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Items: 1 to 50 of 114

1.

CRISPR: A Screener's Guide.

le Sage C, Lawo S, Cross BCS.

SLAS Discov. 2019 Oct 29:2472555219883621. doi: 10.1177/2472555219883621. [Epub ahead of print]

PMID:
31658850
2.

Sustainability in the biopharmaceutical industry: Seeking a holistic perspective.

Lalor F, Fitzpatrick J, Sage C, Byrne E.

Biotechnol Adv. 2019 Sep - Oct;37(5):698-707. doi: 10.1016/j.biotechadv.2019.03.015. Epub 2019 Mar 26. Review.

PMID:
30922993
3.

Drug checking at an electronic dance music festival during the public health overdose emergency in British Columbia.

Mema SC, Sage C, Xu Y, Tupper KW, Ziemianowicz D, McCrae K, Leigh M, Munn MB, Taylor D, Corneil T.

Can J Public Health. 2018 Dec;109(5-6):740-744. doi: 10.17269/s41997-018-0126-6. Epub 2018 Sep 24.

PMID:
30251119
4.

Safe Sleep Practices of Kansas Birthing Hospitals.

Ahlers-Schmidt CR, Schunn C, Sage C, Engel M, Benton M.

Kans J Med. 2018 Feb 28;11(1):1-13. eCollection 2018 Feb.

5.

Expanding harm reduction to include fentanyl urine testing: results from a pilot in rural British Columbia.

Mema SC, Sage C, Popoff S, Bridgeman J, Taylor D, Corneil T.

Harm Reduct J. 2018 Apr 6;15(1):19. doi: 10.1186/s12954-018-0224-z.

6.

Fatal collision? Are wireless headsets a risk in treating patients?

Sage C, Hardell L.

Electromagn Biol Med. 2018;37(2):95-99. doi: 10.1080/15368378.2017.1422261. Epub 2018 Feb 5. Review.

PMID:
29400585
7.

Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance.

le Sage C, Lawo S, Panicker P, Scales TME, Rahman SA, Little AS, McCarthy NJ, Moore JD, Cross BCS.

Sci Rep. 2017 Dec 18;7(1):17693. doi: 10.1038/s41598-017-18172-6.

8.

Environmental trade-offs of pig production systems under varied operational efficiencies.

McAuliffe GA, Takahashi T, Mogensen L, Hermansen JE, Sage CL, Chapman DV, Lee MRF.

J Clean Prod. 2017 Nov 1;165:1163-1173. doi: 10.1016/j.jclepro.2017.07.191.

9.

Factors associated with Type II trauma in occupational groups working with traumatised children: a systematic review.

Sage CAM, Brooks SK, Greenberg N.

J Ment Health. 2018 Oct;27(5):457-467. doi: 10.1080/09638237.2017.1370630. Epub 2017 Sep 12.

PMID:
28898109
10.

Electromagnetic Fields, Pulsed Radiofrequency Radiation, and Epigenetics: How Wireless Technologies May Affect Childhood Development.

Sage C, Burgio E.

Child Dev. 2018 Jan;89(1):129-136. doi: 10.1111/cdev.12824. Epub 2017 May 15. Review.

PMID:
28504324
11.

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV.

György B, Sage C, Indzhykulian AA, Scheffer DI, Brisson AR, Tan S, Wu X, Volak A, Mu D, Tamvakologos PI, Li Y, Fitzpatrick Z, Ericsson M, Breakefield XO, Corey DP, Maguire CA.

Mol Ther. 2017 Feb 1;25(2):379-391. doi: 10.1016/j.ymthe.2016.12.010. Epub 2017 Jan 9.

12.

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

Tran TA, Kramer B, Shin YJ, Vallar P, Boatman PD, Zou N, Sage CR, Gharbaoui T, Krishnan A, Pal B, Shakya SR, Garrido Montalban A, Adams JW, Ramirez J, Behan DP, Shifrina A, Blackburn A, Leakakos T, Shi Y, Morgan M, Sadeque A, Chen W, Unett DJ, Gaidarov I, Chen X, Chang S, Shu HH, Tung SF, Semple G.

J Med Chem. 2017 Feb 9;60(3):913-927. doi: 10.1021/acs.jmedchem.6b00871. Epub 2017 Jan 19.

PMID:
28072531
13.

Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT2C receptor.

Schrader TO, Kasem M, Ren A, Feichtinger K, Al Doori B, Wei J, Wu C, Dang H, Le M, Gatlin J, Chase K, Dong J, Whelan KT, Sage C, Grottick AJ, Semple G.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5877-5882. doi: 10.1016/j.bmcl.2016.11.016. Epub 2016 Nov 9.

PMID:
27864071
14.

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL, Boroviak K, le Sage C, Doe B, Speak AO, Galli A, Jacobsen M, Deriano L, Adams DJ, Blackford AN, Jackson SP.

Genes Dev. 2016 Oct 1;30(19):2152-2157.

15.

microRNAs with AAGUGC seed motif constitute an integral part of an oncogenic signaling network.

Zhou Y, Frings O, Branca RM, Boekel J, le Sage C, Fredlund E, Agami R, Orre LM.

Oncogene. 2017 Feb 9;36(6):731-745. doi: 10.1038/onc.2016.242. Epub 2016 Aug 1.

16.

CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.

Chiang TW, le Sage C, Larrieu D, Demir M, Jackson SP.

Sci Rep. 2016 Apr 15;6:24356. doi: 10.1038/srep24356.

17.

Comments on SCENIHR: Opinion on potential health effects of exposure to electromagnetic fields, Bioelectromagnetics 36:480-484 (2015).

Sage C, Carpenter D, Hardell L.

Bioelectromagnetics. 2016 Apr;37(3):190-192. doi: 10.1002/bem.21949. Epub 2015 Dec 20. No abstract available.

PMID:
26688202
18.

Risk and resilience factors affecting the psychological wellbeing of individuals deployed in humanitarian relief roles after a disaster.

Brooks SK, Dunn R, Sage CA, Amlôt R, Greenberg N, Rubin GJ.

J Ment Health. 2015 Dec;24(6):385-413. doi: 10.3109/09638237.2015.1057334. Epub 2015 Oct 9. Review.

PMID:
26452755
19.

Attitudes towards mental health and help-seeking in railway workers.

Sage CA, Brooks SK, Jones N, Greenberg N.

Occup Med (Lond). 2016 Mar;66(2):118-21. doi: 10.1093/occmed/kqv165. Epub 2015 Oct 8.

PMID:
26449493
20.
21.

Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.

Brown JS, Lukashchuk N, Sczaniecka-Clift M, Britton S, le Sage C, Calsou P, Beli P, Galanty Y, Jackson SP.

Cell Rep. 2015 May 5;11(5):704-14. doi: 10.1016/j.celrep.2015.03.058. Epub 2015 Apr 23.

22.

Adult-born dentate neurons are recruited in both spatial memory encoding and retrieval.

Tronel S, Charrier V, Sage C, Maitre M, Leste-Lasserre T, Abrous DN.

Hippocampus. 2015 Nov;25(11):1472-9. doi: 10.1002/hipo.22468. Epub 2015 May 13.

PMID:
25913775
23.

An enhanced recovery after surgery program for hip and knee arthroplasty.

Christelis N, Wallace S, Sage CE, Babitu U, Liew S, Dugal J, Nyulasi I, Mutalima N, Tran T, Myles PS.

Med J Aust. 2015 Apr 20;202(7):363-8.

PMID:
25877118
24.

Investigating interactions between phentermine, dexfenfluramine, and 5-HT2C agonists, on food intake in the rat.

Grottick AJ, Whelan K, Sanabria EK, Behan DP, Morgan M, Sage C.

Psychopharmacology (Berl). 2015 Jun;232(11):1973-82. doi: 10.1007/s00213-014-3829-2. Epub 2014 Dec 20.

25.

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.

Buzard DJ, Kim SH, Lopez L, Kawasaki A, Zhu X, Moody J, Thoresen L, Calderon I, Ullman B, Han S, Lehmann J, Gharbaoui T, Sengupta D, Calvano L, Montalban AG, Ma YA, Sage C, Gao Y, Semple G, Edwards J, Barden J, Morgan M, Chen W, Usmani K, Chen C, Sadeque A, Christopher RJ, Thatte J, Fu L, Solomon M, Mills D, Whelan K, Al-Shamma H, Gatlin J, Le M, Gaidarov I, Anthony T, Unett DJ, Blackburn A, Rueter J, Stirn S, Behan DP, Jones RM.

ACS Med Chem Lett. 2014 Nov 4;5(12):1313-7. doi: 10.1021/ml500389m. eCollection 2014 Dec 11.

26.

Predicting Suicidal Behavior In Veterans And Active Military Personnel: Possibilities For Electronic Deployment To Discover A Predictive Assessment.

Sage CC, Platko JV, Nokela M.

Value Health. 2014 Nov;17(7):A569-70. doi: 10.1016/j.jval.2014.08.1902. Epub 2014 Oct 26. No abstract available.

27.

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP.

Nat Cell Biol. 2014 Oct;16(10):1016-26, 1-8. doi: 10.1038/ncb3028. Epub 2014 Sep 7.

28.

miR-155 drives telomere fragility in human breast cancer by targeting TRF1.

Dinami R, Ercolani C, Petti E, Piazza S, Ciani Y, Sestito R, Sacconi A, Biagioni F, le Sage C, Agami R, Benetti R, Mottolese M, Schneider C, Blandino G, Schoeftner S.

Cancer Res. 2014 Aug 1;74(15):4145-56. doi: 10.1158/0008-5472.CAN-13-2038. Epub 2014 May 29.

29.

Autism and EMF? Plausibility of a pathophysiological link part II.

Herbert MR, Sage C.

Pathophysiology. 2013 Jun;20(3):211-34. doi: 10.1016/j.pathophys.2013.08.002. Epub 2013 Oct 8.

PMID:
24113318
30.

Autism and EMF? Plausibility of a pathophysiological link - Part I.

Herbert MR, Sage C.

Pathophysiology. 2013 Jun;20(3):191-209. doi: 10.1016/j.pathophys.2013.08.001. Epub 2013 Oct 4.

PMID:
24095003
31.

Dating Violence Prevention Programming: Directions for Future Interventions.

Shorey RC, Zucosky H, Brasfield H, Febres J, Cornelius TL, Sage C, Stuart GL.

Aggress Violent Behav. 2012 Jul;17(4):289-293. Epub 2012 Mar 21.

32.

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.

Boatman PD, Lauring B, Schrader TO, Kasem M, Johnson BR, Skinner P, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Luo WL, Caro L, Cote J, Lai E, Wagner J, Taggart AK, Carballo-Jane E, Hammond M, Colletti SL, Tata JR, Connolly DT, Waters MG, Richman JG.

J Med Chem. 2012 Apr 26;55(8):3644-66. doi: 10.1021/jm2010964. Epub 2012 Apr 9.

PMID:
22435740
33.

Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis.

Wilting SM, Snijders PJ, Verlaat W, Jaspers A, van de Wiel MA, van Wieringen WN, Meijer GA, Kenter GG, Yi Y, le Sage C, Agami R, Meijer CJ, Steenbergen RD.

Oncogene. 2013 Jan 3;32(1):106-16. doi: 10.1038/onc.2012.20. Epub 2012 Feb 13.

PMID:
22330141
34.

WHO recognizes electromagnetic dangers: let us declare human health rights.

Sage C, Huttunen P.

Pathophysiology. 2012 Feb;19(1):1-3. doi: 10.1016/j.pathophys.2011.12.002. Epub 2012 Jan 23. No abstract available.

PMID:
22277810
35.

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile.

Semple G, Lehmann J, Wong A, Ren A, Bruce M, Shin YJ, Sage CR, Morgan M, Chen WC, Sebring K, Chu ZL, Leonard JN, Al-Shamma H, Grottick AJ, Du F, Liang Y, Demarest K, Jones RM.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-5. doi: 10.1016/j.bmcl.2011.12.092. Epub 2011 Dec 30.

PMID:
22264481
36.

miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.

Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D.

Autophagy. 2012 Feb 1;8(2):165-76. doi: 10.4161/auto.8.2.18351. Epub 2012 Feb 1.

PMID:
22248718
37.

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.

Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, Ule J, Esteller M, Ramos A, Agami R.

Nat Commun. 2011 Oct 25;2:513. doi: 10.1038/ncomms1519.

38.

Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P₁ agonists.

Buzard D, Han S, Thoresen L, Moody J, Lopez L, Kawasaki A, Schrader T, Sage C, Gao Y, Edwards J, Barden J, Thatte J, Fu L, Solomon M, Liu L, Al-Shamma H, Gatlin J, Le M, Xing C, Espinola S, Jones RM.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):6013-8. doi: 10.1016/j.bmcl.2011.05.110. Epub 2011 Jun 6.

PMID:
21852130
39.

G-protein coupled receptors virtual screening using genetic algorithm focused chemical space.

Sage C, Wang R, Jones G.

J Chem Inf Model. 2011 Aug 22;51(8):1754-61. doi: 10.1021/ci200043z. Epub 2011 Jul 27.

PMID:
21761904
40.

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

Semple G, Ren A, Fioravanti B, Pereira G, Calderon I, Choi K, Xiong Y, Shin YJ, Gharbaoui T, Sage CR, Morgan M, Xing C, Chu ZL, Leonard JN, Grottick AJ, Al-Shamma H, Liang Y, Demarest KT, Jones RM.

Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41. doi: 10.1016/j.bmcl.2011.03.007. Epub 2011 Mar 13.

PMID:
21444206
41.
42.

Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study.

van der Graaff MM, Sage CA, Caan MW, Akkerman EM, Lavini C, Majoie CB, Nederveen AJ, Zwinderman AH, Vos F, Brugman F, van den Berg LH, de Rijk MC, van Doorn PA, Van Hecke W, Peeters RR, Robberecht W, Sunaert S, de Visser M.

Brain. 2011 Apr;134(Pt 4):1211-28. doi: 10.1093/brain/awr016. Epub 2011 Feb 28.

PMID:
21362631
43.

Tragedy of the commons revisited: the high tech-high risk wireless world.

Sage C.

Rev Environ Health. 2010 Oct-Dec;25(4):319-24.

PMID:
21268444
44.

Scientific panel on electromagnetic field health risks: consensus points, recommendations, and rationales.

Fragopoulou A, Grigoriev Y, Johansson O, Margaritis LH, Morgan L, Richter E, Sage C.

Rev Environ Health. 2010 Oct-Dec;25(4):307-17.

PMID:
21268443
45.

Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs.

Huang M, Sage C, Tang Y, Lee SG, Petrillo M, Hinds PW, Chen ZY.

Cell Cycle. 2011 Jan 15;10(2):337-51. Epub 2011 Jan 15.

46.

Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia.

Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C.

Circulation. 2011 Jan 25;123(3):282-91. doi: 10.1161/CIRCULATIONAHA.110.952325. Epub 2011 Jan 10.

PMID:
21220732
47.

The effect of template selection on diffusion tensor voxel-based analysis results.

Van Hecke W, Leemans A, Sage CA, Emsell L, Veraart J, Sijbers J, Sunaert S, Parizel PM.

Neuroimage. 2011 Mar 15;55(2):566-73. doi: 10.1016/j.neuroimage.2010.12.005. Epub 2010 Dec 10.

PMID:
21146617
48.

Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer.

Wilting SM, van Boerdonk RA, Henken FE, Meijer CJ, Diosdado B, Meijer GA, le Sage C, Agami R, Snijders PJ, Steenbergen RD.

Mol Cancer. 2010 Jun 26;9:167. doi: 10.1186/1476-4598-9-167.

49.

Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).

Boatman PD, Schrader TO, Kasem M, Johnson BR, Skinner PJ, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Taggart AK, Carballo-Jane E, Richman JG.

Bioorg Med Chem Lett. 2010 May 1;20(9):2797-800. doi: 10.1016/j.bmcl.2010.03.062. Epub 2010 Mar 20.

PMID:
20363624
50.

Electromagnetic fields and the precautionary principle.

Kundi M, Hardell L, Sage C, Sobel E.

Environ Health Perspect. 2009 Nov;117(11):A484-5; author reply A485. doi: 10.1289/ehp.0901111. No abstract available.

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