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Shear stress-induced nuclear shrinkage through activation of Piezo1 channels in epithelial cells.

Jetta D, Gottlieb PA, Verma D, Sachs F, Hua SZ.

J Cell Sci. 2019 Jun 12;132(11). pii: jcs226076. doi: 10.1242/jcs.226076.


Investigating the interaction of Grammostola rosea venom peptides and model lipid bilayers with solid-state NMR and electron microscopy techniques.

Polido G, Shi X, Xu D, Guo C, Thai R, Patterson JP, Gianneschi NC, Suchyna TM, Sachs F, Holland GP.

Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):151-160. doi: 10.1016/j.bbamem.2018.08.004. Epub 2018 Aug 12.


Functional analyses of heteromeric human PIEZO1 Channels.

Gnanasambandam R, Bae C, Ziegler L, Sachs F, Gottlieb PA.

PLoS One. 2018 Nov 21;13(11):e0207309. doi: 10.1371/journal.pone.0207309. eCollection 2018.


Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1.

Maneshi MM, Ziegler L, Sachs F, Hua SZ, Gottlieb PA.

Sci Rep. 2018 Sep 24;8(1):14267. doi: 10.1038/s41598-018-32572-2.


Cytoskeletal Contribution to Cell Stiffness Due to Osmotic Swelling; Extending the Donnan Equilibrium.

Chao PC, Sivaselvan M, Sachs F.

Curr Top Membr. 2018;81:83-96. doi: 10.1016/bs.ctm.2018.07.002. Epub 2018 Aug 9. Review.


GsMTx4-D provides protection to the D2.mdx mouse.

Ward CW, Sachs F, Bush ED, Suchyna TM.

Neuromuscul Disord. 2018 Oct;28(10):868-877. doi: 10.1016/j.nmd.2018.07.005. Epub 2018 Jul 21.


The two sides of public debt: Intergenerational altruism and burden shifting.

Fochmann M, Sachs F, Sadrieh A, Weimann J.

PLoS One. 2018 Aug 28;13(8):e0202963. doi: 10.1371/journal.pone.0202963. eCollection 2018.


Heterogeneous Cytoskeletal Force Distribution Delineates the Onset Ca2+ Influx Under Fluid Shear Stress in Astrocytes.

Maneshi MM, Sachs F, Hua SZ.

Front Cell Neurosci. 2018 Mar 16;12:69. doi: 10.3389/fncel.2018.00069. eCollection 2018.


Mechanical Transduction and the Dark Energy of Biology.

Sachs F.

Biophys J. 2018 Jan 9;114(1):3-9. doi: 10.1016/j.bpj.2017.10.035. Review. No abstract available.


Investigating the structural dynamics of the PIEZO1 channel activation and inactivation by coarse-grained modeling.

Zheng W, Sachs F.

Proteins. 2017 Dec;85(12):2198-2208. doi: 10.1002/prot.25384. Epub 2017 Sep 23.


Flow induced adherens junction remodeling driven by cytoskeletal forces.

Verma D, Bajpai VK, Ye N, Maneshi MM, Jetta D, Andreadis ST, Sachs F, Hua SZ.

Exp Cell Res. 2017 Oct 15;359(2):327-336. doi: 10.1016/j.yexcr.2017.08.009. Epub 2017 Aug 10.


The Kinetics and the Permeation Properties of Piezo Channels.

Gnanasambandam R, Gottlieb PA, Sachs F.

Curr Top Membr. 2017;79:275-307. doi: 10.1016/bs.ctm.2016.11.004. Epub 2017 Jan 11. Review.


Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels.

Gnanasambandam R, Nielsen MS, Nicolai C, Sachs F, Hofgaard JP, Dreyer JK.

Front Neuroinform. 2017 Apr 27;11:31. doi: 10.3389/fninf.2017.00031. eCollection 2017.


GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels.

Gnanasambandam R, Ghatak C, Yasmann A, Nishizawa K, Sachs F, Ladokhin AS, Sukharev SI, Suchyna TM.

Biophys J. 2017 Jan 10;112(1):31-45. doi: 10.1016/j.bpj.2016.11.013.


Mechanical stress activates NMDA receptors in the absence of agonists.

Maneshi MM, Maki B, Gnanasambandam R, Belin S, Popescu GK, Sachs F, Hua SZ.

Sci Rep. 2017 Jan 3;7:39610. doi: 10.1038/srep39610.


GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion.

Wang J, Ma Y, Sachs F, Li J, Suchyna TM.

J Mol Cell Cardiol. 2016 Sep;98:83-94. doi: 10.1016/j.yjmcc.2016.07.005. Epub 2016 Jul 14.


Free Volume in Membranes: Viscosity or Tension?

Markin VS, Sachs F.

Open J Biophys. 2015 Jul;5(3):80-83. Epub 2015 Jul 22.


Human PIEZO1 Ion Channel Functions as a Split Protein.

Bae C, Suchyna TM, Ziegler L, Sachs F, Gottlieb PA.

PLoS One. 2016 Mar 10;11(3):e0151289. doi: 10.1371/journal.pone.0151289. eCollection 2016.


Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer.

Peng AW, Gnanasambandam R, Sachs F, Ricci AJ.

J Neurosci. 2016 Mar 9;36(10):2945-56. doi: 10.1523/JNEUROSCI.3011-15.2016.


Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension.

Cox CD, Bae C, Ziegler L, Hartley S, Nikolova-Krstevski V, Rohde PR, Ng CA, Sachs F, Gottlieb PA, Martinac B.

Nat Commun. 2016 Jan 20;7:10366. doi: 10.1038/ncomms10366.


Flow-induced focal adhesion remodeling mediated by local cytoskeletal stresses and reorganization.

Verma D, Meng F, Sachs F, Hua SZ.

Cell Adh Migr. 2015;9(6):432-40. doi: 10.1080/19336918.2015.1089379.


Mechanical transduction by ion channels: A cautionary tale.

Sachs F.

World J Neurol. 2015 Sep 28;5(3):74-87. doi: 10.5316/wjn.v5.i3.74.


Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations.

Nishizawa K, Nishizawa M, Gnanasambandam R, Sachs F, Sukharev SI, Suchyna TM.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt A):2767-78. doi: 10.1016/j.bbamem.2015.09.003. Epub 2015 Sep 2.


Mechanical dynamics in live cells and fluorescence-based force/tension sensors.

Yang C, Zhang X, Guo Y, Meng F, Sachs F, Guo J.

Biochim Biophys Acta. 2015 Aug;1853(8):1889-904. doi: 10.1016/j.bbamcr.2015.05.001. Epub 2015 May 6. Review.


Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels.

Gnanasambandam R, Bae C, Gottlieb PA, Sachs F.

PLoS One. 2015 May 8;10(5):e0125503. doi: 10.1371/journal.pone.0125503. eCollection 2015.


How to get more from less: Comments on "Extracting physics of life at the molecular level: A review of single-molecule data analyses" by W. Colomb and S.K. Sarkar.

Sachs F, Flomenbom O.

Phys Life Rev. 2015 Jun;13:150-2. doi: 10.1016/j.plrev.2015.03.006. Epub 2015 Apr 1. No abstract available.


Cell volume control in three dimensions: Water movement without solute movement.

Sachs F, Sivaselvan MV.

J Gen Physiol. 2015 May;145(5):373-80. doi: 10.1085/jgp.201411297. Epub 2015 Apr 13. No abstract available.


Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells.

Göke J, Lu X, Chan YS, Ng HH, Ly LH, Sachs F, Szczerbinska I.

Cell Stem Cell. 2015 Feb 5;16(2):135-41. doi: 10.1016/j.stem.2015.01.005.


Protonation of the human PIEZO1 ion channel stabilizes inactivation.

Bae C, Sachs F, Gottlieb PA.

J Biol Chem. 2015 Feb 20;290(8):5167-73. doi: 10.1074/jbc.M114.604033. Epub 2015 Jan 5.


A Threshold Shear Force for Calcium Influx in an Astrocyte Model of Traumatic Brain Injury.

Maneshi MM, Sachs F, Hua SZ.

J Neurotrauma. 2015 Jul 1;32(13):1020-9. doi: 10.1089/neu.2014.3677. Epub 2015 Apr 10.


Actin stress in cell reprogramming.

Guo J, Wang Y, Sachs F, Meng F.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5252-61. doi: 10.1073/pnas.1411683111. Epub 2014 Nov 24.


Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy.

Wang Y, Cai E, Rosenkranz T, Ge P, Teng KW, Lim SJ, Smith AM, Chung HJ, Sachs F, Green WN, Gottlieb P, Selvin PR.

Bioconjug Chem. 2014 Dec 17;25(12):2205-11. doi: 10.1021/bc5004179. Epub 2014 Nov 25.


Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5114-22. doi: 10.1073/pnas.1414298111. Epub 2014 Nov 10.


Gigaseal mechanics: creep of the gigaseal under the action of pressure, adhesion, and voltage.

Slavchov RI, Nomura T, Martinac B, Sokabe M, Sachs F.

J Phys Chem B. 2014 Nov 6;118(44):12660-72. doi: 10.1021/jp506965v. Epub 2014 Oct 22.


Hereditary xerocytosis revisited.

Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG.

Am J Hematol. 2014 Dec;89(12):1142-6. doi: 10.1002/ajh.23799. Epub 2014 Jul 21. No abstract available.


Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol.

Han H, Rosenhouse-Dantsker A, Gnanasambandam R, Epshtein Y, Chen Z, Sachs F, Minshall RD, Levitan I.

J Physiol. 2014 Sep 15;592(18):4025-38. doi: 10.1113/jphysiol.2014.273177. Epub 2014 Jul 18.


The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity.

Lu X, Sachs F, Ramsay L, Jacques PÉ, Göke J, Bourque G, Ng HH.

Nat Struct Mol Biol. 2014 Apr;21(4):423-5. doi: 10.1038/nsmb.2799. Epub 2014 Mar 30.


Fluorescence-based force/tension sensors: a novel tool to visualize mechanical forces in structural proteins in live cells.

Guo J, Sachs F, Meng F.

Antioxid Redox Signal. 2014 Feb 20;20(6):986-99. doi: 10.1089/ars.2013.5708. Epub 2014 Jan 15. Review.


Caveolae regulation of mechanosensitive channel function in myotubes.

Huang H, Bae C, Sachs F, Suchyna TM.

PLoS One. 2013 Aug 30;8(8):e72894. doi: 10.1371/journal.pone.0072894. eCollection 2013.


SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells.

Lu X, Göke J, Sachs F, Jacques PÉ, Liang H, Feng B, Bourque G, Bubulya PA, Ng HH.

Nat Cell Biol. 2013 Oct;15(10):1141-1152. doi: 10.1038/ncb2839. Epub 2013 Sep 8.


Human PIEZO1: removing inactivation.

Bae C, Gottlieb PA, Sachs F.

Biophys J. 2013 Aug 20;105(4):880-6. doi: 10.1016/j.bpj.2013.07.019.


Mechanical effects on KATP channel gating in rat ventricular myocytes.

Huang H, Liang L, Liu P, Wei H, Sachs F, Niu W, Wang W.

PLoS One. 2013 May 14;8(5):e63337. doi: 10.1371/journal.pone.0063337. Print 2013.


Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1.

Bae C, Gnanasambandam R, Nicolai C, Sachs F, Gottlieb PA.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1162-8. doi: 10.1073/pnas.1219777110. Epub 2013 Mar 4.


Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth.

Kerstein PC, Jacques-Fricke BT, Rengifo J, Mogen BJ, Williams JC, Gottlieb PA, Sachs F, Gomez TM.

J Neurosci. 2013 Jan 2;33(1):273-85. doi: 10.1523/JNEUROSCI.2142-12.2013.


Interplay between cytoskeletal stresses and cell adaptation under chronic flow.

Verma D, Ye N, Meng F, Sachs F, Rahimzadeh J, Hua SZ.

PLoS One. 2012;7(9):e44167. doi: 10.1371/journal.pone.0044167. Epub 2012 Sep 19.


Microtubules underlie dysfunction in duchenne muscular dystrophy.

Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW.

Sci Signal. 2012 Aug 7;5(236):ra56. doi: 10.1126/scisignal.2002829.


Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.

Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F.

Cell Rep. 2012 Mar 29;1(3):241-50. doi: 10.1016/j.celrep.2012.01.006. Epub 2012 Mar 8.


Molecular force transduction by ion channels: diversity and unifying principles.

Sukharev S, Sachs F.

J Cell Sci. 2012 Jul 1;125(Pt 13):3075-83. doi: 10.1242/jcs.092353. Epub 2012 Jul 13. Review.


Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording.

Gottlieb PA, Bae C, Sachs F.

Channels (Austin). 2012 Jul-Aug;6(4):282-9. doi: 10.4161/chan.21064. Epub 2012 Jul 1.


Piezo1: properties of a cation selective mechanical channel.

Gottlieb PA, Sachs F.

Channels (Austin). 2012 Jul-Aug;6(4):214-9. doi: 10.4161/chan.21050. Epub 2012 Jul 1. Review.

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