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Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol.

Al Rawashdah S, Hamrouni A, Sadek B, Amer R, Metwaly M, Atatreh N, Ghattas MA.

J Mol Graph Model. 2019 Jul 2;92:44-54. doi: 10.1016/j.jmgm.2019.07.001. [Epub ahead of print]


Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models.

Javed H, Nagoor Meeran MF, Azimullah S, Adem A, Sadek B, Ojha SK.

Front Pharmacol. 2019 Mar 19;9:1555. doi: 10.3389/fphar.2018.01555. eCollection 2018. Review.


Histamine H3 receptor antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats.

Alachkar A, Khan N, Łażewska D, Kieć-Kononowicz K, Sadek B.

Neuropsychiatr Dis Treat. 2019 Feb 20;15:531-542. doi: 10.2147/NDT.S193125. eCollection 2019.


Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats.

Alachkar A, Łażewska D, Latacz G, Frank A, Siwek A, Lubelska A, Honkisz-Orzechowska E, Handzlik J, Stark H, Kieć-Kononowicz K, Sadek B.

Int J Mol Sci. 2018 Oct 29;19(11). pii: E3386. doi: 10.3390/ijms19113386.


The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.

Eissa N, Jayaprakash P, Azimullah S, Ojha SK, Al-Houqani M, Jalal FY, Łażewska D, Kieć-Kononowicz K, Sadek B.

Sci Rep. 2018 Aug 30;8(1):13077. doi: 10.1038/s41598-018-31385-7.


Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder.

Eissa N, Al-Houqani M, Sadeq A, Ojha SK, Sasse A, Sadek B.

Front Neurosci. 2018 May 16;12:304. doi: 10.3389/fnins.2018.00304. eCollection 2018. Review.


Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats.

Alachkar A, Latacz G, Siwek A, Lubelska A, Honkisz E, Gryboś A, Łażewska D, Handzlik J, Stark H, Kiec-Kononowicz K, Sadek B.

Pharmacol Biochem Behav. 2018 Jul;170:14-24. doi: 10.1016/j.pbb.2018.04.010. Epub 2018 May 3.


Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands.

Szczepańska K, Karcz T, Mogilski S, Siwek A, Kuder KJ, Latacz G, Kubacka M, Hagenow S, Lubelska A, Olejarz A, Kotańska M, Sadek B, Stark H, Kieć-Kononowicz K.

Eur J Med Chem. 2018 May 25;152:223-234. doi: 10.1016/j.ejmech.2018.04.043. Epub 2018 Apr 25.


The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats.

Eissa N, Khan N, Ojha SK, Łazewska D, Kieć-Kononowicz K, Sadek B.

Front Neurosci. 2018 Feb 12;12:42. doi: 10.3389/fnins.2018.00042. eCollection 2018.


Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice.

Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, Sadek B.

Drug Des Devel Ther. 2018 Jan 19;12:179-194. doi: 10.2147/DDDT.S144730. eCollection 2018.


Nociceptin and the NOP receptor in aversive learning in mice.

Adem A, Madjid N, Kahl U, Holst S, Sadek B, Sandin J, Terenius L, Ögren SO.

Eur Neuropsychopharmacol. 2017 Dec;27(12):1298-1307. doi: 10.1016/j.euroneuro.2017.09.005. Epub 2017 Nov 6.


The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats.

Alachkar A, Łażewska D, Kieć-Kononowicz K, Sadek B.

Front Pharmacol. 2017 Oct 12;8:709. doi: 10.3389/fphar.2017.00709. eCollection 2017.


Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands.

Schübler M, Sadek B, Kottke T, Weizel L, Stark H.

Front Chem. 2017 Sep 12;5:64. doi: 10.3389/fchem.2017.00064. eCollection 2017.


Beneficial effects of phytochemicals in diabetic retinopathy: experimental and clinical evidence.

Ojha S, Balaji V, Sadek B, Rajesh M.

Eur Rev Med Pharmacol Sci. 2017 Jun;21(11):2769-2783. Review.


Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats.

Sadek B, Oz M, Nurulain SM, Jayaprakash P, Latacz G, Kieć-Kononowicz K, Szymańska E.

Epilepsy Res. 2017 Dec;138:124-131. doi: 10.1016/j.eplepsyres.2017.05.008. Epub 2017 May 26.


Thujone inhibits the function of α7-nicotinic acetylcholine receptors and impairs nicotine-induced memory enhancement in one-trial passive avoidance paradigm.

Sultan A, Yang KS, Isaev D, Nebrisi EE, Syed N, Khan N, Howarth CF, Sadek B, Oz M.

Toxicology. 2017 Jun 1;384:23-32. doi: 10.1016/j.tox.2017.04.005. Epub 2017 Apr 7.


Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, Stark H, Kieć-Kononowicz K.

Drug Des Devel Ther. 2016 Nov 25;10:3879-3898. eCollection 2016.


Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists.

Sadek B, Saad A, Schwed JS, Weizel L, Walter M, Stark H.

Drug Des Devel Ther. 2016 Nov 7;10:3633-3651. eCollection 2016.


Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity.

Ojha S, Venkataraman B, Kurdi A, Mahgoub E, Sadek B, Rajesh M.

Oxid Med Cell Longev. 2016;2016:4320374. Epub 2016 Sep 27. Review.


The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats.

Sadek B, Khan N, Darras FH, Pockes S, Decker M.

Physiol Behav. 2016 Oct 15;165:383-91. doi: 10.1016/j.physbeh.2016.08.022. Epub 2016 Aug 24.


Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases.

Sadek B, Saad A, Sadeq A, Jalal F, Stark H.

Behav Brain Res. 2016 Oct 1;312:415-30. doi: 10.1016/j.bbr.2016.06.051. Epub 2016 Jun 27. Review.


Phytochemicals as Prototypes for Pharmaceutical Leads Towards Drug Development Against Diabetic Cardiomyopathy.

Ojha S, Kurdi A, Sadek B, Kaleem M, Cai L, Kamal MA, Rajesh M.

Curr Pharm Des. 2016;22(20):3058-70. Review.


Inhibition of human α7 nicotinic acetylcholine receptors by cyclic monoterpene carveol.

Lozon Y, Sultan A, Lansdell SJ, Prytkova T, Sadek B, Yang KH, Howarth FC, Millar NS, Oz M.

Eur J Pharmacol. 2016 Apr 5;776:44-51. doi: 10.1016/j.ejphar.2016.02.004. Epub 2016 Feb 2.


Protective effects of the antihistamine promethazine aginst acute paraxon-methyl and dicrotophos toxicity in adult rats.

Nurulain SM, Ojha S, Shafiullah M, Khan N, Oz M, Sadek B.

Int J Clin Exp Med. 2015 Oct 15;8(10):17891-901. eCollection 2015.


Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.

Sharma C, Sadek B, Goyal SN, Sinha S, Kamal MA, Ojha S.

Evid Based Complement Alternat Med. 2015;2015:238482. doi: 10.1155/2015/238482. Epub 2015 Nov 17. Review.


Long-term outcomes among breast cancer patients with extensive regional lymph node involvement: implications for locoregional management.

Braunstein LZ, Galland-Girodet S, Goldberg S, Warren LE, Sadek BT, Shenouda MN, Abi-Raad RF, MacDonald SM, Taghian AG.

Breast Cancer Res Treat. 2015 Dec;154(3):633-9. doi: 10.1007/s10549-015-3642-6. Epub 2015 Nov 20.


Cherry-picked ligands at histamine receptor subtypes.

Sadek B, Stark H.

Neuropharmacology. 2016 Jul;106:56-73. doi: 10.1016/j.neuropharm.2015.11.005. Epub 2015 Nov 12. Review.


Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats.

Sadek B, Saad A, Subramanian D, Shafiullah M, Łażewska D, Kieć-Kononowiczc K.

Neuropharmacology. 2016 Jul;106:46-55. doi: 10.1016/j.neuropharm.2015.10.023. Epub 2015 Oct 23.


The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.

Khan N, Saad A, Nurulain SM, Darras FH, Decker M, Sadek B.

Behav Brain Res. 2016 Jan 15;297:155-64. doi: 10.1016/j.bbr.2015.10.022. Epub 2015 Oct 20.


Is a higher boost dose of radiation necessary after breast-conserving therapy for patients with breast cancer with final close or positive margins?

Sadek BT, Homayounfar G, Abi Raad RF, Niemierko A, Shenouda MN, Keruakous AR, Specht MC, Taghian AG.

Breast Cancer Res Treat. 2015 Nov;154(1):71-9. doi: 10.1007/s10549-015-3579-9. Epub 2015 Sep 29.


Investigation of cyclooxygenase and signaling pathways involved in human platelet aggregation mediated by synergistic interaction of various agonists.

Khan N, Farooq AD, Sadek B.

Drug Des Devel Ther. 2015 Jul 6;9:3497-506. doi: 10.2147/DDDT.S84335. eCollection 2015.


The novel non-imidazole histamine H3 receptor antagonist DL77 reduces voluntary alcohol intake and ethanol-induced conditioned place preference in mice.

Bahi A, Sadek B, Nurulain SM, Łażewska D, Kieć-Kononowicz K.

Physiol Behav. 2015 Nov 1;151:189-97. doi: 10.1016/j.physbeh.2015.07.012. Epub 2015 Jul 10.


Radiation therapy risk factors for development of lymphedema in patients treated with regional lymph node irradiation for breast cancer.

Chandra RA, Miller CL, Skolny MN, Warren LE, Horick N, Jammallo LS, Sadek BT, Shenouda MN, O'Toole J, Specht MC, Taghian AG.

Int J Radiat Oncol Biol Phys. 2015 Mar 15;91(4):760-4. doi: 10.1016/j.ijrobp.2014.12.029.


Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study.

Miller CL, Colwell AS, Horick N, Skolny MN, Jammallo LS, O'Toole JA, Shenouda MN, Sadek BT, Swaroop MN, Ferguson CM, Smith BL, Specht MC, Taghian AG.

Ann Surg. 2016 Feb;263(2):399-405. doi: 10.1097/SLA.0000000000001128.


Influence of capsule shell composition on the performance indicators of hypromellose capsule in comparison to hard gelatin capsules.

Al-Tabakha MM, Arida AI, Fahelelbom KM, Sadek B, Saeed DA, Abu Jarad RA, Jawadi J.

Drug Dev Ind Pharm. 2015;41(10):1726-37. doi: 10.3109/03639045.2014.1002409. Epub 2015 Jan 14.


Outcome following local-regional recurrence in women with early-stage breast cancer: impact of biologic subtype.

Braunstein LZ, Niemierko A, Shenouda MN, Truong L, Sadek BT, Abi Raad R, Wong JS, Punglia RS, Taghian AG, Bellon JR.

Breast J. 2015 Mar-Apr;21(2):161-7. doi: 10.1111/tbj.12371. Epub 2015 Jan 6.


Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors.

Sadek B, Khanian SS, Ashoor A, Prytkova T, Ghattas MA, Atatreh N, Nurulain SM, Yang KH, Howarth FC, Oz M.

Eur J Pharmacol. 2015 Jan 5;746:308-16. doi: 10.1016/j.ejphar.2014.10.046. Epub 2014 Nov 8.


Deep inspiration breath-hold technique in left-sided breast cancer radiation therapy: Evaluating cardiac contact distance as a predictor of cardiac exposure for patient selection.

Rochet N, Drake JI, Harrington K, Wolfgang JA, Napolitano B, Sadek BT, Shenouda MN, Keruakous AR, Niemierko A, Taghian AG.

Pract Radiat Oncol. 2015 May-Jun;5(3):e127-34. doi: 10.1016/j.prro.2014.08.003. Epub 2014 Sep 26.


Drug-likeness approach of 2-aminopyrimidines as histamine H3 receptor ligands.

Sadek B, Schreeb A, Schwed JS, Weizel L, Stark H.

Drug Des Devel Ther. 2014 Sep 19;8:1499-513. doi: 10.2147/DDDT.S66179. eCollection 2014.


Studies on molecular properties prediction and histamine H3 receptor affinities of novel ligands with uracil-based motifs.

Lipani L, Odadzic D, Weizel L, Schwed JS, Sadek B, Stark H.

Eur J Med Chem. 2014 Oct 30;86:578-88. doi: 10.1016/j.ejmech.2014.09.011. Epub 2014 Sep 6.


The impact of isolated tumor cells on loco-regional recurrence in breast cancer patients treated with breast-conserving treatment or mastectomy without post-mastectomy radiation therapy.

Keruakous AR, Sadek BT, Shenouda MN, Niemierko A, Abi Raad RF, Specht M, Smith BL, Taghian AG.

Breast Cancer Res Treat. 2014 Jul;146(2):365-70. doi: 10.1007/s10549-014-3027-2. Epub 2014 Jun 22.


Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H₃ receptor antagonist ST-1283.

Bahi A, Schwed JS, Walter M, Stark H, Sadek B.

Drug Des Devel Ther. 2014 May 28;8:627-37. doi: 10.2147/DDDT.S63088. eCollection 2014.


Locoregional recurrence and survival outcomes by type of local therapy and trastuzumab use among women with node-negative, HER2-positive breast cancer.

Peterson DJ, Truong PT, Sadek BT, Alexander CS, Wiksyk B, Shenouda M, Raad RA, Taghian AG.

Ann Surg Oncol. 2014 Oct;21(11):3490-6. doi: 10.1245/s10434-014-3767-6. Epub 2014 May 20.


Anticonvulsive effect of nonimidazole histamine H3 receptor antagonists.

Sadek B, Kuder K, Subramanian D, Shafiullah M, Stark H, Lażewska D, Adem A, Kieć-Kononowicz K.

Behav Pharmacol. 2014 Jun;25(3):245-52. doi: 10.1097/FBP.0000000000000042.


SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.

Handzlik J, Bojarski AJ, Satała G, Kubacka M, Sadek B, Ashoor A, Siwek A, Więcek M, Kucwaj K, Filipek B, Kieć-Kononowicz K.

Eur J Med Chem. 2014 May 6;78:324-39. doi: 10.1016/j.ejmech.2014.01.065. Epub 2014 Mar 18.


Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties.

Sadek B, Schwed JS, Subramanian D, Weizel L, Walter M, Adem A, Stark H.

Eur J Med Chem. 2014 Apr 22;77:269-79. doi: 10.1016/j.ejmech.2014.03.014. Epub 2014 Mar 6.


Risk of lymphedema after mastectomy: potential benefit of applying ACOSOG Z0011 protocol to mastectomy patients.

Miller CL, Specht MC, Skolny MN, Horick N, Jammallo LS, O'Toole J, Shenouda MN, Sadek BT, Smith BL, Taghian AG.

Breast Cancer Res Treat. 2014 Feb;144(1):71-7. doi: 10.1007/s10549-014-2856-3. Epub 2014 Feb 6.


Clinical outcome of isolated locoregional recurrence in patients with breast cancer according to their primary local treatment.

Shenouda MN, Sadek BT, Goldberg SI, Keruakous AR, Croft BJ, Abi Raad RF, Taghian AG.

Clin Breast Cancer. 2014 Jun;14(3):198-204. doi: 10.1016/j.clbc.2013.12.007. Epub 2013 Dec 27.


The impact of radiation therapy on the risk of lymphedema after treatment for breast cancer: a prospective cohort study.

Warren LE, Miller CL, Horick N, Skolny MN, Jammallo LS, Sadek BT, Shenouda MN, O'Toole JA, MacDonald SM, Specht MC, Taghian AG.

Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):565-71. doi: 10.1016/j.ijrobp.2013.11.232. Epub 2014 Jan 7.


Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives.

Sadek B, Alisch R, Buschauer A, Elz S.

Molecules. 2013 Nov 15;18(11):14186-202. doi: 10.3390/molecules181114186.

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