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Coconut Oil and Heart Health: Fact or Fiction?

Sacks FM.

Circulation. 2020 Jan 13. doi: 10.1161/CIRCULATIONAHA.119.044687. [Epub ahead of print] No abstract available.


Predicting Weight Loss Using Psychological and Behavioral Factors: The POUNDSLOST Trial.

Liu X, Hanseman DJ, Champagne CM, Bray GA, Qi L, Williamson DA, Anton SD, Sacks FM, Tong J.

J Clin Endocrinol Metab. 2019 Dec 5. pii: dgz236. doi: 10.1210/clinem/dgz236. [Epub ahead of print]


Genetic Susceptibility, Dietary Protein Intake, and Changes of Blood Pressure: The POUNDS Lost Trial.

Sun D, Zhou T, Li X, Heianza Y, Liang Z, Bray GA, Sacks FM, Qi L.

Hypertension. 2019 Dec;74(6):1460-1467. doi: 10.1161/HYPERTENSIONAHA.119.13510. Epub 2019 Oct 28.


Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice.

Lian Z, Perrard XD, Peng X, Raya JL, Hernandez AA, Johnson CG, Lagor WR, Pownall HJ, Hoogeveen RC, Simon SI, Sacks FM, Ballantyne CM, Wu H.

Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):72-85. doi: 10.1161/ATVBAHA.119.313078. Epub 2019 Oct 17.


Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.

Rodriguez A, Trigatti BL, Mineo C, Knaack D, Wilkins JT, Sahoo D, Asztalos BF, Mora S, Cuchel M, Pownall HJ, Rosales C, Bernatchez P, Ribeiro Martins da Silva A, Getz GS, Barber JL, Shearer GC, Zivkovic AM, Tietge UJF, Sacks FM, Connelly MA, Oda MN, Davidson WS, Sorci-Thomas MG, Vaisar T, Ruotolo G, Vickers KC, Martel C.

Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2457-2467. doi: 10.1161/ATVBAHA.119.313340. Epub 2019 Oct 10.


Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans.

Andraski AB, Singh SA, Lee LH, Higashi H, Smith N, Zhang B, Aikawa M, Sacks FM.

Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2411-2430. doi: 10.1161/ATVBAHA.119.312889. Epub 2019 Sep 26.


Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial.

Zhou T, Heianza Y, Chen Y, Li X, Sun D, DiDonato JA, Pei X, LeBoff MS, Bray GA, Sacks FM, Qi L.

Diabetes Care. 2019 Aug;42(8):1365-1371. doi: 10.2337/dc19-0134. Epub 2019 May 21.


Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk.

Bray GA, Krauss RM, Sacks FM, Qi L.

Curr Obes Rep. 2019 Sep;8(3):262-283. doi: 10.1007/s13679-019-00353-1. Review.


Fiber Intake Predicts Weight Loss and Dietary Adherence in Adults Consuming Calorie-Restricted Diets: The POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study.

Miketinas DC, Bray GA, Beyl RA, Ryan DH, Sacks FM, Champagne CM.

J Nutr. 2019 Oct 1;149(10):1742-1748. doi: 10.1093/jn/nxz117.


Cholesterol efflux capacity, HDL cholesterol, and risk of coronary heart disease: a nested case-control study in men.

Cahill LE, Sacks FM, Rimm EB, Jensen MK.

J Lipid Res. 2019 Aug;60(8):1457-1464. doi: 10.1194/jlr.P093823. Epub 2019 May 29.


Apolipoprotein C-III and its defined lipoprotein subspecies in relation to incident diabetes: the Multi-Ethnic Study of Atherosclerosis.

Aroner SA, Furtado JD, Sacks FM, Tsai MY, Mukamal KJ, McClelland RL, Jensen MK.

Diabetologia. 2019 Jun;62(6):981-992. doi: 10.1007/s00125-019-4847-8. Epub 2019 Apr 4.


Dietary unsaturated fat increases HDL metabolic pathways involving apoE favorable to reverse cholesterol transport.

Morton AM, Furtado JD, Mendivil CO, Sacks FM.

JCI Insight. 2019 Apr 4;4(7). pii: 124620. doi: 10.1172/jci.insight.124620. eCollection 2019 Apr 4.


Pretreatment Fasting Glucose and Insulin as Determinants of Weight Loss on Diets Varying in Macronutrients and Dietary Fibers-The POUNDS LOST Study.

Hjorth MF, Bray GA, Zohar Y, Urban L, Miketinas DC, Williamson DA, Ryan DH, Rood J, Champagne CM, Sacks FM, Astrup A.

Nutrients. 2019 Mar 11;11(3). pii: E586. doi: 10.3390/nu11030586.


Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies.

Furtado JD, Yamamoto R, Melchior JT, Andraski AB, Gamez-Guerrero M, Mulcahy P, He Z, Cai T, Davidson WS, Sacks FM.

Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2827-2842. doi: 10.1161/ATVBAHA.118.311607.


Genetically determined vitamin D levels and change in bone density during a weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) Trial.

Zhou T, Sun D, Heianza Y, Li X, Champagne CM, LeBoff MS, Shang X, Pei X, Bray GA, Sacks FM, Qi L.

Am J Clin Nutr. 2018 Nov 1;108(5):1129-1134. doi: 10.1093/ajcn/nqy197.


JCL roundtable: High-density lipoprotein function and reverse cholesterol transport.

Cuchel M, Rohatgi A, Sacks FM, Guyton JR.

J Clin Lipidol. 2018 Sep - Oct;12(5):1086-1094. doi: 10.1016/j.jacl.2018.09.005. Epub 2018 Oct 9. Review.


Low-Fat vs Low-Carbohydrate Diets and Weight Loss.

Qi L, Bray GA, Sacks FM.

JAMA. 2018 Jul 10;320(2):202-203. doi: 10.1001/jama.2018.6244. No abstract available.


Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.

Heianza Y, Sun D, Li X, DiDonato JA, Bray GA, Sacks FM, Qi L.

Gut. 2019 Feb;68(2):263-270. doi: 10.1136/gutjnl-2018-316155. Epub 2018 Jun 2.


Genetic, epigenetic and transcriptional variations at NFATC2IP locus with weight loss in response to diet interventions: The POUNDS Lost Trial.

Sun D, Heianza Y, Li X, Shang X, Smith SR, Bray GA, Sacks FM, Qi L.

Diabetes Obes Metab. 2018 Sep;20(9):2298-2303. doi: 10.1111/dom.13333. Epub 2018 May 24.


Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.

Heianza Y, Sun D, Ma W, Zheng Y, Champagne CM, Bray GA, Sacks FM, Qi L.

Int J Obes (Lond). 2018 Sep;42(9):1565-1573. doi: 10.1038/s41366-018-0046-9. Epub 2018 Feb 26.


A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial.

Goni L, Sun D, Heianza Y, Wang T, Huang T, Martínez JA, Shang X, Bray GA, Smith SR, Sacks FM, Qi L.

Eur J Nutr. 2019 Jun;58(4):1381-1389. doi: 10.1007/s00394-018-1660-y. Epub 2018 Mar 7.


Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk.

Morton AM, Koch M, Mendivil CO, Furtado JD, Tjønneland A, Overvad K, Wang L, Jensen MK, Sacks FM.

JCI Insight. 2018 Feb 22;3(4). pii: 98045. doi: 10.1172/jci.insight.98045. eCollection 2018 Feb 22.


HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT.

Huang T, Wang T, Heianza Y, Sun D, Ivey K, Durst R, Schwarzfuchs D, Stampfer MJ, Bray GA, Sacks FM, Shai I, Qi L.

Diabetes Obes Metab. 2018 Jun;20(6):1445-1452. doi: 10.1111/dom.13250. Epub 2018 Mar 5.


From High-Density Lipoprotein Cholesterol to Measurements of Function: Prospects for the Development of Tests for High-Density Lipoprotein Functionality in Cardiovascular Disease.

Sacks FM, Jensen MK.

Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):487-499. doi: 10.1161/ATVBAHA.117.307025. Epub 2018 Jan 25. Review.


High density lipoprotein with apolipoprotein C-III is associated with carotid intima-media thickness among generally healthy individuals.

Yamamoto R, Sacks FM, Hu FB, Rosner B, Furtado JD, Aroner SA, Ferrannini E, Baldi S, Kozakova M, Balkau B, Natali A, Jensen MK; RISC Investigators.

Atherosclerosis. 2018 Feb;269:92-99. doi: 10.1016/j.atherosclerosis.2017.12.029. Epub 2018 Jan 2.


Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.

Heianza Y, Sun D, Smith SR, Bray GA, Sacks FM, Qi L.

Diabetes Care. 2018 Mar;41(3):413-419. doi: 10.2337/dc17-2108. Epub 2018 Jan 5.


High-Density Lipoprotein Subspecies Defined by Presence of Apolipoprotein C-III and Incident Coronary Heart Disease in Four Cohorts.

Jensen MK, Aroner SA, Mukamal KJ, Furtado JD, Post WS, Tsai MY, Tjønneland A, Polak JF, Rimm EB, Overvad K, McClelland RL, Sacks FM.

Circulation. 2018 Mar 27;137(13):1364-1373. doi: 10.1161/CIRCULATIONAHA.117.031276. Epub 2017 Nov 21.


Macronutrient-specific effect of the MTNR1B genotype on lipid levels in response to 2 year weight-loss diets.

Goni L, Sun D, Heianza Y, Wang T, Huang T, Cuervo M, Martínez JA, Shang X, Bray GA, Sacks FM, Qi L.

J Lipid Res. 2018 Jan;59(1):155-161. doi: 10.1194/jlr.P078634. Epub 2017 Oct 31.


Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet.

Juraschek SP, Woodward M, Sacks FM, Carey VJ, Miller ER 3rd, Appel LJ.

Hypertension. 2017 Nov;70(5):923-929. doi: 10.1161/HYPERTENSIONAHA.117.10017.


Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

Han L, Ma W, Sun D, Heianza Y, Wang T, Zheng Y, Huang T, Duan D, Bray JGA, Champagne CM, Sacks FM, Qi L.

Am J Clin Nutr. 2017 Nov;106(5):1321-1326. doi: 10.3945/ajcn.117.156232. Epub 2017 Sep 20.


HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology.

Rosenson RS, Brewer HB Jr, Barter PJ, Björkegren JLM, Chapman MJ, Gaudet D, Kim DS, Niesor E, Rye KA, Sacks FM, Tardif JC, Hegele RA.

Nat Rev Cardiol. 2018 Jan;15(1):9-19. doi: 10.1038/nrcardio.2017.115. Epub 2017 Aug 10. Review.


Starch Digestion-Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial.

Heianza Y, Sun D, Wang T, Huang T, Bray GA, Sacks FM, Qi L.

Diabetes. 2017 Sep;66(9):2416-2423. doi: 10.2337/db16-1482. Epub 2017 Jun 28.


Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association.

Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, Miller M, Rimm EB, Rudel LL, Robinson JG, Stone NJ, Van Horn LV; American Heart Association.

Circulation. 2017 Jul 18;136(3):e1-e23. doi: 10.1161/CIR.0000000000000510. Epub 2017 Jun 15. Review. Erratum in: Circulation. 2017 Sep 5;136(10 ):e195.


Frequency of Consuming Foods Predicts Changes in Cravings for Those Foods During Weight Loss: The POUNDS Lost Study.

Apolzan JW, Myers CA, Champagne CM, Beyl RA, Raynor HA, Anton SA, Williamson DA, Sacks FM, Bray GA, Martin CK.

Obesity (Silver Spring). 2017 Aug;25(8):1343-1348. doi: 10.1002/oby.21895. Epub 2017 Jun 15.


Effects of dietary carbohydrate on 1,5-anhydroglucitol in a population without diabetes: results from the OmniCarb trial.

Juraschek SP, Miller ER 3rd, Appel LJ, Christenson RH, Sacks FM, Selvin E.

Diabet Med. 2017 Oct;34(10):1407-1413. doi: 10.1111/dme.13391. Epub 2017 Jul 9.


Apolipoprotein C-III and High-Density Lipoprotein Subspecies Defined by Apolipoprotein C-III in Relation to Diabetes Risk.

Aroner SA, Yang M, Li J, Furtado JD, Sacks FM, Tjønneland A, Overvad K, Cai T, Jensen MK.

Am J Epidemiol. 2017 Sep 15;186(6):736-744. doi: 10.1093/aje/kwx143.


A Systems Genetics Approach Identified GPD1L and its Molecular Mechanism for Obesity in Human Adipose Tissue.

He H, Sun D, Zeng Y, Wang R, Zhu W, Cao S, Bray GA, Chen W, Shen H, Sacks FM, Qi L, Deng HW.

Sci Rep. 2017 May 11;7(1):1799. doi: 10.1038/s41598-017-01517-6.


Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1.

Melchior JT, Street SE, Andraski AB, Furtado JD, Sacks FM, Shute RL, Greve EI, Swertfeger DK, Li H, Shah AS, Lu LJ, Davidson WS.

J Lipid Res. 2017 Jul;58(7):1374-1385. doi: 10.1194/jlr.M075382. Epub 2017 May 5.


Markers of dietary protein intake are associated with successful weight loss in the POUNDS Lost trial.

Bray GA, Ryan DH, Johnson W, Champagne CM, Johnson CM, Rood J, Williamson DA, Sacks FM.

Clin Obes. 2017 Jun;7(3):166-175. doi: 10.1111/cob.12188. Epub 2017 Mar 24.


Dietary Protein Modifies the Effect of the MC4R Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial.

Huang T, Zheng Y, Hruby A, Williamson DA, Bray GA, Shen Y, Sacks FM, Qi L.

J Nutr. 2017 Mar;147(3):439-444. doi: 10.3945/jn.116.242958. Epub 2017 Feb 1.


Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial.

Liu G, Liang L, Bray GA, Qi L, Hu FB, Rood J, Sacks FM, Sun Q.

Int J Obes (Lond). 2017 Jun;41(6):878-886. doi: 10.1038/ijo.2017.28. Epub 2017 Jan 31.


Effect of type and amount of dietary carbohydrate on biomarkers of glucose homeostasis and C reactive protein in overweight or obese adults: results from the OmniCarb trial.

Juraschek SP, Miller ER 3rd, Selvin E, Carey VJ, Appel LJ, Christenson RH, Sacks FM.

BMJ Open Diabetes Res Care. 2016 Nov 14;4(1):e000276. eCollection 2016.


The effect of omega-3 carboxylic acids on apolipoprotein CIII-containing lipoproteins in severe hypertriglyceridemia.

Morton AM, Furtado JD, Lee J, Amerine W, Davidson MH, Sacks FM.

J Clin Lipidol. 2016 Nov - Dec;10(6):1442-1451.e4. doi: 10.1016/j.jacl.2016.09.005. Epub 2016 Sep 13.


Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins.

Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA.

Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600085.


Genetic Variations of Circulating Adiponectin Levels Modulate Changes in Appetite in Response to Weight-Loss Diets.

Ma W, Huang T, Heianza Y, Wang T, Sun D, Tong J, Williamson DA, Bray GA, Sacks FM, Qi L.

J Clin Endocrinol Metab. 2017 Jan 1;102(1):316-325. doi: 10.1210/jc.2016-2909.


FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

Livingstone KM, Celis-Morales C, Papandonatos GD, Erar B, Florez JC, Jablonski KA, Razquin C, Marti A, Heianza Y, Huang T, Sacks FM, Svendstrup M, Sui X, Church TS, Jääskeläinen T, Lindström J, Tuomilehto J, Uusitupa M, Rankinen T, Saris WH, Hansen T, Pedersen O, Astrup A, Sørensen TI, Qi L, Bray GA, Martinez-Gonzalez MA, Martinez JA, Franks PW, McCaffery JM, Lara J, Mathers JC.

BMJ. 2016 Sep 20;354:i4707. doi: 10.1136/bmj.i4707. Review. Erratum in: BMJ. 2017 Jan 17;356:j263.


Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial.

Heianza Y, Ma W, Huang T, Wang T, Zheng Y, Smith SR, Bray GA, Sacks FM, Qi L.

Diabetes Care. 2016 Nov;39(11):1909-1914. Epub 2016 Aug 31.


Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets.

Zheng Y, Ceglarek U, Huang T, Wang T, Heianza Y, Ma W, Bray GA, Thiery J, Sacks FM, Qi L.

J Clin Endocrinol Metab. 2016 Oct;101(10):3820-3826. Epub 2016 Jul 28.


Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial.

Ma W, Huang T, Wang M, Zheng Y, Wang T, Heianza Y, Sun D, Smith SR, Bray GA, Sacks FM, Qi L.

Int J Obes (Lond). 2016 Nov;40(11):1723-1729. doi: 10.1038/ijo.2016.128. Epub 2016 Jul 27.


Salt Sensitivity of Blood Pressure: A Scientific Statement From the American Heart Association.

Elijovich F, Weinberger MH, Anderson CA, Appel LJ, Bursztyn M, Cook NR, Dart RA, Newton-Cheh CH, Sacks FM, Laffer CL; American Heart Association Professional and Public Education Committee of the Council on Hypertension; Council on Functional Genomics and Translational Biology; and Stroke Council.

Hypertension. 2016 Sep;68(3):e7-e46. doi: 10.1161/HYP.0000000000000047. Epub 2016 Jul 21. Review. No abstract available. Erratum in: Hypertension. 2016 Oct;68(4):e62.


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