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Items: 27

1.

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells.

Sun B, Fiskus W, Qian Y, Rajapakshe K, Raina K, Coleman KG, Crew AP, Shen A, Saenz DT, Mill CP, Nowak AJ, Jain N, Zhang L, Wang M, Khoury JD, Coarfa C, Crews CM, Bhalla KN.

Leukemia. 2018 Feb;32(2):343-352. doi: 10.1038/leu.2017.207. Epub 2017 Jun 30.

PMID:
28663582
2.

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells.

Saenz DT, Fiskus W, Qian Y, Manshouri T, Rajapakshe K, Raina K, Coleman KG, Crew AP, Shen A, Mill CP, Sun B, Qiu P, Kadia TM, Pemmaraju N, DiNardo C, Kim MS, Nowak AJ, Coarfa C, Crews CM, Verstovsek S, Bhalla KN.

Leukemia. 2017 Sep;31(9):1951-1961. doi: 10.1038/leu.2016.393. Epub 2017 Feb 2.

3.

BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.

Saenz DT, Fiskus W, Manshouri T, Rajapakshe K, Krieger S, Sun B, Mill CP, DiNardo C, Pemmaraju N, Kadia T, Parmar S, Sharma S, Coarfa C, Qiu P, Verstovsek S, Bhalla KN.

Leukemia. 2017 Mar;31(3):678-687. doi: 10.1038/leu.2016.260. Epub 2016 Sep 28.

4.

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.

Fiskus W, Coothankandaswamy V, Chen J, Ma H, Ha K, Saenz DT, Krieger SS, Mill CP, Sun B, Huang P, Mumm JS, Melnick AM, Bhalla KN.

Cancer Res. 2016 Sep 15;76(18):5467-78. doi: 10.1158/0008-5472.CAN-16-0126. Epub 2016 Aug 8.

5.

Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.

Sun B, Shah B, Fiskus W, Qi J, Rajapakshe K, Coarfa C, Li L, Devaraj SG, Sharma S, Zhang L, Wang ML, Saenz DT, Krieger S, Bradner JE, Bhalla KN.

Blood. 2015 Sep 24;126(13):1565-74. doi: 10.1182/blood-2015-04-639542. Epub 2015 Aug 7. Erratum in: Blood. 2016 Sep 29;128(13):1778.

6.

TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.

Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM.

J Virol. 2014 Sep 1;88(17):9704-17. doi: 10.1128/JVI.01397-14. Epub 2014 Jun 18.

7.

A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection.

Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM.

PLoS Pathog. 2014 Feb 20;10(2):e1003969. doi: 10.1371/journal.ppat.1003969. eCollection 2014 Feb.

8.

Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation.

Morrison JH, Guevara RB, Marcano AC, Saenz DT, Fadel HJ, Rogstad DK, Poeschla EM.

J Virol. 2014 Mar;88(6):3255-72. doi: 10.1128/JVI.03814-13. Epub 2014 Jan 3.

9.

High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.

Bancos I, Bida JP, Tian D, Bundrick M, John K, Holte MN, Her YF, Evans D, Saenz DT, Poeschla EM, Hook D, Georg G, Maher LJ 3rd.

PLoS One. 2013;8(2):e56827. doi: 10.1371/journal.pone.0056827. Epub 2013 Feb 22.

10.

Construction and testing of orfA +/- FIV reporter viruses.

Fadel HJ, Saenz DT, Poeschla EM.

Viruses. 2012 Jan;4(1):184-99. doi: 10.3390/v4010184. Epub 2012 Jan 23.

11.

Feline immunodeficiency virus-based lentiviral vectors.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):71-6. doi: 10.1101/pdb.ip067579. Review.

PMID:
22194268
12.

Titration of feline immunodeficiency virus-based lentiviral vector preparations.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):126-8. doi: 10.1101/pdb.prot067561.

PMID:
22194267
13.

Production and harvest of feline immunodeficiency virus-based lentiviral vector from cells grown in T75 tissue-culture flasks.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):124-5. doi: 10.1101/pdb.prot067553.

PMID:
22194266
14.

Production, harvest, and concentration of feline immunodeficiency virus-based lentiviral vector from cells grown in CF10 or CF2 devices.

Saenz DT, Barraza R, Loewen N, Teo W, Poeschla EM.

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):118-23. doi: 10.1101/pdb.prot067546.

PMID:
22194265
15.

Productive replication and evolution of HIV-1 in ferret cells.

Fadel HJ, Saenz DT, Guevara R, von Messling V, Peretz M, Poeschla EM.

J Virol. 2012 Feb;86(4):2312-22. doi: 10.1128/JVI.06035-11. Epub 2011 Dec 14.

16.

The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak.

Sainski AM, Natesampillai S, Cummins NW, Bren GD, Taylor J, Saenz DT, Poeschla EM, Badley AD.

J Virol. 2011 Aug;85(16):7965-75. doi: 10.1128/JVI.02515-10. Epub 2011 Jun 8.

17.

LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity.

Meehan AM, Saenz DT, Morrison J, Hu C, Peretz M, Poeschla EM.

J Virol. 2011 Apr;85(7):3570-83. doi: 10.1128/JVI.01295-10. Epub 2011 Jan 26.

18.

The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.

Hu C, Saenz DT, Fadel HJ, Walker W, Peretz M, Poeschla EM.

J Virol. 2010 Nov;84(22):11981-93. doi: 10.1128/JVI.00723-10. Epub 2010 Sep 15.

19.

Productive replication of Vif-chimeric HIV-1 in feline cells.

Stern MA, Hu C, Saenz DT, Fadel HJ, Sims O, Peretz M, Poeschla EM.

J Virol. 2010 Jul;84(14):7378-95. doi: 10.1128/JVI.00584-10. Epub 2010 May 12.

20.

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.

Meehan AM, Saenz DT, Morrison JH, Garcia-Rivera JA, Peretz M, Llano M, Poeschla EM.

PLoS Pathog. 2009 Jul;5(7):e1000522. doi: 10.1371/journal.ppat.1000522. Epub 2009 Jul 17.

21.

Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork.

Khare PD, Loewen N, Teo W, Barraza RA, Saenz DT, Johnson DH, Poeschla EM.

Mol Ther. 2008 Jan;16(1):97-106. Epub 2007 Oct 2.

22.

An essential role for LEDGF/p75 in HIV integration.

Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM.

Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.

23.

Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins.

Saenz DT, Teo W, Olsen JC, Poeschla EM.

J Virol. 2005 Dec;79(24):15175-88.

24.

Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants.

Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M, Poeschla EM.

J Virol. 2004 Mar;78(6):2906-20.

25.

FIV: from lentivirus to lentivector.

Saenz DT, Poeschla EM.

J Gene Med. 2004 Feb;6 Suppl 1:S95-104. Review.

PMID:
14978754
26.

Comparison of wild-type and class I integrase mutant-FIV vectors in retina demonstrates sustained expression of integrated transgenes in retinal pigment epithelium.

Loewen N, Leske DA, Chen Y, Teo WL, Saenz DT, Peretz M, Holmes JM, Poeschla EM.

J Gene Med. 2003 Dec;5(12):1009-17.

PMID:
14661176
27.

FIV Vectors.

Loewen N, Barraza R, Whitwam T, Saenz DT, Kemler I, Poeschla EM.

Methods Mol Biol. 2003;229:251-71. No abstract available.

PMID:
12824636

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