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Items: 1 to 50 of 111


Reversible Control of Spacing in Charged Lamellar Membrane Hydrogels by Hydrophobically Mediated Tethering with Symmetric and Asymmetric Double-End-Anchored Poly(ethylene glycol)s.

Liu C, Ewert KK, Wonder E, Kohl P, Li Y, Qiao W, Safinya CR.

ACS Appl Mater Interfaces. 2018 Nov 21. doi: 10.1021/acsami.8b16456. [Epub ahead of print]


Competition of charge-mediated and specific binding by peptide-tagged cationic liposome-DNA nanoparticles in vitro and in vivo.

Wonder E, Simón-Gracia L, Scodeller P, Majzoub RN, Kotamraju VR, Ewert KK, Teesalu T, Safinya CR.

Biomaterials. 2018 Jun;166:52-63. doi: 10.1016/j.biomaterials.2018.02.052. Epub 2018 Mar 2.


Swelling Inhibition of Liquid Crystalline Colloidal Montmorillonite and Beidellite Clays by DNA.

Yamaguchi N, Anraku S, Paineau E, Safinya CR, Davidson P, Michot LJ, Miyamoto N.

Sci Rep. 2018 Mar 12;8(1):4367. doi: 10.1038/s41598-018-22386-7.


Distinct solubility and cytotoxicity regimes of paclitaxel-loaded cationic liposomes at low and high drug content revealed by kinetic phase behavior and cancer cell viability studies.

Steffes VM, Murali MM, Park Y, Fletcher BJ, Ewert KK, Safinya CR.

Biomaterials. 2017 Nov;145:242-255. doi: 10.1016/j.biomaterials.2017.08.026. Epub 2017 Aug 17.


Expression and isolation of recombinant tau.

Best RL, Chung PJ, Benbow SJ, Savage A, LaPointe NE, Safinya CR, Feinstein SC.

Methods Cell Biol. 2017;141:3-26. doi: 10.1016/bs.mcb.2017.06.001. Epub 2017 Jul 24.


Synchrotron small-angle X-ray scattering and electron microscopy characterization of structures and forces in microtubule/Tau mixtures.

Chung PJ, Song C, Miller HP, Li Y, Raviv U, Choi MC, Wilson L, Feinstein SC, Safinya CR.

Methods Cell Biol. 2017;141:155-178. doi: 10.1016/bs.mcb.2017.06.002. Epub 2017 Aug 10.


Hydration forces between aligned DNA helices undergoing B to A conformational change: In-situ X-ray fiber diffraction studies in a humidity and temperature controlled environment.

Case R, Schollmeyer H, Kohl P, Sirota EB, Pynn R, Ewert KE, Safinya CR, Li Y.

J Struct Biol. 2017 Dec;200(3):283-292. doi: 10.1016/j.jsb.2017.07.003. Epub 2017 Jul 19.


Paclitaxel suppresses Tau-mediated microtubule bundling in a concentration-dependent manner.

Choi MC, Chung PJ, Song C, Miller HP, Kiris E, Li Y, Wilson L, Feinstein SC, Safinya CR.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3456-3463. doi: 10.1016/j.bbagen.2016.09.011. Epub 2016 Sep 12.


Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment.

Chung PJ, Song C, Deek J, Miller HP, Li Y, Choi MC, Wilson L, Feinstein SC, Safinya CR.

Nat Commun. 2016 Jul 25;7:12278. doi: 10.1038/ncomms12278.


Quantitative Intracellular Localization of Cationic Lipid-Nucleic Acid Nanoparticles with Fluorescence Microscopy.

Majzoub RN, Ewert KK, Safinya CR.

Methods Mol Biol. 2016;1445:77-108. doi: 10.1007/978-1-4939-3718-9_6.


Cationic liposome-nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing.

Majzoub RN, Ewert KK, Safinya CR.

Philos Trans A Math Phys Eng Sci. 2016 Jul 28;374(2072). pii: 20150129. doi: 10.1098/rsta.2015.0129. Review.


Rab11 and Lysotracker Markers Reveal Correlation between Endosomal Pathways and Transfection Efficiency of Surface-Functionalized Cationic Liposome-DNA Nanoparticles.

Majzoub RN, Wonder E, Ewert KK, Kotamraju VR, Teesalu T, Safinya CR.

J Phys Chem B. 2016 Jul 7;120(26):6439-53. doi: 10.1021/acs.jpcb.6b04441. Epub 2016 Jun 3.


Neurofilament networks: Salt-responsive hydrogels with sidearm-dependent phase behavior.

Deek J, Chung PJ, Safinya CR.

Biochim Biophys Acta. 2016 Jul;1860(7):1560-9. doi: 10.1016/j.bbagen.2016.03.018. Epub 2016 Mar 16.


Synthesis of linear and cyclic peptide-PEG-lipids for stabilization and targeting of cationic liposome-DNA complexes.

Ewert KK, Kotamraju VR, Majzoub RN, Steffes VM, Wonder EA, Teesalu T, Ruoslahti E, Safinya CR.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1618-1623. doi: 10.1016/j.bmcl.2016.01.079. Epub 2016 Feb 4.


The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure.

Safinya CR, Chung PJ, Song C, Li Y, Ewert KK, Choi MC.

Adv Colloid Interface Sci. 2016 Jun;232:9-16. doi: 10.1016/j.cis.2015.11.002. Epub 2015 Nov 11. Review.


Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.

Chung PJ, Choi MC, Miller HP, Feinstein HE, Raviv U, Li Y, Wilson L, Feinstein SC, Safinya CR.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6416-25. doi: 10.1073/pnas.1513172112. Epub 2015 Nov 5.


Patterned Threadlike Micelles and DNA-Tethered Nanoparticles: A Structural Study of PEGylated Cationic Liposome-DNA Assemblies.

Majzoub RN, Ewert KK, Jacovetty EL, Carragher B, Potter CS, Li Y, Safinya CR.

Langmuir. 2015 Jun 30;31(25):7073-83. doi: 10.1021/acs.langmuir.5b00993. Epub 2015 Jun 17.


Fluorescence microscopy colocalization of lipid-nucleic acid nanoparticles with wildtype and mutant Rab5-GFP: A platform for investigating early endosomal events.

Majzoub RN, Chan CL, Ewert KK, Silva BF, Liang KS, Safinya CR.

Biochim Biophys Acta. 2015 Jun;1848(6):1308-18. doi: 10.1016/j.bbamem.2015.03.001. Epub 2015 Mar 6.


Cationic liposome-nucleic acid complexes for gene delivery and gene silencing.

Safinya CR, Ewert KK, Majzoub RN, Leal C.

New J Chem. 2014 Nov 1;38(11):5164-5172.


Nematic director reorientation at solid and liquid interfaces under flow: SAXS studies in a microfluidic device.

Silva BF, Zepeda-Rosales M, Venkateswaran N, Fletcher BJ, Carter LG, Matsui T, Weiss TM, Han J, Li Y, Olsson U, Safinya CR.

Langmuir. 2015 Apr 14;31(14):4361-71. doi: 10.1021/la5034614. Epub 2014 Nov 14.


Optimizing cationic and neutral lipids for efficient gene delivery at high serum content.

Chan CL, Ewert KK, Majzoub RN, Hwu YK, Liang KS, Leal C, Safinya CR.

J Gene Med. 2014 Mar-Apr;16(3-4):84-96. doi: 10.1002/jgm.2762.


Uptake and transfection efficiency of PEGylated cationic liposome-DNA complexes with and without RGD-tagging.

Majzoub RN, Chan CL, Ewert KK, Silva BF, Liang KS, Jacovetty EL, Carragher B, Potter CS, Safinya CR.

Biomaterials. 2014 Jun;35(18):4996-5005. doi: 10.1016/j.biomaterials.2014.03.007. Epub 2014 Mar 21.


Liquid crystal assemblies in biologically inspired systems.

Safinya CR, Deek J, Beck R, Jones JB, Leal C, Ewert KK, Li Y.

Liq Cryst. 2013 Jan 1;40(12):1748-1758.


Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch.

Ojeda-Lopez MA, Needleman DJ, Song C, Ginsburg A, Kohl PA, Li Y, Miller HP, Wilson L, Raviv U, Choi MC, Safinya CR.

Nat Mater. 2014 Feb;13(2):195-203. doi: 10.1038/nmat3858. Epub 2014 Jan 19.


PEGylated cationic liposome-DNA complexation in brine is pathway-dependent.

Silva BF, Majzoub RN, Chan CL, Li Y, Olsson U, Safinya CR.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):398-412. doi: 10.1016/j.bbamem.2013.09.008. Epub 2013 Sep 20.


Neurofilament sidearms modulate parallel and crossed-filament orientations inducing nematic to isotropic and re-entrant birefringent hydrogels.

Deek J, Chung PJ, Kayser J, Bausch AR, Safinya CR.

Nat Commun. 2013;4:2224. doi: 10.1038/ncomms3224.


Stacking of Short DNA Induces the Gyroid Cubic-to-Inverted Hexagonal Phase Transition in Lipid-DNA Complexes.

Leal C, Ewert KK, Bouxsein NF, Shirazi RS, Li Y, Safinya CR.

Soft Matter. 2013 Jan 21;9(3):795-804. Epub 2012 Nov 8.


Ion specific effects in bundling and depolymerization of taxol-stabilized microtubules.

Needleman DJ, Ojeda-Lopez MA, Raviv U, Miller HP, Li Y, Song C, Feinstein SC, Wilson L, Choi MC, Safinya CR.

Faraday Discuss. 2013;166:31-45.


Materials chemistry: Liposomes derived from molecular vases.

Safinya CR, Ewert KK.

Nature. 2012 Sep 20;489(7416):372-4. doi: 10.1038/489372b. No abstract available.


Cationic liposome-nucleic acid complexes: liquid crystal phases with applications in gene therapy.

Safinya CR, Ewert KK, Leal C.

Liq Cryst. 2011 Nov;38(11-12):1715-1723. Epub 2011 Nov 22.


Structural evolution of environmentally responsive cationic liposome-DNA complexes with a reducible lipid linker.

Shirazi RS, Ewert KK, Silva BF, Leal C, Li Y, Safinya CR.

Langmuir. 2012 Jul 17;28(28):10495-503. doi: 10.1021/la301181b. Epub 2012 Jun 6.


Endosomal escape and transfection efficiency of PEGylated cationic liposome-DNA complexes prepared with an acid-labile PEG-lipid.

Chan CL, Majzoub RN, Shirazi RS, Ewert KK, Chen YJ, Liang KS, Safinya CR.

Biomaterials. 2012 Jun;33(19):4928-35. doi: 10.1016/j.biomaterials.2012.03.038. Epub 2012 Apr 1.


Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery.

Shirazi RS, Ewert KK, Leal C, Majzoub RN, Bouxsein NF, Safinya CR.

Biochim Biophys Acta. 2011 Sep;1808(9):2156-66. doi: 10.1016/j.bbamem.2011.04.020. Epub 2011 May 24.


Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing.

Leal C, Ewert KK, Shirazi RS, Bouxsein NF, Safinya CR.

Langmuir. 2011 Jun 21;27(12):7691-7. doi: 10.1021/la200679x. Epub 2011 May 25.


Two-dimensional packing of short DNA with nonpairing overhangs in cationic liposome-DNA complexes: from Onsager nematics to columnar nematics with finite-length columns.

Bouxsein NF, Leal C, McAllister CS, Ewert KK, Li Y, Samuel CE, Safinya CR.

J Am Chem Soc. 2011 May 18;133(19):7585-95. doi: 10.1021/ja202082c. Epub 2011 Apr 26.


Nanoscale assembly in biological systems: from neuronal cytoskeletal proteins to curvature stabilizing lipids.

Safinya CR, Raviv U, Needleman DJ, Zidovska A, Choi MC, Ojeda-Lopez MA, Ewert KK, Li Y, Miller HP, Quispe J, Carragher B, Potter CS, Kim MW, Feinstein SC, Wilson L.

Adv Mater. 2011 May 24;23(20):2260-70. doi: 10.1002/adma.201004647. Epub 2011 Apr 20. Review.


Hierarchical superstructure of alkylamine-coated ZnS nanoparticle assemblies.

Belman N, Israelachvili JN, Li Y, Safinya CR, Ezersky V, Rabkin A, Sima O, Golan Y.

Phys Chem Chem Phys. 2011 Mar 21;13(11):4974-9. doi: 10.1039/c0cp00999g. Epub 2011 Feb 14.


Block Liposome and Nanotube Formation is a General Phenomenon of Two-Component Membranes Containing Multivalent Lipids.

Zidovska A, Ewert KK, Quispe J, Carragher B, Potter CS, Safinya CR.

Soft Matter. 2011 Jan 1;7(18):8363-8369. Epub 2011 Jun 20.


Unconventional salt trend from soft to stiff in single neurofilament biopolymers.

Beck R, Deek J, Choi MC, Ikawa T, Watanabe O, Frey E, Pincus P, Safinya CR.

Langmuir. 2010 Dec 21;26(24):18595-9. doi: 10.1021/la103655x. Epub 2010 Nov 17.


Highly efficient gene silencing activity of siRNA embedded in a nanostructured gyroid cubic lipid matrix.

Leal C, Bouxsein NF, Ewert KK, Safinya CR.

J Am Chem Soc. 2010 Dec 1;132(47):16841-7. doi: 10.1021/ja1059763. Epub 2010 Oct 28.


Materials science. Bundling with x-rays.

Safinya CR, Li Y.

Science. 2010 Jan 29;327(5965):529-30. doi: 10.1126/science.1185868. No abstract available.


Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA.

Ewert KK, Zidovska A, Ahmad A, Bouxsein NF, Evans HM, McAllister CS, Samuel CE, Safinya CR.

Top Curr Chem. 2010;296:191-226. Review.


Gel-expanded to gel-condensed transition in neurofilament networks revealed by direct force measurements.

Beck R, Deek J, Jones JB, Safinya CR.

Nat Mater. 2010 Jan;9(1):40-6. doi: 10.1038/nmat2566. Epub 2009 Nov 15.


Block liposomes vesicles of charged lipids with distinctly shaped nanoscale sphere-, pear-, tube-, or rod-segments.

Zidovska A, Ewert KK, Quispe J, Carragher B, Potter CS, Safinya CR.

Methods Enzymol. 2009;465:111-28. doi: 10.1016/S0076-6879(09)65006-0.


Liquid crystalline phases of dendritic lipid-DNA self-assemblies: lamellar, hexagonal, and DNA bundles.

Zidovska A, Evans HM, Ewert KK, Quispe J, Carragher B, Potter CS, Safinya CR.

J Phys Chem B. 2009 Mar 26;113(12):3694-703.


Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study.

Choi MC, Raviv U, Miller HP, Gaylord MR, Kiris E, Ventimiglia D, Needleman DJ, Kim MW, Wilson L, Feinstein SC, Safinya CR.

Biophys J. 2009 Jul 22;97(2):519-27. doi: 10.1016/j.bpj.2009.04.047.


The effect of salt and pH on block liposomes studied by cryogenic transmission electron microscopy.

Zidovska A, Ewert KK, Quispe J, Carragher B, Potter CS, Safinya CR.

Biochim Biophys Acta. 2009 Sep;1788(9):1869-76. doi: 10.1016/j.bbamem.2009.06.013. Epub 2009 Jun 23.


The temperature-dependent structure of alkylamines and their corresponding alkylammonium-alkylcarbamates.

Belman N, Israelachvili JN, Li Y, Safinya CR, Bernstein J, Golan Y.

J Am Chem Soc. 2009 Jul 1;131(25):9107-13. doi: 10.1021/ja902944t.


Reaction of alkylamine surfactants with carbon dioxide: relevance to nanocrystal synthesis.

Belman N, Israelachvili JN, Li Y, Safinya CR, Bernstein J, Golan Y.

Nano Lett. 2009 May;9(5):2088-93. doi: 10.1021/nl900534m.


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