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Manipulating the tumour-suppressor protein Rb in lung cancer reveals possible drug targets.

Rubin SM, Sage J.

Nature. 2019 May;569(7756):343-344. doi: 10.1038/d41586-019-01319-y. No abstract available.


Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix.

Topacio BR, Zatulovskiy E, Cristea S, Xie S, Tambo CS, Rubin SM, Sage J, Kõivomägi M, Skotheim JM.

Mol Cell. 2019 May 16;74(4):758-770.e4. doi: 10.1016/j.molcel.2019.03.020. Epub 2019 Apr 11.


Road map for fibrolamellar carcinoma: progress and goals of a diversified approach.

Kastenhuber ER, Craig J, Ramsey J, Sullivan KM, Sage J, de Oliveira S, Riehle KJ, Scott JD, Gordan JD, Bardeesy N, Abou-Alfa GK.

J Hepatocell Carcinoma. 2019 Jan 31;6:41-48. doi: 10.2147/JHC.S194764. eCollection 2019.


Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, Heymach JV, Johnson JE, Lehman JM, MacPherson D, Massion PP, Minna JD, Oliver TG, Quaranta V, Sage J, Thomas RK, Vakoc CR, Gazdar AF.

Nat Rev Cancer. 2019 May;19(5):289-297. doi: 10.1038/s41568-019-0133-9. Review.


Taking SCLC on a Bad LSD(1) Trip One NOTCH Further.

Kim J, Sage J.

Trends Mol Med. 2019 Apr;25(4):261-264. doi: 10.1016/j.molmed.2019.02.009. Epub 2019 Mar 6.


Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer.

Sen T, Rodriguez BL, Chen L, Corte CMD, Morikawa N, Fujimoto J, Cristea S, Nguyen T, Diao L, Li L, Fan Y, Yang Y, Wang J, Glisson BS, Wistuba II, Sage J, Heymach JV, Gibbons DL, Byers LA.

Cancer Discov. 2019 May;9(5):646-661. doi: 10.1158/2159-8290.CD-18-1020. Epub 2019 Feb 18.


Experimental evaluation of seven quality control phantoms for digital breast tomosynthesis.

Sage J, Fezzani KL, Fitton I, Hadid L, Moussier A, Pierrat N, Martineau A, Dreuil S, Heulers L, Etard C.

Phys Med. 2019 Jan;57:137-144. doi: 10.1016/j.ejmp.2018.12.031. Epub 2019 Jan 9.


Cancer origins-genetics rules the day.

Kareta MS, Sage J.

Science. 2018 Oct 5;362(6410):30-31. doi: 10.1126/science.aav1044. No abstract available.


Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin.

Yang D, Denny SK, Greenside PG, Chaikovsky AC, Brady JJ, Ouadah Y, Granja JM, Jahchan NS, Lim JS, Kwok S, Kong CS, Berghoff AS, Schmitt A, Reinhardt HC, Park KS, Preusser M, Kundaje A, Greenleaf WJ, Sage J, Winslow MM.

Cancer Discov. 2018 Oct;8(10):1316-1331. doi: 10.1158/2159-8290.CD-17-0987. Epub 2018 Sep 18.


Association of Patient-reported Experiences and Surgical Outcomes Among Group Practices: Retrospective Cohort Study.

Liu JB, Pusic AL, Gibbons CJ, Opelka FG, Sage JS, Thompson VM, Ko CY, Hall BL, Temple LK.

Ann Surg. 2018 Sep 4. doi: 10.1097/SLA.0000000000003034. [Epub ahead of print]


A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer.

Ponath P, Menezes D, Pan C, Chen B, Oyasu M, Strachan D, LeBlanc H, Sun H, Wang XT, Rangan VS, Deshpande S, Cristea S, Park KS, Sage J, Cardarelli PM.

Clin Cancer Res. 2018 Oct 15;24(20):5178-5189. doi: 10.1158/1078-0432.CCR-18-0018. Epub 2018 Jul 18.


How Does a Heme Carbene Differ from Diatomic Ligated (NO, CO, and CN-) Analogues in the Axial Bond?

Peng Q, Sage JT, Liu Y, Wang Z, Hu MY, Zhao J, Alp EE, Scheidt WR, Li J.

Inorg Chem. 2018 Aug 6;57(15):8788-8795. doi: 10.1021/acs.inorgchem.8b00574. Epub 2018 Jul 16.


Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition.

Chaikovsky AC, Sage J.

Mol Cancer Res. 2018 Oct;16(10):1454-1457. doi: 10.1158/1541-7786.MCR-18-0201. Epub 2018 Jun 22.


Inhibitor of apoptosis proteins (IAPs) mediate collagen type XI alpha 1-driven cisplatin resistance in ovarian cancer.

Rada M, Nallanthighal S, Cha J, Ryan K, Sage J, Eldred C, Ullo M, Orsulic S, Cheon DJ.

Oncogene. 2018 Aug;37(35):4809-4820. doi: 10.1038/s41388-018-0297-x. Epub 2018 May 17.


Non-canonical functions of the RB protein in cancer.

Dick FA, Goodrich DW, Sage J, Dyson NJ.

Nat Rev Cancer. 2018 Jul;18(7):442-451. doi: 10.1038/s41568-018-0008-5. Review.


Intracellular Delivery of Nanomaterials via an Inertial Microfluidic Cell Hydroporator.

Deng Y, Kizer M, Rada M, Sage J, Wang X, Cheon DJ, Chung AJ.

Nano Lett. 2018 Apr 11;18(4):2705-2710. doi: 10.1021/acs.nanolett.8b00704. Epub 2018 Mar 23.


Tumor heterogeneity in small cell lung cancer defined and investigated in pre-clinical mouse models.

Shue YT, Lim JS, Sage J.

Transl Lung Cancer Res. 2018 Feb;7(1):21-31. doi: 10.21037/tlcr.2018.01.15. Review.


[Dual tumor suppressive and oncogenic roles for Notch signaling in small cell lung cancer].

Oliverio R, Sage J.

Med Sci (Paris). 2018 Jan;34(1):24-26. doi: 10.1051/medsci/20183401007. Epub 2018 Jan 31. French. No abstract available.


Are there multiple cells of origin of Merkel cell carcinoma?

Sunshine JC, Jahchan NS, Sage J, Choi J.

Oncogene. 2018 Mar;37(11):1409-1416. doi: 10.1038/s41388-017-0073-3. Epub 2018 Jan 11. Review.


Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue.

Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A.

Neurochem Res. 2019 Jan;44(1):228-233. doi: 10.1007/s11064-017-2461-z. Epub 2018 Jan 3.


Platelet phosphorylated TDP-43: an exploratory study for a peripheral surrogate biomarker development for Alzheimer's disease.

Wilhite R, Sage JM, Bouzid A, Primavera T, Agbas A.

Future Sci OA. 2017 Aug 16;3(4):FSO238. doi: 10.4155/fsoa-2017-0090. eCollection 2017 Nov.


Relationship between anti-depressant use and lung cancer survival.

Zingone A, Brown D, Bowman ED, Vidal O, Sage J, Neal J, Ryan BM.

Cancer Treat Res Commun. 2017;10:33-39. doi: 10.1016/j.ctarc.2017.01.001. Epub 2017 Jan 29.


Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4.

Pearson-Leary J, Jahagirdar V, Sage J, McNay EC.

Behav Brain Res. 2018 Feb 15;338:32-39. doi: 10.1016/j.bbr.2017.09.033. Epub 2017 Sep 21.


What Can Be Learned from Nuclear Resonance Vibrational Spectroscopy: Vibrational Dynamics and Hemes.

Scheidt WR, Li J, Sage JT.

Chem Rev. 2017 Oct 11;117(19):12532-12563. doi: 10.1021/acs.chemrev.7b00295. Epub 2017 Sep 18. Review.


Human hepatic organoids for the analysis of human genetic diseases.

Guan Y, Xu D, Garfin PM, Ehmer U, Hurwitz M, Enns G, Michie S, Wu M, Zheng M, Nishimura T, Sage J, Peltz G.

JCI Insight. 2017 Sep 7;2(17). pii: 94954. doi: 10.1172/jci.insight.94954. eCollection 2017 Sep 7.


CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma.

Cooney T, Wei MC, Rangaswami A, Xu L, Sage J, Hazard FK.

Ann Clin Lab Sci. 2017 Aug;47(4):395-402.


Correction: Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.

Oncotarget. 2017 Jul 25;8(30):50323. doi: 10.18632/oncotarget.19510. No abstract available.


Neat1 is a p53-inducible lincRNA essential for transformation suppression.

Mello SS, Sinow C, Raj N, Mazur PK, Bieging-Rolett K, Broz DK, Imam JFC, Vogel H, Wood LD, Sage J, Hirose T, Nakagawa S, Rinn J, Attardi LD.

Genes Dev. 2017 Jun 1;31(11):1095-1108. doi: 10.1101/gad.284661.116. Epub 2017 Jul 11.


Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.

Li LX, Fan LX, Zhou JX, Grantham JJ, Calvet JP, Sage J, Li X.

J Clin Invest. 2017 Jun 30;127(7):2751-2764. doi: 10.1172/JCI90921. Epub 2017 Jun 12.


The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.

Szczepny A, Rogers S, Jayasekara WSN, Park K, McCloy RA, Cochrane CR, Ganju V, Cooper WA, Sage J, Peacock CD, Cain JE, Burgess A, Watkins DN.

Oncogene. 2017 Sep 28;36(39):5544-5550. doi: 10.1038/onc.2017.173. Epub 2017 Jun 5.


CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib.

Sen T, Tong P, Stewart CA, Cristea S, Valliani A, Shames DS, Redwood AB, Fan YH, Li L, Glisson BS, Minna JD, Sage J, Gibbons DL, Piwnica-Worms H, Heymach JV, Wang J, Byers LA.

Cancer Res. 2017 Jul 15;77(14):3870-3884. doi: 10.1158/0008-5472.CAN-16-3409. Epub 2017 May 10.


Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.

Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J.

Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10.


Clinical implementation of a knowledge based planning tool for prostate VMAT.

Powis R, Bird A, Brennan M, Hinks S, Newman H, Reed K, Sage J, Webster G.

Radiat Oncol. 2017 May 8;12(1):81. doi: 10.1186/s13014-017-0814-z.


G1 cyclins protect pluripotency.

Arand J, Sage J.

Nat Cell Biol. 2017 Mar 1;19(3):149-150. doi: 10.1038/ncb3480.


An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S.

Nat Commun. 2017 Feb 21;8:14294. doi: 10.1038/ncomms14294.


Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.

Gardner EE, Lok BH, Schneeberger VE, Desmeules P, Miles LA, Arnold PK, Ni A, Khodos I, de Stanchina E, Nguyen T, Sage J, Campbell JE, Ribich S, Rekhtman N, Dowlati A, Massion PP, Rudin CM, Poirier JT.

Cancer Cell. 2017 Feb 13;31(2):286-299. doi: 10.1016/j.ccell.2017.01.006.


An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes.

Hubner EK, Lechler C, Kohnke-Ertel B, Zmoos AF, Sage J, Schmid RM, Ehmer U.

J Gene Med. 2017 Jan;19(1-2). doi: 10.1002/jgm.2940.


Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.

Oncotarget. 2017 Jan 17;8(3):4373-4386. doi: 10.18632/oncotarget.13875. Erratum in: Oncotarget. 2017 Jul 25;8(30):50323.


Integrated optical addressing of an ion qubit.

Mehta KK, Bruzewicz CD, McConnell R, Ram RJ, Sage JM, Chiaverini J.

Nat Nanotechnol. 2016 Dec;11(12):1066-1070. doi: 10.1038/nnano.2016.139. Epub 2016 Aug 8.


Novel functions for the transcription factor E2F4 in development and disease.

Hsu J, Sage J.

Cell Cycle. 2016 Dec;15(23):3183-3190. Epub 2016 Oct 18. Review.


Scalable loading of a two-dimensional trapped-ion array.

Bruzewicz CD, McConnell R, Chiaverini J, Sage JM.

Nat Commun. 2016 Sep 28;7:13005. doi: 10.1038/ncomms13005.


Wide-dynamic-range kinetic investigations of deep proton tunnelling in proteins.

Salna B, Benabbas A, Sage JT, van Thor J, Champion PM.

Nat Chem. 2016 Sep;8(9):874-80. doi: 10.1038/nchem.2527. Epub 2016 May 30.


Essential role for the planarian intestinal GATA transcription factor in stem cells and regeneration.

Flores NM, Oviedo NJ, Sage J.

Dev Biol. 2016 Oct 1;418(1):179-188. doi: 10.1016/j.ydbio.2016.08.015. Epub 2016 Aug 16.


Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility.

Denny SK, Yang D, Chuang CH, Brady JJ, Lim JS, Grüner BM, Chiou SH, Schep AN, Baral J, Hamard C, Antoine M, Wislez M, Kong CS, Connolly AJ, Park KS, Sage J, Greenleaf WJ, Winslow MM.

Cell. 2016 Jul 14;166(2):328-342. doi: 10.1016/j.cell.2016.05.052. Epub 2016 Jun 30.


Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer.

Jahchan NS, Lim JS, Bola B, Morris K, Seitz G, Tran KQ, Xu L, Trapani F, Morrow CJ, Cristea S, Coles GL, Yang D, Vaka D, Kareta MS, George J, Mazur PK, Nguyen T, Anderson WC, Dylla SJ, Blackhall F, Peifer M, Dive C, Sage J.

Cell Rep. 2016 Jul 19;16(3):644-56. doi: 10.1016/j.celrep.2016.06.021. Epub 2016 Jun 30.


CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.

Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, Guerston H, Barkal A, Trapani F, George J, Poirier JT, Gardner EE, Miles LA, de Stanchina E, Lofgren SM, Vogel H, Winslow MM, Dive C, Thomas RK, Rudin CM, van de Rijn M, Majeti R, Garcia KC, Weissman IL, Sage J.

J Clin Invest. 2016 Jul 1;126(7):2610-20. doi: 10.1172/JCI81603. Epub 2016 Jun 13.


Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase.

Mazur PK, Gozani O, Sage J, Reynoird N.

Transl Cancer Res. 2016 Jun;5(3):330-333. doi: 10.21037/tcr.2016.06.26. No abstract available.


Modeling the temporal variability of zinc concentrations in zinc roof runoff-experimental study and uncertainty analysis.

Sage J, El Oreibi E, Saad M, Gromaire MC.

Environ Sci Pollut Res Int. 2016 Aug;23(16):16552-66. doi: 10.1007/s11356-016-6827-6. Epub 2016 May 13.


Is the Canonical RAF/MEK/ERK Signaling Pathway a Therapeutic Target in SCLC?

Cristea S, Sage J.

J Thorac Oncol. 2016 Aug;11(8):1233-1241. doi: 10.1016/j.jtho.2016.04.018. Epub 2016 Apr 29. Review.


Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors.

Krampitz GW, George BM, Willingham SB, Volkmer JP, Weiskopf K, Jahchan N, Newman AM, Sahoo D, Zemek AJ, Yanovsky RL, Nguyen JK, Schnorr PJ, Mazur PK, Sage J, Longacre TA, Visser BC, Poultsides GA, Norton JA, Weissman IL.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4464-9. doi: 10.1073/pnas.1600007113. Epub 2016 Mar 31. Erratum in: Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5538.

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