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Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure.

Luzum JA, Ting C, Peterson EL, Gui H, Shugg T, Williams LK, Li L, Sadee W, Wang D, Lanfear DE.

Cardiovasc Drugs Ther. 2019 Dec;33(6):693-700. doi: 10.1007/s10557-019-06909-6.


Ligand-Free Estrogen Receptor α (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver.

Wang D, Lu R, Rempala G, Sadee W.

Mol Pharmacol. 2019 Oct;96(4):430-440. doi: 10.1124/mol.119.116897. Epub 2019 Aug 9.


Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population.

Jabeen S, Pinsonneault JK, Sadee W, Lee SH, Zafar MM, Raja MS, Raja GK.

Ann Hum Genet. 2019 Sep;83(5):367-372. doi: 10.1111/ahg.12322. Epub 2019 Apr 26.


Association of Genetic Polymorphisms in the Beta-1 Adrenergic Receptor with Recovery of Left Ventricular Ejection Fraction in Patients with Heart Failure.

Luzum JA, English JD, Ahmad US, Sun JW, Canan BD, Sadee W, Kitzmiller JP, Binkley PF.

J Cardiovasc Transl Res. 2019 Aug;12(4):280-289. doi: 10.1007/s12265-019-09866-5. Epub 2019 Feb 12.


CYP2D6 haplotypes with enhancer single-nucleotide polymorphism rs5758550 and rs16947 (*2 allele): implications for CYP2D6 genotyping panels.

Ray B, Ozcagli E, Sadee W, Wang D.

Pharmacogenet Genomics. 2019 Feb;29(2):39-47. doi: 10.1097/FPC.0000000000000363.


Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.

Lee SH, Ahn WY, Seweryn M, Sadee W.

BMC Genomics. 2018 Nov 20;19(1):826. doi: 10.1186/s12864-018-5219-3.


Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.

Wang D, Hartmann K, Seweryn M, Sadee W.

Circ Genom Precis Med. 2018 Oct;11(10):e002082. doi: 10.1161/CIRCGEN.118.002082.


Testing genetic modifiers of behavior and response to atomoxetine in autism spectrum disorder with ADHD.

Barrie ES, Pinsonneault JK, Sadee W, Hollway JA, Handen BL, Smith T, Arnold LE, Butter E, Hansen-Kiss E, Herman GE, Aman MG.

J Dev Phys Disabil. 2018 Jun;30(3):355-371. doi: 10.1007/s10882-018-9590-4. Epub 2018 Mar 5.


IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.

Locke LW, Crouser ED, White P, Julian MW, Caceres EG, Papp AC, Le VT, Sadee W, Schlesinger LS.

Am J Respir Cell Mol Biol. 2019 Jan;60(1):84-95. doi: 10.1165/rcmb.2018-0053OC.


Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

Sá ACC, Webb A, Gong Y, McDonough CW, Shahin MH, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA.

BMC Med Genomics. 2018 Jun 20;11(1):55. doi: 10.1186/s12920-018-0370-x.


AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection.

Papp AC, Azad AK, Pietrzak M, Williams A, Handelman SK, Igo RP Jr, Stein CM, Hartmann K, Schlesinger LS, Sadee W.

PLoS One. 2018 May 30;13(5):e0198221. doi: 10.1371/journal.pone.0198221. eCollection 2018.


Alpha-synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3'UTR.

Barrie ES, Lee SH, Frater JT, Kataki M, Scharre DW, Sadee W.

Mol Genet Genomic Med. 2018 May 6. doi: 10.1002/mgg3.407. [Epub ahead of print]


Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).

McDonough CW, Magvanjav O, Sá ACC, El Rouby NM, Dave C, Deitchman AN, Kawaguchi-Suzuki M, Mei W, Shen Y, Singh RSP, Solayman M, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, Webb A, Scherer SE, Sadee W, Turner ST, Cooper-DeHoff RM, Gong Y, Johnson JA.

Circ Genom Precis Med. 2018 Apr;11(4):e001854. doi: 10.1161/CIRCGEN.117.001854.


Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.

Sá ACC, Webb A, Gong Y, McDonough CW, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA.

Sci Rep. 2017 Nov 22;7(1):16068. doi: 10.1038/s41598-017-16343-z.


Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis.

Pyle CJ, Azad AK, Papp AC, Sadee W, Knoell DL, Schlesinger LS.

Int J Mol Sci. 2017 Nov 9;18(11). pii: E2375. doi: 10.3390/ijms18112375. Review.


Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile.

Lavalett L, Rodriguez H, Ortega H, Sadee W, Schlesinger LS, Barrera LF.

Tuberculosis (Edinb). 2017 Dec;107:156-167. doi: 10.1016/ Epub 2017 Sep 18.


Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research.

Sá ACC, Sadee W, Johnson JA.

Clin Transl Sci. 2018 Mar;11(2):153-161. doi: 10.1111/cts.12511. Epub 2017 Oct 23. Review. No abstract available.


Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits.

Pinsonneault JK, Frater JT, Kompa B, Mascarenhas R, Wang D, Sadee W.

PLoS One. 2017 Jun 15;12(6):e0179020. doi: 10.1371/journal.pone.0179020. eCollection 2017.


A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.

Crouser ED, White P, Caceres EG, Julian MW, Papp AC, Locke LW, Sadee W, Schlesinger LS.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):487-498. doi: 10.1165/rcmb.2016-0321OC.


Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care.

Sadee W.

Pharm Res. 2017 Aug;34(8):1535-1538. doi: 10.1007/s11095-017-2170-y. Epub 2017 May 10. No abstract available.


Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq.

Suhy AM, Webb A, Papp AC, Geier EG, Sadee W.

Eur J Pharm Sci. 2017 May 30;103:47-51. doi: 10.1016/j.ejps.2017.02.010. Epub 2017 Feb 7.


CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure.

Luzum JA, Sweet KM, Binkley PF, Schmidlen TJ, Jarvis JP, Christman MF, Sadee W, Kitzmiller JP.

Pharm Res. 2017 Aug;34(8):1615-1625. doi: 10.1007/s11095-017-2104-8. Epub 2017 Feb 8.


Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart.

Li L, Zhang L, Binkley PF, Sadee W, Wang D.

Pharm Res. 2017 Aug;34(8):1648-1657. doi: 10.1007/s11095-017-2102-x. Epub 2017 Jan 24.


Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.

Shahin MH, Sá AC, Webb A, Gong Y, Langaee T, McDonough CW, Riva A, Beitleshees AL, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Scherer SE, Sadee W, Cooper-DeHoff RM, Johnson JA.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001404. doi: 10.1161/CIRCGENETICS.116.001404.


The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.

Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, O'Donnell PH, Altman RB, Pereira N, Ratain MJ, Roden DM, Embi PJ, Sadee W, Klein TE, Johnson JA, Relling MV, Wang L, Weinshilboum RM, Shuldiner AR, Freimuth RR; Pharmacogenomics Research Network Translational Pharmacogenetics Program.

Clin Pharmacol Ther. 2017 Sep;102(3):502-510. doi: 10.1002/cpt.630. Epub 2017 Jun 9.


Erratum to: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles.

Hartmann K, Seweryn M, Handelman SK, Rempała GA, Sadee W.

BMC Genomics. 2016 Dec 2;17(1):988. No abstract available.


The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.

Barrie ES, Hartmann K, Lee SH, Frater JT, Seweryn M, Wang D, Sadee W.

Hum Mutat. 2017 Jan;38(1):112-119. doi: 10.1002/humu.23135. Epub 2016 Nov 7.


Gene expression profiling of brain samples from patients with Lewy body dementia.

Pietrzak M, Papp A, Curtis A, Handelman SK, Kataki M, Scharre DW, Rempala G, Sadee W.

Biochem Biophys Res Commun. 2016 Oct 28;479(4):875-880. doi: 10.1016/j.bbrc.2016.09.114. Epub 2016 Sep 22.


Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles.

Hartmann K, Seweryn M, Handelman SK, Rempała GA, Sadee W.

BMC Genomics. 2016 Sep 17;17(1):738. doi: 10.1186/s12864-016-3075-6. Erratum in: BMC Genomics. 2016 Dec 2;17 (1):988.


Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice.

Oberdick J, Ling Y, Phelps MA, Yudovich MS, Schilling K, Sadee W.

J Pharmacol Exp Ther. 2016 Jul;358(1):22-30. doi: 10.1124/jpet.115.231902. Epub 2016 May 5.


Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice.

Cubells JF, Schroeder JP, Barrie ES, Manvich DF, Sadee W, Berg T, Mercer K, Stowe TA, Liles LC, Squires KE, Mezher A, Curtin P, Perdomo DL, Szot P, Weinshenker D.

PLoS One. 2016 May 5;11(5):e0154864. doi: 10.1371/journal.pone.0154864. eCollection 2016.


Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.

Sanford JC, Wang X, Shi J, Barrie ES, Wang D, Zhu HJ, Sadee W.

Pharmacogenet Genomics. 2016 May;26(5):197-207. doi: 10.1097/FPC.0000000000000206.


Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.

Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE.

Pharmacogenomics J. 2017 Mar;17(2):137-145. doi: 10.1038/tpj.2015.93. Epub 2016 Feb 9.


RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles.

Webb A, Papp AC, Curtis A, Newman LC, Pietrzak M, Seweryn M, Handelman SK, Rempala GA, Wang D, Graziosa E, Tyndale RF, Lerman C, Kelsoe JR, Mash DC, Sadee W.

BMC Genomics. 2015 Nov 23;16:990. doi: 10.1186/s12864-015-2207-8.


CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing.

Wang D, Sadee W.

Pharmacogenet Genomics. 2016 Jan;26(1):40-3. doi: 10.1097/FPC.0000000000000183.


The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics.

Higgins GA, Allyn-Feuer A, Handelman S, Sadee W, Athey BD.

Pharmacogenomics. 2015;16(14):1649-69. doi: 10.2217/pgs.15.111. Epub 2015 Sep 4. Review.


Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms.

Mascarenhas R, Pietrzak M, Smith RM, Webb A, Wang D, Papp AC, Pinsonneault JK, Seweryn M, Rempala G, Sadee W.

PLoS One. 2015 Sep 2;10(9):e0136798. doi: 10.1371/journal.pone.0136798. eCollection 2015.


Analyzing allele specific RNA expression using mixture models.

Lu R, Smith RM, Seweryn M, Wang D, Hartmann K, Webb A, Sadee W, Rempala GA.

BMC Genomics. 2015 Aug 1;16:566. doi: 10.1186/s12864-015-1749-0.


Working memory in pregnant women: Relation to estrogen and antepartum depression.

Hampson E, Phillips SD, Duff-Canning SJ, Evans KL, Merrill M, Pinsonneault JK, Sadée W, Soares CN, Steiner M.

Horm Behav. 2015 Aug;74:218-27. doi: 10.1016/j.yhbeh.2015.07.006. Epub 2015 Jul 15.


Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations.

Luzum JA, Theusch E, Taylor KD, Wang A, Sadee W, Binkley PF, Krauss RM, Medina MW, Kitzmiller JP.

J Cardiovasc Pharmacol. 2015 Jul;66(1):80-5. doi: 10.1097/FJC.0000000000000246.


Conditional entropy in variation-adjusted windows detects selection signatures associated with expression quantitative trait loci (eQTLs).

Handelman SK, Seweryn M, Smith RM, Hartmann K, Wang D, Pietrzak M, Johnson AD, Kloczkowski A, Sadee W.

BMC Genomics. 2015;16 Suppl 8:S8. doi: 10.1186/1471-2164-16-S8-S8. Epub 2015 Jun 18.


Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616.

Suhy A, Hartmann K, Papp AC, Wang D, Sadee W.

Pharmacogenet Genomics. 2015 Aug;25(8):394-401. doi: 10.1097/FPC.0000000000000151.


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing.

Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, MacPhee IA.

Clin Pharmacol Ther. 2015 Jul;98(1):19-24. doi: 10.1002/cpt.113. Epub 2015 Jun 3.


Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies.

Handelman SK, Aaronson JM, Seweryn M, Voronkin I, Kwiek JJ, Sadee W, Verducci JS, Janies DA.

Comput Biol Med. 2015 Mar;58:1-13. doi: 10.1016/j.compbiomed.2014.12.013. Epub 2014 Dec 24.


Genomic architecture of pharmacological efficacy and adverse events.

Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA.

Pharmacogenomics. 2014 Dec;15(16):2025-48. doi: 10.2217/pgs.14.144. Review.


Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.

Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, Norman GJ, Sadee W.

Circ Res. 2014 Dec 5;115(12):1017-25. doi: 10.1161/CIRCRESAHA.116.304398. Epub 2014 Oct 17.


Missing heritability of common diseases and treatments outside the protein-coding exome.

Sadee W, Hartmann K, Seweryn M, Pietrzak M, Handelman SK, Rempala GA.

Hum Genet. 2014 Oct;133(10):1199-215. doi: 10.1007/s00439-014-1476-7. Epub 2014 Aug 9. Review. Erratum in: Hum Genet. 2015 May;134(5):509.


Design and implementation of a randomized controlled trial of genomic counseling for patients with chronic disease.

Sweet K, Gordon ES, Sturm AC, Schmidlen TJ, Manickam K, Toland AE, Keller MA, Stack CB, García-España JF, Bellafante M, Tayal N, Embi P, Binkley P, Hershberger RE, Sadee W, Christman M, Marsh C.

J Pers Med. 2014 Jan 8;4(1):1-19. doi: 10.3390/jpm4010001.


DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory.

Di Giorgio A, Smith RM, Fazio L, D'Ambrosio E, Gelao B, Tomasicchio A, Selvaggi P, Taurisano P, Quarto T, Masellis R, Rampino A, Caforio G, Popolizio T, Blasi G, Sadee W, Bertolino A.

PLoS One. 2014 May 12;9(5):e95997. doi: 10.1371/journal.pone.0095997. eCollection 2014.

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