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Items: 1 to 50 of 102

1.

Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT.

Cell Signal. 2017 Dec;40:172-182. doi: 10.1016/j.cellsig.2017.09.006. Epub 2017 Sep 18.

PMID:
28923415
2.

Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer.

Godugu C, Doddapaneni R, Safe SH, Singh M.

Eur J Pharm Biopharm. 2016 Nov;108:168-179. doi: 10.1016/j.ejpb.2016.08.006. Epub 2016 Aug 30.

5.

Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures.

Phillips TD, Richardson M, Cheng YS, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD.

Arch Toxicol. 2015 Jun;89(6):967-77. doi: 10.1007/s00204-014-1285-8. Epub 2014 Jun 3.

6.

Investigation of macrophage polarization using bone marrow derived macrophages.

Ying W, Cheruku PS, Bazer FW, Safe SH, Zhou B.

J Vis Exp. 2013 Jun 23;(76). doi: 10.3791/50323.

7.

Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.

Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I.

Anticancer Agents Med Chem. 2012 Dec;12(10):1211-20. Review.

8.

The Toxicology Education Summit: building the future of toxicology through education.

Barchowsky A, Buckley LA, Carlson GP, Fitsanakis VA, Ford SM, Genter MB, Germolec DR, Leavens TL, Lehman-McKeeman LD, Safe SH, Sulentic CE, Eidemiller BJ.

Toxicol Sci. 2012 Jun;127(2):331-8. doi: 10.1093/toxsci/kfs111. Epub 2012 Mar 29.

9.

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent.

Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH.

Anticancer Res. 2011 Nov;31(11):3799-807.

10.

The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells.

Reddivari L, Vanamala J, Safe SH, Miller JC Jr.

Nutr Cancer. 2010;62(5):601-10. doi: 10.1080/01635580903532358.

PMID:
20574921
11.

Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.

Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL.

Mol Endocrinol. 2010 May;24(5):993-1006. doi: 10.1210/me.2009-0438. Epub 2010 Mar 29.

12.

Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways.

Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JC Jr.

Carcinogenesis. 2007 Oct;28(10):2227-35. Epub 2007 May 23.

PMID:
17522067
13.

Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report.

Harding AK, Daston GP, Boyd GR, Lucier GW, Safe SH, Stewart J, Tillitt DE, Van Der Kraak G.

Environ Health Perspect. 2006 Aug;114(8):1276-82.

14.

Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells.

Konopleva M, Zhang W, Shi YX, McQueen T, Tsao T, Abdelrahim M, Munsell MF, Johansen M, Yu D, Madden T, Safe SH, Hung MC, Andreeff M.

Mol Cancer Ther. 2006 Feb;5(2):317-28.

15.

Role of estrogen receptor (ER) alpha in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells.

Zhang S, Li X, Burghardt R, Smith R 3rd, Safe SH.

J Mol Endocrinol. 2005 Dec;35(3):433-47.

PMID:
16326831
16.

Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements.

Fleming JG, Spencer TE, Safe SH, Bazer FW.

Endocrinology. 2006 Feb;147(2):899-911. Epub 2005 Oct 27.

PMID:
16254027
17.
18.
19.

Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes.

Gross-Steinmeyer K, Stapleton PL, Liu F, Tracy JH, Bammler TK, Quigley SD, Farin FM, Buhler DR, Safe SH, Strom SC, Eaton DL.

Xenobiotica. 2004 Jul;34(7):619-32.

PMID:
15672752
20.

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.

Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW.

Chem Biol. 2004 Dec;11(12):1719-28.

21.

Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions.

Cizmas L, Zhou GD, Safe SH, McDonald TJ, Zhu L, Donnelly KC.

Environ Mol Mutagen. 2004;43(3):159-68.

PMID:
15065203
22.

Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

Zhang S, Qin C, Safe SH.

Environ Health Perspect. 2003 Dec;111(16):1877-82.

23.

Problems for risk assessment of endocrine-active estrogenic compounds.

Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, McDonnell D.

Environ Health Perspect. 2002 Dec;110 Suppl 6:925-9. Review.

24.

Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells.

Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC.

Toxicol Sci. 2002 Aug;68(2):444-50.

PMID:
12151640
25.

Toxicology of environmental estrogens.

Safe SH, Pallaroni L, Yoon K, Gaido K, Ross S, Saville B, McDonnellc D.

Reprod Fertil Dev. 2001;13(4):307-15. Review.

PMID:
11800169
26.

Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats.

McDougal A, Gupta MS, Morrow D, Ramamoorthy K, Lee JE, Safe SH.

Breast Cancer Res Treat. 2001 Mar;66(2):147-57.

PMID:
11437101
27.

Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells.

Stewart MD, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE.

Endocrinology. 2001 Jan;142(1):98-107. Erratum in: Endocrinology. 2010 May;151(5):2400. Stewart, D M [corrected to Stewart, M D].

PMID:
11145571
28.

Endocrine disruptors and human health--is there a problem? An update.

Safe SH.

Environ Health Perspect. 2000 Jun;108(6):487-93. Review.

29.

Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs.

Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ.

Endocrinology. 2000 May;141(5):1897-900.

PMID:
10803601
30.

Transcriptional activation of cathepsin D gene expression by growth factors.

Wang F, Duan R, Chirgwin J, Safe SH.

J Mol Endocrinol. 2000 Apr;24(2):193-202.

PMID:
10750020
31.
32.

Analysis of benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line.

Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC.

Toxicol Sci. 2000 Feb;53(2):264-70.

PMID:
10696774
33.

Altered phenotypic characteristics of T47d human breast cancer cells after prolonged growth in estrogen-deficient medium.

Fernandez P, Wilson C, Hoivik D, Safe SH.

Cell Biol Int. 1998;22(9-10):623-33.

PMID:
10452832
34.
35.

Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA.

Endocrinology. 1998 Oct;139(10):4252-63.

PMID:
9751507
36.
37.

Interactions between hormones and chemicals in breast cancer.

Safe SH.

Annu Rev Pharmacol Toxicol. 1998;38:121-58. Review.

PMID:
9597151
38.

Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene.

Willett KL, Randerath K, Zhou GD, Safe SH.

Biochem Pharmacol. 1998 Mar 15;55(6):831-9.

PMID:
9586956
39.

Ah receptor-independent induction of CYP1A2 gene expression in genetically inbred mice.

Gupta M, Miggens J, Parrish A, Womack J, Ramos KS, Rodriguez LV, Goldstein LS, Holtzapple C, Stanker L, Safe SH.

Environ Toxicol Pharmacol. 1998 May;5(3):205-13.

PMID:
21781866
40.

Halogenated aromatic hydrocarbons suppress CA1 field excitatory postsynaptic potentials in rat hippocampal slices.

Hong SJ, Grover CA, Safe SH, Tiffany-Castiglioni E, Frye GD.

Toxicol Appl Pharmacol. 1998 Jan;148(1):7-13.

PMID:
9465258
43.

17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects.

Wang W, Smith R 3rd, Burghardt R, Safe SH.

Mol Cell Endocrinol. 1997 Sep 30;133(1):49-62.

PMID:
9359472
44.

Xenoestrogens and breast cancer.

Safe SH.

N Engl J Med. 1997 Oct 30;337(18):1303-4. No abstract available.

PMID:
9345081
45.

Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein.

Wilson CL, Thomsen J, Hoivik DJ, Wormke MT, Stanker L, Holtzapple C, Safe SH.

Arch Biochem Biophys. 1997 Oct 1;346(1):65-73.

PMID:
9328285
46.

Characterization of the H4IIE rat hepatoma cell bioassay for evaluation of environmental samples containing polynuclear aromatic hydrocarbons (PAHs).

Willett KL, Gardinali PR, Sericano JL, Wade TL, Safe SH.

Arch Environ Contam Toxicol. 1997 May;32(4):442-8.

PMID:
9175514
47.

Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Wang WL, Porter W, Burghardt R, Safe SH.

Carcinogenesis. 1997 May;18(5):925-33.

PMID:
9163677
48.

Is there an association between exposure to environmental estrogens and breast cancer?

Safe SH.

Environ Health Perspect. 1997 Apr;105 Suppl 3:675-8. Review.

49.

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