Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 700

1.

BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS.

Mohankumar K, Li X, Sung N, Cho YJ, Han SJ, Safe S.

Endocrinology. 2020 Feb 26. pii: bqaa027. doi: 10.1210/endocr/bqaa027. [Epub ahead of print]

PMID:
32099996
2.

CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers.

Kumaravel S, Singh S, Roy S, Venkatasamy L, White TK, Sinha S, Glaser SS, Safe SH, Chakraborty S.

Am J Pathol. 2020 Feb 5. pii: S0002-9440(20)30019-5. doi: 10.1016/j.ajpath.2019.12.004. [Epub ahead of print]

PMID:
32035061
3.

The role of Self Nano Emulsifying drug delivery systems of CDODA-Me in sensitizing Erlotinib resistant Nonsmall cell lung cancer.

Nottingham E, Sekar V, Mondal A, Safe S, Rishi A, Singh M.

J Pharm Sci. 2020 Jan 15. pii: S0022-3549(20)30015-0. doi: 10.1016/j.xphs.2020.01.010. [Epub ahead of print]

PMID:
31954111
4.

A Bis-Indole-Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity.

Karki K, Wright GA, Mohankumar K, Jin UH, Zhang XH, Safe S.

Cancer Res. 2020 Mar 1;80(5):1011-1023. doi: 10.1158/0008-5472.CAN-19-2314. Epub 2020 Jan 7.

PMID:
31911554
5.

Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.

Garcia-Villatoro EL, DeLuca JAA, Callaway ES, Allred KF, Davidson LA, Hensel ME, Menon R, Ivanov I, Safe SH, Jayaraman A, Chapkin RS, Allred CD.

Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G451-G463. doi: 10.1152/ajpgi.00268.2019. Epub 2020 Jan 6.

PMID:
31905023
6.

Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas.

Karki K, Li X, Jin UH, Mohankumar K, Zarei M, Michelhaugh SK, Mittal S, Tjalkens R, Safe S.

J Neurooncol. 2020 Jan;146(1):25-39. doi: 10.1007/s11060-019-03349-y. Epub 2019 Nov 21.

PMID:
31754919
7.

Pharmacological activation of Nr4a rescues age-associated memory decline.

Chatterjee S, Walsh EN, Yan AL, Giese KP, Safe S, Abel T.

Neurobiol Aging. 2020 Jan;85:140-144. doi: 10.1016/j.neurobiolaging.2019.10.001. Epub 2019 Oct 14.

PMID:
31732218
8.

Isoflavones as Ah Receptor Agonists in Colon-Derived Cell Lines: Structure-Activity Relationships.

Park H, Jin UH, Orr AA, Echegaray SP, Davidson LA, Allred CD, Chapkin RS, Jayaraman A, Lee K, Tamamis P, Safe S.

Chem Res Toxicol. 2019 Nov 18;32(11):2353-2364. doi: 10.1021/acs.chemrestox.9b00352. Epub 2019 Oct 29.

9.

Strong adsorption of Polychlorinated Biphenyls by processed montmorillonite clays: Potential applications as toxin enterosorbents during disasters and floods.

Wang M, Safe S, Hearon SE, Phillips TD.

Environ Pollut. 2019 Dec;255(Pt 1):113210. doi: 10.1016/j.envpol.2019.113210. Epub 2019 Sep 7.

PMID:
31542671
10.

Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma.

Hedrick E, Mohankumar K, Lacey A, Safe S.

Mol Cancer Res. 2019 Nov;17(11):2221-2232. doi: 10.1158/1541-7786.MCR-19-0408. Epub 2019 Aug 28.

PMID:
31462501
11.

Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies.

Safe S, Han H, Goldsby J, Mohankumar K, Chapkin RS.

Curr Opin Toxicol. 2018 Oct-Dec;11-12:10-20. doi: 10.1016/j.cotox.2018.11.005. Epub 2018 Nov 22.

12.

The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma.

Jin UH, Karki K, Cheng Y, Michelhaugh SK, Mittal S, Safe S.

J Biol Chem. 2019 Jul 19;294(29):11342-11353. doi: 10.1074/jbc.RA119.008882. Epub 2019 Jun 6.

PMID:
31171720
13.

Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists.

Hedrick E, Li X, Cheng Y, Lacey A, Mohankumar K, Zarei M, Safe S.

Breast Cancer Res Treat. 2019 Aug;177(1):29-40. doi: 10.1007/s10549-019-05279-9. Epub 2019 May 22.

PMID:
31119568
14.

Structure-dependent activation of gene expression by bis-indole and quinoline-derived activators of nuclear receptor 4A2.

Li X, Tjalkens RB, Shrestha R, Safe S.

Chem Biol Drug Des. 2019 Oct;94(4):1711-1720. doi: 10.1111/cbdd.13564. Epub 2019 Jul 21. Review.

PMID:
31102570
15.

Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer.

Mohankumar K, Li X, Sridharan S, Karki K, Safe S.

Gynecol Oncol. 2019 Jul;154(1):218-227. doi: 10.1016/j.ygyno.2019.04.678. Epub 2019 Apr 30.

PMID:
31053403
16.

Activation of COUP-TFI by a Novel Diindolylmethane Derivative.

Yoon K, Chen CC, Orr AA, Barreto PN, Tamamis P, Safe S.

Cells. 2019 Mar 7;8(3). pii: E220. doi: 10.3390/cells8030220.

17.

Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors.

Kasiappan R, Jutooru I, Mohankumar K, Karki K, Lacey A, Safe S.

Mol Cancer Res. 2019 Mar;17(3):794-805. doi: 10.1158/1541-7786.MCR-18-1071. Epub 2019 Jan 4.

18.

Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo.

Jung YS, Lee HS, Cho HR, Kim KJ, Kim JH, Safe S, Lee SO.

Int J Obes (Lond). 2019 May;43(5):952-962. doi: 10.1038/s41366-018-0276-x. Epub 2018 Dec 11.

PMID:
30538281
19.

Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice.

Wu CS, Wei Q, Wang H, Kim DM, Balderas M, Wu G, Lawler J, Safe S, Guo S, Devaraj S, Chen Z, Sun Y.

J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):621-630. doi: 10.1093/gerona/gly256.

PMID:
30407483
20.

Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma.

Lacey A, Hedrick E, Cheng Y, Mohankumar K, Warren M, Safe S.

Mol Cancer Ther. 2018 Dec;17(12):2756-2766. doi: 10.1158/1535-7163.MCT-18-0118. Epub 2018 Sep 6.

21.

Bortezomib Targets Sp Transcription Factors in Cancer Cells.

Karki K, Harishchandra S, Safe S.

Mol Pharmacol. 2018 Oct;94(4):1187-1196. doi: 10.1124/mol.118.112797. Epub 2018 Aug 16.

22.

Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB-Dependent Inflammatory Signaling in Astrocytes.

Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB.

Mol Pharmacol. 2018 Oct;94(4):1174-1186. doi: 10.1124/mol.118.112631. Epub 2018 Aug 15.

23.

TGFβ-Induced Lung Cancer Cell Migration Is NR4A1-Dependent.

Hedrick E, Mohankumar K, Safe S.

Mol Cancer Res. 2018 Dec;16(12):1991-2002. doi: 10.1158/1541-7786.MCR-18-0366. Epub 2018 Aug 2.

24.

A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism.

Afzali MF, Popichak KA, Burton LH, Klochak AL, Wilson WJ, Safe S, Tjalkens RB, Legare ME.

Mol Immunol. 2018 Sep;101:46-54. doi: 10.1016/j.molimm.2018.05.024. Epub 2018 Jun 2.

25.

Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK.

Jin UH, Karki K, Kim SB, Safe S.

Biochem Biophys Res Commun. 2018 Jun 27;501(3):751-757. doi: 10.1016/j.bbrc.2018.05.061.

26.

Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells.

Mohankumar K, Lee J, Wu CS, Sun Y, Safe S.

Endocrinology. 2018 May 1;159(5):1950-1963. doi: 10.1210/en.2017-03049.

27.

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism.

Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale PU, Chong EKP, Backos DS, Safe S, Tjalkens RB.

J Pharmacol Exp Ther. 2018 Jun;365(3):636-651. doi: 10.1124/jpet.117.246389. Epub 2018 Apr 6.

28.

Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model.

Draz H, Goldberg AA, Tomlinson Guns ES, Fazli L, Safe S, Sanderson JT.

Invest New Drugs. 2018 Aug;36(4):718-725. doi: 10.1007/s10637-018-0595-8. Epub 2018 Apr 2.

PMID:
29607466
29.

Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids.

Jin UH, Park H, Li X, Davidson LA, Allred C, Patil B, Jayaprakasha G, Orr AA, Mao L, Chapkin RS, Jayaraman A, Tamamis P, Safe S.

Toxicol Sci. 2018 Jul 1;164(1):205-217. doi: 10.1093/toxsci/kfy075.

30.

Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development.

Safe S, Abbruzzese J, Abdelrahim M, Hedrick E.

Cancer Prev Res (Phila). 2018 Jul;11(7):371-382. doi: 10.1158/1940-6207.CAPR-17-0407. Epub 2018 Mar 15. Review.

31.

Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor.

Choudhary M, Safe S, Malek G.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1583-1595. doi: 10.1016/j.bbadis.2018.02.015. Epub 2018 Feb 23.

32.

Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.

Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S.

PLoS One. 2018 Feb 1;13(2):e0192264. doi: 10.1371/journal.pone.0192264. eCollection 2018.

33.

Metformin-induced anticancer activities: recent insights.

Safe S, Nair V, Karki K.

Biol Chem. 2018 Mar 28;399(4):321-335. doi: 10.1515/hsz-2017-0271. Review.

PMID:
29272251
34.

NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells.

Li Y, Wang F, Lu L, Zhu F, Huang S, Nomie K, Zhang L, Yang DT, Huang W, Kahl BS, Safe S, Wang M, Rui L.

Blood Cancer J. 2017 Nov 23;7(12):632. doi: 10.1038/s41408-017-0005-z. No abstract available.

35.

Carbidopa: a selective Ah receptor modulator (SAhRM).

Safe S.

Biochem J. 2017 Nov 6;474(22):3763-3765. doi: 10.1042/BCJ20170728.

PMID:
29109131
36.

Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).

Draz H, Goldberg AA, Titorenko VI, Tomlinson Guns ES, Safe SH, Sanderson JT.

Cell Signal. 2017 Dec;40:172-182. doi: 10.1016/j.cellsig.2017.09.006. Epub 2017 Sep 18.

PMID:
28923415
37.

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells.

Jin UH, Cheng Y, Park H, Davidson LA, Callaway ES, Chapkin RS, Jayaraman A, Asante A, Allred C, Weaver EA, Safe S.

Sci Rep. 2017 Aug 31;7(1):10163. doi: 10.1038/s41598-017-10824-x.

38.

Correction for Hedrick et al., "NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration".

Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S.

Mol Cell Biol. 2017 Aug 28;37(18). pii: e00197-17. doi: 10.1128/MCB.00197-17. Print 2017 Sep 15. No abstract available.

39.

Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells.

Lee HS, Safe S, Lee SO.

Toxicol Appl Pharmacol. 2017 Oct 1;332:32-39. doi: 10.1016/j.taap.2017.07.017. Epub 2017 Jul 25.

PMID:
28754437
40.

Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

Kolluri SK, Jin UH, Safe S.

Arch Toxicol. 2017 Sep;91(9):3209. doi: 10.1007/s00204-017-2026-6. No abstract available.

PMID:
28695231
41.
42.

Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.

Karki K, Hedrick E, Kasiappan R, Jin UH, Safe S.

Cancer Prev Res (Phila). 2017 Aug;10(8):467-477. doi: 10.1158/1940-6207.CAPR-17-0053. Epub 2017 Jul 3.

43.

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target.

Kolluri SK, Jin UH, Safe S.

Arch Toxicol. 2017 Jul;91(7):2497-2513. doi: 10.1007/s00204-017-1981-2. Epub 2017 May 15. Review. Erratum in: Arch Toxicol. 2017 Sep;91(9):3209.

44.

The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy.

Safe S, Cheng Y, Jin UH.

Curr Opin Toxicol. 2017 Feb;2:24-29. doi: 10.1016/j.cotox.2017.01.012. Epub 2017 Feb 1.

45.

The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.

Hedrick E, Lee SO, Safe S.

Mol Carcinog. 2017 Sep;56(9):2066-2075. doi: 10.1002/mc.22662. Epub 2017 May 9.

46.

CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program.

Taoka R, Jinesh GG, Xue W, Safe S, Kamat AM.

Apoptosis. 2017 May;22(5):719-729. doi: 10.1007/s10495-017-1359-1.

PMID:
28283889
47.

Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells.

Jin UH, Cheng Y, Zhou B, Safe S.

Mol Pharmacol. 2017 May;91(5):438-450. doi: 10.1124/mol.116.106245. Epub 2017 Mar 8.

48.

Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer.

Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe S.

J Biol Chem. 2016 Dec 30;291(53):27122-27133. doi: 10.1074/jbc.M116.746339. Epub 2016 Nov 15.

49.

PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1.

Lacey A, Rodrigues-Hoffman A, Safe S.

Cancer Res. 2017 Feb 1;77(3):732-741. doi: 10.1158/0008-5472.CAN-16-1546. Epub 2016 Nov 18.

50.

Editor's Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling.

Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S.

Toxicol Sci. 2017 Feb;155(2):458-473. doi: 10.1093/toxsci/kfw230. Epub 2016 Nov 11.

Supplemental Content

Support Center