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Items: 5

1.

Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.

Keniya MV, Sabherwal M, Wilson RK, Woods MA, Sagatova AA, Tyndall JDA, Monk BC.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01134-18. doi: 10.1128/AAC.01134-18. Print 2018 Nov.

PMID:
30126961
2.

Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Sagatova AA, Keniya MV, Tyndall JDA, Monk BC.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02242-17. doi: 10.1128/AAC.02242-17. Print 2018 Mar.

3.

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.

Tyndall JD, Sabherwal M, Sagatova AA, Keniya MV, Negroni J, Wilson RK, Woods MA, Tietjen K, Monk BC.

PLoS One. 2016 Dec 1;11(12):e0167485. doi: 10.1371/journal.pone.0167485. eCollection 2016.

4.

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase.

Sagatova AA, Keniya MV, Wilson RK, Sabherwal M, Tyndall JD, Monk BC.

Sci Rep. 2016 May 18;6:26213. doi: 10.1038/srep26213.

5.

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Sagatova AA, Keniya MV, Wilson RK, Monk BC, Tyndall JD.

Antimicrob Agents Chemother. 2015 Aug;59(8):4982-9. doi: 10.1128/AAC.00925-15. Epub 2015 Jun 8.

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