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Items: 1 to 50 of 84

1.

Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.

Shutinoski B, Hakimi M, Harmsen IE, Lunn M, Rocha J, Lengacher N, Zhou YY, Khan J, Nguyen A, Hake-Volling Q, El-Kodsi D, Li J, Alikashani A, Beauchamp C, Majithia J, Coombs K, Shimshek D, Marcogliese PC, Park DS, Rioux JD, Philpott DJ, Woulfe JM, Hayley S, Sad S, Tomlinson JJ, Brown EG, Schlossmacher MG.

Sci Transl Med. 2019 Sep 25;11(511). pii: eaas9292. doi: 10.1126/scitranslmed.aas9292.

PMID:
31554740
2.

Ripk3 licenced protection against microbial infection in the absence of Caspase1-11 inflammasome.

Shutinoski B, Patel R, Tomlinson JJ, Schlossmacher MG, Sad S.

Microbes Infect. 2019 Aug 17. pii: S1286-4579(19)30085-1. doi: 10.1016/j.micinf.2019.08.002. [Epub ahead of print]

PMID:
31430539
3.

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles.

Losier TT, Akuma M, McKee-Muir OC, LeBlond ND, Suk Y, Alsaadi RM, Guo Z, Reshke R, Sad S, Campbell-Valois FX, Gibbings DJ, Fullerton MD, Russell RC.

Cell Rep. 2019 Feb 19;26(8):2150-2165.e5. doi: 10.1016/j.celrep.2019.01.062.

4.

Type I interferons differentially modulate maternal host immunity to infection by Listeria monocytogenes and Salmonella enterica serovar Typhimurium during pregnancy.

Agbayani G, Wachholz K, Murphy SP, Sad S, Krishnan L.

Am J Reprod Immunol. 2019 Jan;81(1):e13068. doi: 10.1111/aji.13068. Epub 2018 Dec 4.

5.

Critical role for the Ly49 family of class I MHC receptors in adaptive natural killer cell responses.

Wight A, Mahmoud AB, Scur M, Tu MM, Rahim MMA, Sad S, Makrigiannis AP.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11579-11584. doi: 10.1073/pnas.1722374115. Epub 2018 Sep 24.

6.

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.

Rijal D, Ariana A, Wight A, Kim K, Alturki NA, Aamir Z, Ametepe ES, Korneluk RG, Tiedje C, Menon MB, Gaestel M, McComb S, Sad S.

J Biol Chem. 2018 Jul 27;293(30):11913-11927. doi: 10.1074/jbc.RA118.003614. Epub 2018 Jun 13.

7.

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis.

Alturki NA, McComb S, Ariana A, Rijal D, Korneluk RG, Sun SC, Alnemri E, Sad S.

Cell Death Dis. 2018 May 22;9(6):592. doi: 10.1038/s41419-018-0672-0.

8.

Lack of functional selectin-ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection.

Agbayani G, Gurnani K, Zafer A, Sad S, Krishnan L.

J Leukoc Biol. 2018 Feb;103(2):355-368. doi: 10.1002/JLB.4A1216-499R. Epub 2017 Dec 27.

PMID:
29345354
9.

Brief Communication; A Heterologous Oncolytic Bacteria-Virus Prime-Boost Approach for Anticancer Vaccination in Mice.

Aitken AS, Roy DG, Martin NT, Sad S, Bell JC, Bourgeois-Daigneault MC.

J Immunother. 2018 Apr;41(3):125-129. doi: 10.1097/CJI.0000000000000208.

10.

Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells.

Patel R, Kim K, Shutinoski B, Wachholz K, Krishnan L, Sad S.

Cell Death Differ. 2017 Nov;24(11):1900-1911. doi: 10.1038/cdd.2017.112. Epub 2017 Jul 7.

11.

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects.

Tomlinson JJ, Shutinoski B, Dong L, Meng F, Elleithy D, Lengacher NA, Nguyen AP, Cron GO, Jiang Q, Roberson ED, Nussbaum RL, Majbour NK, El-Agnaf OM, Bennett SA, Lagace DC, Woulfe JM, Sad S, Brown EG, Schlossmacher MG.

J Neural Transm (Vienna). 2017 Jun;124(6):721-738. doi: 10.1007/s00702-017-1726-7. Epub 2017 May 5.

12.

Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy mice.

Deguise MO, De Repentigny Y, McFall E, Auclair N, Sad S, Kothary R.

Hum Mol Genet. 2017 Feb 15;26(4):801-819. doi: 10.1093/hmg/ddw434.

13.

Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium.

Joseph J, Ametepe ES, Haribabu N, Agbayani G, Krishnan L, Blais A, Sad S.

Nat Commun. 2016 Sep 7;7:12748. doi: 10.1038/ncomms12748.

14.

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis.

Karunakaran D, Geoffrion M, Wei L, Gan W, Richards L, Shangari P, DeKemp EM, Beanlands RA, Perisic L, Maegdefessel L, Hedin U, Sad S, Guo L, Kolodgie FD, Virmani R, Ruddy T, Rayner KJ.

Sci Adv. 2016 Jul 22;2(7):e1600224. doi: 10.1126/sciadv.1600224. eCollection 2016 Jul.

15.

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.

Shutinoski B, Alturki NA, Rijal D, Bertin J, Gough PJ, Schlossmacher MG, Sad S.

Cell Death Differ. 2016 Oct;23(10):1628-37. doi: 10.1038/cdd.2016.51. Epub 2016 Jun 3.

16.

Clinical Isolates of Pseudomonas aeruginosa from Chronically Infected Cystic Fibrosis Patients Fail To Activate the Inflammasome during Both Stable Infection and Pulmonary Exacerbation.

Huus KE, Joseph J, Zhang L, Wong A, Aaron SD, Mah TF, Sad S.

J Immunol. 2016 Apr 1;196(7):3097-108. doi: 10.4049/jimmunol.1501642. Epub 2016 Feb 19.

17.

Transcription factor Batf3 is important for development of CD8+ T-cell response against a phagosomal bacterium regardless of the location of antigen.

Patel R, Sad S.

Immunol Cell Biol. 2016 Apr;94(4):378-87. doi: 10.1038/icb.2015.98. Epub 2015 Dec 8.

PMID:
26567886
18.

A Highly Effective Component Vaccine against Nontyphoidal Salmonella enterica Infections.

Ferreira RB, Valdez Y, Coombes BK, Sad S, Gouw JW, Brown EM, Li Y, Grassl GA, Antunes LC, Gill N, Truong M, Scholz R, Reynolds LA, Krishnan L, Zafer AA, Sal-Man N, Lowden MJ, Auweter SD, Foster LJ, Finlay BB.

mBio. 2015 Sep 22;6(5):e01421-15. doi: 10.1128/mBio.01421-15.

19.

VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection.

Arulanandam R, Batenchuk C, Angarita FA, Ottolino-Perry K, Cousineau S, Mottashed A, Burgess E, Falls TJ, De Silva N, Tsang J, Howe GA, Bourgeois-Daigneault MC, Conrad DP, Daneshmand M, Breitbach CJ, Kirn DH, Raptis L, Sad S, Atkins H, Huh MS, Diallo JS, Lichty BD, Ilkow CS, Le Boeuf F, Addison CL, McCart JA, Bell JC.

Cancer Cell. 2015 Aug 10;28(2):210-24. doi: 10.1016/j.ccell.2015.06.009. Epub 2015 Jul 23.

20.

Complexed soluble IL-7 receptor α and IL-7 increase IL-7-mediated proliferation and viability of CD8⁺ T-cells in vitro.

Côté S, Matte J, Sad S, Angel JB, Crawley AM.

Cell Immunol. 2015 Feb;293(2):122-5. doi: 10.1016/j.cellimm.2015.01.001. Epub 2015 Jan 10.

PMID:
25596474
21.

Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.

McComb S, Cessford E, Alturki NA, Joseph J, Shutinoski B, Startek JB, Gamero AM, Mossman KL, Sad S.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3206-13. doi: 10.1073/pnas.1407068111. Epub 2014 Jul 21.

22.

Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase.

McComb S, Shutinoski B, Thurston S, Cessford E, Kumar K, Sad S.

J Immunol. 2014 Jun 15;192(12):5671-8. doi: 10.4049/jimmunol.1303380. Epub 2014 May 5.

23.

Perioperative influenza vaccination reduces postoperative metastatic disease by reversing surgery-induced dysfunction in natural killer cells.

Tai LH, Zhang J, Scott KJ, de Souza CT, Alkayyal AA, Ananth AA, Sahi S, Adair RA, Mahmoud AB, Sad S, Bell JC, Makrigiannis AP, Melcher AA, Auer RC.

Clin Cancer Res. 2013 Sep 15;19(18):5104-15. doi: 10.1158/1078-0432.CCR-13-0246. Epub 2013 Jul 23.

24.

IL-10 produced by trophoblast cells inhibits phagosome maturation leading to profound intracellular proliferation of Salmonella enterica Typhimurium.

Nguyen T, Robinson N, Allison SE, Coombes BK, Sad S, Krishnan L.

Placenta. 2013 Sep;34(9):765-74. doi: 10.1016/j.placenta.2013.06.003. Epub 2013 Jul 5.

25.

Intrinsic role of FoxO3a in the development of CD8+ T cell memory.

Tzelepis F, Joseph J, Haddad EK, Maclean S, Dudani R, Agenes F, Peng SL, Sekaly RP, Sad S.

J Immunol. 2013 Feb 1;190(3):1066-75. doi: 10.4049/jimmunol.1200639. Epub 2012 Dec 31.

26.

Modulation of antigenic location converts chronic into acute infection by forcing CD8+ T cell recognition.

Tzelepis F, Alcon V, Dudani R, Gurnani K, Zafer A, Everson ES, Young KG, Rüssmann H, Krishnan L, Sad S.

Cell Rep. 2012 Dec 27;2(6):1710-21. doi: 10.1016/j.celrep.2012.10.024. Epub 2012 Dec 6.

27.

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium.

Robinson N, McComb S, Mulligan R, Dudani R, Krishnan L, Sad S.

Nat Immunol. 2012 Oct;13(10):954-62. doi: 10.1038/ni.2397. Epub 2012 Aug 26.

28.

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.

McComb S, Cheung HH, Korneluk RG, Wang S, Krishnan L, Sad S.

Cell Death Differ. 2012 Nov;19(11):1791-801. doi: 10.1038/cdd.2012.59. Epub 2012 May 11.

29.

A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders.

Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J.

Protein Eng Des Sel. 2012 Jun;25(6):313-8. doi: 10.1093/protein/gzs014. Epub 2012 Apr 6.

PMID:
22490957
30.

Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.

Stark FC, Gurnani K, Sad S, Krishnan L.

PLoS One. 2012;7(2):e32211. doi: 10.1371/journal.pone.0032211. Epub 2012 Feb 16.

31.

CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system.

Young KG, Maclean S, Dudani R, Krishnan L, Sad S.

J Immunol. 2011 Aug 1;187(3):1192-200. doi: 10.4049/jimmunol.1100695. Epub 2011 Jun 29.

32.

Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo.

McComb S, Mulligan R, Sad S.

PLoS One. 2010 Dec 22;5(12):e15328. doi: 10.1371/journal.pone.0015328.

33.

Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease.

Chattopadhyay A, Robinson N, Sandhu JK, Finlay BB, Sad S, Krishnan L.

Infect Immun. 2010 May;78(5):2292-301. doi: 10.1128/IAI.01186-09. Epub 2010 Mar 1.

34.

IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells.

Russell MS, Dudani R, Krishnan L, Sad S.

J Immunol. 2009 Dec 15;183(12):7710-8. doi: 10.4049/jimmunol.0901274.

35.

Pregnancy does not deter the development of a potent maternal protective CD8+ T-cell acquired immune response against Listeria monocytogenes despite preferential placental colonization.

Krishnan L, Pejcic-Karapetrovic B, Gurnani K, Zafer A, Sad S.

Am J Reprod Immunol. 2010 Jan;63(1):54-65. doi: 10.1111/j.1600-0897.2009.00766.x. Epub 2009 Nov 12.

PMID:
19912156
36.

Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction.

Wong CE, Sad S, Coombes BK.

Infect Immun. 2009 Nov;77(11):4750-60. doi: 10.1128/IAI.00545-09. Epub 2009 Aug 31.

37.

Selectively reduced intracellular proliferation of Salmonella enterica serovar typhimurium within APCs limits antigen presentation and development of a rapid CD8 T cell response.

Albaghdadi H, Robinson N, Finlay B, Krishnan L, Sad S.

J Immunol. 2009 Sep 15;183(6):3778-87. doi: 10.4049/jimmunol.0900843. Epub 2009 Aug 19.

38.

Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection.

Stark FC, Sad S, Krishnan L.

Cancer Res. 2009 May 15;69(10):4327-34. doi: 10.1158/0008-5472.CAN-08-3160. Epub 2009 May 12.

39.
40.

Effects of different intensities of resistance exercise on hemodynamic variations in young adults.

Bittencourt PF, Sad S, Pereira R, Machado M.

Rev Port Cardiol. 2008 Jan;27(1):55-64. English, Portuguese.

PMID:
18447037
41.

Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells.

Sad S, Dudani R, Gurnani K, Russell M, van Faassen H, Finlay B, Krishnan L.

J Immunol. 2008 May 1;180(9):5853-61.

42.

Mutation in the Fas pathway impairs CD8+ T cell memory.

Dudani R, Russell M, van Faassen H, Krishnan L, Sad S.

J Immunol. 2008 Mar 1;180(5):2933-41.

43.

Pregnancy impairs the innate immune resistance to Salmonella typhimurium leading to rapid fatal infection.

Pejcic-Karapetrovic B, Gurnani K, Russell MS, Finlay BB, Sad S, Krishnan L.

J Immunol. 2007 Nov 1;179(9):6088-96.

44.
45.
46.

Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.

Luu RA, Gurnani K, Dudani R, Kammara R, van Faassen H, Sirard JC, Krishnan L, Sad S.

J Immunol. 2006 Aug 1;177(3):1516-25.

47.

Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.

Saito K, Yajima T, Kumabe S, Doi T, Yamada H, Sad S, Shen H, Yoshikai Y.

J Immunol. 2006 Feb 15;176(4):2496-504.

48.

Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.

Winau F, Weber S, Sad S, de Diego J, Hoops SL, Breiden B, Sandhoff K, Brinkmann V, Kaufmann SH, Schaible UE.

Immunity. 2006 Jan;24(1):105-17.

49.

IL-15 regulates CD8+ T cell contraction during primary infection.

Yajima T, Yoshihara K, Nakazato K, Kumabe S, Koyasu S, Sad S, Shen H, Kuwano H, Yoshikai Y.

J Immunol. 2006 Jan 1;176(1):507-15.

50.

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