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Items: 32

1.

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.

Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT.

Nat Immunol. 2019 Sep 2. doi: 10.1038/s41590-019-0472-4. [Epub ahead of print]

PMID:
31477921
2.

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR.

Am J Transplant. 2019 Jun;19(6):1820-1830. doi: 10.1111/ajt.15305. Epub 2019 Mar 19.

PMID:
30748099
3.

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program.

Hou S, Clement RL, Diallo A, Blazar BR, Rudensky AY, Sharpe AH, Sage PT.

J Exp Med. 2019 Mar 4;216(3):605-620. doi: 10.1084/jem.20181134. Epub 2019 Jan 31.

4.

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.

Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13347-13352. doi: 10.1073/pnas.1804149115. Epub 2018 Dec 10.

5.

Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity.

Ordikhani F, Uehara M, Kasinath V, Dai L, Eskandari SK, Bahmani B, Yonar M, Azzi JR, Haik Y, Sage PT, Murphy GF, Annabi N, Schatton T, Guleria I, Abdi R.

JCI Insight. 2018 Oct 18;3(20). pii: 122700. doi: 10.1172/jci.insight.122700.

6.

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease.

Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Bradner JE, Melnick AM, Blazar BR.

Blood. 2019 Jan 3;133(1):94-99. doi: 10.1182/blood-2018-03-839993. Epub 2018 Oct 2.

PMID:
30279226
7.

Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing.

Maarouf OH, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, Jiang L, Yilmam OA, Guleria I, Lovitch SB, Grogan JL, Fiorina P, Sage PT, Bromberg JS, McGrath MM, Abdi R.

JCI Insight. 2018 Jul 12;3(13). pii: 120546. doi: 10.1172/jci.insight.120546.

8.

DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation.

Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM.

Am J Transplant. 2019 Jan;19(1):77-88. doi: 10.1111/ajt.14995. Epub 2018 Aug 17.

PMID:
29969188
9.

Preventing Antibody-mediated Rejection During Transplantation: The Potential of Tfr Cells.

Sage PT.

Transplantation. 2018 Oct;102(10):1597-1598. doi: 10.1097/TP.0000000000002225. No abstract available.

PMID:
29757906
10.

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH.

J Immunol. 2018 Apr 15;200(8):2592-2602. doi: 10.4049/jimmunol.1701231. Epub 2018 Mar 12.

11.

Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA.

J Immunol. 2018 Apr 1;200(7):2505-2506. doi: 10.4049/jimmunol.1800150. Epub 2018 Feb 23. No abstract available.

12.

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA.

J Immunol. 2017 Dec 15;199(12):3972-3980. doi: 10.4049/jimmunol.1700409. Epub 2017 Nov 1. Erratum in: J Immunol. 2018 Feb 23;:.

13.

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.

Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH.

Nat Immunol. 2016 Dec;17(12):1436-1446. doi: 10.1038/ni.3578. Epub 2016 Oct 3.

14.

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC.

Cell Metab. 2016 Jul 12;24(1):104-17. doi: 10.1016/j.cmet.2016.06.007.

15.

T follicular regulatory cells.

Sage PT, Sharpe AH.

Immunol Rev. 2016 May;271(1):246-59. doi: 10.1111/imr.12411. Review.

PMID:
27088919
16.

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH.

J Exp Med. 2015 Sep 21;212(10):1603-21. doi: 10.1084/jem.20141030. Epub 2015 Sep 14.

17.

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.

Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH.

Cell Rep. 2015 Jul 14;12(2):163-71. doi: 10.1016/j.celrep.2015.06.015. Epub 2015 Jul 2.

18.

T follicular regulatory cells in the regulation of B cell responses.

Sage PT, Sharpe AH.

Trends Immunol. 2015 Jul;36(7):410-8. doi: 10.1016/j.it.2015.05.005. Epub 2015 Jun 17. Review.

19.

In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses.

Sage PT, Sharpe AH.

Methods Mol Biol. 2015;1291:151-60. doi: 10.1007/978-1-4939-2498-1_13.

PMID:
25836309
20.

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA.

Nat Immunol. 2015 Feb;16(2):188-96. doi: 10.1038/ni.3077. Epub 2015 Jan 5.

21.

The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells.

Sage PT, Paterson AM, Lovitch SB, Sharpe AH.

Immunity. 2014 Dec 18;41(6):1026-39. doi: 10.1016/j.immuni.2014.12.005. Epub 2014 Dec 5.

22.

Circulating T follicular regulatory and helper cells have memory-like properties.

Sage PT, Alvarez D, Godec J, von Andrian UH, Sharpe AH.

J Clin Invest. 2014 Dec;124(12):5191-204. doi: 10.1172/JCI76861. Epub 2014 Oct 27.

23.

Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade.

Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA.

Cancer Immunol Res. 2014 Jul;2(7):643-54. doi: 10.1158/2326-6066.CIR-13-0215. Epub 2014 Apr 29.

24.

Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.

Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV.

J Cell Biol. 2013 Apr 29;201(3):449-65. doi: 10.1083/jcb.201209077.

25.

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.

Sage PT, Francisco LM, Carman CV, Sharpe AH.

Nat Immunol. 2013 Feb;14(2):152-61. doi: 10.1038/ni.2496. Epub 2012 Dec 16.

26.

Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.

Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV.

J Immunol. 2012 Apr 15;188(8):3686-99. doi: 10.4049/jimmunol.1102594. Epub 2012 Mar 21.

27.

A novel function for programmed death ligand-1 regulation of angiogenesis.

Jin Y, Chauhan SK, El Annan J, Sage PT, Sharpe AH, Dana R.

Am J Pathol. 2011 Apr;178(4):1922-9. doi: 10.1016/j.ajpath.2010.12.027. Erratum in: Am J Pathol. 2012 Mar;180(3):1324. Annan, Jaafar E I [corrected to El Annan, Jaafar].

28.

Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts.

Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N.

Am J Transplant. 2011 Apr;11(4):832-40. doi: 10.1111/j.1600-6143.2011.03451.x. Epub 2011 Mar 14.

29.

The PD-1 pathway in tolerance and autoimmunity.

Francisco LM, Sage PT, Sharpe AH.

Immunol Rev. 2010 Jul;236:219-42. doi: 10.1111/j.1600-065X.2010.00923.x. Review.

30.

Settings and mechanisms for trans-cellular diapedesis.

Sage PT, Carman CV.

Front Biosci (Landmark Ed). 2009 Jun 1;14:5066-83. Review.

31.

Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots.

Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14753-8. Epub 2007 Sep 4.

32.

Transcellular diapedesis is initiated by invasive podosomes.

Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA.

Immunity. 2007 Jun;26(6):784-97.

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