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Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.

Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, Sharma S.

Autophagy. 2019 Dec 26:1-15. doi: 10.1080/15548627.2019.1707494. [Epub ahead of print]


Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors.

Cheng SB, Nakashima A, Huber WJ, Davis S, Banerjee S, Huang Z, Saito S, Sadovsky Y, Sharma S.

Cell Death Dis. 2019 Dec 5;10(12):927. doi: 10.1038/s41419-019-2162-4.


Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth.

Parry S, Leite R, Sean Esplin M, Bukowski R, Zhang H, Varner M, Andrews WW, Saade GR, Ilekis J, Reddy UM, Huang H, Sadovsky Y, Blair IA, Biggio J; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research.

Am J Obstet Gynecol. 2019 Nov 20. pii: S0002-9378(19)32631-6. doi: 10.1016/j.ajog.2019.11.1252. [Epub ahead of print]


Klf14 is an imprinted transcription factor that regulates placental growth.

Koppes E, Shaffer B, Sadovsky E, Himes K, Barak Y, Sadovsky Y, Chaillet JR.

Placenta. 2019 Dec;88:61-67. doi: 10.1016/j.placenta.2019.09.013. Epub 2019 Sep 27.


The biology of extracellular vesicles: The known unknowns.

Margolis L, Sadovsky Y.

PLoS Biol. 2019 Jul 18;17(7):e3000363. doi: 10.1371/journal.pbio.3000363. eCollection 2019 Jul.


Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.

Dyer MR, Alexander W, Hassoune A, Chen Q, Brzoska T, Alvikas J, Liu Y, Haldeman S, Plautz W, Loughran P, Li H, Boone B, Sadovsky Y, Sundd P, Zuckerbraun BS, Neal MD.

J Thromb Haemost. 2019 Oct;17(10):1733-1745. doi: 10.1111/jth.14563. Epub 2019 Jul 28.


Separating extracellular vesicles and lipoproteins via acoustofluidics.

Wu M, Chen C, Wang Z, Bachman H, Ouyang Y, Huang PH, Sadovsky Y, Huang TJ.

Lab Chip. 2019 Mar 27;19(7):1174-1182. doi: 10.1039/c8lc01134f.


Distinct communication patterns of trophoblastic miRNA among the maternal-placental-fetal compartments.

Paquette AG, Chu T, Wu X, Wang K, Price ND, Sadovsky Y.

Placenta. 2018 Dec;72-73:28-35. doi: 10.1016/j.placenta.2018.10.004. Epub 2018 Oct 22.


PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia.

Bildirici I, Schaiff WT, Chen B, Morizane M, Oh SY, O'Brien M, Sonnenberg-Hirche C, Chu T, Barak Y, Nelson DM, Sadovsky Y.

Endocrinology. 2018 Dec 1;159(12):3937-3949. doi: 10.1210/en.2018-00752.


Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.

Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, Sadovsky Y, Sánchez-Madrid F, Valdes KM, Vickers KC, Weaver AM, Witwer KW, Zeng Y, Das S, Raffai RL, Howcroft TK.

JCI Insight. 2018 Apr 5;3(7). pii: 98942. doi: 10.1172/jci.insight.98942. eCollection 2018 Apr 5. Review.


Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines.

Ander SE, Rudzki EN, Arora N, Sadovsky Y, Coyne CB, Boyle JP.

mBio. 2018 Jan 9;9(1). pii: e01678-17. doi: 10.1128/mBio.01678-17.


Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.

Bayer A, Lennemann NJ, Ouyang Y, Sadovsky E, Sheridan MA, Roberts RM, Coyne CB, Sadovsky Y.

Placenta. 2018 Jan;61:33-38. doi: 10.1016/j.placenta.2017.11.004. Epub 2017 Nov 10.


Research to knowledge: promoting the training of physician-scientists in the biology of pregnancy.

Society for Maternal-Fetal Medicine (SMFM), Sadovsky Y, Caughey AB, DiVito M, D'Alton ME, Murtha AP; SMFM Research Committee.

Am J Obstet Gynecol. 2018 Jan;218(1):B9-B13. doi: 10.1016/j.ajog.2017.09.024. Epub 2017 Oct 7.


Isolation of exosomes from whole blood by integrating acoustics and microfluidics.

Wu M, Ouyang Y, Wang Z, Zhang R, Huang PH, Chen C, Li H, Li P, Quinn D, Dao M, Suresh S, Sadovsky Y, Huang TJ.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10584-10589. doi: 10.1073/pnas.1709210114. Epub 2017 Sep 18.


Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface.

Bukowski R, Sadovsky Y, Goodarzi H, Zhang H, Biggio JR, Varner M, Parry S, Xiao F, Esplin SM, Andrews W, Saade GR, Ilekis JV, Reddy UM, Baldwin DA.

PeerJ. 2017 Sep 1;5:e3685. doi: 10.7717/peerj.3685. eCollection 2017.


"Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions.

Tyurina YY, Shrivastava I, Tyurin VA, Mao G, Dar HH, Watkins S, Epperly M, Bahar I, Shvedova AA, Pitt B, Wenzel SE, Mallampalli RK, Sadovsky Y, Gabrilovich D, Greenberger JS, Bayır H, Kagan VE.

Antioxid Redox Signal. 2018 Nov 1;29(13):1333-1358. doi: 10.1089/ars.2017.7124. Epub 2017 Oct 16. Review.


Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface.

Corry J, Arora N, Good CA, Sadovsky Y, Coyne CB.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9433-9438. doi: 10.1073/pnas.1707513114. Epub 2017 Aug 7.


Microbial Vertical Transmission during Human Pregnancy.

Arora N, Sadovsky Y, Dermody TS, Coyne CB.

Cell Host Microbe. 2017 May 10;21(5):561-567. doi: 10.1016/j.chom.2017.04.007. Review.


The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.

Dumont TMF, Mouillet JF, Bayer A, Gardner CL, Klimstra WB, Wolf DG, Yagel S, Balmir F, Binstock A, Sanfilippo JS, Coyne CB, Larkin JC, Sadovsky Y.

Placenta. 2017 May;53:23-29. doi: 10.1016/j.placenta.2017.03.011. Epub 2017 Mar 16.


Development and Testing of the MyHealthyPregnancy App: A Behavioral Decision Research-Based Tool for Assessing and Communicating Pregnancy Risk.

Krishnamurti T, Davis AL, Wong-Parodi G, Fischhoff B, Sadovsky Y, Simhan HN.

JMIR Mhealth Uhealth. 2017 Apr 10;5(4):e42. doi: 10.2196/mhealth.7036.


Expression and trafficking of placental microRNAs at the feto-maternal interface.

Chang G, Mouillet JF, Mishima T, Chu T, Sadovsky E, Coyne CB, Parks WT, Surti U, Sadovsky Y.

FASEB J. 2017 Jul;31(7):2760-2770. doi: 10.1096/fj.201601146R. Epub 2017 Mar 13.


Formation and size distribution of self-assembled vesicles.

Huang C, Quinn D, Sadovsky Y, Suresh S, Hsia KJ.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2910-2915. doi: 10.1073/pnas.1702065114. Epub 2017 Mar 6. Review.


Vulnerability of primitive human placental trophoblast to Zika virus.

Sheridan MA, Yunusov D, Balaraman V, Alexenko AP, Yabe S, Verjovski-Almeida S, Schust DJ, Franz AW, Sadovsky Y, Ezashi T, Roberts RM.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1587-E1596. doi: 10.1073/pnas.1616097114. Epub 2017 Feb 13.


Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth: a case-control study.

Manuck TA, Watkins WS, Esplin MS, Biggio J, Bukowski R, Parry S, Zhan H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Yandell M, Varner MW, Jorde LB; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomics and Proteomics Network for Preterm Birth Research (GPN-PBR).

BJOG. 2018 Feb;125(3):343-350. doi: 10.1111/1471-0528.14485. Epub 2017 Jan 31.


IFPA meeting 2016 workshop report I: Genomic communication, bioinformatics, trophoblast biology and transport systems.

Albrecht C, Baker JC, Blundell C, Chavez SL, Carbone L, Chamley L, Hannibal RL, Illsley N, Kurre P, Laurent LC, McKenzie C, Morales-Prieto D, Pantham P, Paquette A, Powell K, Price N, Rao BM, Sadovsky Y, Salomon C, Tuteja G, Wilson S, O'Tierney-Ginn PF.

Placenta. 2017 Dec;60 Suppl 1:S5-S9. doi: 10.1016/j.placenta.2017.01.103. Epub 2017 Jan 11. Review.


Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.

Rausch K, Hackett BA, Weinbren NL, Reeder SM, Sadovsky Y, Hunter CA, Schultz DC, Coyne CB, Cherry S.

Cell Rep. 2017 Jan 17;18(3):804-815. doi: 10.1016/j.celrep.2016.12.068.


The function of miR-519d in cell migration, invasion, and proliferation suggests a role in early placentation.

Xie L, Sadovsky Y.

Placenta. 2016 Dec;48:34-37. doi: 10.1016/j.placenta.2016.10.004. Epub 2016 Oct 10. Review.


Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.

Ouyang Y, Bayer A, Chu T, Tyurin VA, Kagan VE, Morelli AE, Coyne CB, Sadovsky Y.

Placenta. 2016 Nov;47:86-95. doi: 10.1016/j.placenta.2016.09.008. Epub 2016 Sep 14.


Intact feto-placental growth in microRNA-210 deficient mice.

Krawczynski K, Mishima T, Huang X, Sadovsky Y.

Placenta. 2016 Nov;47:113-115. doi: 10.1016/j.placenta.2016.09.007. Epub 2016 Sep 23.


Determinants of effective lentivirus-driven microRNA expression in vivo.

Mishima T, Sadovsky E, Gegick ME, Sadovsky Y.

Sci Rep. 2016 Sep 15;6:33345. doi: 10.1038/srep33345.


Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection.

Bayer A, Lennemann NJ, Ouyang Y, Bramley JC, Morosky S, Marques ET Jr, Cherry S, Sadovsky Y, Coyne CB.

Cell Host Microbe. 2016 May 11;19(5):705-12. doi: 10.1016/j.chom.2016.03.008. Epub 2016 Apr 5.


Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas.

Yabe S, Alexenko AP, Amita M, Yang Y, Schust DJ, Sadovsky Y, Ezashi T, Roberts RM.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2598-607. doi: 10.1073/pnas.1601630113. Epub 2016 Apr 5.


Editorial: ZIKA virus and placenta.

Sadovsky Y, Clifton VL, Knöfler M.

Placenta. 2016 Apr;40:A1. doi: 10.1016/j.placenta.2016.03.008. No abstract available.


Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies.

Oh SY, Hwang JR, Lee Y, Choi SJ, Kim JS, Kim JH, Sadovsky Y, Roh CR.

Placenta. 2016 Mar;39:24-32. doi: 10.1016/j.placenta.2016.01.001. Epub 2016 Jan 6.


A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.

McConkey CA, Delorme-Axford E, Nickerson CA, Kim KS, Sadovsky Y, Boyle JP, Coyne CB.

Sci Adv. 2016 Mar 4;2(3):e1501462. doi: 10.1126/sciadv.1501462. eCollection 2016 Mar.


Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Ilekis JV, Tsilou E, Fisher S, Abrahams VM, Soares MJ, Cross JC, Zamudio S, Illsley NP, Myatt L, Colvis C, Costantine MM, Haas DM, Sadovsky Y, Weiner C, Rytting E, Bidwell G.

Am J Obstet Gynecol. 2016 Jul;215(1 Suppl):S1-S46. doi: 10.1016/j.ajog.2016.03.001. Epub 2016 Mar 10.


Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth.

Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomics and Proteomics Network for Preterm Birth Research (GPN-PBR).

Am J Obstet Gynecol. 2016 Mar;214(3):376.e1-8. doi: 10.1016/j.ajog.2015.12.010. Epub 2015 Dec 12.


MicroRNAs in placental health and disease.

Mouillet JF, Ouyang Y, Coyne CB, Sadovsky Y.

Am J Obstet Gynecol. 2015 Oct;213(4 Suppl):S163-72. doi: 10.1016/j.ajog.2015.05.057. Review.


The expression and post-transcriptional regulation of FSTL1 transcripts in placental trophoblasts.

Mouillet JF, Mishima T, Paffaro AM, Parks TW, Ziegler JA, Chu T, Sadovsky Y.

Placenta. 2015 Nov;36(11):1231-8. doi: 10.1016/j.placenta.2015.09.005. Epub 2015 Sep 10.


ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.

Shu Q, Lennemann NJ, Sarkar SN, Sadovsky Y, Coyne CB.

PLoS Pathog. 2015 Sep 15;11(9):e1005150. doi: 10.1371/journal.ppat.1005150. eCollection 2015 Sep.


Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms.

Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J.

Am J Obstet Gynecol. 2015 Sep;213(3):429.e1-9. doi: 10.1016/j.ajog.2015.06.011. Epub 2015 Jun 9.


Perinatal outcomes and unconventional natural gas operations in Southwest Pennsylvania.

Stacy SL, Brink LL, Larkin JC, Sadovsky Y, Goldstein BD, Pitt BR, Talbott EO.

PLoS One. 2015 Jun 3;10(6):e0126425. doi: 10.1371/journal.pone.0126425. eCollection 2015.


The Function of TrophomiRs and Other MicroRNAs in the Human Placenta.

Sadovsky Y, Mouillet JF, Ouyang Y, Bayer A, Coyne CB.

Cold Spring Harb Perspect Med. 2015 Apr 15;5(8):a023036. doi: 10.1101/cshperspect.a023036. Review.


The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool.

Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomics and Proteomics Network for Preterm Birth Research.

Am J Obstet Gynecol. 2015 Apr;212(4):487.e1-487.e11. doi: 10.1016/j.ajog.2015.02.010. Epub 2015 Feb 14.


Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.

Himes KP, Young A, Koppes E, Stolz D, Barak Y, Sadovsky Y, Chaillet JR.

Placenta. 2015 Apr;36(4):389-96. doi: 10.1016/j.placenta.2015.01.012. Epub 2015 Jan 29.


The assembly of miRNA-mRNA-protein regulatory networks using high-throughput expression data.

Chu T, Mouillet JF, Hood BL, Conrads TP, Sadovsky Y.

Bioinformatics. 2015 Jun 1;31(11):1780-7. doi: 10.1093/bioinformatics/btv038. Epub 2015 Jan 24.


A genome-wide association study of early spontaneous preterm delivery.

Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR Jr; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomic and Proteomic Network for Preterm Birth Research (GPN-PBR).

Genet Epidemiol. 2015 Mar;39(3):217-26. doi: 10.1002/gepi.21887. Epub 2015 Jan 19.


Prevention of preterm birth: harnessing science to address the global epidemic.

Rubens CE, Sadovsky Y, Muglia L, Gravett MG, Lackritz E, Gravett C.

Sci Transl Med. 2014 Nov 12;6(262):262sr5. doi: 10.1126/scitranslmed.3009871. Review.


The Placenta as a Barrier to Viral Infections.

Delorme-Axford E, Sadovsky Y, Coyne CB.

Annu Rev Virol. 2014 Nov;1(1):133-46. doi: 10.1146/annurev-virology-031413-085524.



Burton GJ, Clifton V, Sadovsky Y.

Placenta. 2014 Dec;35(12):973. doi: 10.1016/j.placenta.2014.09.013. Epub 2014 Sep 28. No abstract available.


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