expert Rev Respir Med. 2015 Aug;9(4):419-28. doi: 10.1586/17476348.2015.1068693. Epub 2015 Jul 15. Review.


Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation.

Moeller A, Carlsen KH, Sly PD, Baraldi E, Piacentini G, Pavord I, Lex C, Saglani S; ERS Task Force Monitoring Asthma in Children.

Eur Respir Rev. 2015 Jun;24(136):204-15. doi: 10.1183/16000617.00003914. Review.


Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.

Lee DC, Walker SA, Byrne AJ, Gregory LG, Buckley J, Bush A, Shaheen SO, Saglani S, Lloyd CM.

Thorax. 2015 Jun;70(6):528-36. doi: 10.1136/thoraxjnl-2014-205280. Epub 2015 Apr 3.


Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.

Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley CJ, Buckley J, Ullmann N, Grychtol R, Campbell G, Maglione M, Koo S, Fleming L, Gregory L, Snelgrove RJ, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.


Monitoring asthma in children.

Pijnenburg MW, Baraldi E, Brand PL, Carlsen KH, Eber E, Frischer T, Hedlin G, Kulkarni N, Lex C, Mäkelä MJ, Mantzouranis E, Moeller A, Pavord I, Piacentini G, Price D, Rottier BL, Saglani S, Sly PD, Szefler SJ, Tonia T, Turner S, Wooler E, Lødrup Carlsen KC.

Eur Respir J. 2015 Apr;45(4):906-25. doi: 10.1183/09031936.00088814. Epub 2015 Mar 5. Review.


Epithelial cytokines and pulmonary allergic inflammation.

Lloyd CM, Saglani S.

Curr Opin Immunol. 2015 Jun;34:52-8. doi: 10.1016/j.coi.2015.02.001. Epub 2015 Feb 20. Review.


Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons.

Gielen V, Sykes A, Zhu J, Chan B, Macintyre J, Regamey N, Kieninger E, Gupta A, Shoemark A, Bossley C, Davies J, Saglani S, Walker P, Nicholson SE, Dalpke AH, Kon OM, Bush A, Johnston SL, Edwards MR.

J Allergy Clin Immunol. 2015 Jul;136(1):177-188.e11. doi: 10.1016/j.jaci.2014.11.039. Epub 2015 Jan 25.


Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33.

Pfeffer PE, Chen YH, Woszczek G, Matthews NC, Chevretton E, Gupta A, Saglani S, Bush A, Corrigan C, Cousins DJ, Hawrylowicz CM.

J Allergy Clin Immunol. 2015 Mar;135(3):824-7.e3. doi: 10.1016/j.jaci.2014.09.044. Epub 2014 Nov 12. No abstract available.


Lung function, airway remodeling, and inflammation in infants: outcome at 8 years.

Malmström K, Malmberg LP, O'Reilly R, Lindahl H, Kajosaari M, Saarinen KM, Saglani S, Jahnsen FL, Bush A, Haahtela T, Sarna S, Pelkonen AS, Mäkelä MJ.

Ann Allergy Asthma Immunol. 2015 Feb;114(2):90-6. doi: 10.1016/j.anai.2014.09.019. Epub 2014 Oct 25.


Viral infections and the development of asthma in children.

Saglani S.

Ther Adv Infect Dis. 2013 Aug;1(4):139-50. doi: 10.1177/2049936113497202. Review.


Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease.

Vasiliou JE, Lui S, Walker SA, Chohan V, Xystrakis E, Bush A, Hawrylowicz CM, Saglani S, Lloyd CM.

Allergy. 2014 Oct;69(10):1380-9. doi: 10.1111/all.12465. Epub 2014 Aug 4.


Innate immunity in paediatric viral wheezers is virus specific and not interferon dependent.

Saglani S.

Thorax. 2014 Oct;69(10):887-8. doi: 10.1136/thoraxjnl-2014-205561. Epub 2014 May 28. No abstract available.


Lung microbiota promotes tolerance to allergens in neonates via PD-L1.

Gollwitzer ES, Saglani S, Trompette A, Yadava K, Sherburn R, McCoy KD, Nicod LP, Lloyd CM, Marsland BJ.

Nat Med. 2014 Jun;20(6):642-7. doi: 10.1038/nm.3568. Epub 2014 May 11.


Eosinophils in the pathogenesis of paediatric severe asthma.

Saglani S, Lloyd CM.

Curr Opin Allergy Clin Immunol. 2014 Apr;14(2):143-8. doi: 10.1097/ACI.0000000000000045. Review.


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