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Items: 1 to 50 of 321

1.

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia.

Fernández ÁF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou PE, Puyal J, Hu MC, Levine B.

JCI Insight. 2020 Jan 16;5(1). pii: 133282. doi: 10.1172/jci.insight.133282.

2.

Role of YAP/TAZ in Energy Metabolism in the Heart.

Kashihara T, Sadoshima J.

J Cardiovasc Pharmacol. 2019 Dec;74(6):483-490. doi: 10.1097/FJC.0000000000000736.

PMID:
31815864
3.

Nuclear miR-320 Controls Lipotoxicity.

Tong M, Sadoshima J.

Circ Res. 2019 Dec 6;125(12):1121-1123. doi: 10.1161/CIRCRESAHA.119.316199. Epub 2019 Dec 5. No abstract available.

PMID:
31804912
4.

Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart.

Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, Sadoshima J.

JACC Basic Transl Sci. 2019 Sep 23;4(5):611-622. doi: 10.1016/j.jacbts.2019.05.006. eCollection 2019 Sep.

5.

3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB.

Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G.

EMBO Mol Med. 2019 Nov 7;11(11):e10469. doi: 10.15252/emmm.201910469. Epub 2019 Oct 14.

6.

Thioredoxin-1 maintains mitochondrial function via mTOR signaling in the heart.

Oka SI, Chin A, Park JY, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, Einaga Y, Huang CY, Kashihara T, Zhao M, Nah J, Tian B, Hirabayashi Y, Yodoi J, Sadoshima J.

Cardiovasc Res. 2019 Oct 4. pii: cvz251. doi: 10.1093/cvr/cvz251. [Epub ahead of print]

PMID:
31584633
7.

YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells.

Kashihara T, Zablocki D, Sadoshima J.

Biotarget. 2019 Aug;3. pii: 14. doi: 10.21037/biotarget.2019.08.01. Epub 2019 Aug 23. No abstract available.

8.

Scientists on the Spot: Autophagy and heart disease.

Voigt N, Sadoshima J.

Cardiovasc Res. 2019 Aug 1;115(10):e91-e92. doi: 10.1093/cvr/cvz124. No abstract available.

PMID:
31508800
9.

Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.

Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K.

JCI Insight. 2019 Aug 8;5. pii: 129556. doi: 10.1172/jci.insight.129556.

10.

Both gain and loss of Nampt function promote pressure overload-induced heart failure.

Byun J, Oka SI, Imai N, Huang CY, Ralda G, Zhai P, Ikeda Y, Ikeda S, Sadoshima J.

Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H711-H725. doi: 10.1152/ajpheart.00222.2019. Epub 2019 Jul 26.

PMID:
31347918
11.

Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.

Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, Ishikawa Y.

Cell Death Dis. 2019 Jul 18;10(8):549. doi: 10.1038/s41419-019-1787-7.

12.

The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.

Francisco J, Byun J, Zhang Y, Kalloo OB, Mizushima W, Oka S, Zhai P, Sadoshima J, Del Re DP.

J Biol Chem. 2019 Aug 30;294(35):13131-13144. doi: 10.1074/jbc.RA119.008970. Epub 2019 Jul 16.

PMID:
31311858
13.

Scientists on the Spot: Autophagy and heart disease.

Voigt N, Sadoshima J.

Cardiovasc Res. 2019 Aug 1;115(10):e91-e92. doi: 10.1093/cvr/cvz124. No abstract available.

PMID:
31263872
14.

Ketone body can be a fuel substrate for failing heart.

Nakamura M, Sadoshima J.

Cardiovasc Res. 2019 Sep 1;115(11):1567-1569. doi: 10.1093/cvr/cvz104. No abstract available.

PMID:
30989167
15.

Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway.

Zhao WB, Lu Q, Nguyen MN, Su Y, Ziemann M, Wang LN, Kiriazis H, Puthalakath H, Sadoshima J, Hu HY, Du XJ.

Br J Pharmacol. 2019 Jul;176(14):2465-2481. doi: 10.1111/bph.14674. Epub 2019 May 30.

16.

Cardiomyopathy in obesity, insulin resistance and diabetes.

Nakamura M, Sadoshima J.

J Physiol. 2019 Mar 14. doi: 10.1113/JP276747. [Epub ahead of print]

17.

Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation.

Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI.

Circ Heart Fail. 2019 Mar;12(3):e005529. doi: 10.1161/CIRCHEARTFAILURE.118.005529.

18.

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.

Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, Morimoto T, Hasegawa K, Sadoshima J, Vangheluwe P, Hajjar RJ, Park WJ, Kho C.

Circ Res. 2019 Apr 26;124(9):e63-e80. doi: 10.1161/CIRCRESAHA.118.313865. Erratum in: Circ Res. 2019 Jun 7;124(12):e149.

PMID:
30786847
19.

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy.

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J.

Circ Res. 2019 Apr 26;124(9):1360-1371. doi: 10.1161/CIRCRESAHA.118.314607.

PMID:
30786833
20.

The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F.

Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w.

21.

Intermittent Fasting Reverses an Advanced Form of Cardiomyopathy.

Mukai R, Zablocki D, Sadoshima J.

J Am Heart Assoc. 2019 Feb 19;8(4):e011863. doi: 10.1161/JAHA.118.011863.

22.

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration.

Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA, Bhuiyan MS.

Sci Rep. 2019 Feb 14;9(1):2002. doi: 10.1038/s41598-018-37862-3.

23.

Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy.

Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J.

Cell Metab. 2019 May 7;29(5):1119-1134.e12. doi: 10.1016/j.cmet.2019.01.005. Epub 2019 Feb 7.

PMID:
30745182
24.

Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload.

Byun J, Del Re DP, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH, Sadoshima J.

J Biol Chem. 2019 Mar 8;294(10):3603-3617. doi: 10.1074/jbc.RA118.006123. Epub 2019 Jan 11.

25.

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo.

Venkatesh S, Li M, Saito T, Tong M, Rashed E, Mareedu S, Zhai P, Bárcena C, López-Otín C, Yehia G, Sadoshima J, Suzuki CK.

J Mol Cell Cardiol. 2019 Mar;128:38-50. doi: 10.1016/j.yjmcc.2018.12.017. Epub 2019 Jan 6.

PMID:
30625302
26.

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.

Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J.

Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048.

27.

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.

Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M, Sadoshima J.

J Clin Invest. 2019 Feb 1;129(2):802-819. doi: 10.1172/JCI122035. Epub 2019 Jan 22.

28.

Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction.

Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, Kaneko S, Sadoshima J, Takamura M.

J Mol Cell Cardiol. 2019 Jan;126:1-12. doi: 10.1016/j.yjmcc.2018.11.002. Epub 2018 Nov 6.

PMID:
30408466
29.

Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling.

Nguyen MN, Ziemann M, Kiriazis H, Su Y, Thomas Z, Lu Q, Donner DG, Zhao WB, Rafehi H, Sadoshima J, McMullen JR, El-Osta A, Du XJ.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H45-H60. doi: 10.1152/ajpheart.00609.2018. Epub 2018 Nov 2.

30.

Leducq Network: Modulating Autophagy to Treat Cardiovascular Disease.

Madrigal-Matute J, Scorrano L, Sadoshima J.

Circ Res. 2018 Jul 20;123(3):323-325. doi: 10.1161/CIRCRESAHA.118.313091. No abstract available.

31.

Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure.

Nguyen MN, Su Y, Vizi D, Fang L, Ellims AH, Zhao WB, Kiriazis H, Gao XM, Sadoshima J, Taylor AJ, McMullen JR, Dart AM, Kaye DM, Du XJ.

Sci Rep. 2018 May 29;8(1):8213. doi: 10.1038/s41598-018-26115-y.

32.

Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.

Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P, Sadoshima J.

J Am Coll Cardiol. 2018 May 8;71(18):1999-2010. doi: 10.1016/j.jacc.2018.02.066.

33.

Mechanisms of physiological and pathological cardiac hypertrophy.

Nakamura M, Sadoshima J.

Nat Rev Cardiol. 2018 Jul;15(7):387-407. doi: 10.1038/s41569-018-0007-y. Review.

PMID:
29674714
34.

Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids.

Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O, Kroemer G.

EBioMedicine. 2018 Apr;30:261-272. doi: 10.1016/j.ebiom.2018.03.028. Epub 2018 Mar 27.

35.

Aspirin Recapitulates Features of Caloric Restriction.

Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G.

Cell Rep. 2018 Feb 27;22(9):2395-2407. doi: 10.1016/j.celrep.2018.02.024.

36.

New Insights Into the Role of mTOR Signaling in the Cardiovascular System.

Sciarretta S, Forte M, Frati G, Sadoshima J.

Circ Res. 2018 Feb 2;122(3):489-505. doi: 10.1161/CIRCRESAHA.117.311147. Review.

37.

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies.

Tham YK, Huynh K, Mellett NA, Henstridge DC, Kiriazis H, Ooi JYY, Matsumoto A, Patterson NL, Sadoshima J, Meikle PJ, McMullen JR.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. Epub 2017 Dec 6.

PMID:
29217479
38.

HAX-1 regulates SERCA2a oxidation and degradation.

Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, Kranias EG.

J Mol Cell Cardiol. 2018 Jan;114:220-233. doi: 10.1016/j.yjmcc.2017.11.014. Epub 2017 Nov 21.

39.

Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School.

Sadoshima J.

Circ Res. 2017 Oct 27;121(10):1127-1129. doi: 10.1161/CIRCRESAHA.117.311373. No abstract available.

40.

The Role of Autophagy in the Heart.

Sciarretta S, Maejima Y, Zablocki D, Sadoshima J.

Annu Rev Physiol. 2018 Feb 10;80:1-26. doi: 10.1146/annurev-physiol-021317-121427. Epub 2017 Oct 25. Review.

PMID:
29068766
41.

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes.

Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J.

J Biol Chem. 2017 Nov 17;292(46):18988-19000. doi: 10.1074/jbc.M117.807735. Epub 2017 Sep 22.

42.

Mitophagy as a Protective Mechanism against Myocardial Stress.

Nah J, Miyamoto S, Sadoshima J.

Compr Physiol. 2017 Sep 12;7(4):1407-1424. doi: 10.1002/cphy.c170005. Review.

PMID:
28915329
43.

Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury.

Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R.

Circ Res. 2017 Oct 27;121(10):1182-1191. doi: 10.1161/CIRCRESAHA.117.311159. Epub 2017 Aug 23.

44.

What Should We Learn From the Recent Decline of Basic Cardiovascular Science in Japan?

Sadoshima J, Tomoike H.

Circ Res. 2017 Aug 4;121(4):314-316. doi: 10.1161/CIRCRESAHA.117.311411. No abstract available.

45.

BAG3 plays a central role in proteostasis in the heart.

Mizushima W, Sadoshima J.

J Clin Invest. 2017 Aug 1;127(8):2900-2903. doi: 10.1172/JCI95839. Epub 2017 Jul 24.

46.

Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.

Huang C, Alapa M, Shu P, Nagarajan N, Wu C, Sadoshima J, Kholodovych V, Li H, Beuve A.

J Biol Chem. 2017 Sep 1;292(35):14362-14370. doi: 10.1074/jbc.M117.787390. Epub 2017 Jun 28.

47.

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics.

Warren JS, Oka SI, Zablocki D, Sadoshima J.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H584-H596. doi: 10.1152/ajpheart.00103.2017. Epub 2017 Jun 23. Review.

48.

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H221-H223. doi: 10.1152/ajpheart.00329.2017. Epub 2017 Jun 16. No abstract available.

49.

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.

Kang H, Oka S, Lee DY, Park J, Aponte AM, Jung YS, Bitterman J, Zhai P, He Y, Kooshapur H, Ghirlando R, Tjandra N, Lee SB, Kim MK, Sadoshima J, Chung JH.

Nat Commun. 2017 May 15;8:15560. doi: 10.1038/ncomms15560.

50.

A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy.

Byun S, Kim YC, Zhang Y, Kong B, Guo G, Sadoshima J, Ma J, Kemper B, Kemper JK.

EMBO J. 2017 Jun 14;36(12):1755-1769. doi: 10.15252/embj.201695500. Epub 2017 Apr 26.

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