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Items: 1 to 50 of 59

1.

Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots.

Benyettou F, Prakasam T, Ramdas Nair A, Witzel II, Alhashimi M, Skorjanc T, Olsen JC, Sadler KC, Trabolsi A.

Chem Sci. 2019 May 22;10(23):5884-5892. doi: 10.1039/c9sc01218d. eCollection 2019 Jun 21.

2.

Epigenetic Compensation Promotes Liver Regeneration.

Wang S, Zhang C, Hasson D, Desai A, SenBanerjee S, Magnani E, Ukomadu C, Lujambio A, Bernstein E, Sadler KC.

Dev Cell. 2019 Jul 1;50(1):43-56.e6. doi: 10.1016/j.devcel.2019.05.034. Epub 2019 Jun 20.

PMID:
31231040
3.

High resolution annotation of zebrafish transcriptome using long-read sequencing.

Nudelman G, Frasca A, Kent B, Sadler KC, Sealfon SC, Walsh MJ, Zaslavsky E.

Genome Res. 2018 Sep;28(9):1415-1425. doi: 10.1101/gr.223586.117. Epub 2018 Jul 30.

4.

Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish.

Bambino K, Zhang C, Austin C, Amarasiriwardena C, Arora M, Chu J, Sadler KC.

Dis Model Mech. 2018 Feb 26;11(2). pii: dmm031575. doi: 10.1242/dmm.031575.

5.

Variant Histone H2afv reprograms DNA methylation during early zebrafish development.

Madakashira B, Corbett L, Zhang C, Paoli P, Casement JW, Mann J, Sadler KC, Mann DA.

Epigenetics. 2017 Sep;12(9):811-824. doi: 10.1080/15592294.2017.1359382. Epub 2017 Nov 24.

6.

Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling.

Chernyavskaya Y, Mudbhary R, Zhang C, Tokarz D, Jacob V, Gopinath S, Sun X, Wang S, Magnani E, Madakashira BP, Yoder JA, Hoshida Y, Sadler KC.

Development. 2017 Aug 15;144(16):2925-2939. doi: 10.1242/dev.147629. Epub 2017 Jul 11.

7.

MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.

Shtraizent N, DeRossi C, Nayar S, Sachidanandam R, Katz LS, Prince A, Koh AP, Vincek A, Hadas Y, Hoshida Y, Scott DK, Eliyahu E, Freeze HH, Sadler KC, Chu J.

Elife. 2017 Jun 23;6. pii: e22477. doi: 10.7554/eLife.22477.

8.

DNA Methylation, Nuclear Organization, and Cancer.

Madakashira BP, Sadler KC.

Front Genet. 2017 Jun 7;8:76. doi: 10.3389/fgene.2017.00076. eCollection 2017. Review.

9.

Preface.

Sadler KC.

Curr Top Dev Biol. 2017;124:xi-xv. doi: 10.1016/S0070-2153(17)30026-1. No abstract available.

PMID:
28335866
10.

Making It New Again: Insight Into Liver Development, Regeneration, and Disease From Zebrafish Research.

Wang S, Miller SR, Ober EA, Sadler KC.

Curr Top Dev Biol. 2017;124:161-195. doi: 10.1016/bs.ctdb.2016.11.012. Epub 2017 Jan 17. Review.

11.

Comparative Epigenomic Profiling of the DNA Methylome in Mouse and Zebrafish Uncovers High Interspecies Divergence.

Zhang C, Hoshida Y, Sadler KC.

Front Genet. 2016 Jun 17;7:110. doi: 10.3389/fgene.2016.00110. eCollection 2016.

12.

Zebrafish Discoveries in Cancer Epigenetics.

Chernyavskaya Y, Kent B, Sadler KC.

Adv Exp Med Biol. 2016;916:169-97. doi: 10.1007/978-3-319-30654-4_8. Review.

13.

trappc11 is required for protein glycosylation in zebrafish and humans.

DeRossi C, Vacaru A, Rafiq R, Cinaroglu A, Imrie D, Nayar S, Baryshnikova A, Milev MP, Stanga D, Kadakia D, Gao N, Chu J, Freeze HH, Lehrman MA, Sacher M, Sadler KC.

Mol Biol Cell. 2016 Apr 15;27(8):1220-34. doi: 10.1091/mbc.E15-08-0557. Epub 2016 Feb 24.

14.

UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development.

Kent B, Magnani E, Walsh MJ, Sadler KC.

Dev Biol. 2016 Apr 1;412(1):99-113. doi: 10.1016/j.ydbio.2016.01.036. Epub 2016 Feb 3.

15.

Zebrafish: an important tool for liver disease research.

Goessling W, Sadler KC.

Gastroenterology. 2015 Nov;149(6):1361-77. doi: 10.1053/j.gastro.2015.08.034. Epub 2015 Aug 28. Review.

16.

DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos.

Jacob V, Chernyavskaya Y, Chen X, Tan PS, Kent B, Hoshida Y, Sadler KC.

Development. 2015 Feb 1;142(3):510-21. doi: 10.1242/dev.115980. Epub 2015 Jan 6.

17.

Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish.

Vacaru AM, Di Narzo AF, Howarth DL, Tsedensodnom O, Imrie D, Cinaroglu A, Amin S, Hao K, Sadler KC.

Dis Model Mech. 2014 Jul;7(7):823-35. doi: 10.1242/dmm.014472.

18.

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish.

Howarth DL, Lindtner C, Vacaru AM, Sachidanandam R, Tsedensodnom O, Vasilkova T, Buettner C, Sadler KC.

PLoS Genet. 2014 May 29;10(5):e1004335. doi: 10.1371/journal.pgen.1004335. eCollection 2014.

19.

RAF1 mutations in childhood-onset dilated cardiomyopathy.

Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, Nishizawa T, Nakanishi T, Robbins J, Limongelli G, Hajjar RJ, Lebeche D, Bahl A, Khullar M, Rathinavel A, Sadler KC, Tartaglia M, Matsuoka R, Thangaraj K, Gelb BD.

Nat Genet. 2014 Jun;46(6):635-639. doi: 10.1038/ng.2963. Epub 2014 Apr 28.

20.

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.

Mudbhary R, Hoshida Y, Chernyavskaya Y, Jacob V, Villanueva A, Fiel MI, Chen X, Kojima K, Thung S, Bronson RT, Lachenmayer A, Revill K, Alsinet C, Sachidanandam R, Desai A, SenBanerjee S, Ukomadu C, Llovet JM, Sadler KC.

Cancer Cell. 2014 Feb 10;25(2):196-209. doi: 10.1016/j.ccr.2014.01.003. Epub 2014 Jan 30.

21.

In vivo cell biology in zebrafish - providing insights into vertebrate development and disease.

Vacaru AM, Unlu G, Spitzner M, Mione M, Knapik EW, Sadler KC.

J Cell Sci. 2014 Feb 1;127(Pt 3):485-95. doi: 10.1242/jcs.140194. Review.

22.

MKKing the most of liver regeneration: an in vivo screen identifies the MKK4 pathway as a suppressor of regeneration.

Jacob V, Sadler KC.

Hepatology. 2014 Mar;59(3):1201-3. doi: 10.1002/hep.26757. Epub 2014 Jan 17. No abstract available.

PMID:
24123204
23.

Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease.

Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC.

Dis Model Mech. 2013 Sep;6(5):1213-26. doi: 10.1242/dmm.012195. Epub 2013 Jun 20.

24.

Getting the inside tract: new frontiers in zebrafish digestive system biology.

Sadler KC, Rawls JF, Farber SA.

Zebrafish. 2013 Jun;10(2):129-31. doi: 10.1089/zeb.2013.1500. No abstract available.

25.

ROS: redux and paradox in fatty liver disease.

Tsedensodnom O, Sadler KC.

Hepatology. 2013 Oct;58(4):1210-2. doi: 10.1002/hep.26497. Epub 2013 Aug 14. No abstract available.

26.

Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae.

Howarth DL, Yin C, Yeh K, Sadler KC.

Zebrafish. 2013 Jun;10(2):199-210. doi: 10.1089/zeb.2012.0821. Epub 2013 May 22.

27.

A zebrafish model of PMM2-CDG reveals altered neurogenesis and a substrate-accumulation mechanism for N-linked glycosylation deficiency.

Cline A, Gao N, Flanagan-Steet H, Sharma V, Rosa S, Sonon R, Azadi P, Sadler KC, Freeze HH, Lehrman MA, Steet R.

Mol Biol Cell. 2012 Nov;23(21):4175-87. doi: 10.1091/mbc.E12-05-0411. Epub 2012 Sep 5.

28.

A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation.

Chu J, Mir A, Gao N, Rosa S, Monson C, Sharma V, Steet R, Freeze HH, Lehrman MA, Sadler KC.

Dis Model Mech. 2013 Jan;6(1):95-105. doi: 10.1242/dmm.010116. Epub 2012 Aug 16.

29.

Stress management: How the unfolded protein response impacts fatty liver disease.

Imrie D, Sadler KC.

J Hepatol. 2012 Nov;57(5):1147-51. doi: 10.1016/j.jhep.2012.06.018. Epub 2012 Jun 22. Review.

30.

The Cx43-like connexin protein Cx40.8 is differentially localized during fin ontogeny and fin regeneration.

Gerhart SV, Eble DM, Burger RM, Oline SN, Vacaru A, Sadler KC, Jefferis R, Iovine MK.

PLoS One. 2012;7(2):e31364. doi: 10.1371/journal.pone.0031364. Epub 2012 Feb 8.

31.

UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis.

Chu J, Loughlin EA, Gaur NA, SenBanerjee S, Jacob V, Monson C, Kent B, Oranu A, Ding Y, Ukomadu C, Sadler KC.

Mol Biol Cell. 2012 Jan;23(1):59-70. doi: 10.1091/mbc.E11-06-0487. Epub 2011 Nov 9.

32.

Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes.

Howarth DL, Vacaru AM, Tsedensodnom O, Mormone E, Nieto N, Costantini LM, Snapp EL, Sadler KC.

Alcohol Clin Exp Res. 2012 Jan;36(1):14-23. doi: 10.1111/j.1530-0277.2011.01602.x. Epub 2011 Jul 25.

33.

Epigenetics, development, and cancer: zebrafish make their mark..

Mudbhary R, Sadler KC.

Birth Defects Res C Embryo Today. 2011 Jun;93(2):194-203. doi: 10.1002/bdrc.20207. Review.

34.

Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish.

Cinaroglu A, Gao C, Imrie D, Sadler KC.

Hepatology. 2011 Aug;54(2):495-508. doi: 10.1002/hep.24396. Epub 2011 Jun 23.

35.

Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.

Thakur PC, Stuckenholz C, Rivera MR, Davison JM, Yao JK, Amsterdam A, Sadler KC, Bahary N.

Hepatology. 2011 Aug;54(2):452-62. doi: 10.1002/hep.24349. Epub 2011 May 2.

36.

Drinks like a fish: using zebrafish to understand alcoholic liver disease.

Howarth DL, Passeri M, Sadler KC.

Alcohol Clin Exp Res. 2011 May;35(5):826-9. doi: 10.1111/j.1530-0277.2010.01407.x. Epub 2011 Feb 1. Review.

37.

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis.

Tien AL, Senbanerjee S, Kulkarni A, Mudbhary R, Goudreau B, Ganesan S, Sadler KC, Ukomadu C.

Biochem J. 2011 Apr 1;435(1):175-85. doi: 10.1042/BJ20100840.

38.

White adipose tissue development in zebrafish is regulated by both developmental time and fish size.

Imrie D, Sadler KC.

Dev Dyn. 2010 Nov;239(11):3013-23. doi: 10.1002/dvdy.22443.

39.

Inbreeding depression and outbreeding depression are evident in wild-type zebrafish lines.

Monson CA, Sadler KC.

Zebrafish. 2010 Jun;7(2):189-97. doi: 10.1089/zeb.2009.0648.

40.

Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells.

Zhao X, Monson C, Gao C, Gouon-Evans V, Matsumoto N, Sadler KC, Friedman SL.

Dev Biol. 2010 Aug 1;344(1):79-93. doi: 10.1016/j.ydbio.2010.04.018. Epub 2010 Apr 27.

41.

Conservation and divergence of methylation patterning in plants and animals.

Feng S, Cokus SJ, Zhang X, Chen PY, Bostick M, Goll MG, Hetzel J, Jain J, Strauss SH, Halpern ME, Ukomadu C, Sadler KC, Pradhan S, Pellegrini M, Jacobsen SE.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8689-94. doi: 10.1073/pnas.1002720107. Epub 2010 Apr 15.

42.

New school in liver development: lessons from zebrafish.

Chu J, Sadler KC.

Hepatology. 2009 Nov;50(5):1656-63. doi: 10.1002/hep.23157. Review.

43.

A zebrafish retinal graded photochemical stress model.

Eichenbaum JW, Cinaroglu A, Eichenbaum KD, Sadler KC.

J Pharmacol Toxicol Methods. 2009 May-Jun;59(3):121-7. doi: 10.1016/j.vascn.2009.02.006. Epub 2009 Mar 5.

44.

Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation.

Passeri MJ, Cinaroglu A, Gao C, Sadler KC.

Hepatology. 2009 Feb;49(2):443-52. doi: 10.1002/hep.22667.

45.

Endothelial signals modulate hepatocyte apicobasal polarization in zebrafish.

Sakaguchi TF, Sadler KC, Crosnier C, Stainier DY.

Curr Biol. 2008 Oct 28;18(20):1565-71. doi: 10.1016/j.cub.2008.08.065.

46.

The role of insulin receptor signaling in zebrafish embryogenesis.

Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D.

Endocrinology. 2008 Dec;149(12):5996-6005. doi: 10.1210/en.2008-0329. Epub 2008 Aug 7.

47.

Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1.

Sadler KC, Krahn KN, Gaur NA, Ukomadu C.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1570-5. Epub 2007 Jan 22.

48.

A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.

Sadler KC, Amsterdam A, Soroka C, Boyer J, Hopkins N.

Development. 2005 Aug;132(15):3561-72. Epub 2005 Jul 6.

49.

Cryopreservation of starfish oocytes.

Hamarato─člu F, Ero─člu A, Toner M, Sadler KC.

Cryobiology. 2005 Feb;50(1):38-47. Epub 2004 Nov 24.

PMID:
15710368
50.

Many ribosomal protein genes are cancer genes in zebrafish.

Amsterdam A, Sadler KC, Lai K, Farrington S, Bronson RT, Lees JA, Hopkins N.

PLoS Biol. 2004 May;2(5):E139. Epub 2004 May 11.

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