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Items: 27


Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations.

Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y.

J Gen Physiol. 2019 Feb 4;151(2):214-230. doi: 10.1085/jgp.201812192. Epub 2019 Jan 23.


The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation.

Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT.

J Gen Physiol. 2019 Mar 4;151(3):292-315. doi: 10.1085/jgp.201812213. Epub 2018 Nov 5.


Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.

Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS.

Mol Biol Cell. 2018 Oct 1;29(20):2410-2432. doi: 10.1091/mbc.E18-05-0337. Epub 2018 Aug 9.


Taming unruly chloride channel inhibitors with rational design.

Sepela RJ, Sack JT.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5311-5313. doi: 10.1073/pnas.1805589115. Epub 2018 May 7. No abstract available.


Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels.

Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT.

Biochemistry. 2018 May 8;57(18):2733-2743. doi: 10.1021/acs.biochem.8b00292. Epub 2018 Apr 17.


Azide-Alkyne Click Conjugation on Quantum Dots by Selective Copper Coordination.

Mann VR, Powers AS, Tilley DC, Sack JT, Cohen BE.

ACS Nano. 2018 May 22;12(5):4469-4477. doi: 10.1021/acsnano.8b00575. Epub 2018 Apr 4.


The envenomation of general physiology throughout the last century.

Sack JT.

J Gen Physiol. 2017 Nov 6;149(11):975-983. doi: 10.1085/jgp.201711856. Epub 2017 Oct 11. Review.


Cell cycle-dependent changes in localization and phosphorylation of the plasma membrane Kv2.1 K+ channel impact endoplasmic reticulum membrane contact sites in COS-1 cells.

Cobb MM, Austin DC, Sack JT, Trimmer JS.

J Biol Chem. 2016 Mar 11;291(11):5527. doi: 10.1074/jbc.A115.690198. No abstract available.


A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.

Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT.

J Gen Physiol. 2015 Nov;146(5):399-410. doi: 10.1085/jgp.201511444.


What keeps Kv channels small? The molecular physiology of modesty.

Sack JT, Tilley DC.

J Gen Physiol. 2015 Aug;146(2):123-7. doi: 10.1085/jgp.201511469. No abstract available.


Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels.

Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ.

Elife. 2015 May 7;4:e06774. doi: 10.7554/eLife.06774.


Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.


Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells.

Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4789-96. doi: 10.1073/pnas.1406876111. Epub 2014 Oct 20.


Phytochemicals perturb membranes and promiscuously alter protein function.

Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC Jr, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS.

ACS Chem Biol. 2014 Aug 15;9(8):1788-98. doi: 10.1021/cb500086e. Epub 2014 Jun 17.


Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.

Speca DJ, Ogata G, Mandikian D, Bishop HI, Wiler SW, Eum K, Wenzel HJ, Doisy ET, Matt L, Campi KL, Golub MS, Nerbonne JM, Hell JW, Trainor BC, Sack JT, Schwartzkroin PA, Trimmer JS.

Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7.


Antibody-guided photoablation of voltage-gated potassium currents.

Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS.

J Gen Physiol. 2013 Sep;142(3):315-24. doi: 10.1085/jgp.201311023. Epub 2013 Aug 12.


A SUMO-Phospho tag team for wrestling with potassium channel gating.

Mandikian D, Cerda O, Sack JT, Trimmer JS.

J Gen Physiol. 2011 May;137(5):435-9. doi: 10.1085/jgp.201110648. No abstract available.


Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium.

Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO.

J Gen Physiol. 2010 Sep;136(3):273-82. doi: 10.1085/jgp.200910398.


How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits.

Sack JT, Shamotienko O, Dolly JO.

J Gen Physiol. 2008 May;131(5):415-20. doi: 10.1085/jgp.200709939. Epub 2008 Apr 14. No abstract available.


Concatemers of brain Kv1 channel alpha subunits that give similar K+ currents yield pharmacologically distinguishable heteromers.

Sokolov MV, Shamotienko O, Dhochartaigh SN, Sack JT, Dolly JO.

Neuropharmacology. 2007 Aug;53(2):272-82. Epub 2007 May 21.


A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway.

Sack JT, Aldrich RW, Gilly WF.

J Gen Physiol. 2004 Jun;123(6):685-96. Epub 2004 May 17.


Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity.

Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF.

J Biol Chem. 2003 Sep 12;278(37):34934-42. Epub 2003 Jun 18.


Radial nerve palsy caused by open humeral shaft fractures.

Foster RJ, Swiontkowski MF, Bach AW, Sack JT.

J Hand Surg Am. 1993 Jan;18(1):121-4.


Four-bone ligament reconstruction for treatment of chronic complete scapholunate separation.

Almquist EE, Bach AW, Sack JT, Fuhs SE, Newman DM.

J Hand Surg Am. 1991 Mar;16(2):322-7.


Tarsal-tunnel syndrome. Review of the literature and two case reports.

DiStefano V, Sack JT, Whittaker R, Nixon JE.

Clin Orthop Relat Res. 1972;88:76-9. No abstract available.


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