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Revisiting the matricellular concept.

Murphy-Ullrich JE, Sage EH.

Matrix Biol. 2014 Jul;37:1-14. doi: 10.1016/j.matbio.2014.07.005. Epub 2014 Jul 24. Review.


Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix.

Oh DJ, Kang MH, Ooi YH, Choi KR, Sage EH, Rhee DJ.

Invest Ophthalmol Vis Sci. 2013 May 7;54(5):3309-19. doi: 10.1167/iovs.12-11362.


SPARC fusion protein induces cellular adhesive signaling.

Cheng L, Sage EH, Yan Q.

PLoS One. 2013;8(1):e53202. doi: 10.1371/journal.pone.0053202. Epub 2013 Jan 21.


Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells.

Rangel R, Guzman-Rojas L, le Roux LG, Staquicini FI, Hosoya H, Barbu EM, Ozawa MG, Nie J, Dunner K Jr, Langley RR, Sage EH, Koivunen E, Gelovani JG, Lobb RR, Sidman RL, Pasqualini R, Arap W.

Nat Commun. 2012 Apr 17;3:788. doi: 10.1038/ncomms1773.


Lumbar intervertebral disc degeneration associated with axial and radiating low back pain in ageing SPARC-null mice.

Millecamps M, Tajerian M, Naso L, Sage EH, Stone LS.

Pain. 2012 Jun;153(6):1167-79. doi: 10.1016/j.pain.2012.01.027. Epub 2012 Mar 11.


Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.

Kucukdereli H, Allen NJ, Lee AT, Feng A, Ozlu MI, Conatser LM, Chakraborty C, Workman G, Weaver M, Sage EH, Barres BA, Eroglu C.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E440-9. doi: 10.1073/pnas.1104977108. Epub 2011 Jul 25.


Proteolysis of the matricellular protein hevin by matrix metalloproteinase-3 produces a SPARC-like fragment (SLF) associated with neovasculature in a murine glioma model.

Weaver M, Workman G, Schultz CR, Lemke N, Rempel SA, Sage EH.

J Cell Biochem. 2011 Nov;112(11):3093-102. doi: 10.1002/jcb.23235.


Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1.

Workman G, Sage EH.

J Cell Biochem. 2011 Apr;112(4):1003-8. doi: 10.1002/jcb.23015.


Biomaterial topography alters healing in vivo and monocyte/macrophage activation in vitro.

Bota PC, Collie AM, Puolakkainen P, Vernon RB, Sage EH, Ratner BD, Stayton PS.

J Biomed Mater Res A. 2010 Nov;95(2):649-57. doi: 10.1002/jbm.a.32893.


Behavioral signs of chronic back pain in the SPARC-null mouse.

Millecamps M, Tajerian M, Sage EH, Stone LS.

Spine (Phila Pa 1976). 2011 Jan 15;36(2):95-102. doi: 10.1097/BRS.0b013e3181cd9d75.


Inactivation of SPARC enhances high-fat diet-induced obesity in mice.

Nie J, Bradshaw AD, Delany AM, Sage EH.

Connect Tissue Res. 2011 Apr;52(2):99-108. doi: 10.3109/03008207.2010.483747. Epub 2010 Jul 8. Erratum in: Connect Tissue Res. 2015 Feb;56(1):65.


SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery.

Seet LF, Su R, Barathi VA, Lee WS, Poh R, Heng YM, Manser E, Vithana EN, Aung T, Weaver M, Sage EH, Wong TT.

PLoS One. 2010 Feb 25;5(2):e9415. doi: 10.1371/journal.pone.0009415.


Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4.

Weaver MS, Workman G, Cardo-Vila M, Arap W, Pasqualini R, Sage EH.

J Biol Chem. 2010 Feb 19;285(8):5868-77. doi: 10.1074/jbc.M109.070318. Epub 2009 Dec 15.


Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.

Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA.

Dis Model Mech. 2010 Jan-Feb;3(1-2):57-72. doi: 10.1242/dmm.003228. Epub 2009 Dec 9.


Absence of thrombospondin-2 causes age-related dilated cardiomyopathy.

Swinnen M, Vanhoutte D, Van Almen GC, Hamdani N, Schellings MW, D'hooge J, Van der Velden J, Weaver MS, Sage EH, Bornstein P, Verheyen FK, VandenDriessche T, Chuah MK, Westermann D, Paulus WJ, Van de Werf F, Schroen B, Carmeliet P, Pinto YM, Heymans S.

Circulation. 2009 Oct 20;120(16):1585-97. doi: 10.1161/CIRCULATIONAHA.109.863266. Epub 2009 Oct 5.


SPARC functions as an inhibitor of adipogenesis.

Nie J, Sage EH.

J Cell Commun Signal. 2009 Dec;3(3-4):247-54. doi: 10.1007/s12079-009-0064-4. Epub 2009 Oct 2.


Thrombospondins in the heart: potential functions in cardiac remodeling.

Schellings MW, van Almen GC, Sage EH, Heymans S.

J Cell Commun Signal. 2009 Dec;3(3-4):201-13. doi: 10.1007/s12079-009-0070-6. Epub 2009 Oct 2.


A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.

Zhang J, Gratchev A, Riabov V, Mamidi S, Schmuttermaier C, Krusell L, Kremmer E, Workman G, Sage EH, Jalkanen S, Goerdt S, Kzhyshkowska J.

Mol Cell Biol. 2009 Nov;29(22):6097-105. doi: 10.1128/MCB.00505-09. Epub 2009 Sep 14.


Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin.

Mandelin J, Lin EC, Hu DD, Knowles SK, Do KA, Wang X, Sage EH, Smith JW, Arap W, Pasqualini R.

Cancer. 2009 Apr 15;115(8):1753-64. doi: 10.1002/cncr.24170.


SPARC-null mice exhibit lower intraocular pressures.

Haddadin RI, Oh DJ, Kang MH, Filippopoulos T, Gupta M, Hart L, Sage EH, Rhee DJ.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3771-7. doi: 10.1167/iovs.08-2489. Epub 2009 Jan 24.


Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction.

Schellings MW, Vanhoutte D, Swinnen M, Cleutjens JP, Debets J, van Leeuwen RE, d'Hooge J, Van de Werf F, Carmeliet P, Pinto YM, Sage EH, Heymans S.

J Exp Med. 2009 Jan 16;206(1):113-23. doi: 10.1084/jem.20081244. Epub 2008 Dec 22.


SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling.

Nie J, Sage EH.

J Biol Chem. 2009 Jan 9;284(2):1279-90. doi: 10.1074/jbc.M808285200. Epub 2008 Nov 5.


Disruption of the thrombospondin-2 gene alters the lamellar morphology but does not permit vascularization of the adult mouse lumbar disc.

Gruber HE, Bornstein P, Sage EH, Ingram JA, Zinchenko N, Norton HJ, Hanley EN Jr.

Arthritis Res Ther. 2008;10(4):R96. doi: 10.1186/ar2483. Epub 2008 Aug 21.


IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells.

Nie J, Chang B, Traktuev DO, Sun J, March K, Chan L, Sage EH, Pasqualini R, Arap W, Kolonin MG.

Stem Cells. 2008 Oct;26(10):2735-45. doi: 10.1634/stemcells.2008-0212. Epub 2008 Jun 26.


Reduced foreign body reaction to implanted biomaterials by surface treatment with oriented osteopontin.

Liu L, Chen G, Chao T, Ratner BD, Sage EH, Jiang S.

J Biomater Sci Polym Ed. 2008;19(6):821-35. doi: 10.1163/156856208784522083.


The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase.

Weaver MS, Workman G, Sage EH.

J Biol Chem. 2008 Aug 15;283(33):22826-37. doi: 10.1074/jbc.M706563200. Epub 2008 May 23.


HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion.

Golembieski WA, Thomas SL, Schultz CR, Yunker CK, McClung HM, Lemke N, Cazacu S, Barker T, Sage EH, Brodie C, Rempel SA.

Glia. 2008 Aug 1;56(10):1061-75. doi: 10.1002/glia.20679.


Altered tissue repair in hevin-null mice: inhibition of fibroblast migration by a matricellular SPARC homolog.

Sullivan MM, Puolakkainen PA, Barker TH, Funk SE, Sage EH.

Wound Repair Regen. 2008 Mar-Apr;16(2):310-9. doi: 10.1111/j.1524-475X.2008.00370.x.


Automated, computerized, feature-based phenotype analysis of slit lamp images of the mouse lens.

Yuen J, Li Y, Shapiro LG, Clark JI, Arnett E, Sage EH, Brinkley JF.

Exp Eye Res. 2008 Apr;86(4):562-75. doi: 10.1016/j.exer.2007.11.019. Epub 2007 Dec 7.


Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis.

Kzhyshkowska J, Gratchev A, Schmuttermaier C, Brundiers H, Krusell L, Mamidi S, Zhang J, Workman G, Sage EH, Anderle C, Sedlmayr P, Goerdt S.

J Immunol. 2008 Mar 1;180(5):3028-37.


A prototypic matricellular protein in the tumor microenvironment--where there's SPARC, there's fire.

Clark CJ, Sage EH.

J Cell Biochem. 2008 Jun 1;104(3):721-32. doi: 10.1002/jcb.21688. Review.


Purification of SPARC/osteonectin.

Sage EH.

Curr Protoc Cell Biol. 2003 Feb;Chapter 10:Unit 10.11. doi: 10.1002/0471143030.cb1011s17.


SPARC modulates the proliferation of stromal but not melanoma cells unless endogenous SPARC expression is downregulated.

Haber CL, Gottifredi V, Llera AS, Salvatierra E, Prada F, Alonso L, Sage EH, Podhajcer OL.

Int J Cancer. 2008 Apr 1;122(7):1465-75. Erratum in: Int J Cancer. 2008 Jul 1;123(1):245. Helene, Sage E [corrected to Sage, E Helene].


Compositional differences between infant and adult human corneal basement membranes.

Kabosova A, Azar DT, Bannikov GA, Campbell KP, Durbeej M, Ghohestani RF, Jones JC, Kenney MC, Koch M, Ninomiya Y, Patton BL, Paulsson M, Sado Y, Sage EH, Sasaki T, Sorokin LM, Steiner-Champliaud MF, Sun TT, Sundarraj N, Timpl R, Virtanen I, Ljubimov AV.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):4989-99.


An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.

Gotoh N, Perdue NR, Matsushima H, Sage EH, Yan Q, Clark JI.

Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4679-87.


Endothelial cell migration on surface-density gradients of fibronectin, VEGF, or both proteins.

Liu L, Ratner BD, Sage EH, Jiang S.

Langmuir. 2007 Oct 23;23(22):11168-73. Epub 2007 Sep 25.


A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells.

Chen N, Ye XC, Chu K, Navone NM, Sage EH, Yu-Lee LY, Logothetis CJ, Lin SH.

Cancer Res. 2007 Jul 15;67(14):6544-8.


Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice.

Lehmann S, O'Kelly J, Raynaud S, Funk SE, Sage EH, Koeffler HP.

Leukemia. 2007 Sep;21(9):1931-6. Epub 2007 Jul 12.


SPARC from olfactory ensheathing cells stimulates Schwann cells to promote neurite outgrowth and enhances spinal cord repair.

Au E, Richter MW, Vincent AJ, Tetzlaff W, Aebersold R, Sage EH, Roskams AJ.

J Neurosci. 2007 Jul 4;27(27):7208-21.


SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts.

Rentz TJ, Poobalarahi F, Bornstein P, Sage EH, Bradshaw AD.

J Biol Chem. 2007 Jul 27;282(30):22062-71. Epub 2007 May 23.


Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer.

Esposito I, Kayed H, Keleg S, Giese T, Sage EH, Schirmacher P, Friess H, Kleeff J.

Neoplasia. 2007 Jan;9(1):8-17.


Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin.

Tian J, Paquette-Straub C, Sage EH, Funk SE, Patel V, Galileo D, McLane MA.

Toxicon. 2007 Jun 1;49(7):899-908. Epub 2007 Jan 10. Erratum in: Toxicon. 2007 Sep 1;50(3):448.


SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.

Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R.

J Leukoc Biol. 2007 Mar;81(3):748-56. Epub 2006 Dec 18.


Regulation of secreted protein acidic and rich in cysteine during adipose conversion and adipose tissue hyperplasia.

Chavey C, Boucher J, Monthouël-Kartmann MN, Sage EH, Castan-Laurell I, Valet P, Tartare-Deckert S, Van Obberghen E.

Obesity (Silver Spring). 2006 Nov;14(11):1890-7.


Gene expression profiling of human ovarian tumours.

Biade S, Marinucci M, Schick J, Roberts D, Workman G, Sage EH, O'Dwyer PJ, Livolsi VA, Johnson SW.

Br J Cancer. 2006 Oct 23;95(8):1092-100. Epub 2006 Sep 12.


A role for decorin in cutaneous wound healing and angiogenesis.

Järveläinen H, Puolakkainen P, Pakkanen S, Brown EL, Höök M, Iozzo RV, Sage EH, Wight TN.

Wound Repair Regen. 2006 Jul-Aug;14(4):443-52.


Matricellular hevin regulates decorin production and collagen assembly.

Sullivan MM, Barker TH, Funk SE, Karchin A, Seo NS, Höök M, Sanders J, Starcher B, Wight TN, Puolakkainen P, Sage EH.

J Biol Chem. 2006 Sep 15;281(37):27621-32. Epub 2006 Jul 14.


Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC.

Kzhyshkowska J, Workman G, Cardó-Vila M, Arap W, Pasqualini R, Gratchev A, Krusell L, Goerdt S, Sage EH.

J Immunol. 2006 May 15;176(10):5825-32.


Chaperone-like activity revealed in the matricellular protein SPARC.

Emerson RO, Sage EH, Ghosh JG, Clark JI.

J Cell Biochem. 2006 Jul 1;98(4):701-5.


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