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How Do Ethanolamine Plasmalogens Contribute to Order and Structure of Neurological Membranes?

West A, Zoni V, Teague WE, Leonard AN, Vanni S, Gawrisch K, Tristram-Nagle S, Sachs JN, Klauda JB.

J Phys Chem B. 2020 Jan 9. doi: 10.1021/acs.jpcb.9b08850. [Epub ahead of print]


Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies.

Lo CH, Lim CK, Ding Z, Wickramasinghe SP, Braun AR, Ashe KH, Rhoades E, Thomas DD, Sachs JN.

Alzheimers Dement. 2019 Nov;15(11):1489-1502. doi: 10.1016/j.jalz.2019.06.4954. Epub 2019 Oct 22.


Multiscale Computational Modeling of Tubulin-Tubulin Lateral Interaction.

Hemmat M, Castle BT, Sachs JN, Odde DJ.

Biophys J. 2019 Oct 1;117(7):1234-1249. doi: 10.1016/j.bpj.2019.08.011. Epub 2019 Aug 16.


Noncompetitive inhibitors of TNFR1 probe conformational activation states.

Lo CH, Schaaf TM, Grant BD, Lim CK, Bawaskar P, Aldrich CC, Thomas DD, Sachs JN.

Sci Signal. 2019 Jul 30;12(592). pii: eaav5637. doi: 10.1126/scisignal.aav5637.


Correction to: α-Synuclein's Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity.

Braun AR, Lacy MM, Ducas VC, Chen Z, Baumgart T, Rhoades E, Sachs JN.

J Membr Biol. 2018 Dec;251(5-6):757. doi: 10.1007/s00232-018-0042-y.


Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor-Receptor Interactions.

Vunnam N, Lo CH, Grant BD, Thomas DD, Sachs JN.

J Mol Biol. 2017 Sep 15;429(19):2943-2953. doi: 10.1016/j.jmb.2017.08.009. Epub 2017 Aug 20.


Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer.

Vunnam N, Campbell-Bezat CK, Lewis AK, Sachs JN.

Biophys J. 2017 Jul 25;113(2):381-392. doi: 10.1016/j.bpj.2017.05.038.


Minimal Nucleation State of α-Synuclein Is Stabilized by Dynamic Threonine-Water Networks.

Romo TD, Lewis AK, Braun AR, Grossfield A, Sachs JN.

ACS Chem Neurosci. 2017 Sep 20;8(9):1859-1864. doi: 10.1021/acschemneuro.7b00171. Epub 2017 Jul 10.


An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors.

Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN.

SLAS Discov. 2017 Sep;22(8):950-961. doi: 10.1177/2472555217706478. Epub 2017 May 22.


α-Synuclein's Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity.

Braun AR, Lacy MM, Ducas VC, Rhoades E, Sachs JN.

J Membr Biol. 2017 Apr;250(2):183-193. doi: 10.1007/s00232-017-9946-1. Epub 2017 Feb 26. Erratum in: J Membr Biol. 2018 Dec;251(5-6):757.


Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.

Valley CC, Lewis AK, Sachs JN.

Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt A):1398-1416. doi: 10.1016/j.bbamem.2017.01.016. Epub 2017 Jan 12. Review.


The IM30/Vipp1 C-terminus associates with the lipid bilayer and modulates membrane fusion.

Hennig R, West A, Debus M, Saur M, Markl J, Sachs JN, Schneider D.

Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):126-136. doi: 10.1016/j.bbabio.2016.11.004. Epub 2016 Nov 9.


Polyunsaturated chains in asymmetric lipids disorder raft mixtures and preferentially associate with α-Synuclein.

Brummel BE, Braun AR, Sachs JN.

Biochim Biophys Acta Biomembr. 2017 Apr;1859(4):529-536. doi: 10.1016/j.bbamem.2016.10.006. Epub 2016 Oct 11.


Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function.

Lewis AK, Valley CC, Peery SL, Brummel B, Braun AR, Karim CB, Sachs JN.

J Mol Biol. 2016 Dec 4;428(24 Pt A):4843-4855. doi: 10.1016/j.jmb.2016.10.001. Epub 2016 Oct 6.


Oxidation increases the strength of the methionine-aromatic interaction.

Lewis AK, Dunleavy KM, Senkow TL, Her C, Horn BT, Jersett MA, Mahling R, McCarthy MR, Perell GT, Valley CC, Karim CB, Gao J, Pomerantz WC, Thomas DD, Cembran A, Hinderliter A, Sachs JN.

Nat Chem Biol. 2016 Oct;12(10):860-6. doi: 10.1038/nchembio.2159. Epub 2016 Aug 22.


From the New Editor-in-Chief.

Sachs JN.

Appl Biochem Biotechnol. 2016 Sep;180(1):1-2. doi: 10.1007/s12010-016-2088-6. No abstract available.


HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells.

Romeo C, Weber MC, Zarei M, DeCicco D, Chand SN, Lobo AD, Winter JM, Sawicki JA, Sachs JN, Meisner-Kober N, Yeo CJ, Vadigepalli R, Tykocinski ML, Brody JR.

Mol Cancer Res. 2016 Jul;14(7):599-611. doi: 10.1158/1541-7786.MCR-15-0448. Epub 2016 Apr 6.


Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein.

West A, Brummel BE, Braun AR, Rhoades E, Sachs JN.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1594-609. doi: 10.1016/j.bbamem.2016.03.012. Epub 2016 Mar 10. Review.


α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles.

Braun AR, Sachs JN.

Biophys J. 2015 Apr 21;108(8):1848-51. doi: 10.1016/j.bpj.2015.03.029.


Biophysics of α-synuclein induced membrane remodelling.

Shi Z, Sachs JN, Rhoades E, Baumgart T.

Phys Chem Chem Phys. 2015 Jun 28;17(24):15561-8. doi: 10.1039/c4cp05883f. Epub 2015 Feb 10.


Determining Structural and Mechanical Properties from Molecular Dynamics Simulations of Lipid Vesicles.

Braun AR, Sachs JN.

J Chem Theory Comput. 2014 Sep 9;10(9):4160-4168. Epub 2014 Aug 6.


Thermal fluctuations in amphipol A8-35 particles: a neutron scattering and molecular dynamics study.

Tehei M, Perlmutter JD, Giusti F, Sachs JN, Zaccai G, Popot JL.

J Membr Biol. 2014 Oct;247(9-10):897-908. doi: 10.1007/s00232-014-9725-1. Epub 2014 Sep 10.


α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry.

Braun AR, Lacy MM, Ducas VC, Rhoades E, Sachs JN.

J Am Chem Soc. 2014 Jul 16;136(28):9962-72. doi: 10.1021/ja5016958. Epub 2014 Jul 7.


Molecular dynamics simulations of a membrane protein/amphipol complex.

Perlmutter JD, Popot JL, Sachs JN.

J Membr Biol. 2014 Oct;247(9-10):883-95. doi: 10.1007/s00232-014-9690-8. Epub 2014 Jun 15.


Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation.

Lewis AK, James ZM, McCaffrey JE, Braun AR, Karim CB, Thomas DD, Sachs JN.

Biophys J. 2014 Mar 18;106(6):L21-4. doi: 10.1016/j.bpj.2014.01.044.


Comparing simulations of lipid bilayers to scattering data: the GROMOS 43A1-S3 force field.

Braun AR, Sachs JN, Nagle JF.

J Phys Chem B. 2013 May 2;117(17):5065-72. doi: 10.1021/jp401718k. Epub 2013 Apr 22.


The methionine-aromatic motif plays a unique role in stabilizing protein structure.

Valley CC, Cembran A, Perlmutter JD, Lewis AK, Labello NP, Gao J, Sachs JN.

J Biol Chem. 2012 Oct 12;287(42):34979-91. doi: 10.1074/jbc.M112.374504. Epub 2012 Aug 1.


TNFR1 signaling is associated with backbone conformational changes of receptor dimers consistent with overactivation in the R92Q TRAPS mutant.

Lewis AK, Valley CC, Sachs JN.

Biochemistry. 2012 Aug 21;51(33):6545-55. doi: 10.1021/bi3006626. Epub 2012 Aug 8.


HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells.

Pineda DM, Rittenhouse DW, Valley CC, Cozzitorto JA, Burkhart RA, Leiby B, Winter JM, Weber MC, Londin ER, Rigoutsos I, Yeo CJ, Gorospe M, Witkiewicz AK, Sachs JN, Brody JR.

Cancer Biol Ther. 2012 Aug;13(10):946-55. doi: 10.4161/cbt.20952. Epub 2012 Aug 1.


Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces death receptor 5 networks that are highly organized.

Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN.

J Biol Chem. 2012 Jun 15;287(25):21265-78. doi: 10.1074/jbc.M111.306480. Epub 2012 Apr 10.


α-Synuclein induces both positive mean curvature and negative Gaussian curvature in membranes.

Braun AR, Sevcsik E, Chin P, Rhoades E, Tristram-Nagle S, Sachs JN.

J Am Chem Soc. 2012 Feb 8;134(5):2613-20. doi: 10.1021/ja208316h. Epub 2012 Jan 26.


NaCl interactions with phosphatidylcholine bilayers do not alter membrane structure but induce long-range ordering of ions and water.

Valley CC, Perlmutter JD, Braun AR, Sachs JN.

J Membr Biol. 2011 Nov;244(1):35-42. doi: 10.1007/s00232-011-9395-1. Epub 2011 Oct 21.


All-atom and coarse-grained molecular dynamics simulations of a membrane protein stabilizing polymer.

Perlmutter JD, Drasler WJ 2nd, Xie W, Gao J, Popot JL, Sachs JN.

Langmuir. 2011 Sep 6;27(17):10523-37. doi: 10.1021/la202103v. Epub 2011 Aug 15.


Amphipols from A to Z.

Popot JL, Althoff T, Bagnard D, Banères JL, Bazzacco P, Billon-Denis E, Catoire LJ, Champeil P, Charvolin D, Cocco MJ, Crémel G, Dahmane T, de la Maza LM, Ebel C, Gabel F, Giusti F, Gohon Y, Goormaghtigh E, Guittet E, Kleinschmidt JH, Kühlbrandt W, Le Bon C, Martinez KL, Picard M, Pucci B, Sachs JN, Tribet C, van Heijenoort C, Wien F, Zito F, Zoonens M.

Annu Rev Biophys. 2011;40:379-408. doi: 10.1146/annurev-biophys-042910-155219.


Determination of electron density profiles and area from simulations of undulating membranes.

Braun AR, Brandt EG, Edholm O, Nagle JF, Sachs JN.

Biophys J. 2011 May 4;100(9):2112-20. doi: 10.1016/j.bpj.2011.03.009.


Interpretation of fluctuation spectra in lipid bilayer simulations.

Brandt EG, Braun AR, Sachs JN, Nagle JF, Edholm O.

Biophys J. 2011 May 4;100(9):2104-11. doi: 10.1016/j.bpj.2011.03.010.


Interleaflet interaction and asymmetry in phase separated lipid bilayers: molecular dynamics simulations.

Perlmutter JD, Sachs JN.

J Am Chem Soc. 2011 May 4;133(17):6563-77. doi: 10.1021/ja106626r. Epub 2011 Apr 7.


From the gating charge response to pore domain movement: initial motions of Kv1.2 dynamics under physiological voltage changes.

Denning EJ, Crozier PS, Sachs JN, Woolf TB.

Mol Membr Biol. 2009 Dec;26(8):397-421. doi: 10.3109/09687680903278539.


Inhibiting lateral domain formation in lipid bilayers: simulations of alternative steroid headgroup chemistries.

Perlmutter JD, Sachs JN.

J Am Chem Soc. 2009 Nov 18;131(45):16362-3. doi: 10.1021/ja9079258.


Experimental verification of lipid bilayer structure through multi-scale modeling.

Perlmutter JD, Sachs JN.

Biochim Biophys Acta. 2009 Oct;1788(10):2284-90. doi: 10.1016/j.bbamem.2009.07.006. Epub 2009 Jul 17.


What determines the thickness of a biological membrane.

Kucerka N, Nieh MP, Pencer J, Sachs JN, Katsaras J.

Gen Physiol Biophys. 2009 Jun;28(2):117-25.


Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering.

Kajander T, Sachs JN, Goldman A, Regan L.

J Biol Chem. 2009 Sep 11;284(37):25364-74. doi: 10.1074/jbc.M109.033894. Epub 2009 Jul 7.


Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms.

Perlmutter JD, Braun AR, Sachs JN.

J Biol Chem. 2009 Mar 13;284(11):7177-89. doi: 10.1074/jbc.M808895200. Epub 2009 Jan 5.


The effect of cholesterol on short- and long-chain monounsaturated lipid bilayers as determined by molecular dynamics simulations and X-ray scattering.

Kucerka N, Perlmutter JD, Pan J, Tristram-Nagle S, Katsaras J, Sachs JN.

Biophys J. 2008 Sep 15;95(6):2792-805. doi: 10.1529/biophysj.107.122465. Epub 2008 May 30.


Lipid bilayer structure determined by the simultaneous analysis of neutron and X-ray scattering data.

Kucerka N, Nagle JF, Sachs JN, Feller SE, Pencer J, Jackson A, Katsaras J.

Biophys J. 2008 Sep;95(5):2356-67. doi: 10.1529/biophysj.108.132662. Epub 2008 May 23.


Curvature effect on the structure of phospholipid bilayers.

Kucerka N, Pencer J, Sachs JN, Nagle JF, Katsaras J.

Langmuir. 2007 Jan 30;23(3):1292-9.


Transmembrane homodimerization of receptor-like protein tyrosine phosphatases.

Chin CN, Sachs JN, Engelman DM.

FEBS Lett. 2005 Jul 4;579(17):3855-8.


Environmental Effects on Glycophorin A Folding and Structure Examined through Molecular Simulations.

Nanda H, Sachs JN, Petrache HI, Woolf TB.

J Chem Theory Comput. 2005 May;1(3):375-88. doi: 10.1021/ct049928y.


Polymers for cancer gene therapy: browsing the library.

Sachs JN, Shen H, Saltzman WM.

Gene Ther. 2005 Jun;12(12):954-5. No abstract available.


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