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Towards Automated Quantification of Atrial Fibrosis in Images from Catheterized Fiber-Optics Confocal Microscopy Using Convolutional Neural Networks.

Huang C, Wasmund SL, Yamaguchi T, Knighton N, Hitchcock RW, Polejaeva IA, White KL, Marrouche NF, Sachse FB.

Funct Imaging Model Heart. 2019 Jun;11504:168-176. doi: 10.1007/978-3-030-21949-9_19. Epub 2019 May 30.


Extended Bidomain Modeling of Defibrillation: Quantifying Virtual Electrode Strengths in Fibrotic Myocardium.

Bragard J, Sankarankutty AC, Sachse FB.

Front Physiol. 2019 Apr 3;10:337. doi: 10.3389/fphys.2019.00337. eCollection 2019.


Evidence for a Heritable Contribution to Atrial Fibrillation Associated With Fibrosis.

Wilson BD, Wasmund SL, Sachse FB, Kaur G, Marrouche NF, Cannon-Albright LA.

JACC Clin Electrophysiol. 2019 Apr;5(4):493-500. doi: 10.1016/j.jacep.2019.01.002. Epub 2019 Feb 27.


A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues.

Colli DF, Blood SR, Sankarankutty AC, Sachse FB, Frisk M, Louch WE, Kekenes-Huskey PM.

Biophys J. 2019 Apr 23;116(8):1386-1393. doi: 10.1016/j.bpj.2019.03.010. Epub 2019 Mar 22.


An Imaging Protocol to Discriminate Specialized Conduction Tissue During Congenital Heart Surgery.

Mondal A, Lackey J, Saeed M, Wu FY, Johnson JK, Huang C, Sachse FB, Hitchcock R, Kaza AK.

Semin Thorac Cardiovasc Surg. 2019 Feb 6. pii: S1043-0679(19)30023-1. doi: 10.1053/j.semtcvs.2019.02.006. [Epub ahead of print]


Modeling effects of voltage dependent properties of the cardiac muscarinic receptor on human sinus node function.

Moss R, Sachse FB, Moreno-Galindo EG, Navarro-Polanco RA, Tristani-Firouzi M, Seemann G.

PLoS Comput Biol. 2018 Oct 10;14(10):e1006438. doi: 10.1371/journal.pcbi.1006438. eCollection 2018 Oct.


Confocal Microscopy-Based Estimation of Parameters for Computational Modeling of Electrical Conduction in the Normal and Infarcted Heart.

Greiner J, Sankarankutty AC, Seemann G, Seidel T, Sachse FB.

Front Physiol. 2018 Apr 4;9:239. doi: 10.3389/fphys.2018.00239. eCollection 2018.


Catheterized Fiber-Optics Confocal Microscopy of the Beating Heart In Situ.

Huang C, Wasmund S, Hitchcock R, Marrouche NF, Sachse FB.

Circ Cardiovasc Imaging. 2017 Oct;10(10). pii: e006881. doi: 10.1161/CIRCIMAGING.117.006881. No abstract available.


Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.

Seidel T, Sankarankutty AC, Sachse FB.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):302-314. doi: 10.1016/j.pbiomolbio.2017.07.006. Epub 2017 Jul 11.


Physiological and pathophysiological role of transient receptor potential canonical channels in cardiac myocytes.

Ahmad AA, Streiff M, Hunter C, Hu Q, Sachse FB.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):254-263. doi: 10.1016/j.pbiomolbio.2017.06.005. Epub 2017 Jun 16. Review.


No fuzzy space for intracellular Na+ in healthy ventricular myocytes.

Sachse FB, Clark R, Giles WR.

J Gen Physiol. 2017 Jul 3;149(7):683-687. doi: 10.1085/jgp.201711826. Epub 2017 Jun 16. No abstract available.


Modulation of Asymmetric Flux in Heterotypic Gap Junctions by Pore Shape, Particle Size and Charge.

Mondal A, Sachse FB, Moreno AP.

Front Physiol. 2017 Apr 6;8:206. doi: 10.3389/fphys.2017.00206. eCollection 2017.


Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.

Seidel T, Navankasattusas S, Ahmad A, Diakos NA, Xu WD, Tristani-Firouzi M, Bonios MJ, Taleb I, Li DY, Selzman CH, Drakos SG, Sachse FB.

Circulation. 2017 Apr 25;135(17):1632-1645. doi: 10.1161/CIRCULATIONAHA.116.024470. Epub 2017 Jan 10.


Computational simulations of asymmetric fluxes of large molecules through gap junction channel pores.

Mondal A, Appadurai DA, Akoum NW, Sachse FB, Moreno AP.

J Theor Biol. 2017 Jan 7;412:61-73. doi: 10.1016/j.jtbi.2016.08.040. Epub 2016 Aug 31.


Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.

Wu W, Gardner A, Sachse FB, Sanguinetti MC.

Mol Pharmacol. 2016 Oct;90(4):469-82. doi: 10.1124/mol.116.104091. Epub 2016 Aug 8.


Diffusion tensor imaging and histology of developing hearts.

Abdullah OM, Seidel T, Dahl M, Gomez AD, Yiep G, Cortino J, Sachse FB, Albertine KH, Hsu EW.

NMR Biomed. 2016 Oct;29(10):1338-49. doi: 10.1002/nbm.3576. Epub 2016 Aug 3.


Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-β1.

Polejaeva IA, Ranjan R, Davies CJ, Regouski M, Hall J, Olsen AL, Meng Q, Rutigliano HM, Dosdall DJ, Angel NA, Sachse FB, Seidel T, Thomas AJ, Stott R, Panter KE, Lee PM, Van Wettere AJ, Stevens JR, Wang Z, MacLeod RS, Marrouche NF, White KL.

J Cardiovasc Electrophysiol. 2016 Oct;27(10):1220-1229. doi: 10.1111/jce.13049. Epub 2016 Aug 30.


Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.

Clark RB, Schmidt TA, Sachse FB, Boyle D, Firestein GS, Giles WR.

J Physiol. 2017 Feb 1;595(3):635-645. doi: 10.1113/JP270209. Epub 2017 Jan 5. Review.


Measurement of Strain in Cardiac Myocytes at Micrometer Scale Based on Rapid Scanning Confocal Microscopy and Non-Rigid Image Registration.

Lichter J, Li H, Sachse FB.

Ann Biomed Eng. 2016 Oct;44(10):3020-3031. doi: 10.1007/s10439-016-1593-7. Epub 2016 Mar 21.


Sensitivity and Specificity of Cardiac Tissue Discrimination Using Fiber-Optics Confocal Microscopy.

Huang C, Sachse FB, Hitchcock RW, Kaza AK.

PLoS One. 2016 Jan 25;11(1):e0147667. doi: 10.1371/journal.pone.0147667. eCollection 2016.


Analyzing Remodeling of Cardiac Tissue: A Comprehensive Approach Based on Confocal Microscopy and 3D Reconstructions.

Seidel T, Edelmann JC, Sachse FB.

Ann Biomed Eng. 2016 May;44(5):1436-1448. doi: 10.1007/s10439-015-1465-6. Epub 2015 Sep 23.


Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure.

Li H, Lichter JG, Seidel T, Tomaselli GF, Bridge JH, Sachse FB.

Circ Heart Fail. 2015 Nov;8(6):1105-14. doi: 10.1161/CIRCHEARTFAILURE.115.002352. Epub 2015 Aug 20.


Reply: does size matter? In search of a physiological definition of myocardial atrophy.

Diakos NA, Selzman CH, Stehlik J, Sachse FB, Kfoury AG, Koliopoulou A, McKellar S, Fang JC, Li DY, Drakos SG.

J Am Coll Cardiol. 2015 May 19;65(19):2156-7. doi: 10.1016/j.jacc.2015.02.064. No abstract available.


Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.

Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N.

J Mol Cell Cardiol. 2015 Mar;80:186-95. doi: 10.1016/j.yjmcc.2015.01.002. Epub 2015 Jan 26.


Local delivery of fluorescent dye for fiber-optics confocal microscopy of the living heart.

Huang C, Kaza AK, Hitchcock RW, Sachse FB.

Front Physiol. 2014 Sep 25;5:367. doi: 10.3389/fphys.2014.00367. eCollection 2014.


Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery.

Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama M, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG.

J Am Coll Cardiol. 2014 Oct 14;64(15):1602-12. doi: 10.1016/j.jacc.2014.05.073.


Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation.

Abdullah OM, Drakos SG, Diakos NA, Wever-Pinzon O, Kfoury AG, Stehlik J, Selzman CH, Reid BB, Brunisholz K, Verma DR, Myrick C, Sachse FB, Li DY, Hsu EW.

NMR Biomed. 2014 Nov;27(11):1378-86. doi: 10.1002/nbm.3200. Epub 2014 Sep 9.


Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy.

Lichter JG, Carruth E, Mitchell C, Barth AS, Aiba T, Kass DA, Tomaselli GF, Bridge JH, Sachse FB.

J Mol Cell Cardiol. 2014 Jul;72:186-95. doi: 10.1016/j.yjmcc.2014.03.012. Epub 2014 Mar 20.


Stoichiometry of altered hERG1 channel gating by small molecule activators.

Wu W, Sachse FB, Gardner A, Sanguinetti MC.

J Gen Physiol. 2014 Apr;143(4):499-512. doi: 10.1085/jgp.201311038. Epub 2014 Mar 17.


A modified local control model for Ca2+ transients in cardiomyocytes: junctional flux is accompanied by release from adjacent non-junctional RyRs.

Torres NS, Sachse FB, Izu LT, Goldhaber JI, Spitzer KW, Bridge JH.

J Mol Cell Cardiol. 2014 Mar;68:1-11. doi: 10.1016/j.yjmcc.2013.12.019. Epub 2014 Jan 3.


3-OST-7 regulates BMP-dependent cardiac contraction.

Samson SC, Ferrer T, Jou CJ, Sachse FB, Shankaran SS, Shaw RM, Chi NC, Tristani-Firouzi M, Yost HJ.

PLoS Biol. 2013 Dec;11(12):e1001727. doi: 10.1371/journal.pbio.1001727. Epub 2013 Dec 3.


Adaptation of the Voltage Dependent Muscarinic M2 Receptor on Cardiac Ik,Ach to Different Ligands.

Moss R, Seemann G, Dössel O, Sachse FB, Tristani-Firouzi M.

Biomed Tech (Berl). 2013 Aug;58 Suppl 1. pii: /j/bmte.2013.58.issue-s1-N/bmt-2013-4332/bmt-2013-4332.xml. doi: 10.1515/bmt-2013-4332. Epub 2013 Sep 7. No abstract available.


Estimating Intracellular Conductivity Tensors from Confocal Microscopy of Rabbit Ventricular Tissue.

Bauer S, Edelmann JC, Seemann G, Sachse FB, Dössel O.

Biomed Tech (Berl). 2013 Aug;58 Suppl 1. pii: /j/bmte.2013.58.issue-s1-N/bmt-2013-4333/bmt-2013-4333.xml. doi: 10.1515/bmt-2013-4333. Epub 2013 Sep 7. No abstract available.


Identification of nodal tissue in the living heart using rapid scanning fiber-optics confocal microscopy and extracellular fluorophores.

Huang C, Kaza AK, Hitchcock RW, Sachse FB.

Circ Cardiovasc Imaging. 2013 Sep;6(5):739-46. doi: 10.1161/CIRCIMAGING.112.000121. Epub 2013 Jun 27.


Voltage sensitivity of M2 muscarinic receptors underlies the delayed rectifier-like activation of ACh-gated K(+) current by choline in feline atrial myocytes.

Navarro-Polanco RA, Aréchiga-Figueroa IA, Salazar-Fajardo PD, Benavides-Haro DE, Rodríguez-Elías JC, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA, Moreno-Galindo EG.

J Physiol. 2013 Sep 1;591(17):4273-86. doi: 10.1113/jphysiol.2013.255166. Epub 2013 May 7.


Quantitative analysis of cardiac tissue including fibroblasts using three-dimensional confocal microscopy and image reconstruction: towards a basis for electrophysiological modeling.

Schwab BC, Seemann G, Lasher RA, Torres NS, Wulfers EM, Arp M, Carruth ED, Bridge JH, Sachse FB.

IEEE Trans Med Imaging. 2013 May;32(5):862-72. doi: 10.1109/TMI.2013.2240693. Epub 2013 Jan 17.


Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia.

Sohn K, Wende AR, Abel ED, Moreno AP, Sachse FB, Punske BB.

Exp Physiol. 2013 Mar;98(3):746-57. doi: 10.1113/expphysiol.2012.070235. Epub 2012 Nov 23.


Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries.

Kekenes-Huskey PM, Cheng Y, Hake JE, Sachse FB, Bridge JH, Holst MJ, McCammon JA, McCulloch AD, Michailova AP.

Front Physiol. 2012 Sep 10;3:351. doi: 10.3389/fphys.2012.00351. eCollection 2012.


An automated approach to analyze microstructural remodeling from confocal microscopies of ventricular myocytes from diseased hearts.

Wülfers EM, Torres NS, Lenis G, Li H, Seemann G, Dössel O, Bridge JH, Sachse FB.

Biomed Tech (Berl). 2012 Aug 24;57(SI-1 Track-B):46-49. doi: 10.1515/bmt-2012-4438. No abstract available.


Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.

Garg V, Sachse FB, Sanguinetti MC.

J Gen Physiol. 2012 Sep;140(3):307-24. doi: 10.1085/jgp.201210826.


Electrical stimulation directs engineered cardiac tissue to an age-matched native phenotype.

Lasher RA, Pahnke AQ, Johnson JM, Sachse FB, Hitchcock RW.

J Tissue Eng. 2012;3(1):2041731412455354. doi: 10.1177/2041731412455354. Epub 2012 Jul 27.


Mechanical modulation of the transverse tubular system of ventricular cardiomyocytes.

McNary TG, Spitzer KW, Holloway H, Bridge JH, Kohl P, Sachse FB.

Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):218-25. doi: 10.1016/j.pbiomolbio.2012.07.010. Epub 2012 Aug 1.


Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy.

Sachse FB, Torres NS, Savio-Galimberti E, Aiba T, Kass DA, Tomaselli GF, Bridge JH.

Circ Res. 2012 Feb 17;110(4):588-97. doi: 10.1161/CIRCRESAHA.111.257428. Epub 2012 Jan 17.


TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.

Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB, Decher N.

Cell Physiol Biochem. 2011;28(4):613-24. doi: 10.1159/000335757. Epub 2011 Dec 14.


Verification of cardiac tissue electrophysiology simulators using an N-version benchmark.

Niederer SA, Kerfoot E, Benson AP, Bernabeu MO, Bernus O, Bradley C, Cherry EM, Clayton R, Fenton FH, Garny A, Heidenreich E, Land S, Maleckar M, Pathmanathan P, Plank G, Rodríguez JF, Roy I, Sachse FB, Seemann G, Skavhaug O, Smith NP.

Philos Trans A Math Phys Eng Sci. 2011 Nov 13;369(1954):4331-51. doi: 10.1098/rsta.2011.0139.


Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.

Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J, Sachse FB, Maier SK.

Cell Physiol Biochem. 2011;28(1):77-86. doi: 10.1159/000331715. Epub 2011 Aug 16.


The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts.

Sohn K, Sachse FB, Moreno AP, Ershler PR, Wende AR, Abel ED, Punske BB.

IEEE Trans Biomed Eng. 2011 Nov;58(11):3175-83. doi: 10.1109/TBME.2011.2164075. Epub 2011 Aug 18.


Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue.

Lackey DP, Carruth ED, Lasher RA, Boenisch J, Sachse FB, Hitchcock RW.

Ann Biomed Eng. 2011 Nov;39(11):2683-94. doi: 10.1007/s10439-011-0369-3. Epub 2011 Aug 6.


Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, Fink M, Fischmeister R, Franz MR, Garny A, Giles WR, Hannes T, Harding SE, Hunter PJ, Iribe G, Jalife J, Johnson CR, Kass RS, Kodama I, Koren G, Lord P, Markhasin VS, Matsuoka S, McCulloch AD, Mirams GR, Morley GE, Nattel S, Noble D, Olesen SP, Panfilov AV, Trayanova NA, Ravens U, Richard S, Rosenbaum DS, Rudy Y, Sachs F, Sachse FB, Saint DA, Schotten U, Solovyova O, Taggart P, Tung L, Varró A, Volders PG, Wang K, Weiss JN, Wettwer E, White E, Wilders R, Winslow RL, Kohl P.

Prog Biophys Mol Biol. 2011 Oct;107(1):4-10. doi: 10.1016/j.pbiomolbio.2011.07.001. Epub 2011 Jul 6.


Strain transfer in ventricular cardiomyocytes to their transverse tubular system revealed by scanning confocal microscopy.

McNary TG, Bridge JH, Sachse FB.

Biophys J. 2011 May 18;100(10):L53-5. doi: 10.1016/j.bpj.2011.03.046.

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