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Items: 36

1.

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients.

Orrù CD, Soldau K, Cordano C, Llibre-Guerra J, Green AJ, Sanchez H, Groveman BR, Edland SD, Safar JG, Lin JH, Caughey B, Geschwind MD, Sigurdson CJ.

MBio. 2018 Nov 20;9(6). pii: e02095-18. doi: 10.1128/mBio.02095-18.

2.

Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions.

Li Q, Wang F, Xiao X, Kim C, Bohon J, Kiselar J, Safar JG, Ma J, Surewicz WK.

J Biol Chem. 2018 Nov 30;293(48):18494-18503. doi: 10.1074/jbc.RA118.005622. Epub 2018 Oct 1.

3.

Artificial strain of human prions created in vitro.

Kim C, Xiao X, Chen S, Haldiman T, Smirnovas V, Kofskey D, Warren M, Surewicz K, Maurer NR, Kong Q, Surewicz W, Safar JG.

Nat Commun. 2018 Jun 4;9(1):2166. doi: 10.1038/s41467-018-04584-z.

4.

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D.

PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan.

5.

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study.

Cali I, Cohen ML, Haik S, Parchi P, Giaccone G, Collins SJ, Kofskey D, Wang H, McLean CA, Brandel JP, Privat N, Sazdovitch V, Duyckaerts C, Kitamoto T, Belay ED, Maddox RA, Tagliavini F, Pocchiari M, Leschek E, Appleby BS, Safar JG, Schonberger LB, Gambetti P.

Acta Neuropathol Commun. 2018 Jan 8;6(1):5. doi: 10.1186/s40478-017-0503-z.

6.

Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease.

Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaam7785. doi: 10.1126/scitranslmed.aam7785.

7.

Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease.

Drummond E, Nayak S, Faustin A, Pires G, Hickman RA, Askenazi M, Cohen M, Haldiman T, Kim C, Han X, Shao Y, Safar JG, Ueberheide B, Wisniewski T.

Acta Neuropathol. 2017 Jun;133(6):933-954. doi: 10.1007/s00401-017-1691-0. Epub 2017 Mar 4.

8.

Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Correlation of Histopathology and MRI in Prion Disease.

Mente KP, O'Donnell JK, Jones SE, Cohen ML, Thompson NR, Bizzi A, Gambetti P, Safar JG, Appleby BS.

Alzheimer Dis Assoc Disord. 2017 Jan-Mar;31(1):1-7. doi: 10.1097/WAD.0000000000000188.

9.

Novel strain properties distinguishing sporadic prion diseases sharing prion protein genotype and prion type.

Cracco L, Notari S, Cali I, Sy MS, Chen SG, Cohen ML, Ghetti B, Appleby BS, Zou WQ, Caughey B, Safar JG, Gambetti P.

Sci Rep. 2017 Jan 16;7:38280. doi: 10.1038/srep38280.

10.

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.

Foutz A, Appleby BS, Hamlin C, Liu X, Yang S, Cohen Y, Chen W, Blevins J, Fausett C, Wang H, Gambetti P, Zhang S, Hughson A, Tatsuoka C, Schonberger LB, Cohen ML, Caughey B, Safar JG.

Ann Neurol. 2017 Jan;81(1):79-92. doi: 10.1002/ana.24833.

11.

Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease.

Cohen M, Appleby B, Safar JG.

Prion. 2016;10(1):9-17. doi: 10.1080/19336896.2015.1123371.

12.

Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPSc Species.

Mays CE, van der Merwe J, Kim C, Haldiman T, McKenzie D, Safar JG, Westaway D.

J Virol. 2015 Dec;89(24):12418-26. doi: 10.1128/JVI.02142-15. Epub 2015 Sep 30.

13.

Structural determinants of phenotypic diversity and replication rate of human prions.

Safar JG, Xiao X, Kabir ME, Chen S, Kim C, Haldiman T, Cohen Y, Chen W, Cohen ML, Surewicz WK.

PLoS Pathog. 2015 Apr 14;11(4):e1004832. doi: 10.1371/journal.ppat.1004832. eCollection 2015 Apr.

14.

Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β.

Cohen ML, Kim C, Haldiman T, ElHag M, Mehndiratta P, Pichet T, Lissemore F, Shea M, Cohen Y, Chen W, Blevins J, Appleby BS, Surewicz K, Surewicz WK, Sajatovic M, Tatsuoka C, Zhang S, Mayo P, Butkiewicz M, Haines JL, Lerner AJ, Safar JG.

Brain. 2015 Apr;138(Pt 4):1009-22. doi: 10.1093/brain/awv006. Epub 2015 Feb 15.

15.

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation.

Lau A, McDonald A, Daude N, Mays CE, Walter ED, Aglietti R, Mercer RC, Wohlgemuth S, van der Merwe J, Yang J, Gapeshina H, Kim C, Grams J, Shi B, Wille H, Balachandran A, Schmitt-Ulms G, Safar JG, Millhauser GL, Westaway D.

EMBO Mol Med. 2015 Mar;7(3):339-56. doi: 10.15252/emmm.201404588.

16.

Prion disease tempo determined by host-dependent substrate reduction.

Mays CE, Kim C, Haldiman T, van der Merwe J, Lau A, Yang J, Grams J, Di Bari MA, Nonno R, Telling GC, Kong Q, Langeveld J, McKenzie D, Westaway D, Safar JG.

J Clin Invest. 2014 Feb;124(2):847-58. doi: 10.1172/JCI72241. Epub 2014 Jan 16.

17.

Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases.

Kabir ME, Safar JG.

Prion. 2014 Jan-Feb;8(1):111-6. Review.

PMID:
24401672
18.

Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection.

Haldiman T, Kim C, Cohen Y, Chen W, Blevins J, Qing L, Cohen ML, Langeveld J, Telling GC, Kong Q, Safar JG.

J Biol Chem. 2013 Oct 11;288(41):29846-61. doi: 10.1074/jbc.M113.500108. Epub 2013 Aug 23.

19.

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

Kim C, Haldiman T, Surewicz K, Cohen Y, Chen W, Blevins J, Sy MS, Cohen M, Kong Q, Telling GC, Surewicz WK, Safar JG.

PLoS Pathog. 2012;8(8):e1002835. doi: 10.1371/journal.ppat.1002835. Epub 2012 Aug 2.

20.

Sporadic human prion diseases: molecular insights and diagnosis.

Puoti G, Bizzi A, Forloni G, Safar JG, Tagliavini F, Gambetti P.

Lancet Neurol. 2012 Jul;11(7):618-28. doi: 10.1016/S1474-4422(12)70063-7. Review. Erratum in: Lancet Neurol. 2012 Oct;11(10):841.

PMID:
22710755
21.

Molecular pathogenesis of sporadic prion diseases in man.

Safar JG.

Prion. 2012 Apr-Jun;6(2):108-15. doi: 10.4161/pri.18666. Epub 2012 Apr 1. Review.

22.

Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.

Kim C, Haldiman T, Cohen Y, Chen W, Blevins J, Sy MS, Cohen M, Safar JG.

PLoS Pathog. 2011 Sep;7(9):e1002242. doi: 10.1371/journal.ppat.1002242. Epub 2011 Sep 8.

23.

Conserved properties of human and bovine prion strains on transmission to guinea pigs.

Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB.

Lab Invest. 2011 Sep;91(9):1326-36. doi: 10.1038/labinvest.2011.89. Epub 2011 Jul 4.

24.

Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics.

Cali I, Castellani R, Alshekhlee A, Cohen Y, Blevins J, Yuan J, Langeveld JP, Parchi P, Safar JG, Zou WQ, Gambetti P.

Brain. 2009 Oct;132(Pt 10):2643-58. doi: 10.1093/brain/awp196. Epub 2009 Sep 4.

25.

Prion proteins in subpopulations of white blood cells from patients with sporadic Creutzfeldt-Jakob disease.

Choi EM, Geschwind MD, Deering C, Pomeroy K, Kuo A, Miller BL, Safar JG, Prusiner SB.

Lab Invest. 2009 Jun;89(6):624-35. doi: 10.1038/labinvest.2009.30.

26.

Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein.

Wille H, Shanmugam M, Murugesu M, Ollesch J, Stubbs G, Long JR, Safar JG, Prusiner SB.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3740-5. doi: 10.1073/pnas.0812770106. Epub 2009 Feb 17.

27.

Transmission and detection of prions in feces.

Safar JG, Lessard P, Tamgüney G, Freyman Y, Deering C, Letessier F, Dearmond SJ, Prusiner SB.

J Infect Dis. 2008 Jul 1;198(1):81-9. doi: 10.1086/588193.

28.

Thioaptamer interactions with prion proteins: sequence-specific and non-specific binding sites.

King DJ, Safar JG, Legname G, Prusiner SB.

J Mol Biol. 2007 Jun 15;369(4):1001-14. Epub 2007 Feb 9.

PMID:
17481659
29.

Human prions and plasma lipoproteins.

Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11312-7. Epub 2006 Jul 18.

30.

Inactivation of prions by acidic sodium dodecyl sulfate.

Peretz D, Supattapone S, Giles K, Vergara J, Freyman Y, Lessard P, Safar JG, Glidden DV, McCulloch C, Nguyen HO, Scott M, Dearmond SJ, Prusiner SB.

J Virol. 2006 Jan;80(1):322-31.

31.

Selective precipitation of prions by polyoxometalate complexes.

Lee IS, Long JR, Prusiner SB, Safar JG.

J Am Chem Soc. 2005 Oct 12;127(40):13802-3.

PMID:
16201796
32.

Prion clearance in bigenic mice.

Safar JG, DeArmond SJ, Kociuba K, Deering C, Didorenko S, Bouzamondo-Bernstein E, Prusiner SB, Tremblay P.

J Gen Virol. 2005 Oct;86(Pt 10):2913-23.

PMID:
16186247
33.

Search for a prion-specific nucleic acid.

Safar JG, Kellings K, Serban A, Groth D, Cleaver JE, Prusiner SB, Riesner D.

J Virol. 2005 Aug;79(16):10796-806.

34.

Diagnosis of human prion disease.

Safar JG, Geschwind MD, Deering C, Didorenko S, Sattavat M, Sanchez H, Serban A, Vey M, Baron H, Giles K, Miller BL, Dearmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3501-6.

35.

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.

Tremblay P, Ball HL, Kaneko K, Groth D, Hegde RS, Cohen FE, DeArmond SJ, Prusiner SB, Safar JG.

J Virol. 2004 Feb;78(4):2088-99.

36.

Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.

Safar JG, Scott M, Monaghan J, Deering C, Didorenko S, Vergara J, Ball H, Legname G, Leclerc E, Solforosi L, Serban H, Groth D, Burton DR, Prusiner SB, Williamson RA.

Nat Biotechnol. 2002 Nov;20(11):1147-50. Epub 2002 Oct 21.

PMID:
12389035

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