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Items: 21


The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA.

Dauber B, Saffran HA, Smiley JR.

PLoS Pathog. 2019 Oct 18;15(10):e1008111. doi: 10.1371/journal.ppat.1008111. eCollection 2019 Oct.


Expression of the Vaccinia Virus Antiapoptotic F1 Protein Is Blocked by Protein Kinase R in the Absence of the Viral E3 Protein.

Mehta N, Enwere EK, Santos TD, Saffran HA, Hazes B, Evans D, Barry M, Smiley JR.

J Virol. 2018 Sep 12;92(19). pii: e01167-18. doi: 10.1128/JVI.01167-18. Print 2018 Oct 1.


Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway.

Strunk U, Ramos DG, Saffran HA, Smiley JR.

Virology. 2016 Nov;498:31-35. doi: 10.1016/j.virol.2016.08.007. Epub 2016 Aug 17.


The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.

Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR.

J Virol. 2016 Jun 10;90(13):6049-6057. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1.


The herpes simplex virus 1 virion host shutoff protein enhances translation of viral late mRNAs by preventing mRNA overload.

Dauber B, Saffran HA, Smiley JR.

J Virol. 2014 Sep 1;88(17):9624-32. doi: 10.1128/JVI.01350-14. Epub 2014 Jun 11.


Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity.

Eaton HE, Saffran HA, Wu FW, Quach K, Smiley JR.

J Virol. 2014 Jul;88(13):7379-88. doi: 10.1128/JVI.00712-14. Epub 2014 Apr 16.


Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.

Duguay BA, Saffran HA, Ponomarev A, Duley SA, Eaton HE, Smiley JR.

J Virol. 2014 Mar;88(5):2967-76. doi: 10.1128/JVI.03129-13. Epub 2013 Dec 26.


Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

Strunk U, Saffran HA, Wu FW, Smiley JR.

J Virol. 2013 Oct;87(20):11276-86. doi: 10.1128/JVI.01702-13. Epub 2013 Aug 14.


Evidence for translational regulation by the herpes simplex virus virion host shutoff protein.

Saffran HA, Read GS, Smiley JR.

J Virol. 2010 Jun;84(12):6041-9. doi: 10.1128/JVI.01819-09. Epub 2010 Mar 31.


Herpes simplex virus UL12.5 targets mitochondria through a mitochondrial localization sequence proximal to the N terminus.

Corcoran JA, Saffran HA, Duguay BA, Smiley JR.

J Virol. 2009 Mar;83(6):2601-10. doi: 10.1128/JVI.02087-08. Epub 2009 Jan 7.


Herpes simplex virus eliminates host mitochondrial DNA.

Saffran HA, Pare JM, Corcoran JA, Weller SK, Smiley JR.

EMBO Rep. 2007 Feb;8(2):188-93. Epub 2006 Dec 22.


Herpes simplex virus infection stabilizes cellular IEX-1 mRNA.

Hsu WL, Saffran HA, Smiley JR.

J Virol. 2005 Apr;79(7):4090-8.


RNA degradation induced by the herpes simplex virus vhs protein proceeds 5' to 3' in vitro.

Perez-Parada J, Saffran HA, Smiley JR.

J Virol. 2004 Dec;78(23):13391-4.


Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils.

Kumar R, Sharma N, Nath M, Saffran HA, Tyrrell DL.

J Med Chem. 2001 Nov 22;44(24):4225-9.


Herpes simplex virus vhs protein.

Smiley JR, Elgadi MM, Saffran HA.

Methods Enzymol. 2001;342:440-51. No abstract available.


Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.

Kumar R, Rai D, Sharma SK, Saffran HA, Blush R, Tyrrell DL.

J Med Chem. 2001 Oct 11;44(21):3531-8.


Herpes simplex virus ICP0 mutants are hypersensitive to interferon.

Mossman KL, Saffran HA, Smiley JR.

J Virol. 2000 Feb;74(4):2052-6.

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