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Items: 1 to 50 of 83

1.

A Microcavity Array-Based 3D Model System of the Hematopoietic Stem Cell Niche.

Gottwald E, Nies C, Wuchter P, Saffrich R, Truckenmüller R, Giselbrecht S.

Methods Mol Biol. 2019;2017:85-95. doi: 10.1007/978-1-4939-9574-5_7.

PMID:
31197770
2.

The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity.

Rühle A, Huber PE, Saffrich R, Lopez Perez R, Nicolay NH.

Int J Cancer. 2018 Dec 1;143(11):2628-2639. doi: 10.1002/ijc.31619. Epub 2018 Aug 7. Review.

PMID:
29931767
3.

Author Correction: Dynamic cellular phenotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents.

Monzel C, Becker AS, Saffrich R, Wuchter P, Eckstein V, Ho AD, Tanaka M.

Sci Rep. 2018 Apr 30;8(1):6996. doi: 10.1038/s41598-018-25253-7.

4.

The Radiation Resistance of Human Multipotent Mesenchymal Stromal Cells Is Independent of Their Tissue of Origin.

Rühle A, Xia O, Perez RL, Trinh T, Richter W, Sarnowska A, Wuchter P, Debus J, Saffrich R, Huber PE, Nicolay NH.

Int J Radiat Oncol Biol Phys. 2018 Apr 1;100(5):1259-1269. doi: 10.1016/j.ijrobp.2018.01.015. Epub 2018 Jan 9.

PMID:
29452769
5.

Dynamic cellular phynotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1α versus synthetic agents.

Monzel C, Becker AS, Saffrich R, Wuchter P, Eckstein V, Ho AD, Tanaka M.

Sci Rep. 2018 Jan 30;8(1):1841. doi: 10.1038/s41598-018-19557-x. Erratum in: Sci Rep. 2018 Apr 30;8(1):6996.

6.

Human mesenchymal stem cells lose their functional properties after paclitaxel treatment.

Münz F, Lopez Perez R, Trinh T, Sisombath S, Weber KJ, Wuchter P, Debus J, Saffrich R, Huber PE, Nicolay NH.

Sci Rep. 2018 Jan 10;8(1):312. doi: 10.1038/s41598-017-18862-1.

7.

Cisplatin radiosensitizes radioresistant human mesenchymal stem cells.

Rühle A, Perez RL, Glowa C, Weber KJ, Ho AD, Debus J, Saffrich R, Huber PE, Nicolay NH.

Oncotarget. 2017 Sep 23;8(50):87809-87820. doi: 10.18632/oncotarget.21214. eCollection 2017 Oct 20.

8.

Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis.

Bickelhaupt S, Erbel C, Timke C, Wirkner U, Dadrich M, Flechsig P, Tietz A, Pföhler J, Gross W, Peschke P, Hoeltgen L, Katus HA, Gröne HJ, Nicolay NH, Saffrich R, Debus J, Sternlicht MD, Seeley TW, Lipson KE, Huber PE.

J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw339.

PMID:
28376190
9.

Mesenchymal stem cells are sensitive to bleomycin treatment.

Nicolay NH, Rühle A, Perez RL, Trinh T, Sisombath S, Weber KJ, Ho AD, Debus J, Saffrich R, Huber PE.

Sci Rep. 2016 May 24;6:26645. doi: 10.1038/srep26645.

10.

Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells.

Wuchter P, Vetter M, Saffrich R, Diehlmann A, Bieback K, Ho AD, Horn P.

Exp Hematol. 2016 Jun;44(6):508-18. doi: 10.1016/j.exphem.2016.02.004. Epub 2016 Feb 19.

PMID:
26911671
11.

Mesenchymal stem cells exhibit resistance to topoisomerase inhibition.

Nicolay NH, Rühle A, Perez RL, Trinh T, Sisombath S, Weber KJ, Schmezer P, Ho AD, Debus J, Saffrich R, Huber PE.

Cancer Lett. 2016 Apr 28;374(1):75-84. doi: 10.1016/j.canlet.2016.02.007. Epub 2016 Feb 11.

PMID:
26876302
12.

Microcavity arrays as an in vitro model system of the bone marrow niche for hematopoietic stem cells.

Wuchter P, Saffrich R, Giselbrecht S, Nies C, Lorig H, Kolb S, Ho AD, Gottwald E.

Cell Tissue Res. 2016 Jun;364(3):573-584. doi: 10.1007/s00441-015-2348-8. Epub 2016 Jan 30.

PMID:
26829941
13.

Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin.

Nicolay NH, Lopez Perez R, Rühle A, Trinh T, Sisombath S, Weber KJ, Ho AD, Debus J, Saffrich R, Huber PE.

Sci Rep. 2016 Jan 25;6:20035. doi: 10.1038/srep20035.

14.

Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic.

Nicolay NH, Lopez Perez R, Saffrich R, Huber PE.

Oncotarget. 2015 Aug 14;6(23):19366-80. Review.

15.

Quantifying adhesion mechanisms and dynamics of human hematopoietic stem and progenitor cells.

Burk AS, Monzel C, Yoshikawa HY, Wuchter P, Saffrich R, Eckstein V, Tanaka M, Ho AD.

Sci Rep. 2015 Mar 31;5:9370. doi: 10.1038/srep09370.

16.

Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia.

Baran N, ter Braak M, Saffrich R, Woelfle J, Schmitz U.

Mol Cell Endocrinol. 2015 May 15;407:18-25. doi: 10.1016/j.mce.2015.02.021. Epub 2015 Mar 9.

PMID:
25766501
17.

Mesenchymal stem cells are resistant to carbon ion radiotherapy.

Nicolay NH, Liang Y, Lopez Perez R, Bostel T, Trinh T, Sisombath S, Weber KJ, Ho AD, Debus J, Saffrich R, Huber PE.

Oncotarget. 2015 Feb 10;6(4):2076-87.

18.

Mesenchymal stem cells are sensitive to treatment with kinase inhibitors and ionizing radiation.

Nicolay NH, Sommer E, Perez RL, Wirkner U, Bostel T, Ho AD, Lahn M, Debus J, Saffrich R, Huber PE.

Strahlenther Onkol. 2014 Oct;190(11):1037-45. doi: 10.1007/s00066-014-0686-1. Epub 2014 May 27.

PMID:
24863573
19.

Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications.

Wuchter P, Bieback K, Schrezenmeier H, Bornhäuser M, Müller LP, Bönig H, Wagner W, Meisel R, Pavel P, Tonn T, Lang P, Müller I, Renner M, Malcherek G, Saffrich R, Buss EC, Horn P, Rojewski M, Schmitt A, Ho AD, Sanzenbacher R, Schmitt M.

Cytotherapy. 2015 Feb;17(2):128-39. doi: 10.1016/j.jcyt.2014.04.002. Epub 2014 May 20. Review.

PMID:
24856898
20.

Mesenchymal stem cells retain their defining stem cell characteristics after exposure to ionizing radiation.

Nicolay NH, Sommer E, Lopez R, Wirkner U, Trinh T, Sisombath S, Debus J, Ho AD, Saffrich R, Huber PE.

Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1171-8. doi: 10.1016/j.ijrobp.2013.09.003. Epub 2013 Oct 23.

PMID:
24351412
21.

Plerixafor induces the rapid and transient release of stromal cell-derived factor-1 alpha from human mesenchymal stromal cells and influences the migration behavior of human hematopoietic progenitor cells.

Wuchter P, Leinweber C, Saffrich R, Hanke M, Eckstein V, Ho AD, Grunze M, Rosenhahn A.

Cell Tissue Res. 2014 Feb;355(2):315-26. doi: 10.1007/s00441-013-1759-7. Epub 2013 Dec 14.

PMID:
24337688
22.

A novel human glycoprotein ACA is an upstream regulator of human hematopoiesis.

Becker-Kojić ZA, Ureña-Peralta JR, Saffrich R, Rodriguez-Jiménez FJ, Rubio MP, Rios P, Romero A, Ho AD, Stojković M.

Bull Exp Biol Med. 2013 Aug;155(4):536-51.

PMID:
24143385
23.

Functional potentials of human hematopoietic progenitor cells are maintained by mesenchymal stromal cells and not impaired by plerixafor.

Ludwig A, Saffrich R, Eckstein V, Bruckner T, Wagner W, Ho AD, Wuchter P.

Cytotherapy. 2014 Jan;16(1):111-21. doi: 10.1016/j.jcyt.2013.07.007. Epub 2013 Oct 10.

PMID:
24119647
24.

Modeling SDF-1-induced mobilization in leukemia cell lines.

Zepeda-Moreno A, Saffrich R, Walenda T, Hoang VT, Wuchter P, Sánchez-Enríquez S, Corona-Rivera A, Wagner W, Ho AD.

Exp Hematol. 2012 Aug;40(8):666-74. doi: 10.1016/j.exphem.2012.05.001. Epub 2012 May 18.

PMID:
22613469
25.

Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance.

Ran D, Schubert M, Taubert I, Eckstein V, Bellos F, Jauch A, Chen H, Bruckner T, Saffrich R, Wuchter P, Ho AD.

Exp Hematol. 2012 Feb;40(2):155-65.e1. doi: 10.1016/j.exphem.2011.10.005. Epub 2011 Oct 21.

PMID:
22024109
26.

KATP channels in mesenchymal stromal stem cells: strong up-regulation of Kir6.2 subunits upon osteogenic differentiation.

Diehlmann A, Bork S, Saffrich R, Veh RW, Wagner W, Derst C.

Tissue Cell. 2011 Oct;43(5):331-6. doi: 10.1016/j.tice.2011.06.004. Epub 2011 Aug 5.

PMID:
21820692
27.

Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.

Löffler H, Fechter A, Matuszewska M, Saffrich R, Mistrik M, Marhold J, Hornung C, Westermann F, Bartek J, Krämer A.

Cancer Res. 2011 Mar 15;71(6):2129-39. doi: 10.1158/0008-5472.CAN-10-2684.

28.

RhoA regulates peroxisome association to microtubules and the actin cytoskeleton.

Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peränen J, Gorgas K, Just WW.

PLoS One. 2010 Nov 8;5(11):e13886. doi: 10.1371/journal.pone.0013886.

29.

Characterization of hematopoietic stem cell subsets from patients with multiple myeloma after mobilization with plerixafor.

Taubert I, Saffrich R, Zepeda-Moreno A, Hellwig I, Eckstein V, Bruckner T, Ho AD, Wuchter P.

Cytotherapy. 2011 Apr;13(4):459-66. doi: 10.3109/14653249.2010.530652. Epub 2010 Nov 15.

PMID:
21077729
30.

N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells.

Wein F, Pietsch L, Saffrich R, Wuchter P, Walenda T, Bork S, Horn P, Diehlmann A, Eckstein V, Ho AD, Wagner W.

Stem Cell Res. 2010 Mar;4(2):129-39. doi: 10.1016/j.scr.2009.12.004. Epub 2010 Jan 4.

31.

Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells.

Walenda T, Bork S, Horn P, Wein F, Saffrich R, Diehlmann A, Eckstein V, Ho AD, Wagner W.

J Cell Mol Med. 2010 Jan;14(1-2):337-50. doi: 10.1111/j.1582-4934.2009.00776.x. Epub 2009 May 11.

32.

Induction of CD4+ T-cell anergy and apoptosis by activated human B cells.

Tretter T, Venigalla RK, Eckstein V, Saffrich R, Sertel S, Ho AD, Lorenz HM.

Blood. 2008 Dec 1;112(12):4555-64. doi: 10.1182/blood-2008-02-140087. Epub 2008 Sep 18.

33.

PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules.

Wängler C, Moldenhauer G, Saffrich R, Knapp EM, Beijer B, Schnölzer M, Wängler B, Eisenhut M, Haberkorn U, Mier W.

Chemistry. 2008;14(27):8116-30. doi: 10.1002/chem.200800328.

PMID:
18752247
34.

VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma.

Beckermann BM, Kallifatidis G, Groth A, Frommhold D, Apel A, Mattern J, Salnikov AV, Moldenhauer G, Wagner W, Diehlmann A, Saffrich R, Schubert M, Ho AD, Giese N, Büchler MW, Friess H, Büchler P, Herr I.

Br J Cancer. 2008 Aug 19;99(4):622-31. doi: 10.1038/sj.bjc.6604508. Epub 2008 Jul 29.

35.

Replicative senescence of mesenchymal stem cells: a continuous and organized process.

Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, Saffrich R, Benes V, Blake J, Pfister S, Eckstein V, Ho AD.

PLoS One. 2008 May 21;3(5):e2213. doi: 10.1371/journal.pone.0002213.

36.

Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer.

Kallifatidis G, Beckermann BM, Groth A, Schubert M, Apel A, Khamidjanov A, Ryschich E, Wenger T, Wagner W, Diehlmann A, Saffrich R, Krause U, Eckstein V, Mattern J, Chai M, Schütz G, Ho AD, Gebhard MM, Büchler MW, Friess H, Büchler P, Herr I.

Cancer Gene Ther. 2008 Apr;15(4):231-40. doi: 10.1038/sj.cgt.7701097. Epub 2008 Jan 18.

PMID:
18202717
37.

The Stromal Activity of Mesenchymal Stromal Cells.

Wagner W, Saffrich R, Ho AD.

Transfus Med Hemother. 2008;35(3):185-193. Epub 2008 May 16.

38.

Adhesion of human hematopoietic progenitor cells to mesenchymal stromal cells involves CD44.

Wagner W, Wein F, Roderburg C, Saffrich R, Diehlmann A, Eckstein V, Ho AD.

Cells Tissues Organs. 2008;188(1-2):160-9. Epub 2007 Dec 21.

PMID:
18160820
39.

Primitive and committed human hematopoietic progenitor cells interact with primary murine neural cells and are induced to undergo self-renewing cell divisions.

Gottschling S, Eckstein V, Saffrich R, Jonás A, Uhrig M, Krause U, Seckinger A, Miesala K, Horsch K, Straub BK, Ho AD.

Exp Hematol. 2007 Dec;35(12):1858-71. Epub 2007 Aug 13.

PMID:
17697743
40.

The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells.

Faber A, Roderburg C, Wein F, Saffrich R, Seckinger A, Horsch K, Diehlmann A, Wong D, Bridger G, Eckstein V, Ho AD, Wagner W.

J Biomed Biotechnol. 2007;2007(3):26065. Epub 2007 Apr 23.

41.

Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction.

Wagner W, Wein F, Roderburg C, Saffrich R, Faber A, Krause U, Schubert M, Benes V, Eckstein V, Maul H, Ho AD.

Exp Hematol. 2007 Feb;35(2):314-25.

PMID:
17258080
42.

Human mesenchymal stromal cells regulate initial self-renewing divisions of hematopoietic progenitor cells by a beta1-integrin-dependent mechanism.

Gottschling S, Saffrich R, Seckinger A, Krause U, Horsch K, Miesala K, Ho AD.

Stem Cells. 2007 Mar;25(3):798-806. Epub 2006 Nov 16.

43.

MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation.

Yang Y, Marcello M, Endris V, Saffrich R, Fischer R, Trendelenburg MF, Sprengel R, Rappold G.

Exp Cell Res. 2006 Jul 15;312(12):2379-93. Epub 2006 Apr 19.

PMID:
16730001
44.

The heterogeneity of human mesenchymal stem cell preparations--evidence from simultaneous analysis of proteomes and transcriptomes.

Wagner W, Feldmann RE Jr, Seckinger A, Maurer MH, Wein F, Blake J, Krause U, Kalenka A, Bürgers HF, Saffrich R, Wuchter P, Kuschinsky W, Ho AD.

Exp Hematol. 2006 Apr;34(4):536-48.

PMID:
16569600
45.

The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment.

Keiper T, Al-Fakhri N, Chavakis E, Athanasopoulos AN, Isermann B, Herzog S, Saffrich R, Hersemeyer K, Bohle RM, Haendeler J, Preissner KT, Santoso S, Chavakis T.

FASEB J. 2005 Dec;19(14):2078-80. Epub 2005 Sep 29.

PMID:
16195363
46.

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy.

Abdollahi A, Griggs DW, Zieher H, Roth A, Lipson KE, Saffrich R, Gröne HJ, Hallahan DE, Reisfeld RA, Debus J, Niethammer AG, Huber PE.

Clin Cancer Res. 2005 Sep 1;11(17):6270-9.

47.

Hematopoietic progenitor cells and cellular microenvironment: behavioral and molecular changes upon interaction.

Wagner W, Saffrich R, Wirkner U, Eckstein V, Blake J, Ansorge A, Schwager C, Wein F, Miesala K, Ansorge W, Ho AD.

Stem Cells. 2005 Sep;23(8):1180-91. Epub 2005 Jun 13.

48.

Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy.

Huber PE, Bischof M, Jenne J, Heiland S, Peschke P, Saffrich R, Gröne HJ, Debus J, Lipson KE, Abdollahi A.

Cancer Res. 2005 May 1;65(9):3643-55.

49.
50.

Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis.

Wagner W, Ansorge A, Wirkner U, Eckstein V, Schwager C, Blake J, Miesala K, Selig J, Saffrich R, Ansorge W, Ho AD.

Blood. 2004 Aug 1;104(3):675-86. Epub 2004 Apr 13.

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