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Items: 47

1.

The homeobox factor Irx3 maintains adipogenic identity.

Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G.

Metabolism. 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014. [Epub ahead of print]

PMID:
31751577
2.

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty.

Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB.

J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi: 10.1210/clinem/dgz094. [Epub ahead of print]

PMID:
31697832
3.

The Rho GTPase RND3 regulates adipocyte lipolysis.

Dankel SN, Røst TH, Kulyté A, Fandalyuk Z, Skurk T, Hauner H, Sagen JV, Rydén M, Arner P, Mellgren G.

Metabolism. 2019 Dec;101:153999. doi: 10.1016/j.metabol.2019.153999. Epub 2019 Oct 28.

4.

Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis.

Gudbrandsen OA, Dankel SN, Skumsnes L, Flølo TN, Folkestad OH, Nielsen HJ, Våge V, Mohn AC, Nedrebø BG, Sagen JV, Fernø J, Mellgren G.

Sci Rep. 2019 Oct 15;9(1):14817. doi: 10.1038/s41598-019-51347-x.

5.

Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth.

Helgeland Ø, Vaudel M, Juliusson PB, Lingaas Holmen O, Juodakis J, Bacelis J, Jacobsson B, Lindekleiv H, Hveem K, Lie RT, Knudsen GP, Stoltenberg C, Magnus P, Sagen JV, Molven A, Johansson S, Njølstad PR.

Nat Commun. 2019 Oct 1;10(1):4448. doi: 10.1038/s41467-019-12308-0.

6.

Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice.

Svärd J, Røst TH, Sommervoll CEN, Haugen C, Gudbrandsen OA, Mellgren AE, Rødahl E, Fernø J, Dankel SN, Sagen JV, Mellgren G.

Sci Rep. 2019 Mar 15;9(1):4614. doi: 10.1038/s41598-018-37501-x.

7.

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.

Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G.

Int J Obes (Lond). 2019 Nov;43(11):2151-2162. doi: 10.1038/s41366-018-0275-y. Epub 2018 Dec 11.

8.

Serum levels of leptin and adiponectin are not associated with disease activity or treatment response in multiple sclerosis.

Kvistad SS, Myhr KM, Holmøy T, Benth JŠ, Wergeland S, Beiske AG, Bjerve KS, Hovdal H, Midgard R, Sagen JV, Torkildsen Ø.

J Neuroimmunol. 2018 Oct 15;323:73-77. doi: 10.1016/j.jneuroim.2018.07.011. Epub 2018 Jul 24.

PMID:
30196837
9.

Adrenal Venous Sampling for Assessment of Autonomous Cortisol Secretion.

Ueland GÅ, Methlie P, Jøssang DE, Sagen JV, Viste K, Thordarson HB, Heie A, Grytaas M, Løvås K, Biermann M, Husebye ES.

J Clin Endocrinol Metab. 2018 Dec 1;103(12):4553-4560. doi: 10.1210/jc.2018-01198.

PMID:
30137397
10.

A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells.

Bozickovic O, Skartveit L, Engelsen AST, Helland T, Jonsdottir K, Flågeng MH, Fenne IS, Janssen E, Lorens JB, Bjørkhaug L, Sagen JV, Mellgren G.

J Steroid Biochem Mol Biol. 2019 Jan;185:57-70. doi: 10.1016/j.jsbmb.2018.07.011. Epub 2018 Jul 23.

PMID:
30048685
11.

LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells.

Ahmed KEM, Frøysa HG, Karlsen OA, Sagen JV, Mellgren G, Verhaegen S, Ropstad E, Goksøyr A, Kellmann R.

Toxicol In Vitro. 2018 Oct;52:332-341. doi: 10.1016/j.tiv.2018.07.002. Epub 2018 Jul 11.

PMID:
30017865
12.

The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes.

Sagen JV, Bjørkhaug L, Haukanes BI, Grevle L, Molnes J, Nedrebø BG, Søvik O, Njølstad PR, Johansson S, Molven A.

Diabetes Res Clin Pract. 2017 Nov;133:142-149. doi: 10.1016/j.diabres.2017.08.001. Epub 2017 Sep 1.

PMID:
28934671
13.

Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population.

Grytaas MA, Strømsøy SS, Rørvik JT, Arnes JB, Heie A, Arnesen T, Jørstad MD, Nedrebø BG, Jøssang DE, Jensen DK, Rørvik HD, Sagen JV, Mellgren G, Thordarson HB, Husebye ES, Løvås K.

Horm Metab Res. 2017 Nov;49(11):838-846. doi: 10.1055/s-0043-118909. Epub 2017 Sep 18.

PMID:
28922675
14.

Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: a randomized controlled trial.

Veum VL, Laupsa-Borge J, Eng Ø, Rostrup E, Larsen TH, Nordrehaug JE, Nygård OK, Sagen JV, Gudbrandsen OA, Dankel SN, Mellgren G.

Am J Clin Nutr. 2017 Jan;105(1):85-99. doi: 10.3945/ajcn.115.123463. Epub 2016 Nov 30.

PMID:
27903520
15.

[Impaired sensitivity to thyroid hormone].

Kvistad SA, Methlie P, Løvås K, Sagen JV.

Tidsskr Nor Laegeforen. 2016 Apr 19;136(7):618-22. doi: 10.4045/tidsskr.15.0084. eCollection 2016 Apr 19. Review. Norwegian.

16.
17.

Body mass index influence interferon-beta treatment response in multiple sclerosis.

Kvistad SS, Myhr KM, Holmøy T, Šaltytė Benth J, Wergeland S, Beiske AG, Bjerve KS, Hovdal H, Lilleås F, Midgard R, Pedersen T, Bakke SJ, Michelsen AE, Aukrust P, Ueland T, Sagen JV, Torkildsen Ø.

J Neuroimmunol. 2015 Nov 15;288:92-7. doi: 10.1016/j.jneuroim.2015.09.008. Epub 2015 Sep 26.

PMID:
26531700
18.

Clinical reappraisal of SHORT syndrome with PIK3R1 mutations: toward recommendation for molecular testing and management.

Avila M, Dyment DA, Sagen JV, St-Onge J, Moog U, Chung BHY, Mo S, Mansour S, Albanese A, Garcia S, Martin DO, Lopez AA, Claudi T, König R, White SM, Sawyer SL, Bernstein JA, Slattery L, Jobling RK, Yoon G, Curry CJ, Merrer ML, Luyer BL, Héron D, Mathieu-Dramard M, Bitoun P, Odent S, Amiel J, Kuentz P, Thevenon J, Laville M, Reznik Y, Fagour C, Nunes ML, Delesalle D, Manouvrier S, Lascols O, Huet F, Binquet C, Faivre L, Rivière JB, Vigouroux C, Njølstad PR, Innes AM, Thauvin-Robinet C.

Clin Genet. 2016 Apr;89(4):501-506. doi: 10.1111/cge.12688. Epub 2015 Nov 27.

19.

The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity.

Madsen A, Bjune JI, Bjørkhaug L, Mellgren G, Sagen JV.

Mol Cell Endocrinol. 2016 Jan 5;419:92-101. doi: 10.1016/j.mce.2015.10.003. Epub 2015 Oct 9.

PMID:
26455881
20.

Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells.

Bozickovic O, Hoang T, Fenne IS, Helland T, Skartveit L, Ouchida M, Mellgren G, Sagen JV.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2383-91. doi: 10.1016/j.bbamcr.2015.05.016. Epub 2015 May 16.

21.

COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size.

Dankel SN, Svärd J, Matthä S, Claussnitzer M, Klöting N, Glunk V, Fandalyuk Z, Grytten E, Solsvik MH, Nielsen HJ, Busch C, Hauner H, Blüher M, Skurk T, Sagen JV, Mellgren G.

Obesity (Silver Spring). 2014 Aug;22(8):1807-13. doi: 10.1002/oby.20758. Epub 2014 Apr 10.

22.

Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice.

Dankel SN, Degerud EM, Borkowski K, Fjære E, Midtbø LK, Haugen C, Solsvik MH, Lavigne AM, Liaset B, Sagen JV, Kristiansen K, Mellgren G, Madsen L.

Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E210-24. doi: 10.1152/ajpendo.00188.2013. Epub 2013 Dec 3.

23.

GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation.

Negahdar M, Aukrust I, Molnes J, Solheim MH, Johansson BB, Sagen JV, Dahl-Jørgensen K, Kulkarni RN, Søvik O, Flatmark T, Njølstad PR, Bjørkhaug L.

Mol Cell Endocrinol. 2014 Jan 25;382(1):55-65. doi: 10.1016/j.mce.2013.08.020. Epub 2013 Aug 31.

PMID:
24001579
24.

Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells.

Fenne IS, Helland T, Flågeng MH, Dankel SN, Mellgren G, Sagen JV.

PLoS One. 2013 Jul 30;8(7):e70096. doi: 10.1371/journal.pone.0070096. Print 2013.

25.

SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.

Chudasama KK, Winnay J, Johansson S, Claudi T, König R, Haldorsen I, Johansson B, Woo JR, Aarskog D, Sagen JV, Kahn CR, Molven A, Njølstad PR.

Am J Hum Genet. 2013 Jul 11;93(1):150-7. doi: 10.1016/j.ajhg.2013.05.023. Epub 2013 Jun 27.

26.

cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1.

Hoang T, Fenne IS, Madsen A, Bozickovic O, Johannessen M, Bergsvåg M, Lien EA, Stallcup MR, Sagen JV, Moens U, Mellgren G.

Endocrinology. 2013 Apr;154(4):1513-27. doi: 10.1210/en.2012-2049. Epub 2013 Mar 5.

27.

Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family.

York B, Sagen JV, Tsimelzon A, Louet JF, Chopra AR, Reineke EL, Zhou S, Stevens RD, Wenner BR, Ilkayeva O, Bain JR, Xu J, Hilsenbeck SG, Newgard CB, O'Malley BW.

Mol Endocrinol. 2013 Feb;27(2):366-80. doi: 10.1210/me.2012-1324. Epub 2013 Jan 11.

28.

Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.

York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW.

Cell Metab. 2012 May 2;15(5):752-63. doi: 10.1016/j.cmet.2012.03.020.

29.

The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss.

Veum VL, Dankel SN, Gjerde J, Nielsen HJ, Solsvik MH, Haugen C, Christensen BJ, Hoang T, Fadnes DJ, Busch C, Våge V, Sagen JV, Mellgren G.

Int J Obes (Lond). 2012 Sep;36(9):1195-202. doi: 10.1038/ijo.2011.240. Epub 2011 Dec 6.

PMID:
22143616
30.

The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW.

Cell Metab. 2010 Dec 1;12(6):606-18. doi: 10.1016/j.cmet.2010.11.009.

31.

cAMP-mediated regulation of HNF-4alpha depends on the level of coactivator PGC-1alpha.

Dankel SN, Hoang T, Flågeng MH, Sagen JV, Mellgren G.

Biochim Biophys Acta. 2010 Sep;1803(9):1013-9. doi: 10.1016/j.bbamcr.2010.05.008. Epub 2010 Jun 4.

32.

Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss.

Dankel SN, Fadnes DJ, Stavrum AK, Stansberg C, Holdhus R, Hoang T, Veum VL, Christensen BJ, Våge V, Sagen JV, Steen VM, Mellgren G.

PLoS One. 2010 Jun 9;5(6):e11033. doi: 10.1371/journal.pone.0011033.

33.

Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology.

York B, Yu C, Sagen JV, Liu Z, Nikolai BC, Wu RC, Finegold M, Xu J, O'Malley BW.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11122-7. doi: 10.1073/pnas.1005262107. Epub 2010 Jun 1.

34.

Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase.

Fenne IS, Hoang T, Hauglid M, Sagen JV, Lien EA, Mellgren G.

Endocrinology. 2008 Sep;149(9):4336-45. doi: 10.1210/en.2008-0037. Epub 2008 May 22.

PMID:
18499756
35.

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

Sagen JV, Bjørkhaug L, Molnes J, Raeder H, Grevle L, Søvik O, Molven A, Njølstad PR.

Pediatr Diabetes. 2008 Oct;9(5):442-9. doi: 10.1111/j.1399-5448.2008.00399.x. Epub 2008 Apr 9.

PMID:
18399931
36.

Management of neonatal and infancy-onset diabetes mellitus.

Søvik O, Tansek MZ, Sagen JV, Njølstad PR.

Endocr Dev. 2007;11:94-105. doi: 10.1159/000111062. Review.

PMID:
17986830
37.

A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes: studies of HNF4A variants in the Norwegian MODY registry.

Raeder H, Bjørkhaug L, Johansson S, Mangseth K, Sagen JV, Hunting A, Følling I, Johansen O, Bjørgaas M, Paus PN, Søvik O, Molven A, Njølstad PR.

Diabetes. 2006 Jun;55(6):1899-903.

38.

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.

39.

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.

Raeder H, Johansson S, Holm PI, Haldorsen IS, Mas E, Sbarra V, Nermoen I, Eide SA, Grevle L, Bjørkhaug L, Sagen JV, Aksnes L, Søvik O, Lombardo D, Molven A, Njølstad PR.

Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20.

PMID:
16369531
40.

[Molecular diagnostics in diabetes mellitus].

Bjørkhaug L, Johansson S, Raeder H, Thorsby PM, Undlien DE, Søvik O, Molven A, Sagen JV, Njølstad PR.

Tidsskr Nor Laegeforen. 2005 Nov 3;125(21):2968-72. Review. Norwegian.

41.

Diagnostic screening of NEUROD1 (MODY6) in subjects with MODY or gestational diabetes mellitus.

Sagen JV, Baumann ME, Salvesen HB, Molven A, Søvik O, Njølstad PR.

Diabet Med. 2005 Aug;22(8):1012-5.

PMID:
16026366
42.

Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

Sagen JV, Pearson ER, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad PR, Hattersley AT, Hansen T.

Diabet Med. 2005 Apr;22(4):406-9.

PMID:
15787664
43.

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.

Sagen JV, Raeder H, Hathout E, Shehadeh N, Gudmundsson K, Baevre H, Abuelo D, Phornphutkul C, Molnes J, Bell GI, Gloyn AL, Hattersley AT, Molven A, Søvik O, Njølstad PR.

Diabetes. 2004 Oct;53(10):2713-8.

44.

Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.

Njølstad PR, Sagen JV, Bjørkhaug L, Odili S, Shehadeh N, Bakry D, Sarici SU, Alpay F, Molnes J, Molven A, Søvik O, Matschinsky FM.

Diabetes. 2003 Nov;52(11):2854-60.

45.
46.

Hepatocyte nuclear factor-1 alpha gene mutations and diabetes in Norway.

Bjørkhaug L, Sagen JV, Thorsby P, Søvik O, Molven A, Njølstad PR.

J Clin Endocrinol Metab. 2003 Feb;88(2):920-31.

PMID:
12574234
47.

Reduced prevalence of late-diabetic complications in MODY3 with early diagnosis.

Sagen JV, Njølstad PR, Søvik O.

Diabet Med. 2002 Aug;19(8):697-8. No abstract available.

PMID:
12147154

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