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Items: 25


A multi-company assessment of submicron particle levels by NTA and RMM in a wide range of late-phase clinical and commercial biotechnology-derived protein products.

Hubert M, Yang DT, Kwok SC, Rios A, Das TK, Patel A, Wuchner K, Antochshuk V, Junge F, Bou-Assaf GM, Cao S, Saggu M, Montrond L, Afonina N, Kolhe P, Loladze V, Narhi L.

J Pharm Sci. 2019 Oct 21. pii: S0022-3549(19)30662-8. doi: 10.1016/j.xphs.2019.10.025. [Epub ahead of print]


Brentuximab a novel antibody therapy: real-world use confirms efficacy and tolerability for CD30-positive cutaneous lymphoma.

Engelina S, Saggu M, Yoo J, Shah F, Stevens A, Irwin C, Chaganti S, Scarisbrick JJ.

Br J Dermatol. 2019 Sep 16. doi: 10.1111/bjd.18535. [Epub ahead of print] No abstract available.


Local and Global Electric Field Asymmetry in Photosynthetic Reaction Centers.

Saggu M, Fried SD, Boxer SG.

J Phys Chem B. 2019 Feb 21;123(7):1527-1536. doi: 10.1021/acs.jpcb.8b11458. Epub 2019 Feb 7.


A Random Forest Approach for Counting Silicone Oil Droplets and Protein Particles in Antibody Formulations Using Flow Microscopy.

Saggu M, Patel AR, Koulis T.

Pharm Res. 2017 Feb;34(2):479-491. doi: 10.1007/s11095-016-2079-x. Epub 2016 Dec 19.


De-epithelialised radial forearm free flap to recontour the buccal commissure.

Elledge R, Saggu M, Parmar S, Martin T, Praveen P.

Br J Oral Maxillofac Surg. 2017 Feb;55(2):205-206. doi: 10.1016/j.bjoms.2016.07.008. Epub 2016 Jul 21. No abstract available.


Putative hydrogen bond to tyrosine M208 in photosynthetic reaction centers from Rhodobacter capsulatus significantly slows primary charge separation.

Saggu M, Carter B, Zhou X, Faries K, Cegelski L, Holten D, Boxer SG, Kirmaier C.

J Phys Chem B. 2014 Jun 19;118(24):6721-32. doi: 10.1021/jp503422c. Epub 2014 Jun 6.


A bentazone-resistant mutant of cyanobacterium, Synechococcus elongatus PCC7942 adapts different strategies to counteract on bromoxynil- and salt-mediated oxidative stress.

Bagchi SN, Das PK, Banerjee S, Saggu M, Bagchi D.

Physiol Mol Biol Plants. 2012 Apr;18(2):115-23. doi: 10.1007/s12298-012-0111-0. Epub 2012 Mar 31.


Experimental quantification of electrostatics in X-H···π hydrogen bonds.

Saggu M, Levinson NM, Boxer SG.

J Am Chem Soc. 2012 Nov 21;134(46):18986-97. doi: 10.1021/ja305575t. Epub 2012 Nov 7.


Direct measurements of electric fields in weak OH···π hydrogen bonds.

Saggu M, Levinson NM, Boxer SG.

J Am Chem Soc. 2011 Nov 2;133(43):17414-9. doi: 10.1021/ja2069592. Epub 2011 Oct 12.


Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression.

Mahro M, Coelho C, Trincão J, Rodrigues D, Terao M, Garattini E, Saggu M, Lendzian F, Hildebrandt P, Romão MJ, Leimkühler S.

Drug Metab Dispos. 2011 Oct;39(10):1939-45. doi: 10.1124/dmd.111.040873. Epub 2011 Jun 24.


A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase.

Goris T, Wait AF, Saggu M, Fritsch J, Heidary N, Stein M, Zebger I, Lendzian F, Armstrong FA, Friedrich B, Lenz O.

Nat Chem Biol. 2011 May;7(5):310-8. doi: 10.1038/nchembio.555. Epub 2011 Mar 9. Erratum in: Nat Chem Biol. 2011 Sep;7(9):648.


Probing the active site of an O2-tolerant NAD+-reducing [NiFe]-hydrogenase from Ralstonia eutropha H16 by in situ EPR and FTIR spectroscopy.

Horch M, Lauterbach L, Saggu M, Hildebrandt P, Lendzian F, Bittl R, Lenz O, Zebger I.

Angew Chem Int Ed Engl. 2010 Oct 18;49(43):8026-9. doi: 10.1002/anie.201002197. No abstract available.


Impact of amino acid substitutions near the catalytic site on the spectral properties of an O2-tolerant membrane-bound [NiFe] hydrogenase.

Saggu M, Ludwig M, Friedrich B, Hildebrandt P, Bittl R, Lendzian F, Lenz O, Zebger I.

Chemphyschem. 2010 Apr 26;11(6):1215-24. doi: 10.1002/cphc.200900988.


Comparison of the membrane-bound [NiFe] hydrogenases from R. eutropha H16 and D. vulgaris Miyazaki F in the oxidized ready state by pulsed EPR.

Saggu M, Teutloff C, Ludwig M, Brecht M, Pandelia ME, Lenz O, Friedrich B, Lubitz W, Hildebrandt P, Lendzian F, Bittl R.

Phys Chem Chem Phys. 2010 Mar 7;12(9):2139-48. doi: 10.1039/b922236g. Epub 2010 Jan 15.


Biosynthesis of (bacterio)chlorophylls: ATP-dependent transient subunit interaction and electron transfer of dark operative protochlorophyllide oxidoreductase.

Bröcker MJ, Wätzlich D, Saggu M, Lendzian F, Moser J, Jahn D.

J Biol Chem. 2010 Mar 12;285(11):8268-77. doi: 10.1074/jbc.M109.087874. Epub 2010 Jan 14.


Overexpression, isolation, and spectroscopic characterization of the bidirectional [NiFe] hydrogenase from Synechocystis sp. PCC 6803.

Germer F, Zebger I, Saggu M, Lendzian F, Schulz R, Appel J.

J Biol Chem. 2009 Dec 25;284(52):36462-72. doi: 10.1074/jbc.M109.028795. Epub 2009 Sep 28.


Site directed mutagenesis of amino acid residues at the active site of mouse aldehyde oxidase AOX1.

Schumann S, Terao M, Garattini E, Saggu M, Lendzian F, Hildebrandt P, Leimkühler S.

PLoS One. 2009;4(4):e5348. doi: 10.1371/journal.pone.0005348. Epub 2009 Apr 29.


A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo-flavoenzyme from Escherichia coli.

Neumann M, Mittelstädt G, Iobbi-Nivol C, Saggu M, Lendzian F, Hildebrandt P, Leimkühler S.

FEBS J. 2009 May;276(10):2762-74. doi: 10.1111/j.1742-4658.2009.07000.x. Epub 2009 Apr 1.


Spectroscopic insights into the oxygen-tolerant membrane-associated [NiFe] hydrogenase of Ralstonia eutropha H16.

Saggu M, Zebger I, Ludwig M, Lenz O, Friedrich B, Hildebrandt P, Lendzian F.

J Biol Chem. 2009 Jun 12;284(24):16264-76. doi: 10.1074/jbc.M805690200. Epub 2009 Mar 20.


Concerted action of two novel auxiliary proteins in assembly of the active site in a membrane-bound [NiFe] hydrogenase.

Ludwig M, Schubert T, Zebger I, Wisitruangsakul N, Saggu M, Strack A, Lenz O, Hildebrandt P, Friedrich B.

J Biol Chem. 2009 Jan 23;284(4):2159-68. doi: 10.1074/jbc.M808488200. Epub 2008 Nov 18.


Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-beta-lactamase.

Tioni MF, Llarrull LI, Poeylaut-Palena AA, Martí MA, Saggu M, Periyannan GR, Mata EG, Bennett B, Murgida DH, Vila AJ.

J Am Chem Soc. 2008 Nov 26;130(47):15852-63. doi: 10.1021/ja801169j.


Substrate recognition of nitrogenase-like dark operative protochlorophyllide oxidoreductase from Prochlorococcus marinus.

Bröcker MJ, Wätzlich D, Uliczka F, Virus S, Saggu M, Lendzian F, Scheer H, Rüdiger W, Moser J, Jahn D.

J Biol Chem. 2008 Oct 31;283(44):29873-81. doi: 10.1074/jbc.M805206200. Epub 2008 Aug 8.


The mechanism of assembly and cofactor insertion into Rhodobacter capsulatus xanthine dehydrogenase.

Schumann S, Saggu M, Möller N, Anker SD, Lendzian F, Hildebrandt P, Leimkühler S.

J Biol Chem. 2008 Jun 13;283(24):16602-11. doi: 10.1074/jbc.M709894200. Epub 2008 Apr 6.

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