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Items: 1 to 50 of 51

1.

CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems.

Del Rio D, Beucher B, Lavigne M, Wehbi A, Gonzalez Dopeso-Reyes I, Saggio I, Kremer EJ.

Front Mol Neurosci. 2019 Mar 29;12:71. doi: 10.3389/fnmol.2019.00071. eCollection 2019. Review.

2.

A new role for Drosophila Aurora-A in maintaining chromosome integrity.

Merigliano C, Mascolo E, Cesta A, Saggio I, Vernì F.

Chromosoma. 2019 Mar;128(1):41-52. doi: 10.1007/s00412-018-00687-0. Epub 2019 Jan 5.

PMID:
30612150
3.

p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice.

Burla R, La Torre M, Zanetti G, Bastianelli A, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F, Saggio I.

Front Genet. 2018 Nov 27;9:581. doi: 10.3389/fgene.2018.00581. eCollection 2018.

4.

Perils and Promises of Therapeutic Approaches for the Stem Cell Disease Fibrous Dysplasia.

Saggio I.

Stem Cells Transl Med. 2019 Feb;8(2):110-111. doi: 10.1002/sctm.18-0213. Epub 2018 Nov 13. No abstract available.

5.

The Relationship Between Vitamin B6, Diabetes and Cancer.

Merigliano C, Mascolo E, Burla R, Saggio I, Vernì F.

Front Genet. 2018 Sep 13;9:388. doi: 10.3389/fgene.2018.00388. eCollection 2018. Review.

6.

Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes.

Merigliano C, Mascolo E, La Torre M, Saggio I, Vernì F.

Sci Rep. 2018 Jul 30;8(1):11432. doi: 10.1038/s41598-018-29801-z.

7.

Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate.

Mestre-Francés N, Serratrice N, Gennetier A, Devau G, Cobo S, Trouche SG, Fontès P, Zussy C, De Deurwaerdere P, Salinas S, Mennechet FJ, Dusonchet J, Schneider BL, Saggio I, Kalatzis V, Luquin-Piudo MR, Verdier JM, Kremer EJ.

JCI Insight. 2018 Jul 26;3(14). pii: 98202. doi: 10.1172/jci.insight.98202. eCollection 2018 Jul 26.

8.

Genomic instability and DNA replication defects in progeroid syndromes.

Burla R, La Torre M, Merigliano C, Vernì F, Saggio I.

Nucleus. 2018 Dec 31;9(1):368-379. doi: 10.1080/19491034.2018.1476793. Epub 2018 Jun 23.

PMID:
29936894
9.

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.

La Torre M, Merigliano C, Burla R, Mottini C, Zanetti G, Del Giudice S, Carcuro M, Virdia I, Bucciarelli E, Manni I, Vinciguerra GR, Piaggio G, Riminucci M, Cumano A, Bartolazzi A, Vernì F, Soddu S, Gatti M, Saggio I.

Aging Cell. 2018 Aug;17(4):e12730. doi: 10.1111/acel.12730. Epub 2018 Apr 10.

10.

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.

Burla R, Carcuro M, Torre ML, Fratini F, Crescenzi M, D'Apice MR, Spitalieri P, Raffa GD, Astrologo L, Lattanzi G, Cundari E, Raimondo D, Biroccio A, Gatti M, Saggio I.

Open Biol. 2016 Aug;6(8). pii: 160103. doi: 10.1098/rsob.160103.

11.

No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels.

Sacchetti B, Funari A, Remoli C, Giannicola G, Kogler G, Liedtke S, Cossu G, Serafini M, Sampaolesi M, Tagliafico E, Tenedini E, Saggio I, Robey PG, Riminucci M, Bianco P.

Stem Cell Reports. 2016 Jun 14;6(6):897-913. doi: 10.1016/j.stemcr.2016.05.011.

12.

Mammalian telomeres and their partnership with lamins.

Burla R, La Torre M, Saggio I.

Nucleus. 2016 Apr 25;7(2):187-202. doi: 10.1080/19491034.2016.1179409. Review.

13.

Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups.

Piersanti S, Burla R, Licursi V, Brito C, La Torre M, Alves PM, Simao D, Mottini C, Salinas S, Negri R, Tagliafico E, Kremer EJ, Saggio I.

PLoS One. 2015 Jul 24;10(7):e0133607. doi: 10.1371/journal.pone.0133607. eCollection 2015.

14.

Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model.

Simão D, Pinto C, Fernandes P, Peddie CJ, Piersanti S, Collinson LM, Salinas S, Saggio I, Schiavo G, Kremer EJ, Brito C, Alves PM.

Gene Ther. 2016 Jan;23(1):86-94. doi: 10.1038/gt.2015.75. Epub 2015 Aug 20.

15.

The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres.

Cenci G, Ciapponi L, Marzullo M, Raffa GD, Morciano P, Raimondo D, Burla R, Saggio I, Gatti M.

PLoS Genet. 2015 Jun 25;11(6):e1005260. doi: 10.1371/journal.pgen.1005260. eCollection 2015 Jun.

16.

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.

Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I.

PLoS Genet. 2015 Jun 25;11(6):e1005167. doi: 10.1371/journal.pgen.1005167. eCollection 2015 Jun.

17.

Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse.

Remoli C, Michienzi S, Sacchetti B, Consiglio AD, Cersosimo S, Spica E, Robey PG, Holmbeck K, Cumano A, Boyde A, Davis G, Saggio I, Riminucci M, Bianco P.

J Bone Miner Res. 2015 Jun;30(6):1030-43. doi: 10.1002/jbmr.2425.

18.

Modeling human neural functionality in vitro: three-dimensional culture for dopaminergic differentiation.

Simão D, Pinto C, Piersanti S, Weston A, Peddie CJ, Bastos AE, Licursi V, Schwarz SC, Collinson LM, Salinas S, Serra M, Teixeira AP, Saggio I, Lima PA, Kremer EJ, Schiavo G, Brito C, Alves PM.

Tissue Eng Part A. 2015 Feb;21(3-4):654-68. doi: 10.1089/ten.TEA.2014.0079. Epub 2014 Nov 11.

PMID:
25257211
19.

Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes.

Cossetti C, Lugini L, Astrologo L, Saggio I, Fais S, Spadafora C.

PLoS One. 2014 Jul 3;9(7):e101629. doi: 10.1371/journal.pone.0101629. eCollection 2014.

20.

Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history.

Saggio I, Remoli C, Spica E, Cersosimo S, Sacchetti B, Robey PG, Holmbeck K, Cumano A, Boyde A, Bianco P, Riminucci M.

J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267.

21.

DNA microarray to analyze adenovirus-host interactions.

Piersanti S, Tagliafico E, Saggio I.

Methods Mol Biol. 2014;1089:89-104. doi: 10.1007/978-1-62703-679-5_7.

PMID:
24132480
22.

Differentiated neuroprogenitor cells incubated with human or canine adenovirus, or lentiviral vectors have distinct transcriptome profiles.

Piersanti S, Astrologo L, Licursi V, Costa R, Roncaglia E, Gennetier A, Ibanes S, Chillon M, Negri R, Tagliafico E, Kremer EJ, Saggio I.

PLoS One. 2013 Jul 26;8(7):e69808. doi: 10.1371/journal.pone.0069808. Print 2013.

23.

Restriction of neural precursor ability to respond to Nurr1 by early regional specification.

Soldati C, Cacci E, Biagioni S, Carucci N, Lupo G, Perrone-Capano C, Saggio I, Augusti-Tocco G.

PLoS One. 2012;7(12):e51798. doi: 10.1371/journal.pone.0051798. Epub 2012 Dec 11.

24.

Chemical coupling as a potent strategy for preparation of targeted bacteriophage-derived gene nanocarriers into eukaryotic cells.

Khalaj-Kondori M, Sadeghizadeh M, Behmanesh M, Saggio I, Monaci P.

J Gene Med. 2011 Nov;13(11):622-31. doi: 10.1002/jgm.1617.

PMID:
22002551
25.

The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.

Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, Benihoud K, Saggio I, Rosselli F.

Nucleic Acids Res. 2011 Jul;39(13):5459-73. doi: 10.1093/nar/gkr084. Epub 2011 Mar 17.

26.

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.

Riminucci M, Robey PG, Saggio I, Bianco P.

J Mol Endocrinol. 2010 Dec;45(6):355-64. doi: 10.1677/JME-10-0097. Epub 2010 Sep 14. Review.

27.
28.

Transfer, analysis, and reversion of the fibrous dysplasia cellular phenotype in human skeletal progenitors.

Piersanti S, Remoli C, Saggio I, Funari A, Michienzi S, Sacchetti B, Robey PG, Riminucci M, Bianco P.

J Bone Miner Res. 2010 May;25(5):1103-16. doi: 10.1359/jbmr.091036.

29.

Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells.

Caruso P, Burla R, Piersanti S, Cherubini G, Remoli C, Martina Y, Saggio I.

Virology. 2009 Mar 15;385(2):343-50. doi: 10.1016/j.virol.2008.12.005. Epub 2009 Jan 12.

30.

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment.

Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M, Bianco P.

Cell. 2007 Oct 19;131(2):324-36. Erratum in: Cell. 2008 May 30;133(5):928.

31.

Different modulation of cellular transcription by adenovirus 5, DeltaE1/E3 adenovirus and helper-dependent vectors.

Martina Y, Avitabile D, Piersanti S, Cherubini G, Saggio I.

Virus Res. 2007 Dec;130(1-2):71-84. Epub 2007 Jun 29. Erratum in: Virus Res. 2008 May;133(2):291.

PMID:
17601622
32.

Fibrous dysplasia as a stem cell disease.

Riminucci M, Saggio I, Robey PG, Bianco P.

J Bone Miner Res. 2006 Dec;21 Suppl 2:P125-31. Review.

33.

Respective roles of TNF-alpha and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice.

Benihoud K, Esselin S, Descamps D, Jullienne B, Salone B, Bobé P, Bonardelle D, Connault E, Opolon P, Saggio I, Perricaudet M.

Gene Ther. 2007 Mar;14(6):533-44. Epub 2006 Nov 16. Erratum in: Gene Ther. 2007 Mar;14(6):551.

PMID:
17109009
34.

E1B55K-deleted adenovirus (ONYX-015) overrides G1/S and G2/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells.

Cherubini G, Petouchoff T, Grossi M, Piersanti S, Cundari E, Saggio I.

Cell Cycle. 2006 Oct;5(19):2244-52. Epub 2006 Oct 1.

PMID:
16969092
35.

Lentiviral transduction of human postnatal skeletal (stromal, mesenchymal) stem cells: in vivo transplantation and gene silencing.

Piersanti S, Sacchetti B, Funari A, Di Cesare S, Bonci D, Cherubini G, Peschle C, Riminucci M, Bianco P, Saggio I.

Calcif Tissue Int. 2006 Jun;78(6):372-84. Epub 2006 Jun 21.

PMID:
16830199
36.

Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma.

Campo S, Serlupi-Crescenzi O, Arseni B, Rossi S, Saggio I, Salone B, Cherubini G, Carminati P, De Santis R.

Cytokine. 2005 Sep 7;31(5):368-74.

PMID:
16061391
37.

Use of DNA microarrays to monitor host response to virus and virus-derived gene therapy vectors.

Piersanti S, Martina Y, Cherubini G, Avitabile D, Saggio I.

Am J Pharmacogenomics. 2004;4(6):345-56. Review.

PMID:
15651896
38.

Mammalian cell transduction and internalization properties of lambda phages displaying the full-length adenoviral penton base or its central domain.

Piersanti S, Cherubini G, Martina Y, Salone B, Avitabile D, Grosso F, Cundari E, Di Zenzo G, Saggio I.

J Mol Med (Berl). 2004 Jul;82(7):467-76. Epub 2004 May 19.

PMID:
15150649
39.

Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5.

Salone B, Martina Y, Piersanti S, Cundari E, Cherubini G, Franqueville L, Failla CM, Boulanger P, Saggio I.

J Virol. 2003 Dec;77(24):13448-54.

40.

Binding properties, cell delivery, and gene transfer of adenoviral penton base displaying bacteriophage.

Di Giovine M, Salone B, Martina Y, Amati V, Zambruno G, Cundari E, Failla CM, Saggio I.

Virology. 2001 Mar 30;282(1):102-12.

41.

The role of IL-6 in the inflammatory and humoral response to adenoviral vectors.

Benihoud K, Salone B, Esselin S, Opolon P, Poli V, Di Giovine M, Perricaudet M, Saggio I.

J Gene Med. 2000 May-Jun;2(3):194-203.

PMID:
10894265
42.

Efficient, repeated adenovirus-mediated gene transfer in mice lacking both tumor necrosis factor alpha and lymphotoxin alpha.

Benihoud K, Saggio I, Opolon P, Salone B, Amiot F, Connault E, Chianale C, Dautry F, Yeh P, Perricaudet M.

J Virol. 1998 Dec;72(12):9514-25.

43.

Agonistic and antagonistic variants of ciliary neurotrophic factor (CNTF) reveal functional differences between membrane-bound and soluble CNTF alpha-receptor.

Di Marco A, Gloaguen I, Demartis A, Saggio I, Graziani R, Paonessa G, Laufer R.

J Biol Chem. 1997 Sep 12;272(37):23069-75.

44.

Adenovirus-mediated gene transfer of a human IL-6 antagonist.

Saggio I, Ciapponi L, Savino R, Ciliberto G, Perricaudet M.

Gene Ther. 1997 Aug;4(8):839-45.

45.

Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.

Di Marco A, Gloaguen I, Graziani R, Paonessa G, Saggio I, Hudson KR, Laufer R.

Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9247-52.

46.
47.

Functional phage display of ciliary neurotrophic factor.

Saggio I, Gloaguen I, Laufer R.

Gene. 1995 Jan 11;152(1):35-9.

PMID:
7828925
48.

Nonradioactive receptor binding assay for ciliary neurotrophic factor.

Saggio I, Paonessa G, Gloaguen I, Graziani R, De Serio A, Laufer R.

Anal Biochem. 1994 Sep;221(2):387-91.

PMID:
7810882
49.

Biotin binders selected from a random peptide library expressed on phage.

Saggio I, Laufer R.

Biochem J. 1993 Nov 1;295 ( Pt 3):903. No abstract available.

50.

Detection of biotinylated molecules in solid-phase assays using a recombinant biotin-binding bacteriophage.

Saggio I, Laufer R.

Anal Biochem. 1993 Oct;214(1):352-5. No abstract available.

PMID:
8250250

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