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The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.

Peng Q, Wu W, Wu KY, Cao B, Qiang C, Li K, Sacks SH, Zhou W.

Kidney Int. 2019 Jul;96(1):117-128. doi: 10.1016/j.kint.2019.01.039. Epub 2019 Mar 4.


Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.

Hernandez-Fuentes MP, Franklin C, Rebollo-Mesa I, Mollon J, Delaney F, Perucha E, Stapleton C, Borrows R, Byrne C, Cavalleri G, Clarke B, Clatworthy M, Feehally J, Fuggle S, Gagliano SA, Griffin S, Hammad A, Higgins R, Jardine A, Keogan M, Leach T, MacPhee I, Mark PB, Marsh J, Maxwell P, McKane W, McLean A, Newstead C, Augustine T, Phelan P, Powis S, Rowe P, Sheerin N, Solomon E, Stephens H, Thuraisingham R, Trembath R, Topham P, Vaughan R, Sacks SH, Conlon P, Opelz G, Soranzo N, Weale ME, Lord GM; United Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3.

Am J Transplant. 2018 Jun;18(6):1370-1379. doi: 10.1111/ajt.14594. Epub 2018 Feb 1.


Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy.

Yiu WH, Li RX, Wong DWL, Wu HJ, Chan KW, Chan LYY, Leung JCK, Lai KN, Sacks SH, Zhou W, Tang SCW.

Nephrol Dial Transplant. 2018 Aug 1;33(8):1323-1332. doi: 10.1093/ndt/gfx336.


C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli.

Li K, Wu KY, Wu W, Wang N, Zhang T, Choudhry N, Song Y, Farrar CA, Ma L, Wei LL, Duan ZY, Dong X, Liu EQ, Li ZF, Sacks SH, Zhou W.

JCI Insight. 2017 Dec 21;2(24). pii: 97626. doi: 10.1172/jci.insight.97626.


Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis.

Wu W, Liu C, Farrar CA, Ma L, Dong X, Sacks SH, Li K, Zhou W.

J Am Soc Nephrol. 2018 Jan;29(1):168-181. doi: 10.1681/ASN.2017050544. Epub 2017 Nov 15.


Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.

Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH.

Sci Rep. 2017 Nov 7;7(1):14625. doi: 10.1038/s41598-017-15212-z.


Structural and functional diversity of collectins and ficolins and their relationship to disease.

Howard M, Farrar CA, Sacks SH.

Semin Immunopathol. 2018 Jan;40(1):75-85. doi: 10.1007/s00281-017-0642-0. Epub 2017 Sep 11. Review.


Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.

Banda NK, Acharya S, Scheinman RI, Mehta G, Takahashi M, Endo Y, Zhou W, Farrar CA, Sacks SH, Fujita T, Sekine H, Holers VM.

J Immunol. 2017 Sep 1;199(5):1835-1845. doi: 10.4049/jimmunol.1700119. Epub 2017 Jul 24.


Complement Recognition Pathways in Renal Transplantation.

Nauser CL, Farrar CA, Sacks SH.

J Am Soc Nephrol. 2017 Sep;28(9):2571-2578. doi: 10.1681/ASN.2017010079. Epub 2017 Jun 29. Review.


A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial.

Kassimatis T, Qasem A, Douiri A, Ryan EG, Rebollo-Mesa I, Nichols LL, Greenlaw R, Olsburgh J, Smith RA, Sacks SH, Drage M.

Trials. 2017 Jun 6;18(1):255. doi: 10.1186/s13063-017-1972-x.


Thrombalexins: Cell-Localized Inhibition of Thrombin and Its Effects in a Model of High-Risk Renal Transplantation.

Karegli J, Melchionna T, Farrar CA, Greenlaw R, Smolarek D, Horsfield C, Charif R, McVey JH, Dorling A, Sacks SH, Smith RA.

Am J Transplant. 2017 Jan;17(1):272-280. doi: 10.1111/ajt.13951. Epub 2016 Aug 8.


The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis.

Choudhry N, Li K, Zhang T, Wu KY, Song Y, Farrar CA, Wang N, Liu CF, Peng Q, Wu W, Sacks SH, Zhou W.

Kidney Int. 2016 Sep;90(3):540-54. doi: 10.1016/j.kint.2016.04.023. Epub 2016 Jun 28.


Role of the lectin complement pathway in kidney transplantation.

Farrar CA, Zhou W, Sacks SH.

Immunobiology. 2016 Oct;221(10):1068-72. doi: 10.1016/j.imbio.2016.05.004. Epub 2016 May 24. Review.


Complement-here, there and everywhere, but what about the transplanted organ?

Montero RM, Sacks SH, Smith RA.

Semin Immunol. 2016 Jun;28(3):250-9. doi: 10.1016/j.smim.2016.04.007. Epub 2016 May 11. Review.


Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury.

Farrar CA, Tran D, Li K, Wu W, Peng Q, Schwaeble W, Zhou W, Sacks SH.

J Clin Invest. 2016 May 2;126(5):1911-25. doi: 10.1172/JCI83000. Epub 2016 Apr 18.


Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome.

Ermini L, Weale ME, Brown KM, Mesa IR, Howell WM, Vaughan R, Chowdhury P, Sacks SH, Sheerin NS.

Immunobiology. 2016 Apr;221(4):528-34. doi: 10.1016/j.imbio.2015.12.006. Epub 2015 Dec 12.


Kinetics of mast cell migration during transplantation tolerance.

Bond G, Nowocin A, Sacks SH, Wong W.

Transpl Immunol. 2015 Jan;32(1):40-5. doi: 10.1016/j.trim.2014.10.004. Epub 2014 Oct 18.


Control of innate immunological mechanisms as a route to drug minimization.

Asgari E, Farrar CA, Sacks SH.

Curr Opin Organ Transplant. 2014 Aug;19(4):342-7. doi: 10.1097/MOT.0000000000000094. Review.


Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

Asgari E, Farrar CA, Lynch N, Ali YM, Roscher S, Stover C, Zhou W, Schwaeble WJ, Sacks SH.

FASEB J. 2014 Sep;28(9):3996-4003. doi: 10.1096/fj.13-246306. Epub 2014 May 27.


Mechanisms of rejection: role of complement.

Farrar CA, Sacks SH.

Curr Opin Organ Transplant. 2014 Feb;19(1):8-13. doi: 10.1097/MOT.0000000000000037. Review.


The innate immune system and transplantation.

Farrar CA, Kupiec-Weglinski JW, Sacks SH.

Cold Spring Harb Perspect Med. 2013 Oct 1;3(10):a015479. doi: 10.1101/cshperspect.a015479. Review.


C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.

Duehrkop C, Banz Y, Spirig R, Miescher S, Nolte MW, Spycher M, Smith RA, Sacks SH, Rieben R.

PLoS One. 2013 Aug 26;8(8):e72059. doi: 10.1371/journal.pone.0072059. eCollection 2013.


The use of eculizumab in renal transplantation.

Barnett AN, Asgari E, Chowdhury P, Sacks SH, Dorling A, Mamode N.

Clin Transplant. 2013 May-Jun;27(3):E216-29. doi: 10.1111/ctr.12102. Epub 2013 Mar 21. Review.


Which pathways trigger the role of complement in ischaemia/reperfusion injury?

Farrar CA, Asgari E, Schwaeble WJ, Sacks SH.

Front Immunol. 2012 Nov 19;3:341. doi: 10.3389/fimmu.2012.00341. eCollection 2012.


Donor specific transplant tolerance is dependent on complement receptors.

Bartel G, Brown K, Phillips R, Peng Q, Zhou W, Sacks SH, Wong W.

Transpl Int. 2013 Jan;26(1):99-108. doi: 10.1111/tri.12006. Epub 2012 Nov 20.


C3a and C5a promote renal ischemia-reperfusion injury.

Peng Q, Li K, Smyth LA, Xing G, Wang N, Meader L, Lu B, Sacks SH, Zhou W.

J Am Soc Nephrol. 2012 Sep;23(9):1474-85. doi: 10.1681/ASN.2011111072. Epub 2012 Jul 12.


The role of complement in the early immune response to transplantation.

Sacks SH, Zhou W.

Nat Rev Immunol. 2012 May 25;12(6):431-42. doi: 10.1038/nri3225. Review.


Common genetic variants in complement genes other than CFH, CD46 and the CFHRs are not associated with aHUS.

Ermini L, Goodship TH, Strain L, Weale ME, Sacks SH, Cordell HJ, Fremeaux-Bacchi V, Sheerin NS.

Mol Immunol. 2012 Jan;49(4):640-8. doi: 10.1016/j.molimm.2011.11.003. Epub 2011 Dec 5.


Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury.

Farrar CA, Keogh B, McCormack W, O'Shaughnessy A, Parker A, Reilly M, Sacks SH.

FASEB J. 2012 Feb;26(2):799-807. doi: 10.1096/fj.11-195396. Epub 2011 Oct 31. Erratum in: FASEB J. 2012 Jul;26(7):3096.


Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a.

Li K, Fazekasova H, Wang N, Peng Q, Sacks SH, Lombardi G, Zhou W.

Immunobiology. 2012 Jan;217(1):65-73. doi: 10.1016/j.imbio.2011.07.033. Epub 2011 Aug 5.


Coexpression of donor peptide/recipient MHC complex and intact donor MHC: evidence for a link between the direct and indirect pathways.

Brown K, Sacks SH, Wong W.

Am J Transplant. 2011 Apr;11(4):826-31. doi: 10.1111/j.1600-6143.2011.03437.x. Epub 2011 Mar 14.


Expression of complement components, receptors and regulators by human dendritic cells.

Li K, Fazekasova H, Wang N, Sagoo P, Peng Q, Khamri W, Gomes C, Sacks SH, Lombardi G, Zhou W.

Mol Immunol. 2011 May;48(9-10):1121-7. doi: 10.1016/j.molimm.2011.02.003. Epub 2011 Mar 23.


SPECT/CT lymphoscintigraphy of heterotopic cardiac grafts reveals novel sites of lymphatic drainage and T cell priming.

Brown K, Badar A, Sunassee K, Fernandes MA, Shariff H, Jurcevic S, Blower PJ, Sacks SH, Mullen GE, Wong W.

Am J Transplant. 2011 Feb;11(2):225-34. doi: 10.1111/j.1600-6143.2010.03388.x. Epub 2011 Jan 10.


Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejection.

Brown K, Sacks SH, Wong W.

Eur J Immunol. 2011 Jan;41(1):89-96. doi: 10.1002/eji.201040759. Epub 2010 Nov 11.


Deficiency of C5aR prolongs renal allograft survival.

Li Q, Peng Q, Xing G, Li K, Wang N, Farrar CA, Meader L, Sacks SH, Zhou W.

J Am Soc Nephrol. 2010 Aug;21(8):1344-53. doi: 10.1681/ASN.2009090977. Epub 2010 Jul 22.


Toll-like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells.

Giorgini A, Brown HJ, Sacks SH, Robson MG.

Am J Pathol. 2010 Aug;177(2):644-53. doi: 10.2353/ajpath.2010.091279. Epub 2010 Jun 21.


Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction.

Tapmeier TT, Fearn A, Brown K, Chowdhury P, Sacks SH, Sheerin NS, Wong W.

Kidney Int. 2010 Aug;78(4):351-62. doi: 10.1038/ki.2010.177. Epub 2010 Jun 16.


Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction.

Chowdhury P, Sacks SH, Sheerin NS.

Nephron Exp Nephrol. 2010;115(4):e122-30. doi: 10.1159/000313493. Epub 2010 Apr 28.


Complement fragments C3a and C5a: the salt and pepper of the immune response.

Sacks SH.

Eur J Immunol. 2010 Mar;40(3):668-70. doi: 10.1002/eji.201040355. Review.


Dendritic cell function in allostimulation is modulated by C5aR signaling.

Peng Q, Li K, Wang N, Li Q, Asgari E, Lu B, Woodruff TM, Sacks SH, Zhou W.

J Immunol. 2009 Nov 15;183(10):6058-68. doi: 10.4049/jimmunol.0804186. Epub 2009 Oct 28.


The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses.

Peng Q, Li K, Sacks SH, Zhou W.

Inflamm Allergy Drug Targets. 2009 Jul;8(3):236-46. Review.


Synergy between type 1 fimbriae expression and C3 opsonisation increases internalisation of E. coli by human tubular epithelial cells.

Li K, Zhou W, Hong Y, Sacks SH, Sheerin NS.

BMC Microbiol. 2009 Mar 31;9:64. doi: 10.1186/1471-2180-9-64.


C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.

Tang Z, Lu B, Hatch E, Sacks SH, Sheerin NS.

J Am Soc Nephrol. 2009 Mar;20(3):593-603. doi: 10.1681/ASN.2008040434. Epub 2009 Jan 21.


Fc gamma RIII and Fc gamma RIV are indispensable for acute glomerular inflammation induced by switch variant monoclonal antibodies.

Giorgini A, Brown HJ, Lock HR, Nimmerjahn F, Ravetch JV, Verbeek JS, Sacks SH, Robson MG.

J Immunol. 2008 Dec 15;181(12):8745-52.


Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

Li K, Anderson KJ, Peng Q, Noble A, Lu B, Kelly AP, Wang N, Sacks SH, Zhou W.

Blood. 2008 Dec 15;112(13):5084-94. doi: 10.1182/blood-2008-05-156646. Epub 2008 Sep 23.


An antibody combination that targets activated T cells extends graft survival in sensitized recipients.

Greenlaw RE, Gardner NJ, Farrar CA, Shariff H, Sacks SH, Yagita H, Simpson E, Jurcevic S.

Am J Transplant. 2008 Nov;8(11):2272-82. doi: 10.1111/j.1600-6143.2008.02393.x. Epub 2008 Sep 10.


Homeostatic proliferation of lymphocytes results in augmented memory-like function and accelerated allograft rejection.

Moxham VF, Karegli J, Phillips RE, Brown KL, Tapmeier TT, Hangartner R, Sacks SH, Wong W.

J Immunol. 2008 Mar 15;180(6):3910-8.


Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

Rose KL, Paixao-Cavalcante D, Fish J, Manderson AP, Malik TH, Bygrave AE, Lin T, Sacks SH, Walport MJ, Cook HT, Botto M, Pickering MC.

J Clin Invest. 2008 Feb;118(2):608-18. doi: 10.1172/JCI32525.


Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation.

Tapmeier TT, Brown KL, Tang Z, Sacks SH, Sheerin NS, Wong W.

Kidney Int. 2008 Apr;73(7):885-9. doi: 10.1038/ Epub 2008 Jan 16.

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