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Items: 1 to 50 of 123

1.

Cost-Effective, Safe, and Personalized Cell Therapy for Critical Limb Ischemia in Type 2 Diabetes Mellitus.

Soria-Juan B, Escacena N, Capilla-González V, Aguilera Y, Llanos L, Tejedo JR, Bedoya FJ, Juan V, De la Cuesta A, Ruiz-Salmerón R, Andreu E, Grochowicz L, Prósper F, Sánchez-Guijo F, Lozano FS, Miralles M, Del Río-Solá L, Castellanos G, Moraleda JM, Sackstein R, García-Arranz M, García-Olmo D, Martín F, Hmadcha A, Soria B; Collaborative Working Group “Noma Project Team”.

Front Immunol. 2019 Jun 4;10:1151. doi: 10.3389/fimmu.2019.01151. eCollection 2019.

2.

Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis.

Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, Zheng H, Cheung C, Magnani JL, Lin SH, Cristea IM, Sackstein R, Kang Y.

Nat Cell Biol. 2019 May;21(5):627-639. doi: 10.1038/s41556-019-0309-2. Epub 2019 Apr 15.

PMID:
30988423
3.

The First Step in Adoptive Cell Immunotherapeutics: Assuring Cell Delivery via Glycoengineering.

Sackstein R.

Front Immunol. 2019 Jan 11;9:3084. doi: 10.3389/fimmu.2018.03084. eCollection 2018.

4.

Bone marrow mesenchymal stem/stromal cells from risk-stratified acute myeloid leukemia patients are anti-inflammatory in in vivo preclinical models of hematopoietic reconstitution and severe colitis.

de la Guardia RD, Lopez-Millan B, Roca-Ho H, Bueno C, Gutiérrez-Agüera F, Fuster JL, Anguita E, Zanetti SR, Vives S, Nomdedeu J, Sackstein R, Lavoie J, Gónzalez-Rey E, Delgado M, Rosu-Myles M, Menendez P.

Haematologica. 2019 Feb;104(2):e54-e58. doi: 10.3324/haematol.2018.196568. Epub 2018 Sep 20. No abstract available.

5.

Production via good manufacturing practice of exofucosylated human mesenchymal stromal cells for clinical applications.

López-Lucas MD, Pachón-Peña G, García-Hernández AM, Parrado A, Sánchez-Salinas D, García-Bernal D, Algueró MDC, Martinez FI, Blanquer M, Cabañas-Perianes V, Molina-Molina M, Asín-Aguilar C, Moraleda JM, Sackstein R.

Cytotherapy. 2018 Sep;20(9):1110-1123. doi: 10.1016/j.jcyt.2018.07.001. Epub 2018 Aug 29.

PMID:
30170815
6.

Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration.

Videira PA, Silva M, Martin KC, Sackstein R.

J Immunol. 2018 Aug 1;201(3):1030-1043. doi: 10.4049/jimmunol.1800188. Epub 2018 Jun 25.

7.

A functional glycoproteomics approach identifies CD13 as a novel E-selectin ligand in breast cancer.

Carrascal MA, Silva M, Ferreira JA, Azevedo R, Ferreira D, Silva AMN, Ligeiro D, Santos LL, Sackstein R, Videira PA.

Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):2069-2080. doi: 10.1016/j.bbagen.2018.05.013. Epub 2018 May 17.

PMID:
29777742
8.

Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue.

Carrascal MA, Talina C, Borralho P, Gonçalo Mineiro A, Henriques AR, Pen C, Martins M, Braga S, Sackstein R, Videira PA.

BMC Cancer. 2018 May 2;18(1):495. doi: 10.1186/s12885-018-4410-x.

9.

Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.

Mondal N, Dykstra B, Lee J, Ashline DJ, Reinhold VN, Rossi DJ, Sackstein R.

J Biol Chem. 2018 May 11;293(19):7300-7314. doi: 10.1074/jbc.RA117.000775. Epub 2018 Mar 28.

10.

E-Selectin Ligands in the Human Mononuclear Phagocyte System: Implications for Infection, Inflammation, and Immunotherapy.

Silva M, Videira PA, Sackstein R.

Front Immunol. 2018 Jan 19;8:1878. doi: 10.3389/fimmu.2017.01878. eCollection 2017. Review.

11.

Optimizing human Treg immunotherapy by Treg subset selection and E-selectin ligand expression.

Donnelly C, Dykstra B, Mondal N, Huang J, Kaskow BJ, Griffin R, Sackstein R, Baecher-Allan C.

Sci Rep. 2018 Jan 11;8(1):420. doi: 10.1038/s41598-017-17981-z.

12.

Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation.

Carrascal MA, Silva M, Ramalho JS, Pen C, Martins M, Pascoal C, Amaral C, Serrano I, Oliveira MJ, Sackstein R, Videira PA.

Mol Oncol. 2018 May;12(5):579-593. doi: 10.1002/1878-0261.12163. Epub 2018 Mar 30.

13.

Imaging specific cellular glycan structures using glycosyltransferases via click chemistry.

Wu ZL, Person AD, Anderson M, Burroughs B, Tatge T, Khatri K, Zou Y, Wang L, Geders T, Zaia J, Sackstein R.

Glycobiology. 2018 Feb 1;28(2):69-79. doi: 10.1093/glycob/cwx095.

14.

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.

Lee J, Dykstra B, Spencer JA, Kenney LL, Greiner DL, Shultz LD, Brehm MA, Lin CP, Sackstein R, Rossi DJ.

J Clin Invest. 2017 Jun 1;127(6):2433-2437. doi: 10.1172/JCI92030. Epub 2017 May 8.

15.

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy.

Sackstein R, Schatton T, Barthel SR.

Lab Invest. 2017 Jun;97(6):669-697. doi: 10.1038/labinvest.2017.25. Epub 2017 Mar 27. Review.

16.

Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology.

Silva M, Fung RKF, Donnelly CB, Videira PA, Sackstein R.

J Immunol. 2017 May 1;198(9):3576-3587. doi: 10.4049/jimmunol.1601636. Epub 2017 Mar 22.

17.

A Glycovariant of Human CD44 is Characteristically Expressed on Human Mesenchymal Stem Cells.

Pachón-Peña G, Donnelly C, Ruiz-Cañada C, Katz A, Fernández-Veledo S, Vendrell J, Sackstein R.

Stem Cells. 2017 Apr;35(4):1080-1092. doi: 10.1002/stem.2549. Epub 2017 Feb 5.

18.

Leukocyte-borne α(1,3)-fucose is a negative regulator of β2-integrin-dependent recruitment in lung inflammation.

Buffone A Jr, Nasirikenari M, Manhardt CT, Lugade A, Bogner PN, Sackstein R, Thanavala Y, Neelamegham S, Lau JT.

J Leukoc Biol. 2017 Feb;101(2):459-470. doi: 10.1189/jlb.3A0516-215RR. Epub 2016 Aug 26.

19.

Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells.

Dykstra B, Lee J, Mortensen LJ, Yu H, Wu ZL, Lin CP, Rossi DJ, Sackstein R.

Stem Cells. 2016 Oct;34(10):2501-2511. doi: 10.1002/stem.2435. Epub 2016 Jul 17.

20.

Translational glycobiology: Patient-oriented glycoscience research.

Sackstein R.

Glycobiology. 2016 Jun;26(6):544-5. doi: 10.1093/glycob/cww035. No abstract available.

21.

Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology.

Sackstein R.

Glycobiology. 2016 Jun;26(6):560-70. doi: 10.1093/glycob/cww026. Epub 2016 Feb 29. Review.

22.

Training the next generation of biomedical investigators in glycosciences.

Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I.

J Clin Invest. 2016 Feb;126(2):405-8. doi: 10.1172/JCI85905. Epub 2016 Feb 1. Review.

23.

Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis.

Merzaban JS, Imitola J, Starossom SC, Zhu B, Wang Y, Lee J, Ali AJ, Olah M, Abuelela AF, Khoury SJ, Sackstein R.

Glycobiology. 2015 Dec;25(12):1392-409. doi: 10.1093/glycob/cwv046. Epub 2015 Jul 7.

24.

Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells.

Lee J, Dykstra B, Sackstein R, Rossi DJ.

Curr Opin Hematol. 2015 Jul;22(4):317-23. doi: 10.1097/MOH.0000000000000147. Review.

25.

Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay.

Sackstein R, Fuhlbrigge R.

Methods Mol Biol. 2015;1312:399-410. doi: 10.1007/978-1-4939-2694-7_39.

PMID:
26044020
26.

HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice.

Abdi R, Moore R, Sakai S, Donnelly CB, Mounayar M, Sackstein R.

Stem Cells. 2015 May;33(5):1523-31. doi: 10.1002/stem.1948.

27.

G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells.

Silvescu CI, Sackstein R.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10696-701. doi: 10.1073/pnas.1320833111. Epub 2014 Jul 7.

28.

The mechanisms of up-regulation of dendritic cell activity by oxidative stress.

Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R.

J Leukoc Biol. 2014 Aug;96(2):283-93. doi: 10.1189/jlb.3A0113-033RR. Epub 2014 Mar 27.

29.

Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect.

Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R.

Hum Mol Genet. 2014 Jun 1;23(11):2880-7. doi: 10.1093/hmg/ddu001. Epub 2014 Jan 8.

30.

CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.

Peter Y, Sen N, Levantini E, Keller S, Ingenito EP, Ciner A, Sackstein R, Shapiro SD.

J Tissue Eng Regen Med. 2013 Jul;7(7):572-83. doi: 10.1002/term.553. Epub 2012 May 15.

31.

Re: "Ex vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2Rγ(null) mice".

Sackstein R.

Exp Hematol. 2012 Jul;40(7):518-9; author reply 519-20. doi: 10.1016/j.exphem.2012.03.004. Epub 2012 Apr 13. No abstract available.

PMID:
22507642
32.

Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution.

Sackstein R.

Ann N Y Acad Sci. 2012 Apr;1253:193-200. doi: 10.1111/j.1749-6632.2011.06421.x. Epub 2012 Feb 21. Review.

33.

Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.

Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM.

Blood. 2012 Feb 2;119(5):1263-73. doi: 10.1182/blood-2011-05-355628. Epub 2011 Nov 18.

34.

Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration.

Sackstein R.

Ann Biomed Eng. 2012 Apr;40(4):766-76. doi: 10.1007/s10439-011-0461-8. Epub 2011 Nov 9. Review.

35.

CD44 and HCELL: preventing hematogenous metastasis at step 1.

Jacobs PP, Sackstein R.

FEBS Lett. 2011 Oct 20;585(20):3148-58. doi: 10.1016/j.febslet.2011.07.039. Epub 2011 Aug 5. Review.

36.

Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells.

Merzaban JS, Burdick MM, Gadhoum SZ, Dagia NM, Chu JT, Fuhlbrigge RC, Sackstein R.

Blood. 2011 Aug 18;118(7):1774-83. doi: 10.1182/blood-2010-11-320705. Epub 2011 Jun 9.

37.

The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives.

Sackstein R.

Curr Opin Hematol. 2011 Jul;18(4):239-48. doi: 10.1097/MOH.0b013e3283476140. Review.

38.

Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells.

Thankamony SP, Sackstein R.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2258-63. doi: 10.1073/pnas.1018064108. Epub 2011 Jan 21.

39.

Embryonic stem cell-based therapeutics: balancing scientific progress and bioethics.

Chester R, Sackstein R.

Health Matrix Clevel. 2010;20(1):203-17.

PMID:
20862929
40.

Directing stem cell trafficking via GPS.

Sackstein R.

Methods Enzymol. 2010;479:93-105. doi: 10.1016/S0076-6879(10)79005-4.

PMID:
20816161
41.

Hitting the sweet spot for lymphoma.

Sackstein R.

Blood. 2010 Jun 10;115(23):4626-7. doi: 10.1182/blood-2010-03-272955. No abstract available.

42.

Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions.

Lee JY, Buzney CD, Poznansky MC, Sackstein R.

J Leukoc Biol. 2009 Dec;86(6):1285-94. doi: 10.1189/jlb.0309214. Erratum in: J Leukoc Biol. 2010 Mar;87(3):534. Erratum in: J Leukoc Biol. 2010 Mar;87(3):534.

43.

Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration.

Sackstein R.

Immunol Rev. 2009 Jul;230(1):51-74. doi: 10.1111/j.1600-065X.2009.00792.x. Review.

44.

Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay.

Sackstein R, Fuhlbrigge R.

Methods Mol Biol. 2009;536:343-54. doi: 10.1007/978-1-59745-542-8_36.

45.

Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells.

Nigro J, Wang A, Mukhopadhyay D, Lauer M, Midura RJ, Sackstein R, Hascall VC.

J Biol Chem. 2009 Jun 19;284(25):16832-9. doi: 10.1074/jbc.M109.002956. Epub 2009 Apr 3.

46.

CD15 expression in human myeloid cell differentiation is regulated by sialidase activity.

Gadhoum SZ, Sackstein R.

Nat Chem Biol. 2008 Dec;4(12):751-7. doi: 10.1038/nchembio.116. Epub 2008 Oct 19.

47.

SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia.

Ngo HT, Leleu X, Lee J, Jia X, Melhem M, Runnels J, Moreau AS, Burwick N, Azab AK, Roccaro A, Azab F, Sacco A, Farag M, Sackstein R, Ghobrial IM.

Blood. 2008 Jul 1;112(1):150-8. doi: 10.1182/blood-2007-12-129395. Epub 2008 Apr 30.

48.

L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions.

Resto VA, Burdick MM, Dagia NM, McCammon SD, Fennewald SM, Sackstein R.

J Biol Chem. 2008 Jun 6;283(23):15816-24. doi: 10.1074/jbc.M708899200. Epub 2008 Apr 1.

49.

Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival.

Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA.

Exp Hematol. 2008 Apr;36(4):464-72. doi: 10.1016/j.exphem.2007.12.010. Epub 2008 Feb 8.

50.

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.

Sackstein R, Merzaban JS, Cain DW, Dagia NM, Spencer JA, Lin CP, Wohlgemuth R.

Nat Med. 2008 Feb;14(2):181-7. doi: 10.1038/nm1703. Epub 2008 Jan 13.

PMID:
18193058

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