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Items: 1 to 50 of 129

1.

Regulation of the ER stress response by a mitochondrial microprotein.

Chu Q, Martinez TF, Novak SW, Donaldson CJ, Tan D, Vaughan JM, Chang T, Diedrich JK, Andrade L, Kim A, Zhang T, Manor U, Saghatelian A.

Nat Commun. 2019 Oct 25;10(1):4883. doi: 10.1038/s41467-019-12816-z.

2.

Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids.

Wang H, Kolar MJ, Chang T, Rizo J, Konduri S, McNerlin C, Saghatelian A, Siegel D.

Org Lett. 2019 Oct 4;21(19):8080-8084. doi: 10.1021/acs.orglett.9b03054. Epub 2019 Sep 23.

PMID:
31545060
3.

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.

Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB.

J Clin Invest. 2019 Oct 1;129(10):4138-4150. doi: 10.1172/JCI127092.

4.

Substrate-Selective Enzyme Inhibitors.

Chu Q, Chang T, Saghatelian A.

Trends Pharmacol Sci. 2019 Oct;40(10):716-718. doi: 10.1016/j.tips.2019.07.009. Epub 2019 Aug 2.

PMID:
31383375
5.

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

Syed I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB.

J Clin Invest. 2019 Aug 5;129:3717-3731. doi: 10.1172/JCI122445. eCollection 2019 Aug 5.

6.

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals.

Kolar MJ, Konduri S, Chang T, Wang H, McNerlin C, Ohlsson L, Härröd M, Siegel D, Saghatelian A.

J Biol Chem. 2019 Jul 5;294(27):10698-10707. doi: 10.1074/jbc.RA118.006956. Epub 2019 May 31.

PMID:
31152059
7.

Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.

Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A.

J Am Chem Soc. 2019 Jun 5;141(22):8798-8806. doi: 10.1021/jacs.9b00045. Epub 2019 May 13.

PMID:
31056915
8.

Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA.

Wang H, Chang T, Konduri S, Huang J, Saghatelian A, Siegel D.

J Antibiot (Tokyo). 2019 Jun;72(6):498-506. doi: 10.1038/s41429-019-0180-1. Epub 2019 Apr 15.

PMID:
30988370
9.

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.

Choi SH, Martinez TF, Kim S, Donaldson C, Shokhirev MN, Saghatelian A, Jones KA.

Genes Dev. 2019 Apr 1;33(7-8):418-435. doi: 10.1101/gad.322339.118. Epub 2019 Feb 28.

10.

A Hidden ORF Reveals an Immune Protector.

Chu Q, Saghatelian A.

Biochemistry. 2019 Feb 26;58(8):1022-1023. doi: 10.1021/acs.biochem.8b01317. Epub 2019 Feb 6. No abstract available.

PMID:
30724555
11.

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD.

Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ.

Cell Rep. 2019 Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036.

12.

Small, but mighty? Searching for human microproteins and their potential for understanding health and disease.

Rathore A, Martinez TF, Chu Q, Saghatelian A.

Expert Rev Proteomics. 2018 Dec;15(12):963-965. doi: 10.1080/14789450.2018.1547194. Epub 2018 Nov 15. No abstract available.

PMID:
30415582
13.

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB.

Cell Metab. 2018 Oct 2;28(4):543-546. doi: 10.1016/j.cmet.2018.09.007. Epub 2018 Sep 20.

14.

MIEF1 Microprotein Regulates Mitochondrial Translation.

Rathore A, Chu Q, Tan D, Martinez TF, Donaldson CJ, Diedrich JK, Yates JR 3rd, Saghatelian A.

Biochemistry. 2018 Sep 25;57(38):5564-5575. doi: 10.1021/acs.biochem.8b00726. Epub 2018 Sep 14.

15.

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism.

Zarrinpar A, Chaix A, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S.

Nat Commun. 2018 Jul 20;9(1):2872. doi: 10.1038/s41467-018-05336-9.

16.

Author Correction: Blocking Zika virus vertical transmission.

Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR.

Sci Rep. 2018 Jun 5;8(1):8794. doi: 10.1038/s41598-018-26959-4.

17.

The influence of transcript assembly on the proteogenomics discovery of microproteins.

Ma J, Saghatelian A, Shokhirev MN.

PLoS One. 2018 Mar 27;13(3):e0194518. doi: 10.1371/journal.pone.0194518. eCollection 2018.

18.

Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.

Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A.

Anal Chem. 2018 Apr 17;90(8):5358-5365. doi: 10.1021/acs.analchem.8b00503. Epub 2018 Mar 26.

19.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

20.

The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis.

Muñoz SS, Li H, Ruberu K, Chu Q, Saghatelian A, Ooi L, Garner B.

J Biol Chem. 2018 Mar 16;293(11):4071-4084. doi: 10.1074/jbc.RA117.001278. Epub 2018 Feb 2.

21.

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB.

Cell Metab. 2018 Feb 6;27(2):419-427.e4. doi: 10.1016/j.cmet.2018.01.001.

22.

Blocking Zika virus vertical transmission.

Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR.

Sci Rep. 2018 Jan 19;8(1):1218. doi: 10.1038/s41598-018-19526-4. Erratum in: Sci Rep. 2018 Jun 5;8(1):8794.

23.

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence.

Sulli G, Rommel A, Wang X, Kolar MJ, Puca F, Saghatelian A, Plikus MV, Verma IM, Panda S.

Nature. 2018 Jan 18;553(7688):351-355. doi: 10.1038/nature25170. Epub 2018 Jan 10.

24.

Novel Biology and Druggable Targets via Chemoproteomics.

Saghatelian A.

Biochemistry. 2017 Dec 19;56(50):6515-6516. doi: 10.1021/acs.biochem.7b01167. Epub 2017 Dec 7. No abstract available.

PMID:
29214804
25.

Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.

Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM.

PLoS One. 2017 Dec 6;12(12):e0189051. doi: 10.1371/journal.pone.0189051. eCollection 2017.

26.

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport.

Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB.

Cell Rep. 2017 Oct 24;21(4):1021-1035. doi: 10.1016/j.celrep.2017.09.091.

27.

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN.

Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J.

Nature. 2017 Sep 20;549(7673):548-552. doi: 10.1038/nature24023.

28.

Identification of Microprotein-Protein Interactions via APEX Tagging.

Chu Q, Rathore A, Diedrich JK, Donaldson CJ, Yates JR 3rd, Saghatelian A.

Biochemistry. 2017 Jul 5;56(26):3299-3306. doi: 10.1021/acs.biochem.7b00265. Epub 2017 Jun 7.

29.

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.

Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D.

J Am Chem Soc. 2017 Apr 5;139(13):4943-4947. doi: 10.1021/jacs.7b01269. Epub 2017 Mar 28.

30.

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance.

Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U.

Sci Rep. 2017 Feb 27;7:43515. doi: 10.1038/srep43515.

31.

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.

Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD.

Cell Metab. 2017 Feb 7;25(2):463-471. doi: 10.1016/j.cmet.2016.12.009. Epub 2017 Jan 12.

32.

Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.

Chen P, Zuo H, Xiong H, Kolar MJ, Chu Q, Saghatelian A, Siegwart DJ, Wan Y.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):580-585. doi: 10.1073/pnas.1614035114. Epub 2017 Jan 3.

33.

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism.

Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass CK.

Cell Metab. 2017 Feb 7;25(2):412-427. doi: 10.1016/j.cmet.2016.11.009. Epub 2016 Dec 29.

34.

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP.

Nature. 2017 Jan 12;541(7636):228-232. doi: 10.1038/nature21034. Epub 2016 Dec 26.

PMID:
28024296
35.

Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis.

Krzeszinski JY, Schwaid AG, Cheng WY, Jin Z, Gallegos ZR, Saghatelian A, Wan Y.

Endocrinology. 2017 Mar 1;158(3):477-489. doi: 10.1210/en.2016-1570.

36.

A human microprotein that interacts with the mRNA decapping complex.

D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA.

Nat Chem Biol. 2017 Feb;13(2):174-180. doi: 10.1038/nchembio.2249. Epub 2016 Dec 5.

37.

Glucagon and Thyroid Hormone: A Championship Team.

Saghatelian A, Cravatt B.

Cell. 2016 Oct 20;167(3):604-605. doi: 10.1016/j.cell.2016.10.008.

38.

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.

Svensson RU, Parker SJ, Eichner LJ, Kolar MJ, Wallace M, Brun SN, Lombardo PS, Van Nostrand JL, Hutchins A, Vera L, Gerken L, Greenwood J, Bhat S, Harriman G, Westlin WF, Harwood HJ Jr, Saghatelian A, Kapeller R, Metallo CM, Shaw RJ.

Nat Med. 2016 Oct;22(10):1108-1119. doi: 10.1038/nm.4181. Epub 2016 Sep 19.

39.

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.

Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB.

J Biol Chem. 2016 Oct 14;291(42):22207-22217. Epub 2016 Aug 29.

40.

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A.

Biochemistry. 2016 Aug 23;55(33):4636-41. doi: 10.1021/acs.biochem.6b00565. Epub 2016 Aug 10.

41.

Revealing disease-associated pathways by network integration of untargeted metabolomics.

Pirhaji L, Milani P, Leidl M, Curran T, Avila-Pacheco J, Clish CB, White FM, Saghatelian A, Fraenkel E.

Nat Methods. 2016 Sep;13(9):770-6. doi: 10.1038/nmeth.3940. Epub 2016 Aug 1.

42.

HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective.

Chu Q, Diedrich JK, Vaughan JM, Donaldson CJ, Nunn MF, Lee KF, Saghatelian A.

J Am Chem Soc. 2016 Aug 3;138(30):9473-8. doi: 10.1021/jacs.6b03463. Epub 2016 Jul 19.

43.

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.

Moraes-Vieira PM, Saghatelian A, Kahn BB.

Diabetes. 2016 Jul;65(7):1808-15. doi: 10.2337/db16-0221. Epub 2016 Jun 10. Review.

44.

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

Parsons WH, Kolar MJ, Kamat SS, Cognetta AB 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF.

Nat Chem Biol. 2016 May;12(5):367-372. doi: 10.1038/nchembio.2051. Epub 2016 Mar 28.

45.

Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.

Ma J, Diedrich JK, Jungreis I, Donaldson C, Vaughan J, Kellis M, Yates JR 3rd, Saghatelian A.

Anal Chem. 2016 Apr 5;88(7):3967-75. doi: 10.1021/acs.analchem.6b00191. Epub 2016 Mar 24.

46.

A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids.

Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A.

Nat Protoc. 2016 Apr;11(4):747-63. doi: 10.1038/nprot.2016.040. Epub 2016 Mar 17.

47.

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects.

Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, Saghatelian A, Wan Y.

Cell Metab. 2016 Mar 8;23(3):479-91. doi: 10.1016/j.cmet.2015.12.010. Epub 2016 Jan 14.

48.

Editorial overview: Omics: The maturation of chemical biology.

Saghatelian A, Nomura DK, Weerapana E.

Curr Opin Chem Biol. 2016 Feb;30:v-vi. doi: 10.1016/j.cbpa.2015.12.005. Epub 2015 Dec 28. No abstract available.

PMID:
26739665
49.

Discovery and characterization of smORF-encoded bioactive polypeptides.

Saghatelian A, Couso JP.

Nat Chem Biol. 2015 Dec;11(12):909-16. doi: 10.1038/nchembio.1964. Review.

50.

Primate-specific ORF0 contributes to retrotransposon-mediated diversity.

Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH.

Cell. 2015 Oct 22;163(3):583-93. doi: 10.1016/j.cell.2015.09.025. Epub 2015 Oct 22.

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