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Items: 1 to 50 of 301

1.

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary.

Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W.

Heart Rhythm. 2019 Nov;16(11):e373-e407. doi: 10.1016/j.hrthm.2019.09.019.

PMID:
31676023
2.

Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis.

Corrado D, van Tintelen PJ, McKenna WJ, Hauer RNW, Anastastakis A, Asimaki A, Basso C, Bauce B, Brunckhorst C, Bucciarelli-Ducci C, Duru F, Elliott P, Hamilton RM, Haugaa KH, James CA, Judge D, Link MS, Marchlinski FE, Mazzanti A, Mestroni L, Pantazis A, Pelliccia A, Marra MP, Pilichou K, Platonov PGA, Protonotarios A, Rampazzo A, Saffitz JE, Saguner AM, Schmied C, Sharma S, Tandri H, Te Riele ASJM, Thiene G, Tsatsopoulou A, Zareba W, Zorzi A, Wichter T, Marcus FI, Calkins H; International Experts .

Eur Heart J. 2019 Oct 21. pii: ehz669. doi: 10.1093/eurheartj/ehz669. [Epub ahead of print] No abstract available.

PMID:
31637441
3.

Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy.

Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JE.

Circulation. 2019 Oct 29;140(18):1491-1505. doi: 10.1161/CIRCULATIONAHA.119.040676. Epub 2019 Sep 19.

PMID:
31533459
4.

Histopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue.

Barkagan M, Leshem E, Shapira-Daniels A, Sroubek J, Buxton AE, Saffitz JE, Anter E.

JACC Clin Electrophysiol. 2019 Aug;5(8):920-931. doi: 10.1016/j.jacep.2019.05.011. Epub 2019 Jun 26.

PMID:
31439293
5.

Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report.

Elliott PM, Anastasakis A, Asimaki A, Basso C, Bauce B, Brooke MA, Calkins H, Corrado D, Duru F, Green KJ, Judge DP, Kelsell D, Lambiase PD, McKenna WJ, Pilichou K, Protonotarios A, Saffitz JE, Syrris P, Tandri H, Te Riele A, Thiene G, Tsatsopoulou A, van Tintelen JP.

Eur J Heart Fail. 2019 Aug;21(8):955-964. doi: 10.1002/ejhf.1534. Epub 2019 Jun 18.

6.

2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy.

Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W.

Heart Rhythm. 2019 Nov;16(11):e301-e372. doi: 10.1016/j.hrthm.2019.05.007. Epub 2019 May 9.

PMID:
31078652
7.

Molecular mechanisms of arrhythmogenic cardiomyopathy.

Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT.

Nat Rev Cardiol. 2019 Sep;16(9):519-537. doi: 10.1038/s41569-019-0200-7. Review.

8.

Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy.

Te Rijdt WP, Asimaki A, Jongbloed JDH, Hoorntje ET, Lazzarini E, van der Zwaag PA, de Boer RA, van Tintelen JP, Saffitz JE, van den Berg MP, Suurmeijer AJH.

Cardiovasc Pathol. 2019 May - Jun;40:2-6. doi: 10.1016/j.carpath.2018.12.006. Epub 2018 Dec 21.

PMID:
30763825
9.

Response by Thiene and Saffitz to Letter Regarding Article, "Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now".

Thiene G, Saffitz JE.

Circulation. 2019 Jan 22;139(4):568-569. doi: 10.1161/CIRCULATIONAHA.118.038476. No abstract available.

PMID:
30664373
10.

Editorial commentary: Nuclear receptors and a network biology approach to understanding and treating heart disease.

Saffitz JE.

Trends Cardiovasc Med. 2019 Nov;29(8):438-439. doi: 10.1016/j.tcm.2018.12.001. Epub 2018 Dec 11. No abstract available.

PMID:
30559047
11.

Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures.

Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG.

JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. doi: 10.1016/j.jacep.2017.12.003. Epub 2018 Feb 2.

12.

Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now.

Thiene G, Saffitz JE.

Circulation. 2018 Jun 19;137(25):2683-2685. doi: 10.1161/CIRCULATIONAHA.118.033234. No abstract available.

PMID:
29915093
13.

Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy.

Saffitz JE.

Cardiovasc Pathol. 2017 May - Jun;28:51-58. doi: 10.1016/j.carpath.2017.02.005. Epub 2017 Feb 27. Review.

14.

Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRβ.

Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany Z.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H662-H671. doi: 10.1152/ajpheart.00446.2016. Epub 2017 Jan 27.

15.

Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.

Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP.

JCI Insight. 2016 Apr 21;1(5). pii: 85923. doi: 10.1172/jci.insight.85923.

16.

Cardiac sarcoidosis with severe involvement of the right ventricle: a case report.

Siqueira WC, da Cruz SG, Asimaki A, Saffitz JE, Moreira Mda C, Brasileiro G Jr, Rocha LO.

Autops Case Rep. 2015 Dec 30;5(4):53-63. doi: 10.4322/acr.2015.030. eCollection 2015 Oct-Dec.

17.

Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells.

Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H, Saffitz JE.

Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e003688. doi: 10.1161/CIRCEP.115.003688.

18.

Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy.

Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van IJcken WF, Timmer B, van Stuijvenberg M, Verdijk RM, Saffitz JE, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IM.

J Am Coll Cardiol. 2016 Feb 9;67(5):515-25. doi: 10.1016/j.jacc.2015.10.093.

19.

The electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death.

Saffitz JE, Corradi D.

Cardiovasc Pathol. 2016 Mar-Apr;25(2):149-57. doi: 10.1016/j.carpath.2015.11.005. Epub 2015 Dec 2. Review.

PMID:
26764149
20.

Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life-Threatening Arrhythmias.

Spezzacatene A, Sinagra G, Merlo M, Barbati G, Graw SL, Brun F, Slavov D, Di Lenarda A, Salcedo EE, Towbin JA, Saffitz JE, Marcus FI, Zareba W, Taylor MR, Mestroni L; Familial Cardiomyopathy Registry.

J Am Heart Assoc. 2015 Oct 16;4(10):e002149. doi: 10.1161/JAHA.115.002149.

21.

Pathogenesis of Arrhythmogenic Cardiomyopathy.

Asimaki A, Kleber AG, Saffitz JE.

Can J Cardiol. 2015 Nov;31(11):1313-24. doi: 10.1016/j.cjca.2015.04.012. Epub 2015 Apr 24. Review.

22.

Protein trafficking in cardiovascular disease: How the science has evolved and where it must go.

Saffitz JE.

Trends Cardiovasc Med. 2015 Jul;25(5):390-1. doi: 10.1016/j.tcm.2015.01.002. Epub 2015 Jan 12. No abstract available.

PMID:
25666491
23.

Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery.

Asimaki A, Kléber AG, MacRae CA, Saffitz JE.

Prog Pediatr Cardiol. 2014 Dec 1;37(1-2):3-7.

24.

Role of the intercalated disc in cardiac propagation and arrhythmogenesis.

Kleber AG, Saffitz JE.

Front Physiol. 2014 Oct 17;5:404. doi: 10.3389/fphys.2014.00404. eCollection 2014. Review.

25.

Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.

Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang H.

Cardiovasc Res. 2014 Nov 1;104(2):280-9. doi: 10.1093/cvr/cvu212. Epub 2014 Sep 24.

26.

Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C.

Ahmad T, Yin P, Saffitz J, Pockros PJ, Lalezari J, Shiffman M, Freilich B, Zamparo J, Brown K, Dimitrova D, Kumar M, Manion D, Heath-Chiozzi M, Wolf R, Hughes E, Muir AJ, Hernandez AF.

Hepatology. 2015 Aug;62(2):409-16. doi: 10.1002/hep.27488. Epub 2015 May 26.

PMID:
25251156
27.

Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE.

Sci Transl Med. 2014 Jun 11;6(240):240ra74. doi: 10.1126/scitranslmed.3008008. Erratum in: Sci Transl Med. 2014 Nov 5;6(261):261er6.

28.

Postmortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging: an alternative to autopsy?

Saffitz JE, Sanders SP.

Circulation. 2014 May 13;129(19):1909-11. doi: 10.1161/CIRCULATIONAHA.114.009408. Epub 2014 Mar 19. No abstract available.

PMID:
24647276
29.

Persistent lone atrial fibrillation: clinicopathologic study of 19 cases.

Corradi D, Callegari S, Manotti L, Ferrara D, Goldoni M, Alinovi R, Pinelli S, Mozzoni P, Andreoli R, Asimaki A, Pozzoli A, Becchi G, Mutti A, Benussi S, Saffitz JE, Alfieri O.

Heart Rhythm. 2014 Jul;11(7):1250-8. doi: 10.1016/j.hrthm.2014.02.008. Epub 2014 Feb 18.

PMID:
24560692
30.

Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy.

Asimaki A, Saffitz JE.

Cell Commun Adhes. 2014 Feb;21(1):13-23. doi: 10.3109/15419061.2013.876016. Review.

31.

Genomic oncology education: an urgent need, a new approach.

Haspel RL, Saffitz JE.

Cancer J. 2014 Jan-Feb;20(1):91-5. doi: 10.1097/PPO.0000000000000015. Review.

32.

Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations.

Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TA.

Cardiovasc Pathol. 2013 Sep-Oct;22(5):314-8. doi: 10.1016/j.carpath.2013.04.002. Epub 2013 May 17.

PMID:
23688911
33.

Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis.

Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MK.

Rheumatology (Oxford). 2013 Aug;52(8):1529-33. doi: 10.1093/rheumatology/ket184. Epub 2013 May 14.

PMID:
23674817
34.

Medical male circumcision and HIV risk: perceptions of women in a higher learning institution in KwaZulu-Natal, South Africa.

Mantell JE, Smit JA, Saffitz JL, Milford C, Mosery N, Mabude Z, Tesfay N, Sibiya S, Rambally L, Masvawure TB, Kelvin EA, Stein ZA.

Sex Health. 2013 May;10(2):112-8. doi: 10.1071/SH12067.

35.

Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.

Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA.

Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23.

36.

End stage of arrhythmogenic cardiomyopathy with severe involvement of the interventricular septum.

Noorman M, Groeneweg JA, Asimaki A, Rizzo S, Papegaaij M, van Stuijvenberg L, de Jonge N, Dooijes D, Basso C, Saffitz JE, van Veen TA, Vink A, Hauer RN.

Heart Rhythm. 2013 Feb;10(2):283-9. doi: 10.1016/j.hrthm.2012.10.029. Epub 2012 Oct 18.

PMID:
23085127
37.

Gap junctions, slow conduction, and ventricular tachycardia after myocardial infarction.

Saffitz JE, Kléber AG.

J Am Coll Cardiol. 2012 Sep 18;60(12):1111-3. doi: 10.1016/j.jacc.2012.05.020. Epub 2012 Aug 8. No abstract available.

38.

Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy.

van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JP.

Eur J Heart Fail. 2012 Nov;14(11):1199-207. doi: 10.1093/eurjhf/hfs119. Epub 2012 Jul 20.

39.

Genomic pathology: a disruptive innovation.

Saffitz JE.

Per Med. 2012 May;9(3):237-239. doi: 10.2217/pme.12.5. No abstract available.

40.

Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43.

Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG.

Circ Res. 2012 May 25;110(11):1445-53. doi: 10.1161/CIRCRESAHA.111.259705. Epub 2012 Apr 19.

41.

Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.

Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, Tinker A, Lambiase PD.

Eur Heart J. 2012 Aug;33(15):1942-53. doi: 10.1093/eurheartj/ehr472. Epub 2012 Jan 11.

42.

Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death.

Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, Saffitz JE, Duffy HS, Ackerman MJ.

Circulation. 2012 Jan 24;125(3):474-81. doi: 10.1161/CIRCULATIONAHA.111.057224. Epub 2011 Dec 16.

43.

2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology.

Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d'Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL.

Cardiovasc Pathol. 2012 Jul-Aug;21(4):245-74. doi: 10.1016/j.carpath.2011.10.001. Epub 2011 Dec 3.

PMID:
22137237
44.

Gap junctions and arrhythmogenic cardiomyopathy.

Asimaki A, Saffitz JE.

Heart Rhythm. 2012 Jun;9(6):992-5. doi: 10.1016/j.hrthm.2011.11.024. Epub 2011 Nov 16. Review. No abstract available.

45.

Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele.

Gehmlich K, Syrris P, Reimann M, Asimaki A, Ehler E, Evans A, Quarta G, Pantazis A, Saffitz JE, McKenna WJ.

Cardiovasc Pathol. 2012 Jul-Aug;21(4):275-82. doi: 10.1016/j.carpath.2011.09.005. Epub 2011 Oct 27.

PMID:
22036071
46.

Arrhythmogenic cardiomyopathy: advances in diagnosis and disease pathogenesis.

Saffitz JE.

Circulation. 2011 Oct 11;124(15):e390-2. doi: 10.1161/CIRCULATIONAHA.111.064022. Review. No abstract available.

PMID:
21986778
47.

Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy.

Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKenna WJ, Gautam S, Remick DG, Calkins H, Saffitz JE.

Circ Arrhythm Electrophysiol. 2011 Oct;4(5):743-52. doi: 10.1161/CIRCEP.111.964890. Epub 2011 Aug 22.

48.

Fatty acid synthase modulates homeostatic responses to myocardial stress.

Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW 2nd, Nichols CG, Semenkovich CF.

J Biol Chem. 2011 Sep 2;286(35):30949-61. doi: 10.1074/jbc.M111.230508. Epub 2011 Jul 8.

49.
50.

The role of endomyocardial biopsy in ARVC: looking beyond histology in search of new diagnostic markers.

Asimaki A, Saffitz JE.

J Cardiovasc Electrophysiol. 2011 Jan;22(1):111-7. doi: 10.1111/j.1540-8167.2010.01960.x. Epub 2010 Nov 18.

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