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Items: 1 to 50 of 61

1.

High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer's Disease in Human Cerebrospinal Fluid.

Hendrickson RC, Lee AY, Song Q, Liaw A, Wiener M, Paweletz CP, Seeburger JL, Li J, Meng F, Deyanova EG, Mazur MT, Settlage RE, Zhao X, Southwick K, Du Y, Holder D, Sachs JR, Laterza OF, Dallob A, Chappell DL, Snyder K, Modur V, King E, Joachim C, Bondarenko AY, Shearman M, Soper KA, Smith AD, Potter WZ, Koblan KS, Sachs AB, Yates NA.

PLoS One. 2015 Aug 13;10(8):e0135365. doi: 10.1371/journal.pone.0135365. eCollection 2015.

2.

ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).

Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kuklin NA, Mitnaul LJ.

Lipids. 2011 Nov;46(11):991-1003. doi: 10.1007/s11745-011-3596-3. Epub 2011 Aug 9.

3.

Biodistribution of small interfering RNA at the organ and cellular levels after lipid nanoparticle-mediated delivery.

Shi B, Keough E, Matter A, Leander K, Young S, Carlini E, Sachs AB, Tao W, Abrams M, Howell B, Sepp-Lorenzino L.

J Histochem Cytochem. 2011 Aug;59(8):727-40. doi: 10.1369/0022155411410885.

4.

RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.

Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M, Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA.

Mol Pharmacol. 2011 Jun;79(6):953-63. doi: 10.1124/mol.110.070409. Epub 2011 Mar 22.

PMID:
21427169
5.

siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.

Tadin-Strapps M, Peterson LB, Cumiskey AM, Rosa RL, Mendoza VH, Castro-Perez J, Puig O, Zhang L, Strapps WR, Yendluri S, Andrews L, Pickering V, Rice J, Luo L, Chen Z, Tep S, Ason B, Somers EP, Sachs AB, Bartz SR, Tian J, Chin J, Hubbard BK, Wong KK, Mitnaul LJ.

J Lipid Res. 2011 Jun;52(6):1084-97. doi: 10.1194/jlr.M012872. Epub 2011 Mar 11.

6.

Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9.

Ason B, Tep S, Davis HR Jr, Xu Y, Tetzloff G, Galinski B, Soriano F, Dubinina N, Zhu L, Stefanni A, Wong KK, Tadin-Strapps M, Bartz SR, Hubbard B, Ranalletta M, Sachs AB, Flanagan WM, Strack A, Kuklin NA.

J Lipid Res. 2011 Apr;52(4):679-87. doi: 10.1194/jlr.M013664. Epub 2011 Jan 24.

7.

Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses.

Tao W, Mao X, Davide JP, Ng B, Cai M, Burke PA, Sachs AB, Sepp-Lorenzino L.

Mol Ther. 2011 Mar;19(3):567-75. doi: 10.1038/mt.2010.282. Epub 2010 Dec 21.

8.

Persistence of seed-based activity following segmentation of a microRNA guide strand.

Chorn G, Zhao L, Sachs AB, Flanagan WM, Lim LP.

RNA. 2010 Dec;16(12):2336-40. doi: 10.1261/rna.2296210. Epub 2010 Oct 22.

9.

Quantitative evaluation of siRNA delivery in vivo.

Pei Y, Hancock PJ, Zhang H, Bartz R, Cherrin C, Innocent N, Pomerantz CJ, Seitzer J, Koser ML, Abrams MT, Xu Y, Kuklin NA, Burke PA, Sachs AB, Sepp-Lorenzino L, Barnett SF.

RNA. 2010 Dec;16(12):2553-63. doi: 10.1261/rna.2255810. Epub 2010 Oct 12.

10.

Application of an end-to-end biomarker discovery platform to identify target engagement markers in cerebrospinal fluid by high resolution differential mass spectrometry.

Paweletz CP, Wiener MC, Bondarenko AY, Yates NA, Song Q, Liaw A, Lee AY, Hunt BT, Henle ES, Meng F, Sleph HF, Holahan M, Sankaranarayanan S, Simon AJ, Settlage RE, Sachs JR, Shearman M, Sachs AB, Cook JJ, Hendrickson RC.

J Proteome Res. 2010 Mar 5;9(3):1392-401. doi: 10.1021/pr900925d.

PMID:
20095649
11.

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

Kenski DM, Cooper AJ, Li JJ, Willingham AT, Haringsma HJ, Young TA, Kuklin NA, Jones JJ, Cancilla MT, McMasters DR, Mathur M, Sachs AB, Flanagan WM.

Nucleic Acids Res. 2010 Jan;38(2):660-71. doi: 10.1093/nar/gkp913. Epub 2009 Nov 16.

12.

Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.

Abrams MT, Koser ML, Seitzer J, Williams SC, DiPietro MA, Wang W, Shaw AW, Mao X, Jadhav V, Davide JP, Burke PA, Sachs AB, Stirdivant SM, Sepp-Lorenzino L.

Mol Ther. 2010 Jan;18(1):171-80. doi: 10.1038/mt.2009.208. Epub 2009 Sep 8.

13.

MicroRNA-like off-target transcript regulation by siRNAs is species specific.

Burchard J, Jackson AL, Malkov V, Needham RH, Tan Y, Bartz SR, Dai H, Sachs AB, Linsley PS.

RNA. 2009 Feb;15(2):308-15. doi: 10.1261/rna.1326809.

14.

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.

Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17967-72. Epub 2006 Nov 10.

15.

Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment.

Simon JS, Karnoub MC, Devlin DJ, Arreaza MG, Qiu P, Monks SA, Severino ME, Deutsch P, Palmisano J, Sachs AB, Bayne ML, Plump AS, Schadt EE.

Genomics. 2005 Dec;86(6):648-56. Epub 2005 Nov 16.

16.

Skin biopsies for the measurement of clinical pharmacodynamic biomarkers.

Phillips RL, Sachs AB.

Curr Opin Biotechnol. 2005 Dec;16(6):687-90. Epub 2005 Oct 28. Review.

PMID:
16257524
17.

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels.

Cervino AC, Li G, Edwards S, Zhu J, Laurie C, Tokiwa G, Lum PY, Wang S, Castellani LW, Lusis AJ, Carlson S, Sachs AB, Schadt EE.

Genomics. 2005 Nov;86(5):505-17. Epub 2005 Aug 29. Erratum in: Genomics. 2009 Apr;93(4):399. Castellini, Lawrence W [corrected to Castellani, Lawrence W].

PMID:
16126366
18.

An integrative genomics approach to the reconstruction of gene networks in segregating populations.

Zhu J, Lum PY, Lamb J, GuhaThakurta D, Edwards SW, Thieringer R, Berger JP, Wu MS, Thompson J, Sachs AB, Schadt EE.

Cytogenet Genome Res. 2004;105(2-4):363-74.

PMID:
15237224
19.

Loss of translational control in yeast compromised for the major mRNA decay pathway.

Holmes LE, Campbell SG, De Long SK, Sachs AB, Ashe MP.

Mol Cell Biol. 2004 Apr;24(7):2998-3010.

20.

Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.

Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G.

Cell. 2003 Dec 12;115(6):739-50.

21.

Interactions of the eukaryotic translation initiation factor eIF4E.

Gross JD, Matsuo H, Fletcher M, Sachs AB, Wagner G.

Cold Spring Harb Symp Quant Biol. 2001;66:397-402. Review. No abstract available.

PMID:
12762042
22.

One-step affinity purification of the yeast ribosome and its associated proteins and mRNAs.

Inada T, Winstall E, Tarun SZ Jr, Yates JR 3rd, Schieltz D, Sachs AB.

RNA. 2002 Jul;8(7):948-58.

23.

Development and characterization of a reconstituted yeast translation initiation system.

Algire MA, Maag D, Savio P, Acker MG, Tarun SZ Jr, Sachs AB, Asano K, Nielsen KH, Olsen DS, Phan L, Hinnebusch AG, Lorsch JR.

RNA. 2002 Mar;8(3):382-97.

24.

A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols.

Ashe MP, Slaven JW, De Long SK, Ibrahimo S, Sachs AB.

EMBO J. 2001 Nov 15;20(22):6464-74.

25.

The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation.

Fortes P, Inada T, Preiss T, Hentze MW, Mattaj IW, Sachs AB.

Mol Cell. 2000 Jul;6(1):191-6.

26.

Cell cycle-dependent translation initiation: IRES elements prevail.

Sachs AB.

Cell. 2000 Apr 28;101(3):243-5. Review. No abstract available.

27.

Eukaryotic translation initiation: there are (at least) two sides to every story.

Sachs AB, Varani G.

Nat Struct Biol. 2000 May;7(5):356-61. Review.

PMID:
10802729
28.

The Saccharomyces cerevisiae RNA-binding protein Rbp29 functions in cytoplasmic mRNA metabolism.

Winstall E, Sadowski M, Kuhn U, Wahle E, Sachs AB.

J Biol Chem. 2000 Jul 21;275(29):21817-26.

29.

Glucose depletion rapidly inhibits translation initiation in yeast.

Ashe MP, De Long SK, Sachs AB.

Mol Biol Cell. 2000 Mar;11(3):833-48.

31.

The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1.

Hershey PE, McWhirter SM, Gross JD, Wagner G, Alber T, Sachs AB.

J Biol Chem. 1999 Jul 23;274(30):21297-304.

32.

Decapping of stabilized, polyadenylated mRNA in yeast pab1 mutants.

Morrissey JP, Deardorff JA, Hebron C, Sachs AB.

Yeast. 1999 Jun 15;15(8):687-702.

34.
35.

Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant.

Boeck R, Lapeyre B, Brown CE, Sachs AB.

Mol Cell Biol. 1998 Sep;18(9):5062-72.

36.

Circularization of mRNA by eukaryotic translation initiation factors.

Wells SE, Hillner PE, Vale RD, Sachs AB.

Mol Cell. 1998 Jul;2(1):135-40.

38.
39.

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation.

Tarun SZ Jr, Wells SE, Deardorff JA, Sachs AB.

Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9046-51.

40.

Starting at the beginning, middle, and end: translation initiation in eukaryotes.

Sachs AB, Sarnow P, Hentze MW.

Cell. 1997 Jun 13;89(6):831-8. Review. No abstract available.

41.

Common themes in translational and transcriptional regulation.

Sachs AB, Buratowski S.

Trends Biochem Sci. 1997 Jun;22(6):189-92. Review.

PMID:
9204702
43.
44.

PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae.

Brown CE, Tarun SZ Jr, Boeck R, Sachs AB.

Mol Cell Biol. 1996 Oct;16(10):5744-53.

45.

The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.

Boeck R, Tarun S Jr, Rieger M, Deardorff JA, Müller-Auer S, Sachs AB.

J Biol Chem. 1996 Jan 5;271(1):432-8.

46.

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

Tarun SZ Jr, Sachs AB.

Genes Dev. 1995 Dec 1;9(23):2997-3007.

47.

Messenger RNA degradation in eukaryotes.

Sachs AB.

Cell. 1993 Aug 13;74(3):413-21. Review. No abstract available.

PMID:
7688664
48.

3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.

Lowell JE, Rudner DZ, Sachs AB.

Genes Dev. 1992 Nov;6(11):2088-99.

49.

Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast.

Sachs AB, Deardorff JA.

Cell. 1992 Sep 18;70(6):961-73.

PMID:
1339314
50.

The Saccharomyces cerevisiae RPB4 gene is tightly linked to the TIF2 gene.

Foreman PK, Davis RW, Sachs AB.

Nucleic Acids Res. 1991 May 25;19(10):2781. No abstract available.

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