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Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances.

Dreser N, Madjar K, Holzer AK, Kapitza M, Scholz C, Kranaster P, Gutbier S, Klima S, Kolb D, Dietz C, Trefzer T, Meisig J, van Thriel C, Henry M, Berthold MR, Blüthgen N, Sachinidis A, Rahnenführer J, Hengstler JG, Waldmann T, Leist M.

Arch Toxicol. 2019 Nov 11. doi: 10.1007/s00204-019-02612-5. [Epub ahead of print]


Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations.

Hamad S, Derichsweiler D, Papadopoulos S, Nguemo F, Šarić T, Sachinidis A, Brockmeier K, Hescheler J, Boukens BJ, Pfannkuche K.

Theranostics. 2019 Sep 25;9(24):7222-7238. doi: 10.7150/thno.32058. eCollection 2019.


Functional implications of Cav 2.3 R-type voltage-gated calcium channels in the murine auditory system - novel vistas from brainstem-evoked response audiometry.

Lundt A, Soós J, Seidel R, Henseler C, Müller R, Raj Ginde V, Imran Arshaad M, Ehninger D, Hescheler J, Sachinidis A, Broich K, Wormuth C, Papazoglou A, Weiergräber M.

Eur J Neurosci. 2019 Oct 11. doi: 10.1111/ejn.14591. [Epub ahead of print]


IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis.

Czepukojc B, Abuhaliema A, Barghash A, Tierling S, Naß N, Simon Y, Körbel C, Cadenas C, van Hul N, Sachinidis A, Hengstler JG, Helms V, Laschke MW, Walter J, Haybaeck J, Leclercq I, Kiemer AK, Kessler SM.

Front Med (Lausanne). 2019 Sep 4;6:179. doi: 10.3389/fmed.2019.00179. eCollection 2019.


GSK-3β inhibition protects the rat heart from the lipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity.

Li Z, Zhu H, Liu C, Wang Y, Wang D, Liu H, Cao W, Hu Y, Lin Q, Tong C, Lu M, Sachinidis A, Li L, Peng L.

J Cell Mol Med. 2019 Nov;23(11):7796-7809. doi: 10.1111/jcmm.14656. Epub 2019 Sep 10.


Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants.

Santos JMA, Mendes-Silva L, Afonso V, Martins G, Machado RSR, Lopes JA, Cancela L, Futschik ME, Sachinidis A, Gavaia P, Bragança J.

Cell Death Dis. 2019 Aug 5;10(8):582. doi: 10.1038/s41419-019-1816-6.


Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27.


Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice.

Lundt A, Soos J, Henseler C, Arshaad MI, Müller R, Ehninger D, Hescheler J, Sachinidis A, Broich K, Wormuth C, Papazoglou A, Weiergräber M.

J Vis Exp. 2019 May 10;(147). doi: 10.3791/59200.


Road Map for Development of Stem Cell-Based Alternative Test Methods.

Sachinidis A, Albrecht W, Nell P, Cherianidou A, Hewitt NJ, Edlund K, Hengstler JG.

Trends Mol Med. 2019 Jun;25(6):470-481. doi: 10.1016/j.molmed.2019.04.003. Epub 2019 May 23. Review.


Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis.

Argenziano MA, Doss MX, Tabler M, Sachinidis A, Antzelevitch C.

PLoS One. 2019 May 13;14(5):e0216928. doi: 10.1371/journal.pone.0216928. eCollection 2019.


Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications.

Doss MX, Sachinidis A.

Cells. 2019 Apr 30;8(5). pii: E403. doi: 10.3390/cells8050403. Review.


Renovascular Hypertension: Novel Insights.

Boutari C, Georgianou E, Sachinidis A, Katsimardou A, Christou K, Piperidou A, Karagiannis A.

Curr Hypertens Rev. 2019 Apr 16. doi: 10.2174/1573402115666190416153321. [Epub ahead of print]


Cav3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System.

Lundt A, Seidel R, Soós J, Henseler C, Müller R, Bakki M, Arshaad MI, Ehninger D, Hescheler J, Sachinidis A, Broich K, Wormuth C, Papazoglou A, Weiergräber M.

Neuroscience. 2019 Jun 15;409:81-100. doi: 10.1016/j.neuroscience.2019.04.024. Epub 2019 Apr 25.


Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes.

Acharya A, Brungs S, Lichterfeld Y, Hescheler J, Hemmersbach R, Boeuf H, Sachinidis A.

Cells. 2019 Apr 14;8(4). pii: E352. doi: 10.3390/cells8040352.


Hypertension in Metabolic Syndrome: novel insights.

Katsimardou A, Imprialos K, Stavropoulos K, Sachinidis A, Doumas M, Athyros V.

Curr Hypertens Rev. 2019 Apr 15. doi: 10.2174/1573402115666190415161813. [Epub ahead of print]


Macrovascular complications of type 2 diabetes mellitus.

Viigimaa M, Sachinidis A, Toumpourleka M, Koutsampasopoulos K, Alliksoo S, Titma T.

Curr Vasc Pharmacol. 2019 Apr 5. doi: 10.2174/1570161117666190405165151. [Epub ahead of print]


Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway.

Wang D, Wang Y, Liu H, Tong C, Ying Q, Sachinidis A, Li L, Peng L.

J Cell Mol Med. 2019 May;23(5):3629-3640. doi: 10.1111/jcmm.14264. Epub 2019 Mar 25.


Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav3.2 T-type voltage-gated calcium channel.

Lundt A, Henseler C, Wormuth C, Soos J, Seidel R, Müller R, Arshaad MI, Broich K, Hescheler J, Sachinidis A, Ehninger D, Papazoglou A, Weiergräber M.

BMC Res Notes. 2019 Mar 20;12(1):157. doi: 10.1186/s13104-019-4169-4.


Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.

Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L.

EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18.


Psoriasis and acute coronary syndrome risk.

Sachinidis A, Nikolic D, Rizzo M, Cianflone D.

Int J Cardiol. 2019 Jul 1;286:15-16. doi: 10.1016/j.ijcard.2019.02.042. Epub 2019 Feb 22. No abstract available.


Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts.

Heras-Bautista CO, Mikhael N, Lam J, Shinde V, Katsen-Globa A, Dieluweit S, Molcanyi M, Uvarov V, Jütten P, Sahito RGA, Mederos-Henry F, Piechot A, Brockmeier K, Hescheler J, Sachinidis A, Pfannkuche K.

Acta Biomater. 2019 Apr 15;89:180-192. doi: 10.1016/j.actbio.2019.03.017. Epub 2019 Mar 9.


Boosting the Limited Use of Mineralocorticoid Receptor Antagonists Through New Agents for Hyperkalemia.

Athyros VG, Sachinidis AG, Zografou I, Simoulidou E, Piperidou A, Stavropoulos N, Karagiannis A.

Curr Pharm Des. 2018;24(46):5542-5547. doi: 10.2174/1381612825666190306162339.


Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P.

Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.


yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.

Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L.

Cell Stem Cell. 2019 Feb 7;24(2):318-327.e8. doi: 10.1016/j.stem.2018.11.005. Epub 2018 Dec 13.


Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Grinberg M, Stöber RM, Albrecht W, Edlund K, Schug M, Godoy P, Cadenas C, Marchan R, Lampen A, Braeuning A, Buhrke T, Leist M, Oberemm A, Hellwig B, Kamp H, Gardner I, Escher S, Taboureau O, Aguayo-Orozco A, Sachinidis A, Ellinger-Ziegelbauer H, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2018 Dec;92(12):3517-3533. doi: 10.1007/s00204-018-2352-3. Epub 2018 Dec 3.


Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav2.3 R-type voltage-gated calcium channel.

Lundt A, Henseler C, Wormuth C, Soos J, Seidel R, Müller R, Arshaad MI, Broich K, Hescheler J, Sachinidis A, Ehninger D, Papazoglou A, Weiergräber M.

Data Brief. 2018 Oct 24;21:1263-1266. doi: 10.1016/j.dib.2018.10.056. eCollection 2018 Dec.


The Role of PCSK9 in the Pathogenesis of Non-alcoholic Fatty Liver Disease and the Effect of PCSK9 Inhibitors.

Theocharidou E, Papademetriou M, Reklou A, Sachinidis A, Boutari C, Giouleme O.

Curr Pharm Des. 2018;24(31):3654-3657. doi: 10.2174/1381612824666181010123127. Review.


Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart.

Sabour D, Machado RSR, Pinto JP, Rohani S, Sahito RGA, Hescheler J, Futschik ME, Sachinidis A.

Mol Ther Nucleic Acids. 2018 Sep 7;12:158-173. doi: 10.1016/j.omtn.2018.04.018. Epub 2018 May 4.


Combination of SGLT-2 Inhibitors and GLP-1 Receptor Agonists: Potential Benefits in Surrogate and Hard Endpoints.

Doumas M, Imprialos Κ, Stavropoulos K, Reklou A, Sachinidis A, Athyros VG.

Curr Pharm Des. 2018;24(17):1879-1886. doi: 10.2174/1381612824666180604113653. Review.


Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures.

Rodrigues RM, Kollipara L, Chaudhari U, Sachinidis A, Zahedi RP, Sickmann A, Kopp-Schneider A, Jiang X, Keun H, Hengstler J, Oorts M, Annaert P, Hoeben E, Gijbels E, De Kock J, Vanhaecke T, Rogiers V, Vinken M.

Arch Toxicol. 2018 Jun;92(6):1939-1952. doi: 10.1007/s00204-018-2214-z. Epub 2018 May 14.


Modulation of Differentiation Processes in Murine Embryonic Stem Cells Exposed to Parabolic Flight-Induced Acute Hypergravity and Microgravity.

Acharya A, Brungs S, Henry M, Rotshteyn T, Singh Yaduvanshi N, Wegener L, Jentzsch S, Hescheler J, Hemmersbach R, Boeuf H, Sachinidis A.

Stem Cells Dev. 2018 Jun 15;27(12):838-847. doi: 10.1089/scd.2017.0294. Epub 2018 Apr 9.


Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.

Filipova D, Henry M, Rotshteyn T, Brunn A, Carstov M, Deckert M, Hescheler J, Sachinidis A, Pfitzer G, Papadopoulos S.

PLoS One. 2018 Mar 15;13(3):e0194428. doi: 10.1371/journal.pone.0194428. eCollection 2018.


Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

Nemade H, Chaudhari U, Acharya A, Hescheler J, Hengstler JG, Papadopoulos S, Sachinidis A.

Arch Toxicol. 2018 Apr;92(4):1507-1524. doi: 10.1007/s00204-018-2170-7. Epub 2018 Feb 3.


Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.

Gaspar JA, Srinivasan SP, Sureshkumar P, Doss MX, Hescheler J, Papadopoulos S, Sachinidis A.

Sci Rep. 2017 Oct 27;7(1):14285. doi: 10.1038/s41598-017-14561-z.


Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab.

Skalkou A, Manoli SM, Sachinidis A, Ntouros V, Petidis K, Pagkopoulou E, Vakirlis E, Pyrpasopoulou A, Dimitroulas T.

Rheumatol Int. 2018 Jan;38(1):161-167. doi: 10.1007/s00296-017-3861-8. Epub 2017 Oct 26. Review.


Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Nemade H, Sureshkumar P, Vinken M, Ates G, Rogiers V, Hescheler J, Hengstler JG, Sachinidis A.

Arch Toxicol. 2018 Jan;92(1):371-381. doi: 10.1007/s00204-017-2065-z. Epub 2017 Sep 22.


STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation.

Sabour D, Srinivasan SP, Rohani S, Wagh V, Gaspar JA, Panek D, Ardestani MA, Doss MX, Riet N, Abken H, Hescheler J, Papadopoulos S, Sachinidis A.

Mol Ther Methods Clin Dev. 2017 Apr 14;5:116-129. doi: 10.1016/j.omtm.2017.04.001. eCollection 2017 Jun 16.


Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Ellis JK, Wagh V, Nemade H, Hescheler J, Keun HC, Sachinidis A.

Amino Acids. 2017 Dec;49(12):1955-1963. doi: 10.1007/s00726-017-2419-0. Epub 2017 Apr 18.


Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.

Pallocca G, Nyffeler J, Dolde X, Grinberg M, Gstraunthaler G, Waldmann T, Rahnenführer J, Sachinidis A, Leist M.

Arch Toxicol. 2017 Oct;91(10):3385-3402. doi: 10.1007/s00204-017-1966-1. Epub 2017 Apr 1.


Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.

Shinde V, Perumal Srinivasan S, Henry M, Rotshteyn T, Hescheler J, Rahnenführer J, Grinberg M, Meisig J, Blüthgen N, Waldmann T, Leist M, Hengstler JG, Sachinidis A.

Stem Cell Res Ther. 2016 Dec 30;7(1):190. doi: 10.1186/s13287-016-0449-2.


Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

Waldmann T, Grinberg M, König A, Rempel E, Schildknecht S, Henry M, Holzer AK, Dreser N, Shinde V, Sachinidis A, Rahnenführer J, Hengstler JG, Leist M.

Chem Res Toxicol. 2017 Apr 17;30(4):905-922. doi: 10.1021/acs.chemrestox.6b00259. Epub 2016 Dec 21.


Human Embryonic and Induced Pluripotent Stem Cell Based Toxicity Testing Models: Future Applications in New Drug Discovery.

Shinde V, Sureshkumar P, Sotiriadou I, Hescheler J, Sachinidis A.

Curr Med Chem. 2016;23(30):3495-3509. Review.


Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.


Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests.

Shinde V, Hoelting L, Srinivasan SP, Meisig J, Meganathan K, Jagtap S, Grinberg M, Liebing J, Bluethgen N, Rahnenführer J, Rempel E, Stoeber R, Schildknecht S, Förster S, Godoy P, van Thriel C, Gaspar JA, Hescheler J, Waldmann T, Hengstler JG, Leist M, Sachinidis A.

Arch Toxicol. 2017 Feb;91(2):839-864. doi: 10.1007/s00204-016-1741-8. Epub 2016 May 17.


Generation of Cardiomyocytes in Pipe-Based Microbioreactor Under Segmented Flow.

Spitkovsky D, Lemke K, Förster T, Römer R, Wiedemeier S, Hescheler J, Sachinidis A, Gastrock G.

Cell Physiol Biochem. 2016;38(5):1883-96. doi: 10.1159/000445550. Epub 2016 May 9.


"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

Fernando RN, Chaudhari U, Escher SE, Hengstler JG, Hescheler J, Jennings P, Keun HC, Kleinjans JCS, Kolde R, Kollipara L, Kopp-Schneider A, Limonciel A, Nemade H, Nguemo F, Peterson H, Prieto P, Rodrigues RM, Sachinidis A, Schäfer C, Sickmann A, Spitkovsky D, Stöber R, van Breda SGJ, van de Water B, Vivier M, Zahedi RP, Vinken M, Rogiers V.

Arch Toxicol. 2016 Jun;90(6):1529-1539. doi: 10.1007/s00204-016-1719-6. Epub 2016 Apr 29.


Corrigendum: Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel.

Filipova D, Walter AM, Gaspar JA, Brunn A, Linde NF, Ardestani MA, Deckert M, Hescheler J, Pfitzer G, Sachinidis A, Papadopoulos S.

Sci Rep. 2016 Apr 22;6:24450. doi: 10.1038/srep24450. No abstract available.


Highlight report: Cardiotoxicity screening.

Sachinidis A.

EXCLI J. 2016 Feb 22;15:163-5. doi: 10.17179/excli2016-180. eCollection 2016. No abstract available.


Simulated Microgravity Modulates Differentiation Processes of Embryonic Stem Cells.

Shinde V, Brungs S, Henry M, Wegener L, Nemade H, Rotshteyn T, Acharya A, Baumstark-Khan C, Hellweg CE, Hescheler J, Hemmersbach R, Sachinidis A.

Cell Physiol Biochem. 2016;38(4):1483-99. doi: 10.1159/000443090. Epub 2016 Apr 4.


Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

Colaianna M, Ilmjärv S, Peterson H, Kern I, Julien S, Baquié M, Pallocca G, Bosgra S, Sachinidis A, Hengstler JG, Leist M, Krause KH.

Arch Toxicol. 2017 Jan;91(1):365-391. doi: 10.1007/s00204-016-1690-2. Epub 2016 Mar 25.

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