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Items: 13


State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation.

Amcheslavsky A, Safrina O, Cahalan MD.

J Gen Physiol. 2014 May;143(5):621-31. doi: 10.1085/jgp.201411171. Epub 2014 Apr 14.


Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101.

Amcheslavsky A, Safrina O, Cahalan MD.

J Gen Physiol. 2013 Oct;142(4):405-12. doi: 10.1085/jgp.201311030.


Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17832-7. doi: 10.1073/pnas.1114814108. Epub 2011 Oct 10.


A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX.

Circulation. 2009 May 5;119(17):2313-22. doi: 10.1161/CIRCULATIONAHA.108.782458. Epub 2009 Apr 20.


Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block.

Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD.

Immunity. 2008 Oct 17;29(4):602-14. doi: 10.1016/j.immuni.2008.07.015. Epub 2008 Oct 2.


The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, Cahalan MD.

Nature. 2008 Nov 6;456(7218):116-20. doi: 10.1038/nature07338. Epub 2008 Sep 28.


Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2011-6. doi: 10.1073/pnas.0706122105. Epub 2008 Feb 4.


Ca2+ signals in CD4+ T cells during early contacts with antigen-bearing dendritic cells in lymph node.

Wei SH, Safrina O, Yu Y, Garrod KR, Cahalan MD, Parker I.

J Immunol. 2007 Aug 1;179(3):1586-94.


Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).

Yu Y, Platoshyn O, Safrina O, Tsigelny I, Yuan JX, Keller SH.

Biol Cell. 2007 Aug;99(8):433-44.


Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.

Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD.

Nature. 2006 Sep 14;443(7108):226-9. Epub 2006 Aug 20.


Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

Zhang SL, Yeromin AV, Zhang XH, Yu Y, Safrina O, Penna A, Roos J, Stauderman KA, Cahalan MD.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9357-62. Epub 2006 Jun 2.


STIM1, an essential and conserved component of store-operated Ca2+ channel function.

Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA.

J Cell Biol. 2005 May 9;169(3):435-45. Epub 2005 May 2.


Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes.

Miller MJ, Safrina O, Parker I, Cahalan MD.

J Exp Med. 2004 Oct 4;200(7):847-56.

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