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Items: 1 to 50 of 784

1.

A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine.

Navarro-Alvarez N, Gonçalves BMM, Andrews AR, Sachs DH, Huang CA.

Int J Inflam. 2018 Jun 24;2018:6916920. doi: 10.1155/2018/6916920. eCollection 2018.

2.

Transplantation tolerance through mixed chimerism: From allo to xeno.

Sachs DH.

Xenotransplantation. 2018 May;25(3):e12420. doi: 10.1111/xen.12420.

PMID:
29913045
3.

Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates.

Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL Jr, Madsen JC, Sachs DH, Wang Z.

Mol Oncol. 2018 Aug;12(8):1374-1382. doi: 10.1002/1878-0261.12331. Epub 2018 Jul 3.

4.

Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study.

Rivard CJ, Tanabe T, Lanaspa MA, Watanabe H, Nomura S, Andres-Hernando A, Garth K, Sekijima M, Ishimoto T, Ariyoshi Y, Garcia GE, Shah J, Lennan B, Tasaki M, Pomposelli T, Shimizu A, Sachs DH, Johnson RJ, Yamada K.

Transpl Int. 2018 Oct;31(10):1164-1177. doi: 10.1111/tri.13273. Epub 2018 Jun 5.

PMID:
29722117
5.

Absence of interaction between porcine endogenous retrovirus and porcine cytomegalovirus in pig-to-baboon renal xenotransplantation in vivo.

Fishman JA, Sachs DH, Yamada K, Wilkinson RA.

Xenotransplantation. 2018 Sep;25(5):e12395. doi: 10.1111/xen.12395. Epub 2018 Apr 6.

PMID:
29624743
6.

The effects of galectin-3 depletion apheresis on induced skin inflammation in a porcine model.

Navarro-Alvarez N, Goncalves B, Andrews AR, Wang Z, Wang Z, Harrington E, Shah J, Sachs DH, Eliaz I, Huang CA.

J Clin Apher. 2018 Aug;33(4):486-493. doi: 10.1002/jca.21624. Epub 2018 Mar 23.

PMID:
29572917
7.

GalT-KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.

Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake-Alper DK, Boyd LK, Louras NJ, Asfour A, Danton MA, Ho SH, Arn SJ, Hawley RJ, Shimizu A, Nagayasu T, Ayares D, Lorber MI, Sykes M, Sachs DH, Yamada K.

Xenotransplantation. 2018 Sep;25(5):e12391. doi: 10.1111/xen.12391. Epub 2018 Mar 12.

PMID:
29527745
8.

The effects of brain death and ischemia on tolerance induction are organ-specific.

Michel SG, Madariaga MLL, LaMuraglia GM 2nd, Villani V, Sekijima M, Farkash EA, Colvin RB, Sachs DH, Yamada K, Rosengard BR, Allan JS, Madsen JC.

Am J Transplant. 2018 May;18(5):1262-1269. doi: 10.1111/ajt.14674. Epub 2018 Mar 5.

PMID:
29377632
9.

Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet-Kidney Transplantation.

Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH.

Cell Transplant. 2017 Nov;26(11):1755-1762. doi: 10.1177/0963689717732993.

10.

Miscellaneous.

Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN 3rd, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR.

Xenotransplantation. 2017 Nov;24(6). doi: 10.1111/xen.12365. Epub 2017 Nov 28. No abstract available.

PMID:
29193342
11.

Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach.

Sasaki H, Oura T, Spitzer TR, Chen YB, Madsen JC, Allan J, Sachs DH, Cosimi AB, Kawai T.

Hum Immunol. 2018 May;79(5):258-265. doi: 10.1016/j.humimm.2017.11.008. Epub 2017 Nov 22. Review.

PMID:
29175110
12.

Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation.

Sachs DH.

Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S220-S225. doi: 10.1513/AnnalsATS.201607-534MG.

13.

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y.

Biomaterials. 2017 Dec;147:116-132. doi: 10.1016/j.biomaterials.2017.09.019. Epub 2017 Sep 19.

PMID:
28942128
14.

Tolerance in xenotransplantation.

Yamada K, Sykes M, Sachs DH.

Curr Opin Organ Transplant. 2017 Dec;22(6):522-528. doi: 10.1097/MOT.0000000000000466. Review.

15.

Regulation of Clinical Xenotransplantation-Time for a Reappraisal.

Cooper DKC, Pierson RN 3rd, Hering BJ, Mohiuddin MM, Fishman JA, Denner J, Ahn C, Azimzadeh AM, Buhler LH, Cowan PJ, Hawthorne WJ, Kobayashi T, Sachs DH.

Transplantation. 2017 Aug;101(8):1766-1769. doi: 10.1097/TP.0000000000001683. Review.

16.

Topical Delivery of Immunosuppression to Prolong Xenogeneic and Allogeneic Split-Thickness Skin Graft Survival.

Mastroianni M, Ng ZY, Goyal R, Mallard C, Farkash EA, Leonard DA, Albritton A, Shanmugarajah K, Kurtz JM, Sachs DH, Macri LK, Kohn J, Cetrulo CL Jr.

J Burn Care Res. 2018 Apr 20;39(3):363-373. doi: 10.1097/BCR.0000000000000597.

17.

Skin grafts from genetically modified α-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts.

Leonard DA, Mallard C, Albritton A, Torabi R, Mastroianni M, Sachs DH, Kurtz JM, Cetrulo CL Jr.

Burns. 2017 Dec;43(8):1717-1724. doi: 10.1016/j.burns.2017.04.026. Epub 2017 Jun 8.

18.

The promise of organ and tissue preservation to transform medicine.

Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM, Markmann JF, Sachs DH, Chandraker A, Wertheim JA, Rothblatt M, Boyden ES, Eidbo E, Lee WPA, Pomahac B, Brandacher G, Weinstock DM, Elliott G, Nelson D, Acker JP, Uygun K, Schmalz B, Weegman BP, Tocchio A, Fahy GM, Storey KB, Rubinsky B, Bischof J, Elliott JAW, Woodruff TK, Morris GJ, Demirci U, Brockbank KGM, Woods EJ, Ben RN, Baust JG, Gao D, Fuller B, Rabin Y, Kravitz DC, Taylor MJ, Toner M.

Nat Biotechnol. 2017 Jun 7;35(6):530-542. doi: 10.1038/nbt.3889. Review.

19.

Ontak-like human IL-2 fusion toxin.

Wang Z, Zheng Q, Zhang H, Bronson RT, Madsen JC, Sachs DH, Huang CA, Wang Z.

J Immunol Methods. 2017 Sep;448:51-58. doi: 10.1016/j.jim.2017.05.008. Epub 2017 May 24.

20.

Prolonged Survival Following Pig-to-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade.

Shah JA, Patel MS, Elias N, Navarro-Alvarez N, Rosales I, Wilkinson RA, Louras NJ, Hertl M, Fishman JA, Colvin RB, Cosimi AB, Markmann JF, Sachs DH, Vagefi PA.

Am J Transplant. 2017 Aug;17(8):2178-2185. doi: 10.1111/ajt.14341. Epub 2017 Jun 6.

21.

Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients.

Gao B, Gu Y, Rong C, Moore C, Porcheray F, Wong W, Preffer F, Saidman SL, Fu Y, Cosimi B, Sachs DH, Kawai T, Sykes M, Zorn E.

Transplantation. 2017 Nov;101(11):2722-2730. doi: 10.1097/TP.0000000000001789.

PMID:
28422925
22.

Vascularized Composite Allotransplantation-An Emerging Concept for Burn Reconstruction.

Ng ZY, Lellouch AG, Drijkoningen T, Chang IA, Sachs DH, Cetrulo CL Jr.

J Burn Care Res. 2017 Nov/Dec;38(6):371-378. doi: 10.1097/BCR.0000000000000532.

PMID:
28328655
23.

Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19+ tumors.

Zheng Q, Wang Z, Zhang H, Huang Q, Madsen JC, Sachs DH, Huang CA, Wang Z.

Mol Oncol. 2017 May;11(5):584-594. doi: 10.1002/1878-0261.12056. Epub 2017 Apr 4.

24.

Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons.

Machaidze Z, Yeh H, Wei L, Schuetz C, Carvello M, Sgroi A, Smith RN, Schuurman HJ, Sachs DH, Morel P, Markmann JF, Bühler LH.

Xenotransplantation. 2017 May;24(3). doi: 10.1111/xen.12297. Epub 2017 Mar 5.

PMID:
28261903
25.

Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation.

Tanabe T, Watanabe H, Shah JA, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Dardenne Meyers A, Ekanayake-Alper DK, Sachs DH, Yamada K.

Am J Transplant. 2017 Jul;17(7):1778-1790. doi: 10.1111/ajt.14210. Epub 2017 Mar 3.

26.

Methods for the detection and serum depletion of porcine galectin-3.

Eliaz I, Patil A, Navarro-Alvarez N, Wang Z, Eliaz A, Weil E, Wilk B, Sachs DH, Huang CA.

J Clin Apher. 2017 Oct;32(5):335-341. doi: 10.1002/jca.21521. Epub 2017 Jan 13.

PMID:
28083958
27.

The Effect of MHC Antigen Matching Between Donors and Recipients on Skin Tolerance of Vascularized Composite Allografts.

Shanmugarajah K, Powell H, Leonard DA, Mallard C, Albritton A, Harrington E, Randolph MA, Farkash E, Sachs DH, Kurtz JM, Cetrulo CL Jr.

Am J Transplant. 2017 Jul;17(7):1729-1741. doi: 10.1111/ajt.14189. Epub 2017 Feb 8.

28.

Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Wang Z, Navarro-Alvarez N, Shah JA, Zhang H, Huang Q, Zheng Q, Madsen JC, Sachs DH, Huang CA, Wang Z.

Vet Immunol Immunopathol. 2016 Dec;182:150-158. doi: 10.1016/j.vetimm.2016.10.014. Epub 2016 Oct 29.

29.

Blockade of IgM-Mediated Inflammation Alters Wound Progression in a Swine Model of Partial-Thickness Burn.

Sadeghipour H, Torabi R, Gottschall J, Lujan-Hernandez J, Sachs DH, Moore FD Jr, Cetrulo CL Jr.

J Burn Care Res. 2017 May/Jun;38(3):148-160. doi: 10.1097/BCR.0000000000000459.

30.

A Comparative Examination of the Clinical Outcome and Histological Appearance of Cryopreserved and Fresh Split-Thickness Skin Grafts.

Holzer PW, Leonard DA, Shanmugarajah K, Moulton KN, Ng ZY, Cetrulo CL Jr, Sachs DH.

J Burn Care Res. 2017 Jan/Feb;38(1):e55-e61. doi: 10.1097/BCR.0000000000000431.

31.

Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation.

Duran-Struuck R, Matar AJ, Crepeau RL, Teague AGS, Horner BM, Pathiraja V, Spitzer TR, Fishman JA, Bronson RT, Sachs DH, Huang CA.

Biol Blood Marrow Transplant. 2016 Nov;22(11):1953-1960. doi: 10.1016/j.bbmt.2016.08.011. Epub 2016 Aug 16.

32.

Bioengineered Self-assembled Skin as an Alternative to Skin Grafts.

Climov M, Medeiros E, Farkash EA, Qiao J, Rousseau CF, Dong S, Zawadzka A, Racki WJ, Al-Musa A, Sachs DH, Randolph MA, Huang CA, Bollenbach TJ.

Plast Reconstr Surg Glob Open. 2016 Jun 10;4(6):e731. doi: 10.1097/GOX.0000000000000723. eCollection 2016 Jun.

33.

Survival of Allogeneic Self-Assembled Cultured Skin.

Climov M, Matar AJ, Farkash EA, Medeiros E, Qiao J, Harrington E, Gusha A, Al-Musa A, Sachs DH, Randolph M, Bollenbach TJ, Huang CA.

Transplantation. 2016 Oct;100(10):2071-8. doi: 10.1097/TP.0000000000001353.

34.

Induced regulatory T cells in allograft tolerance via transient mixed chimerism.

Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T.

JCI Insight. 2016 Jul 7;1(10). pii: e86419.

35.

Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys.

Pathiraja V, Villani V, Tasaki M, Matar AJ, Duran-Struuck R, Yamada R, Moran SG, Clayman ES, Hanekamp J, Shimizu A, Sachs DH, Huang CA, Yamada K.

Am J Transplant. 2017 Jan;17(1):91-102. doi: 10.1111/ajt.13952. Epub 2016 Aug 9.

36.

Effect of tolerance versus chronic immunosuppression protocols on the quality of life of kidney transplant recipients.

Madariaga ML, Spencer PJ, Shanmugarajah K, Crisalli KA, Chang DC, Markmann JF, Elias N, Cosimi AB, Sachs DH, Kawai T.

JCI Insight. 2016 Jun 2;1(8). pii: e87019.

37.

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47.

Tena AA, Sachs DH, Mallard C, Yang YG, Tasaki M, Farkash E, Rosales IA, Colvin RB, Leonard DA, Hawley RJ.

Transplantation. 2017 Feb;101(2):316-321. doi: 10.1097/TP.0000000000001267.

38.

Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation.

Tasaki M, Villani V, Shimizu A, Sekijima M, Yamada R, Hanekamp IM, Hanekamp JS, Cormack TA, Moran SG, Kawai A, Sachs DH, Yamada K.

Am J Transplant. 2016 Oct;16(10):2877-2891. doi: 10.1111/ajt.13855. Epub 2016 Jun 13.

39.

A Bridge to Somewhere: 25-day Survival After Pig-to-Baboon Liver Xenotransplantation.

Shah JA, Navarro-Alvarez N, DeFazio M, Rosales IA, Elias N, Yeh H, Colvin RB, Cosimi AB, Markmann JF, Hertl M, Sachs DH, Vagefi PA.

Ann Surg. 2016 Jun;263(6):1069-71. doi: 10.1097/SLA.0000000000001659. No abstract available.

PMID:
26825261
40.

Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants.

Buhler L, Illigens BM, Nadazdin O, Tena A, Lee S, Sachs DH, Cooper DK, Benichou G.

Am J Transplant. 2016 Jun;16(6):1917-22. doi: 10.1111/ajt.13695. Epub 2016 Mar 14.

41.

Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model.

Sihag S, Haas MS, Kim KM, Guerrero JL, Beaudoin J, Alicot EM, Schuerpf F, Gottschall JD, Puro RJ, Madsen JC, Sachs DH, Newman W, Carroll MC, Allan JS.

Circ Cardiovasc Interv. 2016 Jan;9(1):e002547. doi: 10.1161/CIRCINTERVENTIONS.115.002547.

42.

Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Wang Z, Pratts SG, Zhang H, Spencer PJ, Yu R, Tonsho M, Shah JA, Tanabe T, Powell HR, Huang CA, Madsen JC, Sachs DH, Wang Z.

Mol Oncol. 2016 Apr;10(4):553-65. doi: 10.1016/j.molonc.2015.11.008. Epub 2015 Nov 19.

43.

The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation.

Navarro-Alvarez N, Shah JA, Zhu A, Ligocka J, Yeh H, Elias N, Rosales I, Colvin R, Cosimi AB, Markmann JF, Hertl M, Sachs DH, Vagefi PA.

Am J Transplant. 2016 Jun;16(6):1715-1725. doi: 10.1111/ajt.13647. Epub 2016 Feb 5.

44.

Tolerance induction via mixed chimerism in vascularized composite allotransplantation: is it time for clinical application?

Cetrulo CL Jr, Drijkoningen T, Sachs DH.

Curr Opin Organ Transplant. 2015 Dec;20(6):602-7. doi: 10.1097/MOT.0000000000000248. Review.

PMID:
26536420
45.

Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.

Duran-Struuck R, Huang CA, Orf K, Bronson RT, Sachs DH, Spitzer TR.

Comp Med. 2015 Oct;65(5):429-43. Review.

46.

Effects of Lung Cotransplantation on Cardiac Allograft Tolerance Across a Full Major Histocompatibility Complex Barrier in Miniature Swine.

Madariaga ML, Spencer PJ, Michel SG, La Muraglia GM 2nd, O'Neil MJ, Mannon EC, Leblang C, Rosales IA, Colvin RB, Sachs DH, Allan JS, Madsen JC.

Am J Transplant. 2016 Mar;16(3):979-86. doi: 10.1111/ajt.13489. Epub 2015 Oct 15.

47.

Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.

Newell KA, Asare A, Sanz I, Wei C, Rosenberg A, Gao Z, Kanaparthi S, Asare S, Lim N, Stahly M, Howell M, Knechtle S, Kirk A, Marks WH, Kawai T, Spitzer T, Tolkoff-Rubin N, Sykes M, Sachs DH, Cosimi AB, Burlingham WJ, Phippard D, Turka LA.

Am J Transplant. 2015 Nov;15(11):2908-20. doi: 10.1111/ajt.13480. Epub 2015 Oct 13.

48.

Postnatal xenogeneic B-cell tolerance in swine following in utero intraportal antigen exposure.

Navarro Alvarez N, Zhu A, Arellano RS, Randolph MA, Duggan M, Scott Arn J, Huang CA, Sachs DH, Vagefi PA.

Xenotransplantation. 2015 Sep-Oct;22(5):368-78. doi: 10.1111/xen.12186. Epub 2015 Aug 28.

PMID:
26314946
49.

Progress towards inducing tolerance of pig-to-primate xenografts.

Vagefi PA, Shah JA, Sachs DH.

Int J Surg. 2015 Nov;23(Pt B):291-295. doi: 10.1016/j.ijsu.2015.07.720. Epub 2015 Aug 18. Review.

50.

Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model.

Villani V, Yamada K, Scalea JR, Gillon BC, Arn JS, Sekijima M, Tasaki M, Cormack TA, Moran SG, Torabi R, Shimizu A, Sachs DH.

Am J Transplant. 2016 Jan;16(1):317-24. doi: 10.1111/ajt.13424. Epub 2015 Aug 10.

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