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Items: 26


A scalable solution for tumor mutational burden from formalin-fixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay.

Chaudhary R, Quagliata L, Martin JP, Alborelli I, Cyanam D, Mittal V, Tom W, Au-Young J, Sadis S, Hyland F.

Transl Lung Cancer Res. 2018 Dec;7(6):616-630. doi: 10.21037/tlcr.2018.08.01.


Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications.

Hovelson DH, Udager AM, McDaniel AS, Grivas P, Palmbos P, Tamura S, Lazo de la Vega L, Palapattu G, Veeneman B, El-Sawy L, Sadis SE, Morgan TM, Montgomery JS, Weizer AZ, Day KC, Neamati N, Liebert M, Keller ET, Day ML, Mehra R, Tomlins SA.

Eur Urol. 2018 Dec;74(6):741-753. doi: 10.1016/j.eururo.2018.06.047. Epub 2018 Jul 20.


Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy.

McDaniel AS, Hovelson DH, Cani AK, Liu CJ, Zhai Y, Zhang Y, Weizer AZ, Mehra R, Feng FY, Alva AS, Morgan TM, Montgomery JS, Siddiqui J, Sadis S, Bandla S, Williams PD, Cho KR, Rhodes DR, Tomlins SA.

Cancer Res. 2015 Dec 15;75(24):5219-27. doi: 10.1158/0008-5472.CAN-15-1004.


Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors.

Hovelson DH, McDaniel AS, Cani AK, Johnson B, Rhodes K, Williams PD, Bandla S, Bien G, Choppa P, Hyland F, Gottimukkala R, Liu G, Manivannan M, Schageman J, Ballesteros-Villagrana E, Grasso CS, Quist MJ, Yadati V, Amin A, Siddiqui J, Betz BL, Knudsen KE, Cooney KA, Feng FY, Roh MH, Nelson PS, Liu CJ, Beer DG, Wyngaard P, Chinnaiyan AM, Sadis S, Rhodes DR, Tomlins SA.

Neoplasia. 2015 Apr;17(4):385-99. doi: 10.1016/j.neo.2015.03.004.


Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.

Cani AK, Hovelson DH, McDaniel AS, Sadis S, Haller MJ, Yadati V, Amin AM, Bratley J, Bandla S, Williams PD, Rhodes K, Liu CJ, Quist MJ, Rhodes DR, Grasso CS, Kleer CG, Tomlins SA.

Mol Cancer Res. 2015 Apr;13(4):613-9. doi: 10.1158/1541-7786.MCR-14-0578. Epub 2015 Jan 15.


Next generation sequencing technologies reveal the tumor-associated somatic mutation profile.

Sadis S, Williams P, Khazanov N.

MLO Med Lab Obs. 2014 Feb;46(2):32, 34. No abstract available.


Identification of targetable FGFR gene fusions in diverse cancers.

Wu YM, Su F, Kalyana-Sundaram S, Khazanov N, Ateeq B, Cao X, Lonigro RJ, Vats P, Wang R, Lin SF, Cheng AJ, Kunju LP, Siddiqui J, Tomlins SA, Wyngaard P, Sadis S, Roychowdhury S, Hussain MH, Feng FY, Zalupski MM, Talpaz M, Pienta KJ, Rhodes DR, Robinson DR, Chinnaiyan AM.

Cancer Discov. 2013 Jun;3(6):636-47. doi: 10.1158/2159-8290.CD-13-0050. Epub 2013 Apr 4.


Monoclonal antibodies against macrophage colony-stimulating factor diminish the number of circulating intermediate and nonclassical (CD14(++)CD16(+)/CD14(+)CD16(++)) monocytes in rheumatoid arthritis patient.

Korkosz M, Bukowska-Strakova K, Sadis S, Grodzicki T, Siedlar M.

Blood. 2012 May 31;119(22):5329-30. doi: 10.1182/blood-2012-02-412551. No abstract available.


Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs.

Fleischmann R, Cutolo M, Genovese MC, Lee EB, Kanik KS, Sadis S, Connell CA, Gruben D, Krishnaswami S, Wallenstein G, Wilkinson BE, Zwillich SH.

Arthritis Rheum. 2012 Mar;64(3):617-29. doi: 10.1002/art.33383.


Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury.

Radi ZA, Koza-Taylor PH, Bell RR, Obert LA, Runnels HA, Beebe JS, Lawton MP, Sadis S.

Am J Pathol. 2011 Jul;179(1):240-7. doi: 10.1016/j.ajpath.2011.03.029. Epub 2011 May 13.


Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.

Marzec M, Kasprzycka M, Lai R, Gladden AB, Wlodarski P, Tomczak E, Nowell P, Deprimo SE, Sadis S, Eck S, Schuster SJ, Diehl JA, Wasik MA.

Blood. 2006 Sep 1;108(5):1744-50. Epub 2006 May 11.


Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341.

Fleming JA, Lightcap ES, Sadis S, Thoroddsen V, Bulawa CE, Blackman RK.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1461-6.


Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1.

Fu H, Sadis S, Rubin DM, Glickman M, van Nocker S, Finley D, Vierstra RD.

J Biol Chem. 1998 Jan 23;273(4):1970-81.


ATPase and ubiquitin-binding proteins of the yeast proteasome.

Rubin DM, van Nocker S, Glickman M, Coux O, Wefes I, Sadis S, Fu H, Goldberg A, Vierstra R, Finley D.

Mol Biol Rep. 1997 Mar;24(1-2):17-26.


The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover.

van Nocker S, Sadis S, Rubin DM, Glickman M, Fu H, Coux O, Wefes I, Finley D, Vierstra RD.

Mol Cell Biol. 1996 Nov;16(11):6020-8.


Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer.

Leung SM, Senisterra G, Ritchie KP, Sadis SE, Lepock JR, Hightower LE.

Cell Stress Chaperones. 1996 Apr;1(1):78-89.


Synthetic signals for ubiquitin-dependent proteolysis.

Sadis S, Atienza C Jr, Finley D.

Mol Cell Biol. 1995 Aug;15(8):4086-94.


A ubiquitin mutant with specific defects in DNA repair and multiubiquitination.

Spence J, Sadis S, Haas AL, Finley D.

Mol Cell Biol. 1995 Mar;15(3):1265-73.


p34Cdc28-mediated control of Cln3 cyclin degradation.

Yaglom J, Linskens MH, Sadis S, Rubin DM, Futcher B, Finley D.

Mol Cell Biol. 1995 Feb;15(2):731-41.


Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.

Finley D, Sadis S, Monia BP, Boucher P, Ecker DJ, Crooke ST, Chau V.

Mol Cell Biol. 1994 Aug;14(8):5501-9.


Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange.

Sadis S, Hightower LE.

Biochemistry. 1992 Oct 6;31(39):9406-12.


Transforming growth factor-beta regulates basal expression of the hsp70 gene family in cultured chicken embryo cells.

Takenaka IM, Sadis S, Hightower LE.

Results Probl Cell Differ. 1991;17:188-209. No abstract available.


Effect of heat shock on RNA metabolism in HeLa cells.

Sadis S, Hickey E, Weber LA.

J Cell Physiol. 1988 Jun;135(3):377-86.


Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia.

Hickey E, Brandon SE, Sadis S, Smale G, Weber LA.

Gene. 1986;43(1-2):147-54.


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