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Items: 1 to 50 of 129

1.

CRISPR/Cas9 Mutagenesis in Phlebotomus papatasi: the Immune Deficiency Pathway Impacts Vector Competence for Leishmania major.

Louradour I, Ghosh K, Inbar E, Sacks DL.

MBio. 2019 Aug 27;10(4). pii: e01941-19. doi: 10.1128/mBio.01941-19.

2.

Inflammasomes and Leishmania: in good times or bad, in sickness or in health.

Zamboni DS, Sacks DL.

Curr Opin Microbiol. 2019 Jun 20;52:70-76. doi: 10.1016/j.mib.2019.05.005. [Epub ahead of print] Review.

PMID:
31229882
3.

Drug Discovery for Kinetoplastid Diseases: Future Directions.

Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT.

ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13.

4.

Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.

Lee SH, Charmoy M, Romano A, Paun A, Chaves MM, Cope FO, Ralph DA, Sacks DL.

J Exp Med. 2018 Jan 2;215(1):357-375. doi: 10.1084/jem.20171389. Epub 2017 Dec 15.

5.

NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis.

Carneiro MBH, Roma EH, Ranson AJ, Doria NA, Debrabant A, Sacks DL, Vieira LQ, Peters NC.

J Immunol. 2018 Jan 1;200(1):196-208. doi: 10.4049/jimmunol.1700899. Epub 2017 Nov 20.

6.

Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage.

Iantorno SA, Durrant C, Khan A, Sanders MJ, Beverley SM, Warren WC, Berriman M, Sacks DL, Cotton JA, Grigg ME.

MBio. 2017 Sep 12;8(5). pii: e01393-17. doi: 10.1128/mBio.01393-17.

7.

Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major.

Romano A, Carneiro MBH, Doria NA, Roma EH, Ribeiro-Gomes FL, Inbar E, Lee SH, Mendez J, Paun A, Sacks DL, Peters NC.

PLoS Pathog. 2017 Jun 30;13(6):e1006479. doi: 10.1371/journal.ppat.1006479. eCollection 2017 Jun.

8.

The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector.

Inbar E, Hughitt VK, Dillon LA, Ghosh K, El-Sayed NM, Sacks DL.

MBio. 2017 Apr 4;8(2). pii: e00029-17. doi: 10.1128/mBio.00029-17.

9.

The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice.

Charmoy M, Hurrell BP, Romano A, Lee SH, Ribeiro-Gomes F, Riteau N, Mayer-Barber K, Tacchini-Cottier F, Sacks DL.

Eur J Immunol. 2016 Apr;46(4):897-911. doi: 10.1002/eji.201546015. Epub 2016 Jan 20.

10.

Cutaneous Infection with Leishmania major Mediates Heterologous Protection against Visceral Infection with Leishmania infantum.

Romano A, Doria NA, Mendez J, Sacks DL, Peters NC.

J Immunol. 2015 Oct 15;195(8):3816-27. doi: 10.4049/jimmunol.1500752. Epub 2015 Sep 14.

11.

Animal models for the analysis of immune responses to leishmaniasis.

Sacks DL, Melby PC.

Curr Protoc Immunol. 2015 Feb 2;108:19.2.1-24. doi: 10.1002/0471142735.im1902s108.

PMID:
25640990
12.

Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection.

Peters NC, Pagán AJ, Lawyer PG, Hand TW, Henrique Roma E, Stamper LW, Romano A, Sacks DL.

PLoS Pathog. 2014 Dec 4;10(12):e1004538. doi: 10.1371/journal.ppat.1004538. eCollection 2014 Dec.

13.

Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector.

Romano A, Inbar E, Debrabant A, Charmoy M, Lawyer P, Ribeiro-Gomes F, Barhoumi M, Grigg M, Shaik J, Dobson D, Beverley SM, Sacks DL.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16808-13. doi: 10.1073/pnas.1415109111. Epub 2014 Nov 10.

14.

Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem.

Sacks DL.

Nat Immunol. 2014 May;15(5):403-5. doi: 10.1038/ni.2853. No abstract available.

15.

Site-dependent recruitment of inflammatory cells determines the effective dose of Leishmania major.

Ribeiro-Gomes FL, Roma EH, Carneiro MB, Doria NA, Sacks DL, Peters NC.

Infect Immun. 2014 Jul;82(7):2713-27. doi: 10.1128/IAI.01600-13. Epub 2014 Apr 14.

16.

Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

Pagán AJ, Peters NC, Debrabant A, Ribeiro-Gomes F, Pepper M, Karp CL, Jenkins MK, Sacks DL.

Eur J Immunol. 2013 Feb;43(2):427-38. doi: 10.1002/eji.201242715. Epub 2012 Dec 11.

17.

Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice.

Peters NC, Bertholet S, Lawyer PG, Charmoy M, Romano A, Ribeiro-Gomes FL, Stamper LW, Sacks DL.

J Immunol. 2012 Nov 15;189(10):4832-41. doi: 10.4049/jimmunol.1201676. Epub 2012 Oct 8.

18.

Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.

Ribeiro-Gomes FL, Peters NC, Debrabant A, Sacks DL.

PLoS Pathog. 2012 Feb;8(2):e1002536. doi: 10.1371/journal.ppat.1002536. Epub 2012 Feb 16.

19.

Infection parameters in the sand fly vector that predict transmission of Leishmania major.

Stamper LW, Patrick RL, Fay MP, Lawyer PG, Elnaiem DE, Secundino N, Debrabant A, Sacks DL, Peters NC.

PLoS Negl Trop Dis. 2011 Aug;5(8):e1288. doi: 10.1371/journal.pntd.0001288. Epub 2011 Aug 23.

20.

Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern.

Dobson DE, Kamhawi S, Lawyer P, Turco SJ, Beverley SM, Sacks DL.

PLoS Pathog. 2010 Nov 11;6(11):e1001185. doi: 10.1371/journal.ppat.1001185.

21.

Why does immunity to parasites take so long to develop?

Yazdanbakhsh M, Sacks DL.

Nat Rev Immunol. 2010 Feb;10(2):80-1. doi: 10.1038/nri2673. No abstract available.

22.

The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis.

Peters NC, Sacks DL.

Cell Microbiol. 2009 Sep;11(9):1290-6. doi: 10.1111/j.1462-5822.2009.01348.x. Epub 2009 Jun 22. Review.

23.

Vector transmission of leishmania abrogates vaccine-induced protective immunity.

Peters NC, Kimblin N, Secundino N, Kamhawi S, Lawyer P, Sacks DL.

PLoS Pathog. 2009 Jun;5(6):e1000484. doi: 10.1371/journal.ppat.1000484. Epub 2009 Jun 19.

24.

Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector.

Akopyants NS, Kimblin N, Secundino N, Patrick R, Peters N, Lawyer P, Dobson DE, Beverley SM, Sacks DL.

Science. 2009 Apr 10;324(5924):265-8. doi: 10.1126/science.1169464.

25.

Animal models for the analysis of immune responses to leishmaniasis.

Sacks DL, Melby PC.

Curr Protoc Immunol. 2001 May;Chapter 19:Unit 19.2. doi: 10.1002/0471142735.im1902s28.

26.

Uninfected mosquito bites confer protection against infection with malaria parasites.

Donovan MJ, Messmore AS, Scrafford DA, Sacks DL, Kamhawi S, McDowell MA.

Infect Immun. 2007 May;75(5):2523-30. Epub 2007 Mar 5.

27.
28.

Characterization of a blood activated chitinolytic system in the midgut of the sand fly vectors Lutzomyia longipalpis and Phlebotomus papatasi.

Ramalho-Ortigão JM, Kamhawi S, Joshi MB, Reynoso D, Lawyer PG, Dwyer DM, Sacks DL, Valenzuela JG.

Insect Mol Biol. 2005 Dec;14(6):703-12.

PMID:
16313571
29.

Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells.

Bertholet S, Debrabant A, Afrin F, Caler E, Mendez S, Tabbara KS, Belkaid Y, Sacks DL.

Infect Immun. 2005 Oct;73(10):6620-8.

30.
31.

Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection.

Tabbara KS, Peters NC, Afrin F, Mendez S, Bertholet S, Belkaid Y, Sacks DL.

Infect Immun. 2005 Aug;73(8):4714-22.

32.
33.

A role for insect galectins in parasite survival.

Kamhawi S, Ramalho-Ortigao M, Pham VM, Kumar S, Lawyer PG, Turco SJ, Barillas-Mury C, Sacks DL, Valenzuela JG.

Cell. 2004 Oct 29;119(3):329-41.

34.

Memory may not need reminding.

Seder RA, Sacks DL.

Nat Med. 2004 Oct;10(10):1045-7. No abstract available.

PMID:
15459703
35.

Control of Leishmania-sand fly interactions by polymorphisms in lipophosphoglycan structure.

Turco SJ, Sacks DL.

Methods Enzymol. 2003;363:377-81. No abstract available.

PMID:
14579590
36.

Persistence without pathology in phosphoglycan-deficient Leishmania major.

Späth GF, Lye LF, Segawa H, Sacks DL, Turco SJ, Beverley SM.

Science. 2003 Aug 29;301(5637):1241-3.

37.
38.

Immunological and pathological evaluation of rhesus macaques infected with Leishmania major.

Freidag BL, Mendez S, Cheever AW, Kenney RT, Flynn B, Sacks DL, Seder RA.

Exp Parasitol. 2003 Mar-Apr;103(3-4):160-8.

PMID:
12880593
39.

Comparison of the A2 gene locus in Leishmania donovani and Leishmania major and its control over cutaneous infection.

Zhang WW, Mendez S, Ghosh A, Myler P, Ivens A, Clos J, Sacks DL, Matlashewski G.

J Biol Chem. 2003 Sep 12;278(37):35508-15. Epub 2003 Jun 26.

40.

The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.

Noben-Trauth N, Lira R, Nagase H, Paul WE, Sacks DL.

J Immunol. 2003 May 15;170(10):5152-8.

41.

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.

Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL.

Nature. 2002 Dec 5;420(6915):502-7.

PMID:
12466842
43.

Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infection.

Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, Davey DF, Davis H, Klinman DM, Coler RN, Sacks DL, Seder RA.

J Exp Med. 2002 Jun 17;195(12):1565-73.

44.

Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.

Joshi PB, Kelly BL, Kamhawi S, Sacks DL, McMaster WR.

Mol Biochem Parasitol. 2002 Mar;120(1):33-40.

PMID:
11849703
45.

Skin dendritic cells in murine cutaneous leishmaniasis.

Udey MC, von Stebut E, Mendez S, Sacks DL, Belkaid Y.

Immunobiology. 2001 Dec;204(5):590-4. Review.

PMID:
11846222
46.
47.

Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein.

Valenzuela JG, Belkaid Y, Garfield MK, Mendez S, Kamhawi S, Rowton ED, Sacks DL, Ribeiro JM.

J Exp Med. 2001 Aug 6;194(3):331-42.

48.

Leishmania-sand fly interactions controlling species-specific vector competence.

Sacks DL.

Cell Microbiol. 2001 Apr;3(4):189-96. Review.

PMID:
11298643
49.
50.

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