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Items: 1 to 50 of 117

1.

Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy.

Rabal O, San José-Enériz E, Agirre X, Sánchez-Arias JA, Vilas-Zornoza A, Ugarte A, de Miguel I, Miranda E, Garate L, Fraga M, Santamarina P, Fernandez Perez R, Ordoñez R, Sáez E, Roa S, García-Barchino MJ, Martínez-Climent JA, Liu Y, Wu W, Xu M, Prosper F, Oyarzabal J.

J Med Chem. 2018 Aug 9;61(15):6518-6545. doi: 10.1021/acs.jmedchem.7b01926. Epub 2018 Jul 19.

PMID:
29953809
2.

Detailed Exploration around 4-Aminoquinolines Chemical Space to Navigate the Lysine Methyltransferase G9a and DNA Methyltransferase Biological Spaces.

Rabal O, Sánchez-Arias JA, San José-Enériz E, Agirre X, de Miguel I, Garate L, Miranda E, Sáez E, Roa S, Martínez-Climent JA, Liu Y, Wu W, Xu M, Prosper F, Oyarzabal J.

J Med Chem. 2018 Aug 9;61(15):6546-6573. doi: 10.1021/acs.jmedchem.7b01925. Epub 2018 Jul 19.

PMID:
29890830
3.

Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents.

de Miguel I, Orbe J, Sánchez-Arias JA, Rodríguez JA, Salicio A, Rabal O, Belzunce M, Sáez E, Xu M, Wu W, Tan H, Ma H, Páramo JA, Oyarzabal J.

ACS Med Chem Lett. 2018 Apr 16;9(5):428-433. doi: 10.1021/acsmedchemlett.7b00549. eCollection 2018 May 10.

PMID:
29795754
4.

Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments.

Galmozzi A, Parker CG, Kok BP, Cravatt BF, Saez E.

Methods Mol Biol. 2018;1787:115-127. doi: 10.1007/978-1-4939-7847-2_9.

PMID:
29736714
5.

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.

Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J.

Eur J Med Chem. 2018 Apr 25;150:506-524. doi: 10.1016/j.ejmech.2018.03.005. Epub 2018 Mar 20.

PMID:
29549837
6.

Zc3h10 is a novel mitochondrial regulator.

Audano M, Pedretti S, Cermenati G, Brioschi E, Diaferia GR, Ghisletti S, Cuomo A, Bonaldi T, Salerno F, Mora M, Grigore L, Garlaschelli K, Baragetti A, Bonacina F, Catapano AL, Norata GD, Crestani M, Caruso D, Saez E, De Fabiani E, Mitro N.

EMBO Rep. 2018 Apr;19(4). pii: e45531. doi: 10.15252/embr.201745531. Epub 2018 Mar 5.

PMID:
29507079
7.

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.

Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, Cravatt BF.

ACS Cent Sci. 2017 Dec 27;3(12):1276-1285. doi: 10.1021/acscentsci.7b00420. Epub 2017 Dec 6.

8.

Bevacizumab for recurrent, persistent or advanced cervical cancer: reproducibility of GOG 240 study results in "real world" patients.

Godoy-Ortiz A, Plata Y, Alcaide J, Galeote A, Pajares B, Saez E, Alba E, Sánchez-Muñoz A.

Clin Transl Oncol. 2018 Jul;20(7):922-927. doi: 10.1007/s12094-017-1808-x. Epub 2017 Dec 8.

PMID:
29222647
9.

Cutaneous leishmaniasis mimicking dactylitis in a patient with rheumatoid arthritis treated with certolizumab.

Herrerias-Moreno J, Expósito-Serrano V, Agut-Busquet E, Corbacho M, Sáez E, Luelmo J.

Clin Exp Dermatol. 2018 Apr;43(3):348-350. doi: 10.1111/ced.13307. Epub 2017 Dec 8. No abstract available.

PMID:
29218754
10.

Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation.

Beyer BA, Fang M, Sadrian B, Montenegro-Burke JR, Plaisted WC, Kok BPC, Saez E, Kondo T, Siuzdak G, Lairson LL.

Nat Chem Biol. 2018 Jan;14(1):22-28. doi: 10.1038/nchembio.2517. Epub 2017 Nov 13.

11.

The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans.

Finlin BS, Zhu B, Kok BP, Godio C, Westgate PM, Grayson N, Sims R, Bland JS, Saez E, Kern PA.

Front Endocrinol (Lausanne). 2017 Sep 29;8:255. doi: 10.3389/fendo.2017.00255. eCollection 2017.

12.

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

Bar-Peled L, Kemper EK, Suciu RM, Vinogradova EV, Backus KM, Horning BD, Paul TA, Ichu TA, Svensson RU, Olucha J, Chang MW, Kok BP, Zhu Z, Ihle NT, Dix MM, Jiang P, Hayward MM, Saez E, Shaw RJ, Cravatt BF.

Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28.

13.

MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation.

Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude Elferink RP, LaRusso NF, Bujanda L, Marin JJG, Banales JM.

Hepatology. 2018 Apr;67(4):1420-1440. doi: 10.1002/hep.29533. Epub 2018 Feb 21.

PMID:
28922472
14.

GPR55: A therapeutic target for Parkinson's disease?

Celorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E, Estella-Hermoso de Mendoza A, Müller CE, Ramírez MJ, Oyarzábal J, Franco R, Aymerich MS.

Neuropharmacology. 2017 Oct;125:319-332. doi: 10.1016/j.neuropharm.2017.08.017. Epub 2017 Aug 12.

PMID:
28807673
15.

Sulfur Groups Improve the Performance of Triazole- and Triazolium-Based Interaction Units in Anion Binding.

Álvarez-Pérez M, Velado M, García-Puentes D, Sáez E, Vicent C, Fernández de la Pradilla R, Viso A, de la Torre MC, Sierra MA.

J Org Chem. 2017 Mar 17;82(6):3341-3346. doi: 10.1021/acs.joc.7b00261. Epub 2017 Feb 24.

PMID:
28218535
16.

RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.

Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P.

J Clin Invest. 2017 Mar 1;127(3):987-1004. doi: 10.1172/JCI89484. Epub 2017 Feb 13.

17.

Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF.

Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.

18.

Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease.

Sánchez-Arias JA, Rabal O, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, Ugarte A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J.

ACS Chem Neurosci. 2017 Mar 15;8(3):638-661. doi: 10.1021/acschemneuro.6b00370. Epub 2016 Dec 27.

PMID:
27936591
19.

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

Rabal O, Sánchez-Arias JA, Cuadrado-Tejedor M, de Miguel I, Pérez-González M, García-Barroso C, Ugarte A, Estella-Hermoso de Mendoza A, Sáez E, Espelosin M, Ursua S, Haizhong T, Wei W, Musheng X, Garcia-Osta A, Oyarzabal J.

J Med Chem. 2016 Oct 13;59(19):8967-9004. Epub 2016 Sep 27.

PMID:
27606546
20.

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW.

J Am Chem Soc. 2016 Jun 15;138(23):7353-64. doi: 10.1021/jacs.6b02960. Epub 2016 Jun 2.

21.

Asistole after electroconvusise therapy.

Romero P, Telletxea S S, Saez E, Arzuaga MÁ.

Rev Psiquiatr Salud Ment. 2017 Jan - Mar;10(1):61-62. doi: 10.1016/j.rpsm.2016.03.001. Epub 2016 Mar 31. English, Spanish. No abstract available.

PMID:
27049462
22.

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

Parsons WH, Kolar MJ, Kamat SS, Cognetta AB 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF.

Nat Chem Biol. 2016 May;12(5):367-372. doi: 10.1038/nchembio.2051. Epub 2016 Mar 28.

23.

Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans.

Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, Saltiel AR, Vendrell J, Fernández-Veledo S.

Mol Metab. 2015 Oct 16;5(1):5-18. doi: 10.1016/j.molmet.2015.10.001. eCollection 2016 Jan.

24.

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.

Concepcion AR, Salas JT, Sáez E, Sarvide S, Ferrer A, Portu A, Uriarte I, Hervás-Stubbs S, Oude Elferink RP, Prieto J, Medina JF.

Oncotarget. 2015 Oct 6;6(30):28588-606. doi: 10.18632/oncotarget.5665.

25.

Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease.

Munoz-Garrido P, Marin JJ, Perugorria MJ, Urribarri AD, Erice O, Sáez E, Úriz M, Sarvide S, Portu A, Concepcion AR, Romero MR, Monte MJ, Santos-Laso Á, Hijona E, Jimenez-Agüero R, Marzioni M, Beuers U, Masyuk TV, LaRusso NF, Prieto J, Bujanda L, Drenth JP, Banales JM.

J Hepatol. 2015 Oct;63(4):952-61. doi: 10.1016/j.jhep.2015.05.023. Epub 2015 Jun 1.

26.

Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy.

Cermenati G, Audano M, Giatti S, Carozzi V, Porretta-Serapiglia C, Pettinato E, Ferri C, D'Antonio M, De Fabiani E, Crestani M, Scurati S, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N.

Cell Metab. 2015 Apr 7;21(4):571-83. doi: 10.1016/j.cmet.2015.02.016. Epub 2015 Mar 26.

27.

A Non-inferiority Pilot Study Comparing the Clinical Efficacy and Safety of Generic Wide-spectrum Antibiotic Use in Septic Oncology Patients.

Araya I, Fasce G, Núñez E, Opazo JL, Saez E, Hurtado V, Contreras S, Quiñones LA.

Drug Res (Stuttg). 2015 Dec;65(12):635-9. doi: 10.1055/s-0034-1396884. Epub 2015 Mar 26.

PMID:
25811220
28.

First report of a Klebsiella pneumoniae ST466 strain causing neonatal sepsis harbouring the blaCTX-M-15 gene in Rabat, Morocco.

Ballén V, Sáez E, Benmessaoud R, Houssain T, Alami H, Barkat A, Kabiri M, Moraleda C, Bezad R, Vila J, Bosch J, Bassat Q, Soto SM.

FEMS Microbiol Lett. 2015 Jan;362(1):1-4. doi: 10.1093/femsle/fnu026. Epub 2014 Dec 4.

29.

The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.

Mitro N, Cermenati G, Audano M, Giatti S, D'Antonio M, Fabiani ED, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D.

Springerplus. 2015 Jun 12;4(Suppl 1):L45. doi: 10.1186/2193-1801-4-S1-L45. eCollection 2015. No abstract available.

30.

ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue.

Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IHN, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S.

Cell Rep. 2014 Dec 11;9(5):1584-1593. doi: 10.1016/j.celrep.2014.10.066. Epub 2014 Nov 26.

31.

Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.

Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH.

J Biol Chem. 2015 Jan 2;290(1):184-96. doi: 10.1074/jbc.M114.587030. Epub 2014 Nov 5.

32.

Activating PI3-kinase to dampen inflammation.

Kok BP, Saez E.

Chem Biol. 2014 Aug 14;21(8):917-8. doi: 10.1016/j.chembiol.2014.07.012.

33.

Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway.

Montorfano I, Becerra A, Cerro R, Echeverría C, Sáez E, Morales MG, Fernández R, Cabello-Verrugio C, Simon F.

Lab Invest. 2014 Oct;94(10):1068-82. doi: 10.1038/labinvest.2014.100. Epub 2014 Jul 28.

34.

One-pot synthesis of 1,3,5-triazine derivatives via controlled cross-cyclotrimerization of nitriles: a mechanism approach.

Herrera A, Riaño A, Moreno R, Caso B, Pardo ZD, Fernández I, Sáez E, Molero D, Sánchez-Vázquez A, Martínez-Alvarez R.

J Org Chem. 2014 Aug 1;79(15):7012-24. doi: 10.1021/jo501144v. Epub 2014 Jul 18.

PMID:
25010006
35.

Inequality in the long run.

Piketty T, Saez E.

Science. 2014 May 23;344(6186):838-43. doi: 10.1126/science.1251936. Review.

PMID:
24855258
36.

Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism.

Del Pozo JL, Fernández-Ros N, Sáez E, Herrero JI, Yuste JR, Banales JM.

Antimicrob Agents Chemother. 2014 Jul;58(7):4227-9. doi: 10.1128/AAC.02856-14. Epub 2014 May 5.

37.

Application of activity-based protein profiling to study enzyme function in adipocytes.

Galmozzi A, Dominguez E, Cravatt BF, Saez E.

Methods Enzymol. 2014;538:151-69. doi: 10.1016/B978-0-12-800280-3.00009-8.

38.

Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses.

Concepcion AR, Salas JT, Sarvide S, Sáez E, Ferrer A, López M, Portu A, Banales JM, Hervás-Stubbs S, Oude Elferink RP, Prieto J, Medina JF.

Eur J Immunol. 2014 May;44(5):1341-51. doi: 10.1002/eji.201344218. Epub 2014 Mar 11.

39.

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.

Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E.

Nat Chem Biol. 2014 Feb;10(2):113-21. doi: 10.1038/nchembio.1429. Epub 2013 Dec 22.

40.

Identification of regulatory elements that control PPARγ expression in adipocyte progenitors.

Chou WL, Galmozzi A, Partida D, Kwan K, Yeung H, Su AI, Saez E.

PLoS One. 2013 Aug 29;8(8):e72511. doi: 10.1371/journal.pone.0072511. eCollection 2013.

41.

ROS and Sympathetically Mediated Mitochondria Activation in Brown Adipose Tissue Contribute to Methamphetamine-Induced Hyperthermia.

Sanchez-Alavez M, Conti B, Wood MR, Bortell N, Bustamante E, Saez E, Fox HS, Marcondes MC.

Front Endocrinol (Lausanne). 2013 Apr 23;4:44. doi: 10.3389/fendo.2013.00044. eCollection 2013.

42.

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.

Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P.

Cell Metab. 2013 Mar 5;17(3):423-35. doi: 10.1016/j.cmet.2013.01.016.

43.

Safety profile of biological intravenous therapy in a rheumatoid arthritis patients cohort. Clinical nursing monitoring (Sebiol study).

Corominas H, Sánchez-Eslava L, García G, Padró I, Aimarich C, Gonzàlez J, Franco M, Mur E, Sanchez S, Roldán G, Iniesta S, Sesma M, Martín J, Rodriguez MC, Capellan MR, Gosálvez C, Garcia-Diaz S, Sáez E, Luna Y, Plana P.

Reumatol Clin. 2013 Mar-Apr;9(2):80-4. doi: 10.1016/j.reuma.2012.06.001. Epub 2012 Oct 24. English, Spanish.

44.

Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue.

Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, Godio C, Cermenati G, Gualerzi A, Donetti E, Rotili D, Valente S, Guerrini U, Caruso D, Mai A, Saez E, De Fabiani E, Crestani M.

Diabetes. 2013 Mar;62(3):732-42. doi: 10.2337/db12-0548. Epub 2012 Oct 15.

45.

Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis.

Banales JM, Sáez E, Uriz M, Sarvide S, Urribarri AD, Splinter P, Tietz Bogert PS, Bujanda L, Prieto J, Medina JF, LaRusso NF.

Hepatology. 2012 Aug;56(2):687-97. doi: 10.1002/hep.25691. Epub 2012 Jul 10.

46.

How does your kindergarten classroom affect your earnings? Evidence from Project Star.

Chetty R, Friedman JN, Hilger N, Saez E, Schanzenbach DW, Yagan D.

Q J Econ. 2011;126(4):1593-660.

PMID:
22256342
47.

In situ electroporation of surface-bound siRNAs in microwell arrays.

Jain T, Papas A, Jadhav A, McBride R, Saez E.

Lab Chip. 2012 Mar 7;12(5):939-47. doi: 10.1039/c2lc20931d. Epub 2012 Jan 16.

48.

Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.

Úriz M, Sáez E, Prieto J, Medina JF, Banales JM.

PLoS One. 2011;6(12):e28717. doi: 10.1371/journal.pone.0028717. Epub 2011 Dec 14.

49.

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation.

Cermenati G, Abbiati F, Cermenati S, Brioschi E, Volonterio A, Cavaletti G, Saez E, De Fabiani E, Crestani M, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N.

J Lipid Res. 2012 Feb;53(2):300-10. doi: 10.1194/jlr.M021188. Epub 2011 Dec 7.

50.

Listeriosis: An emerging public health problem especially among the elderly.

Muñoz P, Rojas L, Bunsow E, Saez E, Sánchez-Cambronero L, Alcalá L, Rodríguez-Creixems M, Bouza E.

J Infect. 2012 Jan;64(1):19-33. doi: 10.1016/j.jinf.2011.10.006. Epub 2011 Oct 21.

PMID:
22037557

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