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Items: 1 to 50 of 62

1.

In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration.

Sangaré LO, Ólafsson EB, Wang Y, Yang N, Julien L, Camejo A, Pesavento P, Sidik SM, Lourido S, Barragan A, Saeij JPJ.

Cell Host Microbe. 2019 Oct 9;26(4):478-492.e8. doi: 10.1016/j.chom.2019.09.008.

PMID:
31600500
2.

The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability.

Paredes-Santos T, Wang Y, Waldman B, Lourido S, Saeij JP.

Front Cell Infect Microbiol. 2019 Sep 12;9:321. doi: 10.3389/fcimb.2019.00321. eCollection 2019.

3.

Toxoplasma GRA15 Activates the NF-κB Pathway through Interactions with TNF Receptor-Associated Factors.

Sangaré LO, Yang N, Konstantinou EK, Lu D, Mukhopadhyay D, Young LH, Saeij JPJ.

MBio. 2019 Jul 16;10(4). pii: e00808-19. doi: 10.1128/mBio.00808-19.

4.

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis.

Wang Y, Cirelli KM, Barros PDC, Sangaré LO, Butty V, Hassan MA, Pesavento P, Mete A, Saeij JPJ.

MBio. 2019 Jan 8;10(1). pii: e02388-18. doi: 10.1128/mBio.02388-18.

5.

Clonal and atypical Toxoplasma strain differences in virulence vary with mouse sub-species.

Hassan MA, Olijnik AA, Frickel EM, Saeij JP.

Int J Parasitol. 2019 Jan;49(1):63-70. doi: 10.1016/j.ijpara.2018.08.007. Epub 2018 Nov 22.

6.

Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts.

Krishnamurthy S, Saeij JPJ.

Front Cell Infect Microbiol. 2018 Oct 18;8:366. doi: 10.3389/fcimb.2018.00366. eCollection 2018.

7.

Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum.

Arranz-Solís D, Regidor-Cerrillo J, Lourido S, Ortega-Mora LM, Saeij JPJ.

Int J Parasitol. 2018 Jul;48(8):597-600. doi: 10.1016/j.ijpara.2018.03.002. Epub 2018 Apr 3.

PMID:
29625127
8.

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death.

Saeij JP, Frickel EM.

Curr Opin Microbiol. 2017 Dec;40:72-80. doi: 10.1016/j.mib.2017.10.021. Epub 2017 Nov 12. Review.

9.

The human immune response to Toxoplasma: Autophagy versus cell death.

Krishnamurthy S, Konstantinou EK, Young LH, Gold DA, Saeij JP.

PLoS Pathog. 2017 Mar 9;13(3):e1006176. doi: 10.1371/journal.ppat.1006176. eCollection 2017 Mar. Review. No abstract available.

10.

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.

Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JPJ, Carruthers VB, Niles JC, Lourido S.

Cell. 2016 Sep 8;166(6):1423-1435.e12. doi: 10.1016/j.cell.2016.08.019. Epub 2016 Sep 2.

11.

Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19.

Fink A, Hassan MA, Okan NA, Sheffer M, Camejo A, Saeij JP, Kasper DL.

MBio. 2016 Mar 15;7(2):e02243. doi: 10.1128/mBio.02243-15.

12.

Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.

Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD.

Nat Commun. 2016 Jan 7;7:10147. doi: 10.1038/ncomms10147.

13.

Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.

Hassan MA, Jensen KD, Butty V, Hu K, Boedec E, Prins P, Saeij JP.

PLoS Genet. 2015 Oct 28;11(10):e1005619. doi: 10.1371/journal.pgen.1005619. eCollection 2015 Oct.

14.

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.

Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP.

Cell Host Microbe. 2015 May 13;17(5):642-52. doi: 10.1016/j.chom.2015.04.003.

15.

Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.

Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP.

MBio. 2015 Feb 24;6(2):e02280. doi: 10.1128/mBio.02280-14.

16.

Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits.

Hassan MA, Saeij JP.

Bioessays. 2014 Nov;36(11):1032-40. doi: 10.1002/bies.201400079. Epub 2014 Aug 29.

17.

Macrophage activation and polarization: nomenclature and experimental guidelines.

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.

Immunity. 2014 Jul 17;41(1):14-20. doi: 10.1016/j.immuni.2014.06.008.

18.

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.

Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M.

PLoS Pathog. 2014 Mar 13;10(3):e1003927. doi: 10.1371/journal.ppat.1003927. eCollection 2014 Mar.

19.

miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.

Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA.

Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27.

20.

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.

Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME.

MBio. 2014 Feb 18;5(1). pii: e01117-13. doi: 10.1128/mBio.01117-13.

21.

Toxoplasma gondii Inhibits gamma interferon (IFN-γ)- and IFN-β-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA.

Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP.

Infect Immun. 2014 Feb;82(2):706-19. doi: 10.1128/IAI.01291-13. Epub 2013 Nov 25.

22.

Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways.

Melo MB, Nguyen QP, Cordeiro C, Hassan MA, Yang N, McKell R, Rosowski EE, Julien L, Butty V, Dardé ML, Ajzenberg D, Fitzgerald K, Young LH, Saeij JP.

PLoS Pathog. 2013;9(12):e1003779. doi: 10.1371/journal.ppat.1003779. Epub 2013 Dec 19.

23.

The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages.

Hassan MA, Butty V, Jensen KD, Saeij JP.

Genome Res. 2014 Mar;24(3):377-89. doi: 10.1101/gr.166033.113. Epub 2013 Nov 18.

24.

Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.

Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP.

J Biol Chem. 2013 Nov 29;288(48):34968-80. doi: 10.1074/jbc.M113.523266. Epub 2013 Oct 15.

25.

Identification of three novel Toxoplasma gondii rhoptry proteins.

Camejo A, Gold DA, Lu D, McFetridge K, Julien L, Yang N, Jensen KD, Saeij JP.

Int J Parasitol. 2014 Feb;44(2):147-60. doi: 10.1016/j.ijpara.2013.08.002. Epub 2013 Sep 24.

26.

Cell death of gamma interferon-stimulated human fibroblasts upon Toxoplasma gondii infection induces early parasite egress and limits parasite replication.

Niedelman W, Sprokholt JK, Clough B, Frickel EM, Saeij JP.

Infect Immun. 2013 Dec;81(12):4341-9. doi: 10.1128/IAI.00416-13. Epub 2013 Sep 16.

27.

Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains.

Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP.

BMC Genomics. 2013 Jul 10;14:467. doi: 10.1186/1471-2164-14-467.

28.

Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.

Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP.

Infect Immun. 2013 Jun;81(6):2156-67. doi: 10.1128/IAI.01185-12. Epub 2013 Apr 1.

30.
31.

Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity.

Minot S, Melo MB, Li F, Lu D, Niedelman W, Levine SS, Saeij JP.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13458-63. doi: 10.1073/pnas.1117047109. Epub 2012 Jul 30.

32.

The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.

Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP.

PLoS Pathog. 2012;8(6):e1002784. doi: 10.1371/journal.ppat.1002784. Epub 2012 Jun 28.

33.

Cactin is essential for G1 progression in Toxoplasma gondii.

Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ.

Mol Microbiol. 2012 May;84(3):566-77. doi: 10.1111/j.1365-2958.2012.08044.x. Epub 2012 Apr 9.

34.

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.

Lim DC, Cooke BM, Doerig C, Saeij JP.

Int J Parasitol. 2012 Jan;42(1):21-32. doi: 10.1016/j.ijpara.2011.11.007. Epub 2011 Dec 4. Review.

35.

Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it.

Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM.

PLoS One. 2011;6(9):e24434. doi: 10.1371/journal.pone.0024434. Epub 2011 Sep 8.

36.

Toxoplasma gondii effectors are master regulators of the inflammatory response.

Melo MB, Jensen KD, Saeij JP.

Trends Parasitol. 2011 Nov;27(11):487-95. doi: 10.1016/j.pt.2011.08.001. Epub 2011 Sep 3. Review.

37.

Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.

Jensen KD, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong YC, Chien YH, Hunter CA, Boothroyd JC, Saeij JP.

Cell Host Microbe. 2011 Jun 16;9(6):472-83. doi: 10.1016/j.chom.2011.04.015.

38.

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence.

Reese ML, Zeiner GM, Saeij JP, Boothroyd JC, Boyle JP.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9625-30. doi: 10.1073/pnas.1015980108. Epub 2011 Mar 21.

39.

Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.

Rosowski EE, Lu D, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP.

J Exp Med. 2011 Jan 17;208(1):195-212. doi: 10.1084/jem.20100717. Epub 2011 Jan 3.

40.

Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence.

Blader IJ, Saeij JP.

APMIS. 2009 May;117(5-6):458-76. doi: 10.1111/j.1600-0463.2009.02453.x. Review.

41.

Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression.

Boyle JP, Saeij JP, Harada SY, Ajioka JW, Boothroyd JC.

Eukaryot Cell. 2008 Aug;7(8):1403-14. doi: 10.1128/EC.00073-08. Epub 2008 Jun 13.

42.

A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence.

Saeij JP, Arrizabalaga G, Boothroyd JC.

Infect Immun. 2008 Jun;76(6):2402-10. doi: 10.1128/IAI.01494-07. Epub 2008 Mar 17.

43.

Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice.

Boyle JP, Saeij JP, Boothroyd JC.

Exp Parasitol. 2007 Jul;116(3):302-5. Epub 2007 Jan 25.

PMID:
17335814
44.

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue.

Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC.

Nature. 2007 Jan 18;445(7125):324-7. Epub 2006 Dec 20.

45.

Polymorphic secreted kinases are key virulence factors in toxoplasmosis.

Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC.

Science. 2006 Dec 15;314(5806):1780-3.

46.

Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii.

Boyle JP, Rajasekar B, Saeij JPJ, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10514-10519. doi: 10.1073/pnas.0510319103. Epub 2006 Jun 26.

47.

Analysis of gene expression during development: lessons from the Apicomplexa.

Boyle JP, Saeij JP, Cleary MD, Boothroyd JC.

Microbes Infect. 2006 May;8(6):1623-30. Epub 2006 Jan 25. Review.

PMID:
16697685
48.

Ontogeny of the common carp (Cyprinus carpio L.) innate immune system.

Huttenhuis HB, Taverne-Thiele AJ, Grou CP, Bergsma J, Saeij JP, Nakayasu C, Rombout JH.

Dev Comp Immunol. 2006;30(6):557-74. Epub 2005 Sep 6.

PMID:
16406121
49.

Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host.

Saeij JP, Boyle JP, Boothroyd JC.

Trends Parasitol. 2005 Oct;21(10):476-81. Review.

PMID:
16098810
50.

Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains.

Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, Boothroyd JC.

Infect Immun. 2005 Feb;73(2):695-702.

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