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Items: 1 to 50 of 71

1.

Phenotypically distinct neutrophils patrol uninfected human and mouse lymph nodes.

Lok LSC, Dennison TW, Mahbubani KM, Saeb-Parsy K, Chilvers ER, Clatworthy MR.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19083-19089. doi: 10.1073/pnas.1905054116. Epub 2019 Sep 4.

2.

Upper Tract Urothelial Carcinoma Grade Prediction Based on the Ureteroscopic Appearance: Caution Should be Taken.

Freund JE, Legemate JD, Baard J, Saeb-Parsy K, Wiseman O, Doizi S, Emiliani E, Breda A, Boodt BJ, van Haarst EP, Leeflang MMG, Kamphuis GM.

Urology. 2019 Oct;132:69-74. doi: 10.1016/j.urology.2019.05.046. Epub 2019 Jul 11.

PMID:
31302135
3.

Three-year experience of a dedicated prostate mpMRI pre-biopsy programme and effect on timed cancer diagnostic pathways.

Barrett T, Slough R, Sushentsev N, Shaida N, Koo BC, Caglic I, Kozlov V, Warren AY, Thankappannair V, Pinnock C, Shah N, Saeb-Parsy K, Gnanapragasam VJ, Sala E, Kastner C.

Clin Radiol. 2019 Jul 6. pii: S0009-9260(19)30279-X. doi: 10.1016/j.crad.2019.06.004. [Epub ahead of print]

PMID:
31288924
4.

A cellular census of human lungs identifies novel cell states in health and in asthma.

Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA.

Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17.

PMID:
31209336
5.

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.

Tysoe OC, Justin AW, Brevini T, Chen SE, Mahbubani KT, Frank AK, Zedira H, Melum E, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F.

Nat Protoc. 2019 Jun;14(6):1884-1925. doi: 10.1038/s41596-019-0168-0. Epub 2019 May 20.

PMID:
31110298
6.

Clinical and Patient-reported Outcome Measures in Men Referred for Consideration of Surgery to Treat Lower Urinary Tract Symptoms: Baseline Results and Diagnostic Findings of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM).

Lewis AL, Young GJ, Abrams P, Blair PS, Chapple C, Glazener CMA, Horwood J, McGrath JS, Noble S, Taylor GT, Ito H, Belal M, Davies MC, Dickinson AJ, Foley CL, Foley S, Fulford S, Gammal MM, Garthwaite M, Harris MRE, Ilie PC, Jones R, Sabbagh S, Mason RG, McLarty E, Mishra V, Mom J, Morley R, Natale S, Nitkunan T, Page T, Payne D, Rashid TG, Saeb-Parsy K, Sandhu SS, Simoes A, Singh G, Sullivan M, Tempest HV, Viswanath S, Walker RMH, Lane JA, Drake MJ.

Eur Urol Focus. 2019 May;5(3):340-350. doi: 10.1016/j.euf.2019.04.006. Epub 2019 Apr 30.

PMID:
31047905
7.

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, Jing C, Strongili K, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR.

Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12.

8.

Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop.

Stacey G, Andrews P, Asante C, Barbaric I, Barry J, Bisset L, Braybrook J, Buckle R, Chandra A, Coffey P, Crouch S, Driver P, Evans A, Gardner J, Ginty P, Goldring C, Hay DC, Healy L, Hows A, Hutchinson C, Jesson H, Kalber T, Kimber S, Leathers R, Moyle S, Murray T, Neale M, Pan D, Park BK, Rebolledo RE, Rees I, Rivolta MN, Ritchie A, Roos EJ, Saeb-Parsy K, Schröder B, Sebastian S, Thomas A, Thomas RJ, Turner M, Vallier L, Vitillo L, Webster A, Williams D.

Regen Med. 2018 Dec;13(8):935-944. doi: 10.2217/rme-2018-0120. Epub 2018 Nov 29.

PMID:
30488776
9.

Somatic mutant clones colonize the human esophagus with age.

Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH.

Science. 2018 Nov 23;362(6417):911-917. doi: 10.1126/science.aau3879. Epub 2018 Oct 18.

10.

Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.

Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST.

Biomaterials. 2018 Nov;182:299-311. doi: 10.1016/j.biomaterials.2018.07.043. Epub 2018 Jul 27.

11.

NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.

Rodrigues P, Patel SA, Harewood L, Olan I, Vojtasova E, Syafruddin SE, Zaini MN, Richardson EK, Burge J, Warren AY, Stewart GD, Saeb-Parsy K, Samarajiwa SA, Vanharanta S.

Cancer Discov. 2018 Jul;8(7):850-865. doi: 10.1158/2159-8290.CD-17-1211. Epub 2018 Jun 6.

12.

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.

Martin JL, Gruszczyk AV, Beach TE, Murphy MP, Saeb-Parsy K.

Pediatr Nephrol. 2019 Jul;34(7):1167-1174. doi: 10.1007/s00467-018-3984-5. Epub 2018 Jun 2. Review.

13.

Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.

Kohlhauer M, Dawkins S, Costa ASH, Lee R, Young T, Pell VR, Choudhury RP, Banning AP, Kharbanda RK; Oxford Acute Myocardial Infarction (OxAMI) Study, Saeb-Parsy K, Murphy MP, Frezza C, Krieg T, Channon KM.

J Am Heart Assoc. 2018 Apr 6;7(8). pii: e007546. doi: 10.1161/JAHA.117.007546.

14.

Progression and treatment rates using an active surveillance protocol incorporating image-guided baseline biopsies and multiparametric magnetic resonance imaging monitoring for men with favourable-risk prostate cancer.

Thurtle D, Barrett T, Thankappan-Nair V, Koo B, Warren A, Kastner C, Saeb-Parsy K, Kimberley-Duffell J, Gnanapragasam VJ.

BJU Int. 2018 Jul;122(1):59-65. doi: 10.1111/bju.14166. Epub 2018 Mar 8.

15.

Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys.

Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaam6764. doi: 10.1126/scitranslmed.aam6764.

16.

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.

Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Gavarró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O, Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJ, Huch M.

Nat Med. 2017 Dec;23(12):1424-1435. doi: 10.1038/nm.4438. Epub 2017 Nov 13.

17.

Advances in the generation of bioengineered bile ducts.

Justin AW, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1532-1538. doi: 10.1016/j.bbadis.2017.10.034. Epub 2017 Oct 31. Review.

18.

Engaging Cold to Upregulate Cell Proliferation in Alginate-Encapsulated Liver Spheroids.

Kilbride P, Mahbubani KT, Saeb-Parsy K, Morris GJ.

Tissue Eng Part C Methods. 2017 Aug;23(8):455-464. doi: 10.1089/ten.tec.2017.0131. Epub 2017 Jul 20.

PMID:
28727981
19.

Pancreatic allograft thrombosis: Suggestion for a CT grading system and management algorithm.

Hakeem A, Chen J, Iype S, Clatworthy MR, Watson CJE, Godfrey EM, Upponi S, Saeb-Parsy K.

Am J Transplant. 2018 Jan;18(1):163-179. doi: 10.1111/ajt.14433. Epub 2017 Sep 14.

20.

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL 3rd, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander GJ, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, Melum E, Markaki AE, Saeb-Parsy K, Vallier L.

Nat Med. 2017 Aug;23(8):954-963. doi: 10.1038/nm.4360. Epub 2017 Jul 3.

21.

Assessment of H2S in vivo using the newly developed mitochondria-targeted mass spectrometry probe MitoA.

Arndt S, Baeza-Garza CD, Logan A, Rosa T, Wedmann R, Prime TA, Martin JL, Saeb-Parsy K, Krieg T, Filipovic MR, Hartley RC, Murphy MP.

J Biol Chem. 2017 May 12;292(19):7761-7773. doi: 10.1074/jbc.M117.784678. Epub 2017 Mar 20.

22.
23.

Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal transplantation.

Hosgood SA, Saeb-Parsy K, Wilson C, Callaghan C, Collett D, Nicholson ML.

BMJ Open. 2017 Jan 23;7(1):e012237. doi: 10.1136/bmjopen-2016-012237.

24.

Ureteric complications in recipients of kidneys from donation after circulatory death donors.

Mah TJ, Mallon DH, Brewster O, Saeb-Parsy K, Butler AJ, Bradley JA, Kosmoliaptsis V.

Clin Transplant. 2017 Apr;31(4). doi: 10.1111/ctr.12912. Epub 2017 Feb 13.

PMID:
28111805
25.

A single-centre experience of Roux-en-Y enteric drainage for pancreas transplantation.

Amin I, Butler AJ, Defries G, Russell NK, Harper SJ, Jah A, Saeb-Parsy K, Pettigrew GJ, Watson CJ.

Transpl Int. 2017 Apr;30(4):410-419. doi: 10.1111/tri.12920. Epub 2017 Mar 2.

26.

Successful Transplantation of Human Kidneys Deemed Untransplantable but Resuscitated by Ex Vivo Normothermic Machine Perfusion.

Hosgood SA, Saeb-Parsy K, Hamed MO, Nicholson ML.

Am J Transplant. 2016 Nov;16(11):3282-3285. doi: 10.1111/ajt.13906. Epub 2016 Jul 13.

27.

Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant.

Harper IG, Ali JM, Harper SJ, Wlodek E, Alsughayyir J, Negus MC, Qureshi MS, Motalleb-Zadeh R, Saeb-Parsy K, Bolton EM, Bradley JA, Clatworthy MR, Conlon TM, Pettigrew GJ.

Cell Rep. 2016 May 10;15(6):1214-27. doi: 10.1016/j.celrep.2016.04.009. Epub 2016 Apr 28.

28.

Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It.

Ali JM, Negus MC, Conlon TM, Harper IG, Qureshi MS, Motallebzadeh R, Willis R, Saeb-Parsy K, Bolton EM, Bradley JA, Pettigrew GJ.

Cell Rep. 2016 Feb 9;14(5):1232-1245. doi: 10.1016/j.celrep.2015.12.099. Epub 2016 Jan 21.

29.

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.

Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.

Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.

30.

Transplanting suboptimum organs: medico-legal implications.

Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K.

Lancet. 2015 Aug 22;386(9995):719-21. doi: 10.1016/S0140-6736(15)61413-1. No abstract available.

PMID:
26333958
31.

Targeting indirect pathway CD4 T-cell alloresponses in the prevention of chronic transplant rejection.

Ali J, Bolton E, Saeb-Parsy K, Bradley JA, Pettigrew G.

Lancet. 2015 Feb 26;385 Suppl 1:S17. doi: 10.1016/S0140-6736(15)60332-4.

PMID:
26312839
32.

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.

Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L.

Nat Biotechnol. 2015 Aug;33(8):845-852. doi: 10.1038/nbt.3275. Epub 2015 Jul 13.

33.

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model.

Dare AJ, Logan A, Prime TA, Rogatti S, Goddard M, Bolton EM, Bradley JA, Pettigrew GJ, Murphy MP, Saeb-Parsy K.

J Heart Lung Transplant. 2015 Nov;34(11):1471-80. doi: 10.1016/j.healun.2015.05.007. Epub 2015 Jun 11.

34.

Successful transplantation of kidneys from elderly circulatory death donors by using microscopic and macroscopic characteristics to guide single or dual implantation.

Mallon DH, Riddiough GE, Summers DM, Butler AJ, Callaghan CJ, Bradbury LL, Bardsley V, Broecker V, Saeb-Parsy K, Torpey N, Bradley JA, Pettigrew GJ.

Am J Transplant. 2015 Nov;15(11):2931-9. doi: 10.1111/ajt.13349. Epub 2015 Jun 24.

35.

Use of Ex Vivo Normothermic Perfusion for Quality Assessment of Discarded Human Donor Pancreases.

Barlow AD, Hamed MO, Mallon DH, Brais RJ, Gribble FM, Scott MA, Howat WJ, Bradley JA, Bolton EM, Pettigrew GJ, Hosgood SA, Nicholson ML, Saeb-Parsy K.

Am J Transplant. 2015 Sep;15(9):2475-82. doi: 10.1111/ajt.13303. Epub 2015 May 18.

36.

Protection against renal ischemia-reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ.

Dare AJ, Bolton EA, Pettigrew GJ, Bradley JA, Saeb-Parsy K, Murphy MP.

Redox Biol. 2015 Aug;5:163-168. doi: 10.1016/j.redox.2015.04.008. Epub 2015 Apr 29.

37.

Early graft loss after kidney transplantation: risk factors and consequences.

Hamed MO, Chen Y, Pasea L, Watson CJ, Torpey N, Bradley JA, Pettigrew G, Saeb-Parsy K.

Am J Transplant. 2015 Jun;15(6):1632-43. doi: 10.1111/ajt.13162. Epub 2015 Feb 23.

38.

Baseline donor chronic renal injury confers the same transplant survival disadvantage for DCD and DBD kidneys.

Kosmoliaptsis V, Salji M, Bardsley V, Chen Y, Thiru S, Griffiths MH, Copley HC, Saeb-Parsy K, Bradley JA, Torpey N, Pettigrew GJ.

Am J Transplant. 2015 Mar;15(3):754-63. doi: 10.1111/ajt.13009. Epub 2015 Jan 29.

39.

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP.

Nature. 2014 Nov 20;515(7527):431-435. doi: 10.1038/nature13909. Epub 2014 Nov 5.

40.

Evolution of repeat prostate biopsy strategies incorporating transperineal and MRI-TRUS fusion techniques.

Kuru TH, Saeb-Parsy K, Cantiani A, Frey J, Lombardo R, Serrao E, Gaziev G, Koo B, Roethke M, Gnanapragasam V, Warren A, Doble A, Hadaschik B, Kastner C.

World J Urol. 2014 Aug;32(4):945-50. doi: 10.1007/s00345-014-1334-1. Epub 2014 Jun 11.

PMID:
24917295
41.

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.

Li J, Kent DG, Godfrey AL, Manning H, Nangalia J, Aziz A, Chen E, Saeb-Parsy K, Fink J, Sneade R, Hamilton TL, Pask DC, Silber Y, Zhao X, Ghevaert C, Liu P, Green AR.

Blood. 2014 May 15;123(20):3139-51. doi: 10.1182/blood-2013-06-510222. Epub 2014 Apr 1.

PMID:
24692758
42.

Preoperative assessment of the deceased-donor kidney: from macroscopic appearance to molecular biomarkers.

Dare AJ, Pettigrew GJ, Saeb-Parsy K.

Transplantation. 2014 Apr 27;97(8):797-807. doi: 10.1097/01.TP.0000441361.34103.53. Review.

PMID:
24553618
43.

The discard of deceased donor kidneys in the UK.

Callaghan CJ, Harper SJ, Saeb-Parsy K, Hudson A, Gibbs P, Watson CJ, Praseedom RK, Butler AJ, Pettigrew GJ, Bradley JA.

Clin Transplant. 2014 Mar;28(3):345-53. doi: 10.1111/ctr.12319. Epub 2014 Feb 8.

PMID:
24506794
44.

BAFF and associated TNF superfamily members in renal transplantation: an end to BLySful ignorance.

Chhabra M, Conlon TM, Saeb-Parsy K, Pettigrew GJ.

Transplantation. 2013 Nov 27;96(10):853-9. doi: 10.1097/TP.0b013e3182997d34. Review.

PMID:
23774811
45.

Copresentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells.

Sivaganesh S, Harper SJ, Conlon TM, Callaghan CJ, Saeb-Parsy K, Negus MC, Motallebzadeh R, Bolton EM, Bradley JA, Pettigrew GJ.

J Immunol. 2013 Jun 1;190(11):5829-38. doi: 10.4049/jimmunol.1300458. Epub 2013 Apr 29.

46.

Unlinked memory helper responses promote long-lasting humoral alloimmunity.

Conlon TM, Cole JL, Motallebzadeh R, Harper I, Callaghan CJ, Bolton EM, Bradley JA, Saeb-Parsy K, Pettigrew GJ.

J Immunol. 2012 Dec 15;189(12):5703-12. doi: 10.4049/jimmunol.1202257. Epub 2012 Nov 16.

47.

Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine.

Saeb-Parsy K, Wilson A, Scarpini C, Corcoran M, Chilcott S, McKean M, Thottakam B, Rai B, Nabi G, Rana D, Perera M, Stewart K, Laskey RA, Neal DE, Coleman N.

Br J Cancer. 2012 Oct 9;107(8):1384-91. doi: 10.1038/bjc.2012.381. Epub 2012 Sep 11.

48.

Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells.

Conlon TM, Saeb-Parsy K, Cole JL, Motallebzadeh R, Qureshi MS, Rehakova S, Negus MC, Callaghan CJ, Bolton EM, Bradley JA, Pettigrew GJ.

J Immunol. 2012 Mar 15;188(6):2643-52. doi: 10.4049/jimmunol.1102830. Epub 2012 Feb 8.

49.

Risk profiles of prostate cancers identified from UK primary care using national referral guidelines.

Serag H, Banerjee S, Saeb-Parsy K, Irving S, Wright K, Stearn S, Doble A, Gnanapragasam VJ.

Br J Cancer. 2012 Jan 31;106(3):436-9. doi: 10.1038/bjc.2011.596. Epub 2012 Jan 12.

50.

Trends in the use of radiotherapy and radical surgery for patients with bladder urothelial cell carcinoma in East Anglia, 1995-2006.

Barbiere JM, Saeb-Parsy K, Greenberg DC, Wright KA, Brown CH, Neal DE, Lyratzopoulos G.

BJU Int. 2011 Oct;108(7):1106-14. doi: 10.1111/j.1464-410X.2010.10058.x. Epub 2011 Feb 14.

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