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Targeted photoredox catalysis in cancer cells.

Huang H, Banerjee S, Qiu K, Zhang P, Blacque O, Malcomson T, Paterson MJ, Clarkson GJ, Staniforth M, Stavros VG, Gasser G, Chao H, Sadler PJ.

Nat Chem. 2019 Sep 23. doi: 10.1038/s41557-019-0328-4. [Epub ahead of print]


Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells.

Ballesta A, Billy F, Coverdale JPC, Song JI, Sanchez-Cano C, Romero-Canelón I, Sadler PJ.

Metallomics. 2019 Oct 16;11(10):1648-1656. doi: 10.1039/c9mt00173e.


Metal Ion Binding to the Amyloid β Monomer Studied by Native Top-Down FTICR Mass Spectrometry.

Lermyte F, Everett J, Lam YPY, Wootton CA, Brooks J, Barrow MP, Telling ND, Sadler PJ, O'Connor PB, Collingwood JF.

J Am Soc Mass Spectrom. 2019 Jul 26. doi: 10.1007/s13361-019-02283-7. [Epub ahead of print]


New Designs for Phototherapeutic Transition Metal Complexes.

Imberti C, Zhang P, Huang H, Sadler PJ.

Angew Chem Int Ed Engl. 2019 Jul 16. doi: 10.1002/anie.201905171. [Epub ahead of print] Review.


Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells.

Sanchez-Cano C, Gianolio D, Romero-Canelon I, Tucoulou R, Sadler PJ.

Chem Commun (Camb). 2019 Jun 13;55(49):7065-7068. doi: 10.1039/c9cc01675a.


Photoactive platinum(iv) complex conjugated to a cancer-cell-targeting cyclic peptide.

Shi H, Wang Q, Venkatesh V, Feng G, Young LS, Romero-Canelón I, Zeng M, Sadler PJ.

Dalton Trans. 2019 Jun 28;48(24):8560-8564. doi: 10.1039/c9dt00909d. Epub 2019 May 31.


Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.

Gondim ACS, Roberta da Silva S, Mathys L, Noppen S, Liekens S, Holanda Sampaio A, Nagano CS, Renata Costa Rocha C, Nascimento KS, Cavada BS, Sadler PJ, Balzarini J.

Medchemcomm. 2019 Jan 14;10(3):390-398. doi: 10.1039/c8md00508g. eCollection 2019 Mar 1.


Generation of maghemite nanocrystals from iron-sulfur centres.

Banerjee S, Omlor A, Wolny JA, Han Y, Lermyte F, Godfrey AE, O'Connor PB, Schünemann V, Danaie M, Sadler PJ.

Dalton Trans. 2019 Jul 2;48(26):9564-9569. doi: 10.1039/c9dt00514e.


Structural analysis of peptides modified with organo-iridium complexes, opportunities from multi-mode fragmentation.

Wootton CA, Millett AJ, Lopez-Clavijo AF, Chiu CKC, Barrow MP, Clarkson GJ, Sadler PJ, O'Connor PB.

Analyst. 2019 Feb 25;144(5):1575-1581. doi: 10.1039/c8an02094a.


Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy.

Zhang P, Huang H, Banerjee S, Clarkson GJ, Ge C, Imberti C, Sadler PJ.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2350-2354. doi: 10.1002/anie.201813002. Epub 2019 Jan 21.


Photoactivatable platinum anticancer complex can generate tryptophan radicals.

Vallotto C, Shaili E, Shi H, Butler JS, Wedge CJ, Newton ME, Sadler PJ.

Chem Commun (Camb). 2018 Dec 6;54(98):13845-13848. doi: 10.1039/c8cc06496b.


Photoactivatable Cell-Selective Dinuclear trans-Diazidoplatinum(IV) Anticancer Prodrugs.

Shi H, Romero-Canelón I, Hreusova M, Novakova O, Venkatesh V, Habtemariam A, Clarkson GJ, Song JI, Brabec V, Sadler PJ.

Inorg Chem. 2018 Nov 19;57(22):14409-14420. doi: 10.1021/acs.inorgchem.8b02599. Epub 2018 Oct 26.


In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance.

Coverdale JPC, Bridgewater HE, Song JI, Smith NA, Barry NPE, Bagley I, Sadler PJ, Romero-Canelón I.

J Med Chem. 2018 Oct 25;61(20):9246-9255. doi: 10.1021/acs.jmedchem.8b00958. Epub 2018 Oct 5.


Rigid dinuclear ruthenium-arene complexes showing strong DNA interactions.

Wu Q, Liu LY, Li S, Wang FX, Li J, Qian Y, Su Z, Mao ZW, Sadler PJ, Liu HK.

J Inorg Biochem. 2018 Dec;189:30-39. doi: 10.1016/j.jinorgbio.2018.08.013. Epub 2018 Aug 24.


Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.

Chen F, Moat J, McFeely D, Clarkson G, Hands-Portman IJ, Furner-Pardoe JP, Harrison F, Dowson CG, Sadler PJ.

J Med Chem. 2018 Aug 23;61(16):7330-7344. doi: 10.1021/acs.jmedchem.8b00906. Epub 2018 Aug 2.


Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy.

Huang H, Banerjee S, Sadler PJ.

Chembiochem. 2018 Aug 6;19(15):1574-1589. doi: 10.1002/cbic.201800182. Epub 2018 Jul 18. Review.


Transfer Hydrogenation and Antiproliferative Activity of Tethered Half-Sandwich Organoruthenium Catalysts.

Chen F, Romero-Canelón I, Soldevila-Barreda JJ, Song JI, Coverdale JPC, Clarkson GJ, Kasparkova J, Habtemariam A, Wills M, Brabec V, Sadler PJ.

Organometallics. 2018 May 29;37(10):1555-1566. doi: 10.1021/acs.organomet.8b00132. Epub 2018 Apr 23.


Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein.

Martin EM, Kondrat FDL, Stewart AJ, Scrivens JH, Sadler PJ, Blindauer CA.

Sci Rep. 2018 Jun 5;8(1):8646. doi: 10.1038/s41598-018-26924-1.


New activation mechanism for half-sandwich organometallic anticancer complexes.

Banerjee S, Soldevila-Barreda JJ, Wolny JA, Wootton CA, Habtemariam A, Romero-Canelón I, Chen F, Clarkson GJ, Prokes I, Song L, O'Connor PB, Schünemann V, Sadler PJ.

Chem Sci. 2018 Mar 1;9(12):3177-3185. doi: 10.1039/c7sc05058e. eCollection 2018 Mar 28.


Sequence-dependent attack on peptides by photoactivated platinum anticancer complexes.

Wootton CA, Sanchez-Cano C, Lopez-Clavijo AF, Shaili E, Barrow MP, Sadler PJ, O'Connor PB.

Chem Sci. 2018 Feb 12;9(10):2733-2739. doi: 10.1039/c7sc05135b. eCollection 2018 Mar 14.


Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex.

Sanchez-Cano C, Romero-Canelón I, Geraki K, Sadler PJ.

J Inorg Biochem. 2018 Aug;185:26-29. doi: 10.1016/j.jinorgbio.2018.04.014. Epub 2018 Apr 25.


Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity.

Gatti A, Habtemariam A, Romero-Canelón I, Song JI, Heer B, Clarkson GJ, Rogolino D, Sadler PJ, Carcelli M.

Organometallics. 2018 Mar 26;37(6):891-899. doi: 10.1021/acs.organomet.7b00875. Epub 2018 Feb 20.


Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance.

Chellan P, Avery VM, Duffy S, Triccas JA, Nagalingam G, Tam C, Cheng LW, Liu J, Land KM, Clarkson GJ, Romero-Canelón I, Sadler PJ.

Chemistry. 2018 Apr 13. doi: 10.1002/chem.201801090. [Epub ahead of print]


Effect of sulfonamidoethylenediamine substituents in RuII arene anticancer catalysts on transfer hydrogenation of coenzyme NAD+ by formate.

Chen F, Soldevila-Barreda JJ, Romero-Canelón I, Coverdale JPC, Song JI, Clarkson GJ, Kasparkova J, Habtemariam A, Brabec V, Wolny JA, Schünemann V, Sadler PJ.

Dalton Trans. 2018 May 29;47(21):7178-7189. doi: 10.1039/c8dt00438b.


Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes.

Venkatesh V, Berrocal-Martin R, Wedge CJ, Romero-Canelón I, Sanchez-Cano C, Song JI, Coverdale JPC, Zhang P, Clarkson GJ, Habtemariam A, Magennis SW, Deeth RJ, Sadler PJ.

Chem Sci. 2017 Dec 1;8(12):8271-8278. doi: 10.1039/c7sc03216a. Epub 2017 Oct 20.


Platinum(iv) azido complexes undergo copper-free click reactions with alkynes.

Farrer NJ, Sharma G, Sayers R, Shaili E, Sadler PJ.

Dalton Trans. 2018 Aug 7;47(31):10553-10560. doi: 10.1039/c7dt04183g.


Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells.

Coverdale JPC, Romero-Canelón I, Sanchez-Cano C, Clarkson GJ, Habtemariam A, Wills M, Sadler PJ.

Nat Chem. 2018 Mar;10(3):347-354. doi: 10.1038/nchem.2918. Epub 2018 Jan 8.


Platinum(IV) Prodrugs.

Venkatesh V, Sadler PJ.

Met Ions Life Sci. 2018 Feb 5;18. pii: /books/9783110470734/9783110470734-007/9783110470734-009.xml. doi: 10.1515/9783110470734-009. Review.


Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ].

Vernooij RR, Joshi T, Horbury MD, Graham B, Izgorodina EI, Stavros VG, Sadler PJ, Spiccia L, Wood BR.

Chemistry. 2018 Apr 17;24(22):5790-5803. doi: 10.1002/chem.201705349. Epub 2018 Feb 5.


Rapid screening of photoactivatable metallodrugs: photonic crystal fibre microflow reactor coupled to ESI mass spectrometry.

McQuitty RJ, Unterkofler S, Euser TG, Russell PSJ, Sadler PJ.

RSC Adv. 2017 Jul 29;7(59):37340-37348. doi: 10.1039/c7ra06735f. Epub 2017 Jul 26.


Halide Control of N,N-Coordination versus N,C-Cyclometalation and Stereospecific Phenyl Ring Deuteration of Osmium(II) p-Cymene Phenylazobenzothiazole Complexes.

Needham RJ, Habtemariam A, Barry NPE, Clarkson G, Sadler PJ.

Organometallics. 2017 Nov 27;36(22):4367-4375. doi: 10.1021/acs.organomet.7b00501. Epub 2017 Nov 9.


A novel strategy to construct Janus metallamacrocycles with both a Ru-arene face and an imidazolium face.

Li J, Zhang P, Xu Y, Su Z, Qian Y, Li S, Yu T, Sadler PJ, Liu HK.

Dalton Trans. 2017 Nov 28;46(46):16205-16215. doi: 10.1039/c7dt03374e.


Cyclic Peptide-Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes.

Larnaudie SC, Brendel JC, Romero-Canelón I, Sanchez-Cano C, Catrouillet S, Sanchis J, Coverdale JPC, Song JI, Habtemariam A, Sadler PJ, Jolliffe KA, Perrier S.

Biomacromolecules. 2018 Jan 8;19(1):239-247. doi: 10.1021/acs.biomac.7b01491. Epub 2017 Dec 14.


Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action.

Hearn JM, Hughes GM, Romero-Canelón I, Munro AF, Rubio-Ruiz B, Liu Z, Carragher NO, Sadler PJ.

Metallomics. 2018 Jan 24;10(1):93-107. doi: 10.1039/c7mt00242d.


Controlled fabrication of osmium nanocrystals by electron, laser and microwave irradiation and characterisation by microfocus X-ray absorption spectroscopy.

Pitto-Barry A, Geraki K, Horbury MD, Stavros VG, Mosselmans JFW, Walton RI, Sadler PJ, Barry NPE.

Chem Commun (Camb). 2017 Nov 30;53(96):12898-12901. doi: 10.1039/c7cc07133g.


Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells.

Zhang P, Chiu CKC, Huang H, Lam YPY, Habtemariam A, Malcomson T, Paterson MJ, Clarkson GJ, O'Connor PB, Chao H, Sadler PJ.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14898-14902. doi: 10.1002/anie.201709082. Epub 2017 Oct 19.


The potent anti-cancer activity of Dioclea lasiocarpa lectin.

Gondim ACS, Romero-Canelón I, Sousa EHS, Blindauer CA, Butler JS, Romero MJ, Sanchez-Cano C, Sousa BL, Chaves RP, Nagano CS, Cavada BS, Sadler PJ.

J Inorg Biochem. 2017 Oct;175:179-189. doi: 10.1016/j.jinorgbio.2017.07.011. Epub 2017 Jul 16.


Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV.

Xie MJ, Zhu MR, Lu CM, Jin Y, Gao LH, Li L, Zhou J, Li FF, Zhao QH, Liu HK, Sadler PJ, Sanchez-Cano C.

J Inorg Biochem. 2017 Oct;175:29-35. doi: 10.1016/j.jinorgbio.2017.06.014. Epub 2017 Jun 29.


Automatic assignment of metal-containing peptides in proteomic LC-MS and MS/MS data sets.

Wootton CA, Lam YPY, Willetts M, van Agthoven MA, Barrow MP, Sadler PJ, O Connor PB.

Analyst. 2017 Jun 7;142(11):2029-2037. doi: 10.1039/c7an00075h. Epub 2017 May 17.


Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

Smith NA, Zhang P, Greenough SE, Horbury MD, Clarkson GJ, McFeely D, Habtemariam A, Salassa L, Stavros VG, Dowson CG, Sadler PJ.

Chem Sci. 2017 Jan 1;8(1):395-404. doi: 10.1039/c6sc03028a. Epub 2016 Aug 30.


Supramolecular Photoactivatable Anticancer Hydrogels.

Venkatesh V, Mishra NK, Romero-Canelón I, Vernooij RR, Shi H, Coverdale JPC, Habtemariam A, Verma S, Sadler PJ.

J Am Chem Soc. 2017 Apr 26;139(16):5656-5659. doi: 10.1021/jacs.7b00186. Epub 2017 Apr 17.


Recent developments in drug discovery against the protozoal parasites Cryptosporidium and Toxoplasma.

Chellan P, Sadler PJ, Land KM.

Bioorg Med Chem Lett. 2017 Apr 1;27(7):1491-1501. doi: 10.1016/j.bmcl.2017.01.046. Epub 2017 Jan 17. Review.


Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells.

Sanchez-Cano C, Romero-Canelón I, Yang Y, Hands-Portman IJ, Bohic S, Cloetens P, Sadler PJ.

Chemistry. 2017 Feb 21;23(11):2512-2516. doi: 10.1002/chem.201605911. Epub 2017 Jan 26.


In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.

Needham RJ, Sanchez-Cano C, Zhang X, Romero-Canelón I, Habtemariam A, Cooper MS, Meszaros L, Clarkson GJ, Blower PJ, Sadler PJ.

Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1017-1020. doi: 10.1002/anie.201610290. Epub 2016 Dec 21.


"Head-to-head" double-hamburger-like structure of di-ruthenated d(GpG) adducts of mono-functional Ru-arene anticancer complexes.

Liu HK, Kostrhunova H, Habtemariam A, Kong Y, Deeth RJ, Brabec V, Sadler PJ.

Dalton Trans. 2016 Nov 22;45(46):18676-18688.


Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate.

Vernooij RR, Joshi T, Shaili E, Kubeil M, Appadoo DR, Izgorodina EI, Graham B, Sadler PJ, Wood BR, Spiccia L.

Inorg Chem. 2016 Jun 20;55(12):5983-92. doi: 10.1021/acs.inorgchem.6b00476. Epub 2016 Jun 3.


Os2 -Os4 Switch Controls DNA Knotting and Anticancer Activity.

Fu Y, Romero MJ, Salassa L, Cheng X, Habtemariam A, Clarkson GJ, Prokes I, Rodger A, Costantini G, Sadler PJ.

Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8909-12. doi: 10.1002/anie.201602995. Epub 2016 May 30.


Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1α Inhibition for Cancer Therapy.

Silva Sousa EH, Ridnour LA, Gouveia FS Jr, Silva da Silva CD, Wink DA, de França Lopes LG, Sadler PJ.

ACS Chem Biol. 2016 Jul 15;11(7):2057-65. doi: 10.1021/acschembio.6b00222. Epub 2016 May 31.


Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex.

Venkatesh V, Wedge CJ, Romero-Canelón I, Habtemariam A, Sadler PJ.

Dalton Trans. 2016 Aug 16;45(33):13034-7. doi: 10.1039/c6dt01382a.


The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts.

Fu Y, Sanchez-Cano C, Soni R, Romero-Canelon I, Hearn JM, Liu Z, Wills M, Sadler PJ.

Dalton Trans. 2016 May 28;45(20):8367-78. doi: 10.1039/c6dt01242f. Epub 2016 Apr 25.


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