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Items: 13


Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.

Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, Kaya T, Shi X, Robers MB, Machleidt T, Wilkinson J, Hermine O, Kung A, Stein AJ, Lakshminarasimhan D, Hemann MT, Scolnick E, Zhang YL, Pan JQ, Stegmaier K, Holson EB.

Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. doi: 10.1126/scitranslmed.aam8460.


Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

Weïwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, D Ordevic L, Sacher JR, Skepner A, Fei D, Dennehy K, Nguyen S, Faloon PW, Perez J, Cottrell JR, Liu F, Palmer M, Pan JQ, Hooker JM, Zhang YL, Scolnick E, Wagner FF, Holson EB.

ACS Chem Biol. 2018 Apr 20;13(4):1038-1047. doi: 10.1021/acschembio.8b00168. Epub 2018 Mar 14.


Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators.

Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS.

In Vivo. 2017 Jan 2;31(1):39-43.


A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis.

Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P.

ACS Cent Sci. 2016 Sep 28;2(9):653-659. Epub 2016 Sep 7.


Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

Wagner FF, Bishop JA, Gale JP, Shi X, Walk M, Ketterman J, Patnaik D, Barker D, Walpita D, Campbell AJ, Nguyen S, Lewis M, Ross L, Weïwer M, An WF, Germain AR, Nag PP, Metkar S, Kaya T, Dandapani S, Olson DE, Barbe AL, Lazzaro F, Sacher JR, Cheah JH, Fei D, Perez J, Munoz B, Palmer M, Stegmaier K, Schreiber SL, Scolnick E, Zhang YL, Haggarty SJ, Holson EB, Pan JQ.

ACS Chem Biol. 2016 Jul 15;11(7):1952-63. doi: 10.1021/acschembio.6b00306. Epub 2016 May 13.


Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells.

Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4828-4833. doi: 10.1016/j.bmcl.2015.06.073. Epub 2015 Jun 26.


Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence.

Chauhan PS, Sacher JR, Weinreb SM.

Org Lett. 2015 Feb 20;17(4):806-8. doi: 10.1021/ol503571a. Epub 2015 Feb 6.


Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.

Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S.

J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016/j.yjmcc.2014.10.009. Epub 2014 Oct 23.


An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.

Skoda EM, Sacher JR, Kazancioglu MZ, Saha J, Wipf P.

ACS Med Chem Lett. 2014 Jun 27;5(8):900-4. doi: 10.1021/ml5001504. eCollection 2014 Aug 14.


Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria.

Frantz MC, Skoda EM, Sacher JR, Epperly MW, Goff JP, Greenberger JS, Wipf P.

Org Biomol Chem. 2013 Jul 7;11(25):4147-53. doi: 10.1039/c3ob40489g.


Construction of the azocane (azacyclooctane) moiety of the Lycopodium alkaloid lycopladine H via an intramolecular hydroaminomethylation strategy.

Sacher JR, Weinreb SM.

Org Lett. 2012 Apr 20;14(8):2172-5. doi: 10.1021/ol3007277. Epub 2012 Apr 9.


Antireflection-coated blue GaN laser diodes in an external cavity and Doppler-free indium absorption spectroscopy.

Hildebrandt L, Knispel R, Stry S, Sacher JR, Schael F.

Appl Opt. 2003 Apr 20;42(12):2110-8.


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