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Idiopathic Pulmonary Fibrosis and Lung Transplantation: When it is Feasible.

Balestro E, Cocconcelli E, Tinè M, Biondini D, Faccioli E, Saetta M, Rea F.

Medicina (Kaunas). 2019 Oct 19;55(10). pii: E702. doi: 10.3390/medicina55100702. Review.


High-Resolution CT Change over Time in Patients with Idiopathic Pulmonary Fibrosis on Antifibrotic Treatment.

Balestro E, Cocconcelli E, Giraudo C, Polverosi R, Biondini D, Lacedonia D, Bazzan E, Mazzai L, Rizzon G, Lococo S, Turato G, Tinè M, Cosio MG, Saetta M, Spagnolo P.

J Clin Med. 2019 Sep 15;8(9). pii: E1469. doi: 10.3390/jcm8091469.


Exome Sequencing Reveals Immune Genes as Susceptibility Modifiers in Individuals with α1-Antitrypsin Deficiency.

Rigobello C, Baraldo S, Tinè M, Ferrarotti I, Corsico AG, Bazzan E, Turato G, Balestro E, Biondini D, Valle G, Saetta M, Cosio MG.

Sci Rep. 2019 Sep 11;9(1):13088. doi: 10.1038/s41598-019-49409-1.


Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing.

Bonato M, Tiné M, Bazzan E, Biondini D, Saetta M, Baraldo S.

J Clin Med. 2019 Aug 7;8(8). pii: E1180. doi: 10.3390/jcm8081180. Review.


Reassessing the Role of Eosinophils as a Biomarker in Chronic Obstructive Pulmonary Disease.

Tinè M, Biondini D, Semenzato U, Bazzan E, Cosio MG, Saetta M, Turato G.

J Clin Med. 2019 Jul 2;8(7). pii: E962. doi: 10.3390/jcm8070962. Review.


Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof-of-concept cohort study.

Contoli M, Baraldo S, Conti V, Gnesini G, Marku B, Casolari P, Scrigner P, Morelli P, Saetta M, Spanevello A, Papi A.

Respirology. 2019 Jun 28. doi: 10.1111/resp.13607. [Epub ahead of print]


High-flow nasal cannula oxygen therapy to treat acute respiratory failure in patients with acute exacerbation of idiopathic pulmonary fibrosis.

Vianello A, Arcaro G, Molena B, Turato C, Braccioni F, Paladini L, Vio S, Ferrarese S, Peditto P, Gallan F, Saetta M.

Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619847130. doi: 10.1177/1753466619847130.


High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology.

Cocconcelli E, Balestro E, Biondini D, Barbiero G, Polverosi R, Calabrese F, Pezzuto F, Lacedonia D, Rea F, Schiavon M, Bazzan E, Foschino Barbaro MP, Turato G, Spagnolo P, Cosio MG, Saetta M.

J Clin Med. 2019 Mar 22;8(3). pii: E399. doi: 10.3390/jcm8030399.


Pirfenidone improves the survival of patients with idiopathic pulmonary fibrosis hospitalized for acute exacerbation.

Vianello A, Molena B, Turato C, Braccioni F, Arcaro G, Paladini L, Andretta M, Saetta M.

Curr Med Res Opin. 2019 Jul;35(7):1187-1190. doi: 10.1080/03007995.2019.1565530. Epub 2019 Jan 24.


Looking for Airways Periostin in Severe Asthma: Could It Be Useful for Clustering Type 2 Endotype?

Carpagnano GE, Scioscia G, Lacedonia D, Soccio P, Lepore G, Saetta M, Foschino Barbaro MP, Barnes PJ.

Chest. 2018 Nov;154(5):1083-1090. doi: 10.1016/j.chest.2018.08.1032. Epub 2018 Oct 15.


Anti-inflammatory effects of roflumilast in chronic obstructive pulmonary disease (ROBERT): a 16-week, randomised, placebo-controlled trial.

Rabe KF, Watz H, Baraldo S, Pedersen F, Biondini D, Bagul N, Hanauer G, Göhring UM, Purkayastha D, Román J, Alagappan VKT, Saetta M.

Lancet Respir Med. 2018 Nov;6(11):827-836. doi: 10.1016/S2213-2600(18)30331-X. Epub 2018 Sep 14. Erratum in: Lancet Respir Med. 2018 Oct 12;:.


Clinical and Pathologic Factors Predicting Future Asthma in Wheezing Children. A Longitudinal Study.

Bonato M, Bazzan E, Snijders D, Tinè M, Biondini D, Turato G, Balestro E, Papi A, Cosio MG, Barbato A, Baraldo S, Saetta M.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):458-466. doi: 10.1165/rcmb.2018-0009OC.


Natural Killer Cell: Looks Like a Sniper but Is Part of the Team.

Saetta M, Turato G, Cosio MG.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1109-1110. doi: 10.1164/rccm.201805-0841ED. No abstract available.


α1-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α1-Antitrypsin Deficiency.

Bazzan E, Tinè M, Biondini D, Benetti R, Baraldo S, Turato G, Fagiuoli S, Sonzogni A, Rigobello C, Rea F, Calabrese F, Foschino-Barbaro MP, Miranda E, Lomas DA, Saetta M, Cosio MG.

Chest. 2018 Sep;154(3):607-616. doi: 10.1016/j.chest.2018.04.039. Epub 2018 May 12.


Pretreatment rate of decay in forced vital capacity predicts long-term response to pirfenidone in patients with idiopathic pulmonary fibrosis.

Biondini D, Balestro E, Lacedonia D, Cerri S, Milaneschi R, Luppi F, Cocconcelli E, Bazzan E, Clini E, Foschino Barbaro MP, Gregori D, Cosio MG, Saetta M, Spagnolo P.

Sci Rep. 2018 Apr 13;8(1):5961. doi: 10.1038/s41598-018-24303-4.


Blood Eosinophilia Neither Reflects Tissue Eosinophils nor Worsens Clinical Outcomes in Chronic Obstructive Pulmonary Disease.

Turato G, Semenzato U, Bazzan E, Biondini D, Tinè M, Torrecilla N, Forner M, Marin JM, Cosio MG, Saetta M.

Am J Respir Crit Care Med. 2018 May 1;197(9):1216-1219. doi: 10.1164/rccm.201708-1684LE. No abstract available.


Deficient Immune Response to Viral Infections in Children Predicts Later Asthma Persistence.

Baraldo S, Contoli M, Bonato M, Snijders D, Biondini D, Bazzan E, Cosio MG, Barbato A, Papi A, Saetta M.

Am J Respir Crit Care Med. 2018 Mar 1;197(5):673-675. doi: 10.1164/rccm.201706-1249LE. No abstract available.


IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma.

Baraldo S, Papi A, Saetta M, Contoli M.

Eur Respir J. 2017 Mar 29;49(3). pii: 1602489. doi: 10.1183/13993003.02489-2016. Print 2017 Mar. No abstract available.


Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity.

Bazzan E, Turato G, Tinè M, Radu CM, Balestro E, Rigobello C, Biondini D, Schiavon M, Lunardi F, Baraldo S, Rea F, Simioni P, Calabrese F, Saetta M, Cosio MG.

Respir Res. 2017 Feb 23;18(1):40. doi: 10.1186/s12931-017-0522-0.


Severe asthma: phenotyping to endotyping or vice versa?

Papi A, Saetta M, Fabbri L.

Eur Respir J. 2017 Feb 8;49(2). pii: 1700053. doi: 10.1183/13993003.00053-2017. Print 2017 Feb. No abstract available.


Alpha-1 Antitrypsin Deficiency: Beyond the Protease/Antiprotease Paradigm.

Cosio MG, Bazzan E, Rigobello C, Tinè M, Turato G, Baraldo S, Saetta M.

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S305-10. doi: 10.1513/AnnalsATS.201510-671KV. Review.


Which CD8+ T-cells in asthma? Attacking or defending?

Baraldo S, Turato G, Cosio MG, Saetta M.

Eur Respir J. 2016 Aug;48(2):287-90. doi: 10.1183/13993003.01037-2016. No abstract available.


Alpha-1 Antitrypsin Deficiency Today: New Insights in the Immunological Pathways.

Baraldo S, Balestro E, Bazzan E, Tiné ME, Biondini D, Turato G, Cosio MG, Saetta M.

Respiration. 2016;91(5):380-5. doi: 10.1159/000445692. Epub 2016 May 12. Review.


Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis.

Balestro E, Calabrese F, Turato G, Lunardi F, Bazzan E, Marulli G, Biondini D, Rossi E, Sanduzzi A, Rea F, Rigobello C, Gregori D, Baraldo S, Spagnolo P, Cosio MG, Saetta M.

PLoS One. 2016 May 9;11(5):e0154516. doi: 10.1371/journal.pone.0154516. eCollection 2016.


Quality standards for the management of bronchiectasis in Italy: a national audit.

Aliberti S, Hill AT, Mantero M, Battaglia S, Centanni S, Lo Cicero S, Lacedonia D, Saetta M, Chalmers JD, Blasi F; SIP Bronchiectasis Audit Working Group.

Eur Respir J. 2016 Jul;48(1):244-8. doi: 10.1183/13993003.00232-2016. Epub 2016 Apr 13. No abstract available.


Inhaled glucocorticoids and COPD exacerbations.

Cosio M, Baraldo S, Saetta M.

N Engl J Med. 2015 Jan 1;372(1):92. doi: 10.1056/NEJMc1413308. No abstract available.


Regular versus as-needed budesonide and formoterol combination treatment for moderate asthma: a non-inferiority, randomised, double-blind clinical trial.

Papi A, Marku B, Scichilone N, Maestrelli P, Paggiaro P, Saetta M, Nava S, Folletti I, Bertorelli G, Bertacco S, Contoli M, Plebani M, Barbaro MPF, Spanevello A, Aliani M, Pannacci M, Morelli P, Beghé B, Fabbri LM; AIFASMA Study Group.

Lancet Respir Med. 2015 Feb;3(2):109-119. doi: 10.1016/S2213-2600(14)70266-8. Epub 2014 Dec 4.


COPD-related adenocarcinoma presents low aggressiveness morphological and molecular features compared to smoker tumours.

Schiavon M, Marulli G, Nannini N, Pasello G, Lunardi F, Balestro E, Perissinotto E, Rebusso A, Saetta M, Rea F, Calabrese F.

Lung Cancer. 2014 Dec;86(3):311-7. doi: 10.1016/j.lungcan.2014.10.004. Epub 2014 Oct 16.


Immune activation in α1-antitrypsin-deficiency emphysema. Beyond the protease-antiprotease paradigm.

Baraldo S, Turato G, Lunardi F, Bazzan E, Schiavon M, Ferrarotti I, Molena B, Cazzuffi R, Damin M, Balestro E, Luisetti M, Rea F, Calabrese F, Cosio MG, Saetta M.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):402-9. doi: 10.1164/rccm.201403-0529OC.


Is chronic obstructive pulmonary disease a disease of aging?

Cosio MG, Cazzuffi R, Saetta M.

Respiration. 2014;87(6):508-12. doi: 10.1159/000360770. Epub 2014 May 6.


Rhinovirus-induced interferon production in asthma.

Baraldo S, Saetta M, Barbato A, Contoli M, Papi A.

Thorax. 2014 Aug;69(8):772. doi: 10.1136/thoraxjnl-2013-204922. Epub 2014 Apr 2. No abstract available.


Decreased maturation of dendritic cells in the central airways of COPD patients is associated with VEGF, TGF-β and vascularity.

Zanini A, Spanevello A, Baraldo S, Majori M, Della Patrona S, Gumiero F, Aiello M, Olivieri D, Saetta M, Chetta A.

Respiration. 2014;87(3):234-42. doi: 10.1159/000356749. Epub 2014 Jan 14.


Mechanisms of decrease in fractional exhaled nitric oxide during acute bronchoconstriction.

Cattoni I, Guarnieri G, Tosetto A, Mason P, Scarpa MC, Saetta M, Maestrelli P.

Chest. 2013 May;143(5):1269-1276. doi: 10.1378/chest.12-1374.


Ceramide expression and cell homeostasis in chronic obstructive pulmonary disease.

Scarpa MC, Baraldo S, Marian E, Turato G, Calabrese F, Saetta M, Maestrelli P.

Respiration. 2013;85(4):342-9. doi: 10.1159/000341185. Epub 2012 Sep 25.


Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma.

Baraldo S, Contoli M, Bazzan E, Turato G, Padovani A, Marku B, Calabrese F, Caramori G, Ballarin A, Snijders D, Barbato A, Saetta M, Papi A.

J Allergy Clin Immunol. 2012 Dec;130(6):1307-14. doi: 10.1016/j.jaci.2012.08.005. Epub 2012 Sep 13.


Pathophysiology of the small airways in chronic obstructive pulmonary disease.

Baraldo S, Turato G, Saetta M.

Respiration. 2012;84(2):89-97. doi: 10.1159/000341382. Epub 2012 Aug 6. Review.


Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD.

Bazzan E, Saetta M, Turato G, Borroni EM, Cancellieri C, Baraldo S, Savino B, Calabrese F, Ballarin A, Balestro E, Mantovani A, Cosio MG, Bonecchi R, Locati M.

Chest. 2013 Jan;143(1):98-106. doi: 10.1378/chest.11-3220.


Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease.

Ballarin A, Bazzan E, Zenteno RH, Turato G, Baraldo S, Zanovello D, Mutti E, Hogg JC, Saetta M, Cosio MG.

Am J Respir Crit Care Med. 2012 Aug 1;186(3):233-9. doi: 10.1164/rccm.201112-2142OC. Epub 2012 Jun 7.


Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis.

Calabrese F, Lunardi F, Balestro E, Marulli G, Perissinotto E, Loy M, Nannini N, Valente M, Saetta M, Agostini C, Rea F.

Pathology. 2012 Apr;44(3):192-8. doi: 10.1097/PAT.0b013e3283511b61.


Evasion of COPD in smokers: at what price?

Cosio MG, Saetta M.

Eur Respir J. 2012 Jun;39(6):1298-303. doi: 10.1183/09031936.00135711. Epub 2011 Oct 17. Review.


Lung cancer in patients with chronic obstructive pulmonary disease-- incidence and predicting factors.

de Torres JP, Marín JM, Casanova C, Cote C, Carrizo S, Cordoba-Lanus E, Baz-Dávila R, Zulueta JJ, Aguirre-Jaime A, Saetta M, Cosio MG, Celli BR.

Am J Respir Crit Care Med. 2011 Oct 15;184(8):913-9. doi: 10.1164/rccm.201103-0430OC.


Reduced apoptosis of CD8+ T-lymphocytes in the airways of smokers with mild/moderate COPD.

Siena L, Gjomarkaj M, Elliot J, Pace E, Bruno A, Baraldo S, Saetta M, Bonsignore MR, James A.

Respir Med. 2011 Oct;105(10):1491-500. doi: 10.1016/j.rmed.2011.04.014. Epub 2011 May 25.


Noneosinophilic asthma in children: relation with airway remodelling.

Baraldo S, Turato G, Bazzan E, Ballarin A, Damin M, Balestro E, Lokar Oliani K, Calabrese F, Maestrelli P, Snijders D, Barbato A, Saetta M.

Eur Respir J. 2011 Sep;38(3):575-83. doi: 10.1183/09031936.00168210. Epub 2011 Feb 10.


A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family.

Polverino F, Baraldo S, Bazzan E, Agostini S, Turato G, Lunardi F, Balestro E, Damin M, Papi A, Maestrelli P, Calabrese F, Saetta M.

Am J Respir Crit Care Med. 2010 Oct 15;182(8):1011-9. doi: 10.1164/rccm.200911-1700OC. Epub 2010 Jun 25.


For whom the "alarm" tolls: how we sense the danger of cigarette smoke and react to it.

Baraldo S, Saetta M, Cosio MG.

Am J Respir Crit Care Med. 2010 May 1;181(9):879-80. doi: 10.1164/rccm.201001-0099ED. No abstract available.


Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up.

Contoli M, Baraldo S, Marku B, Casolari P, Marwick JA, Turato G, Romagnoli M, Caramori G, Saetta M, Fabbri LM, Papi A.

J Allergy Clin Immunol. 2010 Apr;125(4):830-7. doi: 10.1016/j.jaci.2010.01.003. Epub 2010 Mar 15.


Markers of eosinophilic and neutrophilic inflammation in bronchoalveolar lavage of asthmatic and atopic children.

Snijders D, Agostini S, Bertuola F, Panizzolo C, Baraldo S, Turato G, Faggian D, Plebani M, Saetta M, Barbato A.

Allergy. 2010 Aug;65(8):978-85. doi: 10.1111/j.1398-9995.2009.02282.x. Epub 2009 Dec 11.


Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment.

Zanini A, Chetta A, Saetta M, Baraldo S, Castagnetti C, Nicolini G, Neri M, Olivieri D.

Thorax. 2009 Dec;64(12):1019-24. doi: 10.1136/thx.2009.114629. Epub 2009 Sep 6.


MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

Caramori G, Casolari P, Di Gregorio C, Saetta M, Baraldo S, Boschetto P, Ito K, Fabbri LM, Barnes PJ, Adcock IM, Cavallesco G, Chung KF, Papi A.

Histopathology. 2009 Sep;55(3):321-31. doi: 10.1111/j.1365-2559.2009.03377.x.


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