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Items: 29


Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge.

Cox F, van der Fits L, Abbink P, Larocca RA, van Huizen E, Saeland E, Verhagen J, Peterson R, Tolboom J, Kaufmann B, Schuitemaker H, Barouch DH, Zahn R.

PLoS One. 2018 Aug 24;13(8):e0202820. doi: 10.1371/journal.pone.0202820. eCollection 2018.


HA Antibody-Mediated FcγRIIIa Activity Is Both Dependent on FcR Engagement and Interactions between HA and Sialic Acids.

Cox F, Kwaks T, Brandenburg B, Koldijk MH, Klaren V, Smal B, Korse HJ, Geelen E, Tettero L, Zuijdgeest D, Stoop EJ, Saeland E, Vogels R, Friesen RH, Koudstaal W, Goudsmit J.

Front Immunol. 2016 Sep 29;7:399. eCollection 2016.


Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.

Streng-Ouwehand I, Ho NI, Litjens M, Kalay H, Boks MA, Cornelissen LA, Kaur Singh S, Saeland E, Garcia-Vallejo JJ, Ossendorp FA, Unger WW, van Kooyk Y.

Elife. 2016 Mar 21;5. pii: e11765. doi: 10.7554/eLife.11765.


Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells.

Cox F, Baart M, Huizingh J, Tolboom J, Dekking L, Goudsmit J, Saeland E, Radošević K.

PLoS One. 2015 Dec 22;10(12):e0145243. doi: 10.1371/journal.pone.0145243. eCollection 2015.


Matrix-M™ adjuvation broadens protection induced by seasonal trivalent virosomal influenza vaccine.

Cox F, Saeland E, Baart M, Koldijk M, Tolboom J, Dekking L, Koudstaal W, Lövgren Bengtsson K, Goudsmit J, Radošević K.

Virol J. 2015 Dec 8;12:210. doi: 10.1186/s12985-015-0435-9.


Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge.

Cox F, Roos A, Hafkemeijer N, Baart M, Tolboom J, Dekking L, Stittelaar K, Goudsmit J, Radošević K, Saeland E.

PLoS One. 2015 Sep 24;10(9):e0135723. doi: 10.1371/journal.pone.0135723. eCollection 2015.


Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans.

de Kivit S, Saeland E, Kraneveld AD, van de Kant HJ, Schouten B, van Esch BC, Knol J, Sprikkelman AB, van der Aa LB, Knippels LM, Garssen J, van Kooyk Y, Willemsen LE.

Allergy. 2012 Mar;67(3):343-52. doi: 10.1111/j.1398-9995.2011.02771.x. Epub 2012 Jan 9.


Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients.

Saeland E, Belo AI, Mongera S, van Die I, Meijer GA, van Kooyk Y.

Int J Cancer. 2012 Jul 1;131(1):117-28. doi: 10.1002/ijc.26354. Epub 2011 Nov 28.


Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization.

Singh SK, Streng-Ouwehand I, Litjens M, Kalay H, Burgdorf S, Saeland E, Kurts C, Unger WW, van Kooyk Y.

Eur J Immunol. 2011 Apr;41(4):916-25. doi: 10.1002/eji.201040762. Epub 2011 Mar 14.


Highly glycosylated tumour antigens: interactions with the immune system.

Saeland E, van Kooyk Y.

Biochem Soc Trans. 2011 Jan;39(1):388-92. doi: 10.1042/BST0390388. Review.


Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1.

Triantis V, Saeland E, Bijl N, Oude-Elferink RP, Jansen PL.

Hepatology. 2010 Aug;52(2):656-66. doi: 10.1002/hep.23708.


Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses.

Singh SK, Streng-Ouwehand I, Litjens M, Kalay H, Saeland E, van Kooyk Y.

Int J Cancer. 2011 Mar 15;128(6):1371-83. doi: 10.1002/ijc.25458.


Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation.

Singh SK, Stephani J, Schaefer M, Kalay H, García-Vallejo JJ, den Haan J, Saeland E, Sparwasser T, van Kooyk Y.

Mol Immunol. 2009 Dec;47(2-3):164-74. doi: 10.1016/j.molimm.2009.09.026. Epub 2009 Oct 8.


N-glycosylated proteins and distinct lipooligosaccharide glycoforms of Campylobacter jejuni target the human C-type lectin receptor MGL.

van Sorge NM, Bleumink NM, van Vliet SJ, Saeland E, van der Pol WL, van Kooyk Y, van Putten JP.

Cell Microbiol. 2009 Dec;11(12):1768-81. doi: 10.1111/j.1462-5822.2009.01370.x. Epub 2009 Aug 13.


MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells.

Saeland E, de Jong MA, Nabatov AA, Kalay H, Geijtenbeek TB, van Kooyk Y.

Mol Immunol. 2009 Jul;46(11-12):2309-16. doi: 10.1016/j.molimm.2009.03.025. Epub 2009 Apr 29.


Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties.

Singh SK, Streng-Ouwehand I, Litjens M, Weelij DR, García-Vallejo JJ, van Vliet SJ, Saeland E, van Kooyk Y.

Mol Immunol. 2009 Mar;46(6):1240-9. doi: 10.1016/j.molimm.2008.11.021. Epub 2009 Jan 21.


Sweet preferences of MGL: carbohydrate specificity and function.

van Vliet SJ, Saeland E, van Kooyk Y.

Trends Immunol. 2008 Feb;29(2):83-90. doi: 10.1016/ Epub 2008 Jan 14. Review.


The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.

Saeland E, van Vliet SJ, Bäckström M, van den Berg VC, Geijtenbeek TB, Meijer GA, van Kooyk Y.

Cancer Immunol Immunother. 2007 Aug;56(8):1225-36. Epub 2006 Dec 29.


Recognition of tumor glycans by antigen-presenting cells.

Aarnoudse CA, Garcia Vallejo JJ, Saeland E, van Kooyk Y.

Curr Opin Immunol. 2006 Feb;18(1):105-11. Epub 2005 Nov 21. Review.


DC-SIGN specifically recognizes Streptococcus pneumoniae serotypes 3 and 14.

Koppel EA, Saeland E, de Cooker DJ, van Kooyk Y, Geijtenbeek TB.

Immunobiology. 2005;210(2-4):203-10.


A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice.

van Royen-Kerkhof A, Sanders EA, Walraven V, Voorhorst-Ogink M, Saeland E, Teeling JL, Gerritsen A, van Dijk MA, Kuis W, Rijkers GT, Vitale L, Keler T, McKenzie SE, Leusen JH, van de Winkel JG.

Br J Haematol. 2005 Jul;130(1):130-7.


Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells.

van Vliet SJ, van Liempt E, Saeland E, Aarnoudse CA, Appelmelk B, Irimura T, Geijtenbeek TB, Blixt O, Alvarez R, van Die I, van Kooyk Y.

Int Immunol. 2005 May;17(5):661-9. Epub 2005 Mar 31.


Central role of complement in passive protection by human IgG1 and IgG2 anti-pneumococcal antibodies in mice.

Saeland E, Vidarsson G, Leusen JH, Van Garderen E, Nahm MH, Vile-Weekhout H, Walraven V, Stemerding AM, Verbeek JS, Rijkers GT, Kuis W, Sanders EA, Van De Winkel JG.

J Immunol. 2003 Jun 15;170(12):6158-64.


Role of leukocyte immunoglobuin G receptors in vaccine-induced immunity to Streptococcus pneumoniae.

Saeland E, Leusen JH, Vidarsson G, Kuis W, Sanders EA, Jonsdottir I, van de Winkel JG.

J Infect Dis. 2003 Jun 1;187(11):1686-93. Epub 2003 May 12.


Human C-reactive protein does not bind to FcgammaRIIa on phagocytic cells.

Saeland E, van Royen A, Hendriksen K, Vilé-Weekhout H, Rijkers GT, Sanders LA, van de Winkel JG.

J Clin Invest. 2001 Mar;107(5):641-3. No abstract available.


Are the opsonophagocytic activities of antibodies in infant sera measured by different pneumococcal phagocytosis assays comparable?

Väkeväinen M, Jansen W, Saeland E, Jonsdottir I, Snippe H, Verheul A, Käyhty H.

Clin Diagn Lab Immunol. 2001 Mar;8(2):363-9.


Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B.

Saeland E, Jakobsen H, Ingolfsdottir G, Sigurdardottir ST, Jonsdottir I.

J Infect Dis. 2001 Jan 15;183(2):253-260. Epub 2000 Dec 8.


Pneumococcal pneumonia and bacteremia model in mice for the analysis of protective antibodies.

Saeland E, Vidarsson G, Jonsdottir I.

Microb Pathog. 2000 Aug;29(2):81-91.


Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infections.

Jakobsen H, Saeland E, Gizurarson S, Schulz D, Jónsdóttir I.

Infect Immun. 1999 Aug;67(8):4128-33.

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