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Items: 32

1.

Malaria Vaccines: Recent Advances and New Horizons.

Draper SJ, Sack BK, King CR, Nielsen CM, Rayner JC, Higgins MK, Long CA, Seder RA.

Cell Host Microbe. 2018 Jul 11;24(1):43-56. doi: 10.1016/j.chom.2018.06.008. Review.

2.

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo.

Foquet L, Schafer C, Minkah NK, Alanine DGW, Flannery EL, Steel RWJ, Sack BK, Camargo N, Fishbaugher M, Betz W, Nguyen T, Billman ZP, Wilson EM, Bial J, Murphy SC, Draper SJ, Mikolajczak SA, Kappe SHI.

Front Immunol. 2018 Mar 14;9:524. doi: 10.3389/fimmu.2018.00524. eCollection 2018.

3.

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.

Tan J, Sack BK, Oyen D, Zenklusen I, Piccoli L, Barbieri S, Foglierini M, Fregni CS, Marcandalli J, Jongo S, Abdulla S, Perez L, Corradin G, Varani L, Sallusto F, Sim BKL, Hoffman SL, Kappe SHI, Daubenberger C, Wilson IA, Lanzavecchia A.

Nat Med. 2018 May;24(4):401-407. doi: 10.1038/nm.4513. Epub 2018 Mar 19.

4.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Kisalu NK, Idris AH, Weidle C, Flores-Garcia Y, Flynn BJ, Sack BK, Murphy S, Schön A, Freire E, Francica JR, Miller AB, Gregory J, March S, Liao HX, Haynes BF, Wiehe K, Trama AM, Saunders KO, Gladden MA, Monroe A, Bonsignori M, Kanekiyo M, Wheatley AK, McDermott AB, Farney SK, Chuang GY, Zhang B, Kc N, Chakravarty S, Kwong PD, Sinnis P, Bhatia SN, Kappe SHI, Sim BKL, Hoffman SL, Zavala F, Pancera M, Seder RA.

Nat Med. 2018 May;24(4):408-416. doi: 10.1038/nm.4512. Epub 2018 Mar 19.

5.

A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice.

Vaughan AM, Sack BK, Dankwa D, Minkah N, Nguyen T, Cardamone H, Kappe SHI.

Infect Immun. 2018 Apr 23;86(5). pii: e00088-18. doi: 10.1128/IAI.00088-18. Print 2018 May.

6.

Immunization of Malaria-Preexposed Volunteers With PfSPZ Vaccine Elicits Long-Lived IgM Invasion-Inhibitory and Complement-Fixing Antibodies.

Zenklusen I, Jongo S, Abdulla S, Ramadhani K, Lee Sim BK, Cardamone H, Flannery EL, Nguyen T, Fishbaugher M, Steel RWJ, Betz W, Carmago N, Mikolajczak S, Kappe SHI, Hoffman SL, Sack BK, Daubenberger C.

J Infect Dis. 2018 Apr 23;217(10):1569-1578. doi: 10.1093/infdis/jiy080.

PMID:
29438525
7.

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.

Flannery EL, Foquet L, Chuenchob V, Fishbaugher M, Billman Z, Navarro MJ, Betz W, Olsen TM, Lee J, Camargo N, Nguyen T, Schafer C, Sack BK, Wilson EM, Saunders J, Bial J, Campo B, Charman SA, Murphy SC, Phillips MA, Kappe SH, Mikolajczak SA.

JCI Insight. 2018 Jan 11;3(1). pii: 92587. doi: 10.1172/jci.insight.92587. [Epub ahead of print]

8.

Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.

Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nguyen T, Betz W, Jane Navarro M, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI.

NPJ Vaccines. 2017 Oct 9;2:27. doi: 10.1038/s41541-017-0028-2. eCollection 2017.

9.

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.

Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H.

Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.007. Epub 2017 Nov 29.

PMID:
29195810
10.

Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects.

Kublin JG, Mikolajczak SA, Sack BK, Fishbaugher ME, Seilie A, Shelton L, VonGoedert T, Firat M, Magee S, Fritzen E, Betz W, Kain HS, Dankwa DA, Steel RW, Vaughan AM, Noah Sather D, Murphy SC, Kappe SH.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaad9099. doi: 10.1126/scitranslmed.aad9099.

PMID:
28053159
11.

An Opsonic Phagocytosis Assay for Plasmodium falciparum Sporozoites.

Steel RW, Sack BK, Tsuji M, Navarro MJ, Betz W, Fishbaugher ME, Flannery EL, Kappe SH.

Clin Vaccine Immunol. 2017 Feb 6;24(2). pii: e00445-16. doi: 10.1128/CVI.00445-16. Print 2017 Feb.

12.
13.

Corrigendum: Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, Holman LA, James ER, Billingsley PF, Gunasekera A, Chakravarty S, Manoj A, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, K C N, Murshedkar T, DeCederfelt H, Plummer SH, Hendel CS, Novik L, Costner PJ, Saunders JG, Laurens MB, Plowe CV, Flynn B, Whalen WR, Todd JP, Noor J, Rao S, Sierra-Davidson K, Lynn GM, Epstein JE, Kemp MA, Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA; VRC 312 and VRC 314 Study Teams.

Nat Med. 2016 Jun 7;22(6):692. doi: 10.1038/nm0616-692c. No abstract available.

PMID:
27270781
14.

Protection against malaria at 1 year and immune correlates following PfSPZ vaccination.

Ishizuka AS, Lyke KE, DeZure A, Berry AA, Richie TL, Mendoza FH, Enama ME, Gordon IJ, Chang LJ, Sarwar UN, Zephir KL, Holman LA, James ER, Billingsley PF, Gunasekera A, Chakravarty S, Manoj A, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, K C N, Murshedkar T, DeCederfelt H, Plummer SH, Hendel CS, Novik L, Costner PJ, Saunders JG, Laurens MB, Plowe CV, Flynn B, Whalen WR, Todd JP, Noor J, Rao S, Sierra-Davidson K, Lynn GM, Epstein JE, Kemp MA, Fahle GA, Mikolajczak SA, Fishbaugher M, Sack BK, Kappe SH, Davidson SA, Garver LS, Björkström NK, Nason MC, Graham BS, Roederer M, Sim BK, Hoffman SL, Ledgerwood JE, Seder RA.

Nat Med. 2016 Jun;22(6):614-23. doi: 10.1038/nm.4110. Epub 2016 May 9. Erratum in: Nat Med. 2016 Jun 7;22(6):692.

PMID:
27158907
15.

Novel approaches to whole sporozoite vaccination against malaria.

Bijker EM, Borrmann S, Kappe SH, Mordmüller B, Sack BK, Khan SM.

Vaccine. 2015 Dec 22;33(52):7462-8. doi: 10.1016/j.vaccine.2015.09.095. Epub 2015 Oct 23. Review.

16.

Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging.

Sack BK, Miller JL, Vaughan AM, Kappe SH.

Methods Mol Biol. 2015;1325:69-80. doi: 10.1007/978-1-4939-2815-6_6.

PMID:
26450380
17.

Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.

Sack BK, Keitany GJ, Vaughan AM, Miller JL, Wang R, Kappe SH.

PLoS Pathog. 2015 May 14;11(5):e1004855. doi: 10.1371/journal.ppat.1004855. eCollection 2015 May.

18.

Development of Gene Transfer for Induction of Antigen-specific Tolerance.

Sack BK, Herzog RW, Terhorst C, Markusic DM.

Mol Ther Methods Clin Dev. 2014 Apr 30;1:14013.

19.

A novel immune regulator links malaria and inflammatory bowel disease.

Sack BK, Kappe SH.

J Exp Med. 2014 Dec 15;211(13):2482. doi: 10.1084/jem.21113insight1. No abstract available.

20.

Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4.

Sack BK, Wang X, Sherman A, Rogers GL, Markusic DM.

Haemophilia. 2015 Jan;21(1):133-9. doi: 10.1111/hae.12522. Epub 2014 Nov 23.

21.

SSP3 is a novel Plasmodium yoelii sporozoite surface protein with a role in gliding motility.

Harupa A, Sack BK, Lakshmanan V, Arang N, Douglass AN, Oliver BG, Stuart AB, Sather DN, Lindner SE, Hybiske K, Torii M, Kappe SH.

Infect Immun. 2014 Nov;82(11):4643-53. doi: 10.1128/IAI.01800-14. Epub 2014 Aug 25.

22.

Interferon-mediated innate immune responses against malaria parasite liver stages.

Miller JL, Sack BK, Baldwin M, Vaughan AM, Kappe SH.

Cell Rep. 2014 Apr 24;7(2):436-47. doi: 10.1016/j.celrep.2014.03.018. Epub 2014 Apr 3.

23.

Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum.

Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH.

Infect Immun. 2014 Feb;82(2):808-17. doi: 10.1128/IAI.01249-13. Epub 2013 Dec 9.

24.

Still seeking an effective "one-two" malaria vaccine punch.

Smith JD, Sack BK.

Mol Ther. 2012 Dec;20(12):2198-200. doi: 10.1038/mt.2012.241. No abstract available.

25.

Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.

Sack BK, Merchant S, Markusic DM, Nathwani AC, Davidoff AM, Byrne BJ, Herzog RW.

PLoS One. 2012;7(5):e37671. doi: 10.1371/journal.pone.0037671. Epub 2012 May 24.

26.

Induction of tolerance to factor VIII by transient co-administration with rapamycin.

Moghimi B, Sack BK, Nayak S, Markusic DM, Mah CS, Herzog RW.

J Thromb Haemost. 2011 Aug;9(8):1524-33. doi: 10.1111/j.1538-7836.2011.04351.x.

27.

High Efficiency Ex Vivo Gene Transfer to Primary Murine B Cells Using Plasmid or Viral Vectors.

Moghimi B, Zolotukhin I, Sack BK, Herzog RW, Cao O.

J Genet Syndr Gene Ther. 2011 Mar 15;2(103). pii: 1000103.

28.

Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer.

Hoffman BE, Martino AT, Sack BK, Cao O, Liao G, Terhorst C, Herzog RW.

Mol Ther. 2011 Jul;19(7):1263-72. doi: 10.1038/mt.2011.33. Epub 2011 Mar 8.

29.

Evading the immune response upon in vivo gene therapy with viral vectors.

Sack BK, Herzog RW.

Curr Opin Mol Ther. 2009 Oct;11(5):493-503. Review.

30.

Optimized adeno-associated virus (AAV)-protein phosphatase-5 helper viruses for efficient liver transduction by single-stranded AAV vectors: therapeutic expression of factor IX at reduced vector doses.

Jayandharan GR, Zhong L, Sack BK, Rivers AE, Li M, Li B, Herzog RW, Srivastava A.

Hum Gene Ther. 2010 Mar;21(3):271-83. doi: 10.1089/hum.2009.100.

31.

Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings.

George SZ, Dover GC, Wallace MR, Sack BK, Herbstman DM, Aydog E, Fillingim RB.

Clin J Pain. 2008 Nov-Dec;24(9):793-801. doi: 10.1097/AJP.0b013e31817bcb65.

32.

Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings.

George SZ, Wallace MR, Wright TW, Moser MW, Greenfield WH 3rd, Sack BK, Herbstman DM, Fillingim RB.

Pain. 2008 May;136(1-2):53-61. Epub 2007 Aug 7.

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