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Items: 32


The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.

Nielsen LD, Foged MM, Albert A, Bertelsen AB, Søltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K, Ellgaard L.

J Biol Chem. 2019 May 31;294(22):8745-8759. doi: 10.1074/jbc.RA119.007491. Epub 2019 Apr 11.


Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.

Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Flórez Salcedo P, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Hung-Chieh Chou D, Safavi-Hemami H.

Elife. 2019 Feb 12;8. pii: e41574. doi: 10.7554/eLife.41574.


Discovery of Novel Conotoxin Candidates Using Machine Learning.

Li Q, Watkins M, Robinson SD, Safavi-Hemami H, Yandell M.

Toxins (Basel). 2018 Dec 1;10(12). pii: E503. doi: 10.3390/toxins10120503.


Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins.

O'Brien H, Kanemura S, Okumura M, Baskin RP, Bandyopadhyay PK, Olivera BM, Ellgaard L, Inaba K, Safavi-Hemami H.

Int J Mol Sci. 2018 Oct 31;19(11). pii: E3418. doi: 10.3390/ijms19113418.


Conopeptides promote itch through human itch receptor hMgprX1.

Espino SS, Robinson SD, Safavi-Hemami H, Gajewiak J, Yang W, Olivera BM, Liu Q.

Toxicon. 2018 Nov;154:28-34. doi: 10.1016/j.toxicon.2018.09.002. Epub 2018 Sep 21.


Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways.

Safavi-Hemami H, Brogan SE, Olivera BM.

J Proteomics. 2019 Jan 6;190:12-20. doi: 10.1016/j.jprot.2018.05.009. Epub 2018 May 16.


Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus.

Li Q, Barghi N, Lu A, Fedosov AE, Bandyopadhyay PK, Lluisma AO, Concepcion GP, Yandell M, Olivera BM, Safavi-Hemami H.

Genome Biol Evol. 2017 Sep 1;9(9):2211-2225. doi: 10.1093/gbe/evx157.


Venom peptides as pharmacological tools and therapeutics for diabetes.

Robinson SD, Safavi-Hemami H.

Neuropharmacology. 2017 Dec;127:79-86. doi: 10.1016/j.neuropharm.2017.07.001. Epub 2017 Jul 5. Review.


Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

Olivera BM, Raghuraman S, Schmidt EW, Safavi-Hemami H.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Sep;203(9):717-735. doi: 10.1007/s00359-017-1183-7. Epub 2017 May 27. Review.


The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.

Robinson SD, Li Q, Lu A, Bandyopadhyay PK, Yandell M, Olivera BM, Safavi-Hemami H.

Mar Drugs. 2017 May 20;15(5). pii: E145. doi: 10.3390/md15050145.


Isolation and characterization of Conohyal-P1, a hyaluronidase from the injected venom of Conus purpurascens.

Möller C, Clark E, Safavi-Hemami H, DeCaprio A, Marí F.

J Proteomics. 2017 Jul 5;164:73-84. doi: 10.1016/j.jprot.2017.05.002. Epub 2017 May 4.


Insulin as a weapon.

Robinson SD, Safavi-Hemami H.

Toxicon. 2016 Dec 1;123:56-61. doi: 10.1016/j.toxicon.2016.10.010. Epub 2016 Oct 21. Review.


A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.


Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa.

Safavi-Hemami H, Lu A, Li Q, Fedosov AE, Biggs J, Showers Corneli P, Seger J, Yandell M, Olivera BM.

Mol Biol Evol. 2016 Nov;33(11):2924-2934. Epub 2016 Aug 14.


Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides.

Safavi-Hemami H, Li Q, Jackson RL, Song AS, Boomsma W, Bandyopadhyay PK, Gruber CW, Purcell AW, Yandell M, Olivera BM, Ellgaard L.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3227-32. doi: 10.1073/pnas.1525790113. Epub 2016 Mar 8.


A prominent role of PDIA6 in processing of misfolded proinsulin.

Gorasia DG, Dudek NL, Safavi-Hemami H, Perez RA, Schittenhelm RB, Saunders PM, Wee S, Mangum JE, Hubbard MJ, Purcell AW.

Biochim Biophys Acta. 2016 Jun;1864(6):715-723. doi: 10.1016/j.bbapap.2016.03.002. Epub 2016 Mar 3.


A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold.

Robinson SD, Chhabra S, Belgi A, Chittoor B, Safavi-Hemami H, Robinson AJ, Papenfuss AT, Purcell AW, Norton RS.

Structure. 2016 Feb 2;24(2):293-9. doi: 10.1016/j.str.2015.11.015. Epub 2016 Jan 7.


Hormone-like peptides in the venoms of marine cone snails.

Robinson SD, Li Q, Bandyopadhyay PK, Gajewiak J, Yandell M, Papenfuss AT, Purcell AW, Norton RS, Safavi-Hemami H.

Gen Comp Endocrinol. 2017 Apr 1;244:11-18. doi: 10.1016/j.ygcen.2015.07.012. Epub 2015 Aug 22.


Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus.

Aman JW, Imperial JS, Ueberheide B, Zhang MM, Aguilar M, Taylor D, Watkins M, Yoshikami D, Showers-Corneli P, Safavi-Hemami H, Biggs J, Teichert RW, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5087-92. doi: 10.1073/pnas.1424435112. Epub 2015 Apr 6.


Specialized insulin is used for chemical warfare by fish-hunting cone snails.

Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8. doi: 10.1073/pnas.1423857112. Epub 2015 Jan 20.


Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom.

Robinson SD, Safavi-Hemami H, Raghuraman S, Imperial JS, Papenfuss AT, Teichert RW, Purcell AW, Olivera BM, Norton RS.

J Proteomics. 2015 Jan 30;114:38-47. doi: 10.1016/j.jprot.2014.11.003. Epub 2014 Nov 15.


Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes.

Gorasia DG, Dudek NL, Veith PD, Shankar R, Safavi-Hemami H, Williamson NA, Reynolds EC, Hubbard MJ, Purcell AW.

J Proteome Res. 2015 Feb 6;14(2):688-99. doi: 10.1021/pr500643h. Epub 2014 Dec 8.


The Opisthorchis viverrini genome provides insights into life in the bile duct.

Young ND, Nagarajan N, Lin SJ, Korhonen PK, Jex AR, Hall RS, Safavi-Hemami H, Kaewkong W, Bertrand D, Gao S, Seet Q, Wongkham S, Teh BT, Wongkham C, Intapan PM, Maleewong W, Yang X, Hu M, Wang Z, Hofmann A, Sternberg PW, Tan P, Wang J, Gasser RB.

Nat Commun. 2014 Jul 9;5:4378. doi: 10.1038/ncomms5378.


Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae.

Robinson SD, Safavi-Hemami H, McIntosh LD, Purcell AW, Norton RS, Papenfuss AT.

PLoS One. 2014 Feb 5;9(2):e87648. doi: 10.1371/journal.pone.0087648. eCollection 2014.


Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization.

Safavi-Hemami H, Hu H, Gorasia DG, Bandyopadhyay PK, Veith PD, Young ND, Reynolds EC, Yandell M, Olivera BM, Purcell AW.

Mol Cell Proteomics. 2014 Apr;13(4):938-53. doi: 10.1074/mcp.M113.031351. Epub 2014 Jan 29.


High molecular weight components of the injected venom of fish-hunting cone snails target the vascular system.

Safavi-Hemami H, Möller C, Marí F, Purcell AW.

J Proteomics. 2013 Oct 8;91:97-105. doi: 10.1016/j.jprot.2013.07.007. Epub 2013 Jul 19.


Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.

Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G, Purcell AW.

J Biol Chem. 2012 Oct 5;287(41):34288-303. doi: 10.1074/jbc.M112.366781. Epub 2012 Aug 13.


Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway.

Safavi-Hemami H, Siero WA, Gorasia DG, Young ND, Macmillan D, Williamson NA, Purcell AW.

J Proteome Res. 2011 Sep 2;10(9):3904-19. doi: 10.1021/pr1012976. Epub 2011 Aug 11.


Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?

Safavi-Hemami H, Siero WA, Kuang Z, Williamson NA, Karas JA, Page LR, MacMillan D, Callaghan B, Kompella SN, Adams DJ, Norton RS, Purcell AW.

J Biol Chem. 2011 Jun 24;286(25):22546-57. doi: 10.1074/jbc.M110.217703. Epub 2011 Apr 19.


Proteomic interrogation of venom delivery in marine cone snails: novel insights into the role of the venom bulb.

Safavi-Hemami H, Young ND, Williamson NA, Purcell AW.

J Proteome Res. 2010 Nov 5;9(11):5610-9. doi: 10.1021/pr100431x. Epub 2010 Sep 29.


Characterisation of nitric oxide synthase in three cnidarian-dinoflagellate symbioses.

Safavi-Hemami H, Young ND, Doyle J, Llewellyn L, Klueter A.

PLoS One. 2010 Apr 28;5(4):e10379. doi: 10.1371/journal.pone.0010379.


Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins.

Safavi-Hemami H, Bulaj G, Olivera BM, Williamson NA, Purcell AW.

J Biol Chem. 2010 Apr 23;285(17):12735-46. doi: 10.1074/jbc.M109.078691. Epub 2010 Feb 10.

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